Motif ID: Ctcfl_Ctcf

Z-value: 0.903

Transcription factors associated with Ctcfl_Ctcf:

Gene SymbolEntrez IDGene Name
Ctcf ENSMUSG00000005698.9 Ctcf
Ctcfl ENSMUSG00000070495.5 Ctcfl

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ctcflmm10_v2_chr2_-_173119402_173119525-0.455.5e-03Click!
Ctcfmm10_v2_chr8_+_105636509_105636589-0.251.4e-01Click!


Activity profile for motif Ctcfl_Ctcf.

activity profile for motif Ctcfl_Ctcf


Sorted Z-values histogram for motif Ctcfl_Ctcf

Sorted Z-values for motif Ctcfl_Ctcf



Network of associatons between targets according to the STRING database.



First level regulatory network of Ctcfl_Ctcf

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_34486125 8.497 ENSMUST00000115148.2
ENSMUST00000183580.1
 Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr13_-_54055650 7.351 ENSMUST00000021932.5
 Drd1a
dopamine receptor D1A
chr18_-_66291770 5.825 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1
chr6_-_136173492 5.291 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr15_-_44788016 4.820 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr5_-_123132651 4.696 ENSMUST00000031401.5
 Rhof
ras homolog gene family, member f
chr11_-_109298066 4.686 ENSMUST00000106706.1
 Rgs9
regulator of G-protein signaling 9
chr11_+_32286946 4.669 ENSMUST00000101387.3
 Hbq1b
hemoglobin, theta 1B
chr16_-_26371828 4.560 ENSMUST00000023154.2
 Cldn1
claudin 1
chr2_+_65620829 4.288 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr18_+_36952621 4.225 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr14_+_62555737 4.159 ENSMUST00000039064.7
 Fam124a
family with sequence similarity 124, member A
chr11_-_76577701 4.008 ENSMUST00000176179.1
 Abr
active BCR-related gene
chr2_-_32353283 3.893 ENSMUST00000091089.5
ENSMUST00000113350.1
 Dnm1

dynamin 1

chr2_-_32353247 3.853 ENSMUST00000078352.5
ENSMUST00000113352.2
ENSMUST00000113365.1
 Dnm1


dynamin 1


chr9_-_102354685 3.717 ENSMUST00000035129.7
ENSMUST00000085169.5
 Ephb1

Eph receptor B1

chr11_-_109298121 3.714 ENSMUST00000020920.3
 Rgs9
regulator of G-protein signaling 9
chr7_+_121392266 3.600 ENSMUST00000084628.3
 Hs3st2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr11_+_103103051 3.444 ENSMUST00000152971.1
 Acbd4
acyl-Coenzyme A binding domain containing 4
chr11_-_45944910 3.281 ENSMUST00000129820.1
 Lsm11
U7 snRNP-specific Sm-like protein LSM11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 200 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.3 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 9.7 GO:0007416 synapse assembly(GO:0007416)
1.0 9.3 GO:1900034 regulation of cellular response to heat(GO:1900034)
1.7 8.5 GO:0002121 inter-male aggressive behavior(GO:0002121)
1.1 7.7 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
1.5 5.8 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
1.4 5.7 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
1.3 5.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
1.5 4.6 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
1.3 4.0 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.8 4.0 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
1.0 3.9 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.7 3.7 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
1.2 3.5 GO:0043181 vacuolar sequestering(GO:0043181)
0.0 3.5 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.4 3.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.2 3.2 GO:0051764 actin crosslink formation(GO:0051764)
0.8 3.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
1.0 3.0 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.5 3.0 GO:0032439 endosome localization(GO:0032439)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 10.4 GO:0043196 varicosity(GO:0043196)
0.1 10.3 GO:0070382 exocytic vesicle(GO:0070382)
0.1 10.0 GO:0043198 dendritic shaft(GO:0043198)
0.9 9.3 GO:0045298 tubulin complex(GO:0045298)
0.3 9.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 8.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.4 5.3 GO:0043083 synaptic cleft(GO:0043083)
0.1 5.2 GO:0005581 collagen trimer(GO:0005581)
0.0 5.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 5.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.6 4.8 GO:0097433 dense body(GO:0097433)
0.0 4.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 4.4 GO:0001650 fibrillar center(GO:0001650)
0.2 3.6 GO:0032433 filopodium tip(GO:0032433)
0.7 3.3 GO:0005683 U7 snRNP(GO:0005683)
0.0 3.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 3.0 GO:0014069 postsynaptic density(GO:0014069)
0.1 2.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.3 GO:0002102 podosome(GO:0002102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 13.0 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 12.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 10.3 GO:0030165 PDZ domain binding(GO:0030165)
1.3 9.3 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 5.8 GO:0051117 ATPase binding(GO:0051117)
0.2 4.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.4 4.6 GO:0001618 virus receptor activity(GO:0001618)
0.1 4.4 GO:0005518 collagen binding(GO:0005518)
1.0 4.0 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
1.3 3.9 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 3.6 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
1.2 3.5 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
1.1 3.3 GO:0071209 U7 snRNA binding(GO:0071209)
0.4 3.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 3.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.8 3.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.6 3.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.6 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 2.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.8 9.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.5 9.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 6.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 5.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 5.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 5.7 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 5.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 4.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 3.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 2.9 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.2 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.9 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 1.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.7 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.2 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 1.1 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.0 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.4 9.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 8.1 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.3 7.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 6.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 5.7 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.2 5.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 5.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 5.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 4.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 3.9 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 3.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.6 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 3.2 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 3.0 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 2.9 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 2.6 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 2.4 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
0.2 2.1 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 2.1 REACTOME_GLYCOLYSIS Genes involved in Glycolysis