Motif ID: Dmc1

Z-value: 1.097


Transcription factors associated with Dmc1:

Gene SymbolEntrez IDGene Name
Dmc1 ENSMUSG00000022429.10 Dmc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmc1mm10_v2_chr15_-_79605084_796051140.222.0e-01Click!


Activity profile for motif Dmc1.

activity profile for motif Dmc1


Sorted Z-values histogram for motif Dmc1

Sorted Z-values for motif Dmc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Dmc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_14229390 5.127 ENSMUST00000028045.2
 Mrc1
mannose receptor, C type 1
chr16_-_43979050 4.131 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr14_+_75955003 3.449 ENSMUST00000050120.2
 Kctd4
potassium channel tetramerisation domain containing 4
chr8_+_66386292 3.329 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr18_+_61105561 3.128 ENSMUST00000025523.6
 Csf1r
colony stimulating factor 1 receptor
chr4_+_118961578 2.953 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr18_-_82406777 2.707 ENSMUST00000065224.6
 Galr1
galanin receptor 1
chr4_+_128058962 2.679 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr7_-_45103747 2.557 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr12_-_84876479 2.543 ENSMUST00000163189.1
ENSMUST00000110254.2
ENSMUST00000002073.6
 Ltbp2


latent transforming growth factor beta binding protein 2


chr8_+_104340594 2.468 ENSMUST00000034343.4
 Cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr1_-_173942445 2.423 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr10_-_105841323 2.386 ENSMUST00000046638.9
 Mettl25
methyltransferase like 25
chr3_+_66219909 2.200 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr2_-_104257400 2.196 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr19_+_8929628 2.030 ENSMUST00000096241.4
 Eml3
echinoderm microtubule associated protein like 3
chr11_+_116532441 2.003 ENSMUST00000106386.1
ENSMUST00000145737.1
ENSMUST00000155102.1
ENSMUST00000063446.6
 Sphk1



sphingosine kinase 1



chr5_+_112255813 1.978 ENSMUST00000031286.6
ENSMUST00000131673.1
ENSMUST00000112375.1
 Crybb1


crystallin, beta B1


chr3_+_95526777 1.965 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr7_+_35119285 1.803 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0007416 synapse assembly(GO:0007416)
0.2 5.1 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.1 4.1 GO:0018345 protein palmitoylation(GO:0018345)
0.9 3.7 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.2 3.3 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.9 2.7 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
0.0 2.6 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.4 2.5 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.4 2.2 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.5 2.0 GO:0006710 androgen catabolic process(GO:0006710)
0.2 2.0 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.1 2.0 GO:0030574 collagen catabolic process(GO:0030574)
0.0 2.0 GO:0007601 visual perception(GO:0007601)
0.1 1.9 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.2 1.7 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.5 1.6 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.3 1.6 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.2 1.6 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.1 1.6 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 1.6 GO:0031102 neuron projection regeneration(GO:0031102)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 4.7 GO:0010008 endosome membrane(GO:0010008)
1.2 3.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 3.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.3 GO:0005811 lipid particle(GO:0005811)
0.6 1.8 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.2 1.8 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 1.7 GO:0008021 synaptic vesicle(GO:0008021)
0.3 1.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 1.6 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1 1.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 1.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.4 1.1 GO:0044299 C-fiber(GO:0044299)
0.2 1.1 GO:0030670 phagocytic vesicle membrane(GO:0030670) tertiary granule(GO:0070820)
0.0 1.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.3 1.0 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.1 1.0 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.9 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.9 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.0 GO:0005537 mannose binding(GO:0005537)
0.1 4.6 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 4.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 3.3 GO:0042287 MHC protein binding(GO:0042287)
0.2 3.1 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
1.0 3.0 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 3.0 GO:0008168 methyltransferase activity(GO:0008168)
0.6 2.8 GO:0019770 IgG receptor activity(GO:0019770)
0.7 2.7 GO:0004966 galanin receptor activity(GO:0004966)
0.0 2.3 GO:0008201 heparin binding(GO:0008201)
0.3 2.2 GO:0001849 complement component C1q binding(GO:0001849)
0.0 2.2 GO:0005125 cytokine activity(GO:0005125)
0.0 2.2 GO:0001047 core promoter binding(GO:0001047)
0.5 2.0 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.3 2.0 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.2 2.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 2.0 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.8 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.3 1.7 GO:0001846 opsonin binding(GO:0001846)
0.5 1.6 GO:0003796 lysozyme activity(GO:0003796)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.8 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 2.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.6 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 2.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 ST_ADRENERGIC Adrenergic Pathway
0.0 1.5 PID_ATM_PATHWAY ATM pathway
0.1 1.3 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.2 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 1.2 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 1.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.8 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID_IL27_PATHWAY IL27-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
1.0 3.1 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 2.6 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 2.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.1 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 1.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.1 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 0.9 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 0.9 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.8 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.8 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.7 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 0.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex