Motif ID: Dlx5_Dlx4

Z-value: 1.321

Transcription factors associated with Dlx5_Dlx4:

Gene SymbolEntrez IDGene Name
Dlx4 ENSMUSG00000020871.7 Dlx4
Dlx5 ENSMUSG00000029755.9 Dlx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx5mm10_v2_chr6_-_6882068_6882092-0.701.5e-06Click!


Activity profile for motif Dlx5_Dlx4.

activity profile for motif Dlx5_Dlx4


Sorted Z-values histogram for motif Dlx5_Dlx4

Sorted Z-values for motif Dlx5_Dlx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx5_Dlx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 15.166 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr8_-_4779513 9.461 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr3_+_55782500 7.033 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr12_-_55014329 6.477 ENSMUST00000172875.1
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chr1_+_6487231 5.923 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr9_+_65890237 5.524 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr15_+_25773985 5.517 ENSMUST00000125667.1
 Myo10
myosin X
chr9_-_66514567 4.859 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr9_-_16378231 4.785 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr2_-_121235689 4.619 ENSMUST00000142400.1
 Trp53bp1
transformation related protein 53 binding protein 1
chr2_+_118814237 4.495 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr9_-_36726374 4.489 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr3_+_146121655 4.396 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr1_+_139454747 4.360 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr7_-_62464505 4.211 ENSMUST00000094339.2
 Peg12
paternally expressed 12
chr2_+_118814195 4.087 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr2_+_172550991 4.087 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chrM_+_9870 4.072 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr17_-_59013264 4.035 ENSMUST00000174122.1
ENSMUST00000025065.5
 Nudt12

nudix (nucleoside diphosphate linked moiety X)-type motif 12

chr2_+_118813995 3.987 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 222 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 16.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.7 12.8 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.2 10.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 9.3 GO:0008347 glial cell migration(GO:0008347)
0.5 9.0 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 9.0 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.1 6.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 6.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 6.5 GO:0006338 chromatin remodeling(GO:0006338)
0.5 5.9 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 5.5 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.5 5.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.2 4.8 GO:0010842 retina layer formation(GO:0010842)
0.3 4.6 GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400)
0.3 4.6 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.6 4.5 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
1.1 4.3 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.4 4.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 4.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 4.2 GO:0000578 embryonic axis specification(GO:0000578)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.4 GO:1990752 microtubule plus-end(GO:0035371) microtubule end(GO:1990752)
0.0 9.8 GO:0005694 chromosome(GO:0005694)
2.2 9.0 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 8.2 GO:0032993 protein-DNA complex(GO:0032993)
0.1 7.7 GO:0016459 myosin complex(GO:0016459)
0.1 7.6 GO:0005814 centriole(GO:0005814)
0.1 7.4 GO:0070469 respiratory chain(GO:0070469)
1.6 6.5 GO:0008623 CHRAC(GO:0008623)
0.0 5.9 GO:0000776 kinetochore(GO:0000776)
0.1 5.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 4.6 GO:0035861 site of double-strand break(GO:0035861)
0.9 4.4 GO:0036449 microtubule minus-end(GO:0036449)
0.7 4.3 GO:0044305 calyx of Held(GO:0044305)
0.1 4.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 4.2 GO:0005657 replication fork(GO:0005657)
1.1 3.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 3.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 2.7 GO:0001741 XY body(GO:0001741)
0.7 2.6 GO:0060187 cell pole(GO:0060187)
0.4 2.6 GO:0031262 Ndc80 complex(GO:0031262)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 23.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 9.5 GO:0042169 SH2 domain binding(GO:0042169)
0.4 8.6 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 7.5 GO:0030507 spectrin binding(GO:0030507)
0.0 7.2 GO:0001047 core promoter binding(GO:0001047)
0.4 6.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 6.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.9 5.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 4.9 GO:0061659 ubiquitin-like protein ligase activity(GO:0061659)
0.8 4.6 GO:0061649 ubiquitinated histone binding(GO:0061649)
1.5 4.5 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 4.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.4 4.3 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.1 4.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
1.0 4.0 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 3.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 3.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 3.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 3.4 GO:0031492 nucleosomal DNA binding(GO:0031492)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 7.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 7.2 PID_ATR_PATHWAY ATR signaling pathway
0.2 6.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 3.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.8 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 2.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 2.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.9 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.6 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.4 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 1.4 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 1.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 8.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 7.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.7 7.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 6.2 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 5.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 4.7 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 3.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 3.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 3.0 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 3.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 2.9 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.8 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 1.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.4 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.1 1.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.3 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions