Motif ID: Dbp
Z-value: 0.955
Transcription factors associated with Dbp:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Dbp | ENSMUSG00000059824.4 | Dbp |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Dbp | mm10_v2_chr7_+_45705088_45705292 | -0.50 | 1.5e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 5.9 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
| 1.5 | 4.4 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
| 0.9 | 2.8 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 0.9 | 3.5 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.8 | 10.0 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.7 | 6.7 | GO:0014824 | artery smooth muscle contraction(GO:0014824) |
| 0.6 | 1.9 | GO:0098923 | retrograde trans-synaptic signaling by soluble gas(GO:0098923) |
| 0.6 | 2.4 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.6 | 3.5 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.6 | 9.8 | GO:1902993 | positive regulation of amyloid precursor protein catabolic process(GO:1902993) |
| 0.6 | 3.4 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
| 0.5 | 2.7 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.5 | 1.4 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 0.5 | 2.7 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.5 | 2.3 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.4 | 1.8 | GO:1904800 | regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) |
| 0.4 | 3.4 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.4 | 2.9 | GO:0061368 | maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.4 | 3.3 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.3 | 2.1 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.3 | 3.1 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 0.3 | 0.8 | GO:2000224 | regulation of testosterone biosynthetic process(GO:2000224) |
| 0.3 | 2.5 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.3 | 0.8 | GO:1902630 | regulation of membrane hyperpolarization(GO:1902630) |
| 0.3 | 1.3 | GO:0010993 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 0.2 | 4.4 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.2 | 0.5 | GO:0060167 | regulation of adenosine receptor signaling pathway(GO:0060167) |
| 0.2 | 1.1 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.2 | 4.0 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.2 | 1.4 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.2 | 2.2 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.2 | 1.8 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.2 | 1.1 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.2 | 1.2 | GO:0098909 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 0.2 | 0.3 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.2 | 0.5 | GO:0071707 | immunoglobulin heavy chain V-D-J recombination(GO:0071707) |
| 0.2 | 0.6 | GO:2000211 | regulation of glutamate metabolic process(GO:2000211) |
| 0.2 | 0.8 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.1 | 1.9 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.1 | 1.0 | GO:0021937 | cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937) |
| 0.1 | 0.9 | GO:0061052 | negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052) |
| 0.1 | 1.4 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.1 | 0.6 | GO:0036324 | negative regulation of toll-like receptor 4 signaling pathway(GO:0034144) vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) |
| 0.1 | 0.1 | GO:0070366 | regulation of hepatocyte differentiation(GO:0070366) |
| 0.1 | 1.3 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.1 | 1.4 | GO:1901898 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.1 | 0.3 | GO:2000569 | T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570) |
| 0.1 | 0.5 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.1 | 7.4 | GO:0060395 | SMAD protein signal transduction(GO:0060395) |
| 0.1 | 7.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.1 | 0.6 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.1 | 0.1 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.1 | 0.4 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.1 | 0.4 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.1 | 1.5 | GO:0035584 | calcium-mediated signaling using intracellular calcium source(GO:0035584) |
| 0.1 | 0.2 | GO:0007223 | Wnt signaling pathway, calcium modulating pathway(GO:0007223) progesterone secretion(GO:0042701) |
| 0.1 | 0.9 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.1 | 0.3 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.1 | 0.5 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.1 | 3.9 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.1 | 1.7 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 3.1 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.1 | 0.9 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
| 0.1 | 0.2 | GO:0002408 | myeloid dendritic cell chemotaxis(GO:0002408) |
| 0.1 | 0.3 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.1 | 0.2 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 0.1 | 1.1 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.1 | 0.2 | GO:2000170 | positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170) |
| 0.1 | 1.4 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 0.3 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.1 | 1.3 | GO:0051968 | positive regulation of synaptic transmission, glutamatergic(GO:0051968) |
| 0.1 | 0.3 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.0 | 1.5 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.0 | 0.6 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.0 | 0.2 | GO:0060050 | positive regulation of protein glycosylation(GO:0060050) |
| 0.0 | 3.8 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 0.9 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.0 | 0.8 | GO:0010155 | regulation of proton transport(GO:0010155) |
| 0.0 | 0.6 | GO:2000811 | negative regulation of anoikis(GO:2000811) |
| 0.0 | 0.9 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.0 | 3.2 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.0 | 0.1 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.0 | 0.7 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.0 | 2.0 | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200) |
| 0.0 | 0.8 | GO:0034308 | primary alcohol metabolic process(GO:0034308) |
| 0.0 | 1.2 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.5 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
| 0.0 | 0.6 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.4 | GO:0045003 | DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003) |
| 0.0 | 0.6 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
| 0.0 | 0.2 | GO:0036438 | positive regulation of heterotypic cell-cell adhesion(GO:0034116) maintenance of lens transparency(GO:0036438) |
| 0.0 | 0.5 | GO:0021702 | cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.0 | 0.6 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.3 | GO:0042473 | outer ear morphogenesis(GO:0042473) |
| 0.0 | 3.0 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 1.3 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 0.2 | GO:0021593 | rhombomere morphogenesis(GO:0021593) |
| 0.0 | 0.1 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
| 0.0 | 0.3 | GO:1902969 | mitotic DNA replication(GO:1902969) |
| 0.0 | 2.0 | GO:0007173 | epidermal growth factor receptor signaling pathway(GO:0007173) |
| 0.0 | 2.3 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 1.4 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.0 | 0.5 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.0 | 0.6 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 0.0 | 0.4 | GO:0050884 | neuromuscular process controlling posture(GO:0050884) |
| 0.0 | 0.7 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 0.0 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.0 | 0.4 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.0 | 0.1 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 0.0 | 0.2 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.0 | 0.2 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.0 | 1.4 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 0.2 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.0 | 0.1 | GO:0043312 | neutrophil degranulation(GO:0043312) |
| 0.0 | 0.3 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.0 | 0.3 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 0.2 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 0.4 | GO:2001240 | negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240) |
| 0.0 | 0.4 | GO:0070306 | lens fiber cell differentiation(GO:0070306) |
| 0.0 | 0.1 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.0 | 0.2 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.0 | 1.5 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.0 | 0.9 | GO:0050775 | positive regulation of dendrite morphogenesis(GO:0050775) |
| 0.0 | 0.1 | GO:0071107 | post-embryonic body morphogenesis(GO:0040032) response to parathyroid hormone(GO:0071107) |
| 0.0 | 1.2 | GO:0031398 | positive regulation of protein ubiquitination(GO:0031398) |
| 0.0 | 1.6 | GO:0006836 | neurotransmitter transport(GO:0006836) |
| 0.0 | 1.1 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.0 | 0.1 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.0 | 0.1 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) aggresome assembly(GO:0070842) |
| 0.0 | 0.4 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.0 | 0.4 | GO:0030317 | sperm motility(GO:0030317) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.5 | GO:0042627 | chylomicron(GO:0042627) |
| 0.5 | 6.9 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.4 | 1.3 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.4 | 1.7 | GO:0031673 | H zone(GO:0031673) |
| 0.4 | 3.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.3 | 1.4 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.3 | 0.8 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.2 | 1.5 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.2 | 4.4 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.2 | 1.1 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.2 | 1.8 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.2 | 0.6 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.2 | 0.9 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.1 | 3.5 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 8.0 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 5.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 0.5 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.1 | 0.2 | GO:1990812 | growth cone filopodium(GO:1990812) |
| 0.1 | 2.7 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 2.5 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.1 | 1.1 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.1 | 28.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 1.5 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 5.4 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 0.4 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.1 | 12.2 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.1 | 1.4 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 1.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 0.4 | GO:0033061 | DNA recombinase mediator complex(GO:0033061) |
| 0.1 | 0.5 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.3 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.0 | 0.2 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.2 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.2 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.3 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 0.3 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 0.2 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 1.9 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 1.3 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.2 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 0.7 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.4 | GO:0070461 | SAGA-type complex(GO:0070461) |
| 0.0 | 0.5 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.9 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.5 | GO:0016235 | aggresome(GO:0016235) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.5 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.6 | 2.5 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.5 | 8.6 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.5 | 2.3 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.4 | 4.0 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.4 | 1.3 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.4 | 3.2 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.4 | 6.9 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.4 | 2.5 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.4 | 2.5 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.3 | 1.4 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 0.3 | 3.5 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.3 | 1.1 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.2 | 12.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.2 | 4.4 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.2 | 0.9 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.2 | 2.1 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.2 | 0.8 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.2 | 0.8 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.2 | 1.4 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795) |
| 0.2 | 0.8 | GO:0031800 | type 3 metabotropic glutamate receptor binding(GO:0031800) |
| 0.2 | 0.8 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.2 | 1.3 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.2 | 3.1 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.2 | 0.5 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.2 | 5.6 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 0.7 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.1 | 2.8 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.1 | 0.4 | GO:0042284 | sphingolipid delta-4 desaturase activity(GO:0042284) |
| 0.1 | 1.2 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
| 0.1 | 0.4 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.1 | 1.1 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.1 | 0.5 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.1 | 1.5 | GO:0030955 | potassium ion binding(GO:0030955) |
| 0.1 | 1.4 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.1 | 1.3 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.1 | 0.7 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.1 | 0.6 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.1 | 1.3 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.1 | 0.6 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.1 | 2.4 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 6.7 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.1 | 0.9 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 0.2 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.1 | 0.1 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.1 | 1.4 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 3.0 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 6.4 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.1 | 0.5 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.1 | 0.2 | GO:0001032 | RNA polymerase III type 3 promoter DNA binding(GO:0001032) |
| 0.0 | 1.3 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.8 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 1.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 1.4 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.5 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 1.5 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 1.2 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 0.4 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.3 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.2 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.0 | 0.1 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.0 | 1.3 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 0.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.3 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 0.4 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 1.2 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.2 | GO:0004690 | cyclic nucleotide-dependent protein kinase activity(GO:0004690) |
| 0.0 | 0.9 | GO:0008081 | phosphoric diester hydrolase activity(GO:0008081) |
| 0.0 | 2.8 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 0.3 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 1.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.1 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.0 | 0.3 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.2 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.0 | 0.2 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 1.4 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.3 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.6 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 2.9 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.1 | 1.3 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.1 | 2.4 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 4.4 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.1 | 1.9 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 1.9 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 1.5 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.0 | 1.3 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 3.3 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.9 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.6 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.5 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 2.2 | PID_ERBB1_DOWNSTREAM_PATHWAY | ErbB1 downstream signaling |
| 0.0 | 1.4 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.6 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.5 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 3.5 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.6 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.2 | PID_GMCSF_PATHWAY | GMCSF-mediated signaling events |
| 0.0 | 1.2 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.3 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.3 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 10.4 | REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.2 | 6.0 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.2 | 3.5 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 3.5 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 2.8 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.1 | 2.3 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 1.9 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 4.4 | REACTOME_SIGNAL_TRANSDUCTION_BY_L1 | Genes involved in Signal transduction by L1 |
| 0.1 | 2.5 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 1.1 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 1.3 | REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING | Genes involved in GRB2 events in ERBB2 signaling |
| 0.1 | 1.6 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 1.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 0.8 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 1.4 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.6 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.0 | 3.6 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.6 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.6 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.5 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.0 | 1.3 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 1.5 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.4 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 3.4 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 1.2 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.5 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.5 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 1.1 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.3 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.8 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.3 | REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 0.8 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
