Motif ID: Crx_Gsc
Z-value: 0.412
Transcription factors associated with Crx_Gsc:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Crx | ENSMUSG00000041578.9 | Crx |
| Gsc | ENSMUSG00000021095.4 | Gsc |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Crx | mm10_v2_chr7_-_15879844_15879968 | 0.21 | 2.1e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 86 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.8 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.1 | 1.8 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.1 | 1.8 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.2 | 1.7 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.3 | 1.6 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.0 | 1.3 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.1 | 1.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.2 | 1.1 | GO:0090273 | regulation of somatostatin secretion(GO:0090273) |
| 0.0 | 1.1 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 1.1 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.2 | 0.9 | GO:2000705 | regulation of dense core granule biogenesis(GO:2000705) |
| 0.1 | 0.9 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.0 | 0.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 0.8 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.1 | 0.8 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 0.1 | 0.7 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
| 0.1 | 0.7 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.0 | 0.7 | GO:0033574 | response to testosterone(GO:0033574) |
| 0.1 | 0.6 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
| 0.1 | 0.6 | GO:0046541 | saliva secretion(GO:0046541) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 33 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.3 | 3.2 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.4 | 1.8 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.0 | 1.8 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.8 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.7 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 0.7 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.6 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.5 | GO:0042581 | specific granule(GO:0042581) |
| 0.0 | 0.5 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 0.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.4 | GO:0002177 | manchette(GO:0002177) |
| 0.1 | 0.3 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 0.3 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.0 | 0.3 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 0.2 | GO:0032127 | dense core granule membrane(GO:0032127) |
| 0.0 | 0.2 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 0.2 | GO:0031983 | vesicle lumen(GO:0031983) |
| 0.0 | 0.2 | GO:0005859 | muscle myosin complex(GO:0005859) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 66 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.1 | 2.4 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 2.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.4 | 1.8 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 0.1 | 1.8 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.1 | 1.8 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.2 | 1.7 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.1 | 1.5 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 1.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 1.1 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.0 | 1.1 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 1.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.2 | 0.9 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.1 | 0.9 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 0.9 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.1 | 0.7 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.0 | 0.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.7 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 0.6 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.1 | 0.6 | GO:0015279 | store-operated calcium channel activity(GO:0015279) inositol 1,4,5 trisphosphate binding(GO:0070679) |
Gene overrepresentation in C2:CP category:
Showing 1 to 10 of 10 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.9 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 2.2 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 1.7 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.0 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.9 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 0.8 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.7 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.7 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.2 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.1 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 21 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 1.9 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 1.7 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 1.1 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.0 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.6 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.6 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.5 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.4 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.4 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.4 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.3 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.3 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 0.3 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.2 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 0.2 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 0.1 | REACTOME_CD28_DEPENDENT_VAV1_PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.1 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.1 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.1 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
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