Motif ID: Ddit3

Z-value: 0.559


Transcription factors associated with Ddit3:

Gene SymbolEntrez IDGene Name
Ddit3 ENSMUSG00000025408.9 Ddit3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ddit3mm10_v2_chr10_+_127290774_127290803-0.563.4e-04Click!


Activity profile for motif Ddit3.

activity profile for motif Ddit3


Sorted Z-values histogram for motif Ddit3

Sorted Z-values for motif Ddit3



Network of associatons between targets according to the STRING database.



First level regulatory network of Ddit3

PNG image of the network

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Top targets:


Showing 1 to 20 of 138 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66948419 3.696 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr19_-_59076069 3.181 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chrX_+_103422010 2.625 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr10_-_109823585 2.400 ENSMUST00000161582.1
 Nav3
neuron navigator 3
chr6_+_21215472 2.302 ENSMUST00000081542.5
 Kcnd2
potassium voltage-gated channel, Shal-related family, member 2
chr3_-_53657339 2.256 ENSMUST00000091137.4
 Frem2
Fras1 related extracellular matrix protein 2
chr4_+_103619580 2.000 ENSMUST00000106827.1
 Dab1
disabled 1
chr5_+_137288273 1.957 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr18_+_37421418 1.888 ENSMUST00000053073.4
 Pcdhb11
protocadherin beta 11
chr9_-_121495678 1.741 ENSMUST00000035120.4
 Cck
cholecystokinin
chr14_-_66868572 1.553 ENSMUST00000022629.8
 Dpysl2
dihydropyrimidinase-like 2
chr3_+_9403049 1.516 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
 C030034L19Rik


RIKEN cDNA C030034L19 gene


chr16_-_60605226 1.515 ENSMUST00000068860.6
 Epha6
Eph receptor A6
chrX_-_162565514 1.420 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr11_-_120643643 1.245 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
 Pycr1




pyrroline-5-carboxylate reductase 1




chr1_-_126492900 1.217 ENSMUST00000161954.1
 Nckap5
NCK-associated protein 5
chr3_-_127409014 1.175 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
 Ank2


ankyrin 2, brain


chr13_+_42680565 1.156 ENSMUST00000128646.1
 Phactr1
phosphatase and actin regulator 1
chr3_-_49757257 1.115 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr3_-_127408937 1.104 ENSMUST00000183095.1
ENSMUST00000182610.1
 Ank2

ankyrin 2, brain


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 3.7 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 3.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.9 GO:0007416 synapse assembly(GO:0007416)
0.4 2.7 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 2.3 GO:0045475 locomotor rhythm(GO:0045475)
0.7 2.0 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.3 2.0 GO:0019695 choline metabolic process(GO:0019695)
0.2 1.7 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.1 1.6 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.0 1.3 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.2 1.2 GO:0006561 proline biosynthetic process(GO:0006561)
0.4 1.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.3 1.0 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.2 1.0 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.0 GO:0015809 arginine transport(GO:0015809)
0.0 1.0 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.3 0.9 GO:0051715 cytolysis in other organism(GO:0051715)
0.1 0.9 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.2 0.8 GO:0018364 peptidyl-glutamine methylation(GO:0018364)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 GO:0031430 M band(GO:0031430)
0.1 3.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.4 2.5 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.2 2.5 GO:0043083 synaptic cleft(GO:0043083)
0.1 2.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.3 GO:0005604 basement membrane(GO:0005604)
0.1 1.7 GO:0043203 axon hillock(GO:0043203)
0.0 1.6 GO:0005903 brush border(GO:0005903)
0.1 1.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.0 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.2 0.8 GO:0031673 H zone(GO:0031673)
0.1 0.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.8 GO:0016600 flotillin complex(GO:0016600)
0.1 0.7 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.7 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.5 GO:0031045 dense core granule(GO:0031045)
0.0 0.5 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 GO:0030507 spectrin binding(GO:0030507)
0.1 3.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 2.7 GO:0051787 misfolded protein binding(GO:0051787)
0.5 2.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.5 2.0 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.0 2.0 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.6 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.1 1.5 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 1.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 1.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.4 1.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.2 1.1 GO:0001849 complement component C1q binding(GO:0001849)
0.1 1.0 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 1.0 GO:0070412 R-SMAD binding(GO:0070412)
0.2 0.9 GO:0042834 peptidoglycan binding(GO:0042834)
0.3 0.8 GO:0015928 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.1 0.8 GO:0045294 alpha-catenin binding(GO:0045294)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.0 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 0.9 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.8 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.6 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.6 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation