Motif ID: Cux1

Z-value: 0.987


Transcription factors associated with Cux1:

Gene SymbolEntrez IDGene Name
Cux1 ENSMUSG00000029705.11 Cux1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cux1mm10_v2_chr5_-_136567242_1365672870.802.0e-09Click!


Activity profile for motif Cux1.

activity profile for motif Cux1


Sorted Z-values histogram for motif Cux1

Sorted Z-values for motif Cux1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cux1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78499087 8.883 ENSMUST00000017488.4
 Vtn
vitronectin
chr7_-_103827922 5.357 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr11_-_42182924 5.255 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr2_+_71528657 5.032 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr2_+_71529085 4.679 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr10_-_117282262 4.631 ENSMUST00000092163.7
 Lyz2
lysozyme 2
chr9_-_112232449 3.753 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr11_+_32286946 3.572 ENSMUST00000101387.3
 Hbq1b
hemoglobin, theta 1B
chr5_+_66968559 3.462 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr9_-_77347816 3.270 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr3_-_53657339 3.257 ENSMUST00000091137.4
 Frem2
Fras1 related extracellular matrix protein 2
chr7_-_140154712 3.145 ENSMUST00000059241.7
 Sprn
shadow of prion protein
chr2_-_164171113 3.074 ENSMUST00000045196.3
 Kcns1
K+ voltage-gated channel, subfamily S, 1
chr2_-_25224653 3.056 ENSMUST00000043584.4
 Tubb4b
tubulin, beta 4B class IVB
chr4_+_119814495 3.016 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr7_-_19166119 3.011 ENSMUST00000094790.3
 Gipr
gastric inhibitory polypeptide receptor
chr9_-_112185726 2.953 ENSMUST00000160240.1
ENSMUST00000162065.1
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr9_-_112185939 2.896 ENSMUST00000070218.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr15_+_21111452 2.882 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr17_-_68004075 2.836 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 184 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.4 GO:0034605 cellular response to heat(GO:0034605)
3.2 9.7 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.8 9.0 GO:0097421 liver regeneration(GO:0097421)
0.0 7.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.6 5.3 GO:0071420 cellular response to histamine(GO:0071420)
0.2 5.3 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1 5.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.7 5.0 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
1.5 4.6 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 3.8 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.0 3.2 GO:0007416 synapse assembly(GO:0007416)
0.1 2.9 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.9 2.8 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.7 2.8 GO:1904425 negative regulation of GTP binding(GO:1904425)
1.2 2.5 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.8 2.5 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.1 2.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 2.5 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.5 2.4 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.3 2.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 13.5 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
1.3 5.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.4 5.3 GO:1902711 GABA-A receptor complex(GO:1902711)
1.7 5.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 4.2 GO:0005604 basement membrane(GO:0005604)
0.0 4.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.4 GO:0031225 anchored component of membrane(GO:0031225)
0.3 3.1 GO:0045298 tubulin complex(GO:0045298)
0.3 3.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 3.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.8 GO:0016605 PML body(GO:0016605)
0.8 2.5 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.6 2.5 GO:0042627 chylomicron(GO:0042627)
0.0 2.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 2.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 2.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 2.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 1.9 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.5 1.8 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 1.7 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.9 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 7.7 GO:0005516 calmodulin binding(GO:0005516)
0.1 5.9 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
1.3 5.4 GO:0031720 haptoglobin binding(GO:0031720)
0.9 5.3 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 5.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.7 5.0 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.5 4.6 GO:0003796 lysozyme activity(GO:0003796)
0.1 3.3 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.2 3.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 3.1 GO:0031489 myosin V binding(GO:0031489)
0.1 3.1 GO:0017046 peptide hormone binding(GO:0017046)
0.1 3.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 3.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.9 2.8 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 2.7 GO:0051087 chaperone binding(GO:0051087)
0.2 2.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 2.5 GO:0043274 phospholipase binding(GO:0043274)
0.0 2.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.5 2.4 GO:0019960 C-X3-C chemokine binding(GO:0019960)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 7.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 3.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 2.2 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.3 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.0 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.8 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.8 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.6 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.5 PID_GLYPICAN_1PATHWAY Glypican 1 network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.1 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 8.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 5.3 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 5.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 4.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 4.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 2.6 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.5 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.3 2.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 2.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.4 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 2.3 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 2.2 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.2 2.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.2 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 2.2 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.8 REACTOME_SIGNALING_BY_NOTCH2 Genes involved in Signaling by NOTCH2
0.2 1.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis