Motif ID: Cxxc1

Z-value: 0.495


Transcription factors associated with Cxxc1:

Gene SymbolEntrez IDGene Name
Cxxc1 ENSMUSG00000024560.6 Cxxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cxxc1mm10_v2_chr18_+_74216118_74216145-0.642.1e-05Click!


Activity profile for motif Cxxc1.

activity profile for motif Cxxc1


Sorted Z-values histogram for motif Cxxc1

Sorted Z-values for motif Cxxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cxxc1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_97415527 3.564 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr11_-_89302545 1.870 ENSMUST00000061728.3
 Nog
noggin
chr5_+_30588078 1.686 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr3_-_8964037 1.230 ENSMUST00000091354.5
ENSMUST00000094381.4
 Tpd52

tumor protein D52

chr19_-_19111181 1.230 ENSMUST00000112832.1
 Rorb
RAR-related orphan receptor beta
chr8_+_70594466 1.041 ENSMUST00000019283.9
 Isyna1
myo-inositol 1-phosphate synthase A1
chr11_-_69921057 0.999 ENSMUST00000108609.1
ENSMUST00000108608.1
ENSMUST00000164359.1
 Eif5a


eukaryotic translation initiation factor 5A


chr8_-_122443404 0.907 ENSMUST00000006692.4
 Mvd
mevalonate (diphospho) decarboxylase
chr11_-_69920581 0.891 ENSMUST00000108610.1
 Eif5a
eukaryotic translation initiation factor 5A
chr17_-_14203695 0.858 ENSMUST00000053218.5
 Dact2
dapper homolog 2, antagonist of beta-catenin (xenopus)
chr5_-_125389177 0.836 ENSMUST00000108707.2
 Ubc
ubiquitin C
chrX_-_158043266 0.820 ENSMUST00000026750.8
ENSMUST00000112513.1
 Cnksr2

connector enhancer of kinase suppressor of Ras 2

chr1_-_124045523 0.818 ENSMUST00000112606.1
 Dpp10
dipeptidylpeptidase 10
chr11_-_69920892 0.817 ENSMUST00000152589.1
ENSMUST00000108612.1
ENSMUST00000108611.1
 Eif5a


eukaryotic translation initiation factor 5A


chr1_-_124045247 0.727 ENSMUST00000112603.2
 Dpp10
dipeptidylpeptidase 10
chr2_+_112239468 0.567 ENSMUST00000028554.3
 Lpcat4
lysophosphatidylcholine acyltransferase 4
chr18_-_43477764 0.554 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr10_+_50895651 0.508 ENSMUST00000020071.3
 Sim1
single-minded homolog 1 (Drosophila)
chr7_+_45896941 0.494 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chrX_-_7375830 0.492 ENSMUST00000115744.1
 Usp27x
ubiquitin specific peptidase 27, X chromosome
chr5_-_125389915 0.468 ENSMUST00000136312.1
 Ubc
ubiquitin C
chr15_+_74516196 0.448 ENSMUST00000042035.9
 Bai1
brain-specific angiogenesis inhibitor 1
chr5_+_125389284 0.425 ENSMUST00000100700.2
 Gm10382
predicted gene 10382
chr9_-_78108617 0.407 ENSMUST00000085311.6
 Fbxo9
f-box protein 9
chr7_-_49636847 0.398 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr10_+_128058947 0.376 ENSMUST00000052798.7
 Ptges3
prostaglandin E synthase 3 (cytosolic)
chr15_-_77153772 0.368 ENSMUST00000166610.1
ENSMUST00000111581.2
 Rbfox2

RNA binding protein, fox-1 homolog (C. elegans) 2

chrX_+_53607918 0.366 ENSMUST00000114827.1
 Cxx1c
CAAX box 1C
chrX_+_53607987 0.351 ENSMUST00000063384.3
ENSMUST00000169626.1
 Cxx1c

CAAX box 1C

chr10_+_128058974 0.341 ENSMUST00000084771.2
 Ptges3
prostaglandin E synthase 3 (cytosolic)
chr19_-_5273080 0.337 ENSMUST00000025786.7
 Pacs1
phosphofurin acidic cluster sorting protein 1
chr9_-_78108587 0.307 ENSMUST00000162625.1
ENSMUST00000159099.1
 Fbxo9

f-box protein 9

chr9_-_78109020 0.283 ENSMUST00000001402.7
 Fbxo9
f-box protein 9
chr5_-_45857473 0.280 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
 Lcorl


ligand dependent nuclear receptor corepressor-like


chr16_-_4420416 0.243 ENSMUST00000120080.1
 Adcy9
adenylate cyclase 9
chr10_+_80249441 0.242 ENSMUST00000020361.6
 Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr12_-_54656496 0.239 ENSMUST00000056228.6
 Sptssa
serine palmitoyltransferase, small subunit A
chr10_-_79766872 0.227 ENSMUST00000047203.8
 Rnf126
ring finger protein 126
chr10_+_85928491 0.220 ENSMUST00000170396.1
 Ascl4
achaete-scute complex homolog 4 (Drosophila)
chr3_+_68869563 0.214 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr19_-_36919606 0.208 ENSMUST00000057337.7
 Fgfbp3
fibroblast growth factor binding protein 3
chrX_+_48623737 0.186 ENSMUST00000114936.1
 Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr5_+_143403819 0.158 ENSMUST00000110731.2
 Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr5_-_65391380 0.150 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
 Rpl9


ribosomal protein L9


chr5_-_65391408 0.144 ENSMUST00000057885.6
 Rpl9
ribosomal protein L9
chr10_-_7681118 0.135 ENSMUST00000159977.1
ENSMUST00000162682.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr11_+_71019593 0.124 ENSMUST00000133413.1
ENSMUST00000164220.1
ENSMUST00000048807.5
 Mis12


MIS12 homolog (yeast)


chr2_+_147012996 0.074 ENSMUST00000028921.5
 Xrn2
5'-3' exoribonuclease 2
chr8_+_92357787 0.071 ENSMUST00000034184.10
 Irx5
Iroquois related homeobox 5 (Drosophila)
chr11_-_77489666 0.052 ENSMUST00000037593.7
ENSMUST00000092892.3
 Ankrd13b

ankyrin repeat domain 13b

chr5_-_35679416 0.050 ENSMUST00000114233.2
 Htra3
HtrA serine peptidase 3
chr5_+_125441546 0.039 ENSMUST00000049040.9
 Bri3bp
Bri3 binding protein
chr2_+_181680284 0.028 ENSMUST00000103042.3
 Tcea2
transcription elongation factor A (SII), 2
chr4_+_109000606 0.021 ENSMUST00000065977.4
ENSMUST00000102736.2
 Nrd1

nardilysin, N-arginine dibasic convertase, NRD convertase 1

chr4_+_109000770 0.009 ENSMUST00000106644.2
 Nrd1
nardilysin, N-arginine dibasic convertase, NRD convertase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.5 2.7 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.3 0.9 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.2 0.9 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 1.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.7 GO:0046549 retinal cone cell development(GO:0046549)
0.1 1.0 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.7 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.3 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 1.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.2 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.4 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 1.5 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078)
0.0 0.2 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.5 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 3.6 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0051315 protein localization to kinetochore(GO:0034501) attachment of mitotic spindle microtubules to kinetochore(GO:0051315)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.0 0.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0030137 COPI-coated vesicle(GO:0030137)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.3 1.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 0.6 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.2 0.7 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 2.7 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 1.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.9 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.5 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0004534 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160) 5'-3' exoribonuclease activity(GO:0004534)
0.0 1.9 GO:0019955 cytokine binding(GO:0019955)
0.0 0.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.2 GO:0048038 quinone binding(GO:0048038)
0.0 3.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.3 GO:0002020 protease binding(GO:0002020)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.9 PID_TGFBR_PATHWAY TGF-beta receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.7 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 0.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 1.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.2 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.2 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway