Motif ID: Ddit3
Z-value: 0.559
Transcription factors associated with Ddit3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Ddit3 | ENSMUSG00000025408.9 | Ddit3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ddit3 | mm10_v2_chr10_+_127290774_127290803 | -0.56 | 3.4e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.0 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 0.5 | 4.2 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.4 | 2.7 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.4 | 1.1 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.3 | 3.7 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
| 0.3 | 2.0 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.3 | 1.0 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
| 0.3 | 0.9 | GO:0051715 | cytolysis in other organism(GO:0051715) |
| 0.2 | 0.6 | GO:0034334 | adherens junction maintenance(GO:0034334) |
| 0.2 | 0.6 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) |
| 0.2 | 1.2 | GO:0006561 | proline biosynthetic process(GO:0006561) |
| 0.2 | 1.7 | GO:0051901 | positive regulation of mitochondrial depolarization(GO:0051901) |
| 0.2 | 1.0 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.2 | 0.8 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
| 0.2 | 0.8 | GO:0060066 | oviduct development(GO:0060066) response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681) |
| 0.1 | 2.3 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.1 | 0.8 | GO:0006004 | fucose metabolic process(GO:0006004) |
| 0.1 | 0.3 | GO:0097360 | chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382) |
| 0.1 | 0.7 | GO:0051004 | regulation of lipoprotein lipase activity(GO:0051004) |
| 0.1 | 0.6 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
| 0.1 | 0.6 | GO:0036089 | cleavage furrow formation(GO:0036089) |
| 0.1 | 0.9 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 0.1 | 1.6 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.1 | 0.3 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 0.1 | 0.5 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane(GO:0071816) |
| 0.1 | 1.0 | GO:0015809 | arginine transport(GO:0015809) |
| 0.1 | 0.5 | GO:2000258 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
| 0.1 | 0.3 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.1 | 0.3 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.0 | 1.3 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.0 | 0.2 | GO:0002481 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476) antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481) |
| 0.0 | 0.2 | GO:0099527 | postsynapse to nucleus signaling pathway(GO:0099527) |
| 0.0 | 1.0 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.0 | 0.7 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.0 | 0.2 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.0 | 3.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.8 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 0.4 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.0 | 0.2 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.0 | 0.3 | GO:0031125 | rRNA 3'-end processing(GO:0031125) |
| 0.0 | 0.1 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.0 | 0.7 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
| 0.0 | 0.2 | GO:0033184 | positive regulation of histone ubiquitination(GO:0033184) |
| 0.0 | 0.1 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.0 | 0.3 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.0 | 0.1 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
| 0.0 | 0.1 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.0 | 0.3 | GO:0042407 | cristae formation(GO:0042407) |
| 0.0 | 2.9 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.0 | 0.2 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.0 | 0.1 | GO:0051103 | DNA ligation involved in DNA repair(GO:0051103) |
| 0.0 | 0.5 | GO:0000305 | response to oxygen radical(GO:0000305) |
| 0.0 | 0.1 | GO:2000973 | regulation of pro-B cell differentiation(GO:2000973) |
| 0.0 | 0.1 | GO:0070086 | ubiquitin-dependent endocytosis(GO:0070086) |
| 0.0 | 0.8 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.0 | 0.1 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.5 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.2 | 0.8 | GO:0031673 | H zone(GO:0031673) |
| 0.2 | 2.5 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.1 | 4.2 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 0.4 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
| 0.1 | 1.7 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 0.8 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 2.4 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 3.7 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 1.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 0.7 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 0.8 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.1 | 1.0 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.1 | 0.2 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.0 | 0.7 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.0 | 0.3 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.0 | 0.3 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.5 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 2.3 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.9 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.1 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.0 | 0.6 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.5 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 0.3 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 1.6 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 0.2 | GO:0005682 | U5 snRNP(GO:0005682) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.0 | GO:0004104 | cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
| 0.5 | 2.3 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.4 | 1.1 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.3 | 1.2 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.3 | 0.8 | GO:0015928 | alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928) |
| 0.2 | 0.9 | GO:0042834 | peptidoglycan binding(GO:0042834) |
| 0.2 | 1.1 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 0.6 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.1 | 1.0 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.1 | 2.7 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 0.3 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
| 0.1 | 0.5 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.1 | 3.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 1.7 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 4.8 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 0.3 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.1 | 1.5 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.1 | 1.3 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 0.2 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.1 | 0.8 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 0.8 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
| 0.0 | 2.0 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.3 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 1.2 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.2 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.0 | 1.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.2 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.0 | 0.1 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 1.0 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.7 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.3 | GO:0008106 | alcohol dehydrogenase (NADP+) activity(GO:0008106) |
| 0.0 | 0.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.1 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.0 | 0.4 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.6 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 0.1 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
| 0.0 | 1.6 | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810) |
| 0.0 | 0.6 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.0 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.5 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 2.0 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.8 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 1.1 | PID_ENDOTHELIN_PATHWAY | Endothelins |
| 0.0 | 0.9 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.8 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.3 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.6 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 2.0 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.1 | 1.6 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 1.3 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 2.7 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.3 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 2.7 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.6 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.0 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.5 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.6 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.2 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
