Motif ID: E2f1

Z-value: 2.483


Transcription factors associated with E2f1:

Gene SymbolEntrez IDGene Name
E2f1 ENSMUSG00000027490.11 E2f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f1mm10_v2_chr2_-_154569720_1545697990.901.7e-14Click!


Activity profile for motif E2f1.

activity profile for motif E2f1


Sorted Z-values histogram for motif E2f1

Sorted Z-values for motif E2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_34372004 21.079 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chrX_-_60893430 20.652 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr5_-_106458440 15.113 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr5_+_45669907 14.968 ENSMUST00000117396.1
 Ncapg
non-SMC condensin I complex, subunit G
chr4_+_126556935 14.228 ENSMUST00000048391.8
 Clspn
claspin
chr17_+_56303396 14.092 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr4_-_59549314 12.668 ENSMUST00000148331.2
ENSMUST00000030076.5
 Ptbp3

polypyrimidine tract binding protein 3

chr17_+_56303321 11.929 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr9_+_65890237 11.917 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr14_-_52020698 11.629 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr15_-_78773452 11.618 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr10_-_128704978 11.132 ENSMUST00000026416.7
ENSMUST00000026415.7
 Cdk2

cyclin-dependent kinase 2

chr15_+_55557399 10.911 ENSMUST00000022998.7
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr4_-_59549243 10.774 ENSMUST00000173699.1
ENSMUST00000173884.1
ENSMUST00000102883.4
ENSMUST00000174586.1
 Ptbp3



polypyrimidine tract binding protein 3



chr2_+_163054682 10.645 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr9_-_61946768 10.351 ENSMUST00000034815.7
 Kif23
kinesin family member 23
chr4_+_115000156 10.042 ENSMUST00000030490.6
 Stil
Scl/Tal1 interrupting locus
chr12_+_24708241 9.628 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr2_+_172550761 9.602 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr1_-_20820213 9.545 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 411 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 36.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
2.0 29.5 GO:0043249 erythrocyte maturation(GO:0043249)
1.3 27.9 GO:0040034 regulation of development, heterochronic(GO:0040034)
1.5 26.8 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.7 25.8 GO:0007076 mitotic chromosome condensation(GO:0007076)
4.8 24.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
2.3 22.9 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.2 22.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.8 22.0 GO:0006270 DNA replication initiation(GO:0006270)
1.4 21.7 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
4.3 21.5 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
1.8 20.0 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.0 19.1 GO:0007530 sex determination(GO:0007530)
2.7 18.6 GO:0098535 de novo centriole assembly(GO:0098535)
2.0 18.1 GO:0033504 floor plate development(GO:0033504)
0.8 14.3 GO:0030261 chromosome condensation(GO:0030261)
1.2 14.0 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
1.0 12.3 GO:2000381 negative regulation of mesoderm development(GO:2000381)
2.9 11.6 GO:2000768 positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.5 11.6 GO:0031297 replication fork processing(GO:0031297)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 195 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 58.3 GO:0005657 replication fork(GO:0005657)
0.1 46.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 43.2 GO:0005654 nucleoplasm(GO:0005654)
0.3 42.7 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 38.3 GO:0005634 nucleus(GO:0005634)
0.9 30.1 GO:0000788 nuclear nucleosome(GO:0000788)
2.9 28.7 GO:0000796 condensin complex(GO:0000796)
0.3 25.5 GO:0005814 centriole(GO:0005814)
0.1 24.0 GO:0000228 nuclear chromosome(GO:0000228)
4.8 23.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.8 16.6 GO:0098536 deuterosome(GO:0098536)
5.4 16.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
1.1 13.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 12.8 GO:0005694 chromosome(GO:0005694)
0.7 11.3 GO:0044453 nuclear membrane part(GO:0044453)
2.2 11.0 GO:0031523 Myb complex(GO:0031523)
3.6 10.9 GO:1990423 RZZ complex(GO:1990423)
2.7 10.9 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
2.1 10.4 GO:0097149 centralspindlin complex(GO:0097149)
1.0 10.3 GO:0001739 sex chromatin(GO:0001739)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 262 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 56.9 GO:0042393 histone binding(GO:0042393)
0.0 55.2 GO:0003677 DNA binding(GO:0003677)
0.2 32.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
7.4 29.5 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.2 25.8 GO:0004386 helicase activity(GO:0004386)
0.5 24.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
4.8 23.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
3.7 22.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.6 20.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.4 17.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.5 14.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.9 13.8 GO:0003680 AT DNA binding(GO:0003680)
1.9 13.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.1 12.9 GO:0035173 histone kinase activity(GO:0035173)
0.1 12.2 GO:0003714 transcription corepressor activity(GO:0003714)
2.4 12.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.5 12.0 GO:0070182 DNA polymerase binding(GO:0070182)
3.9 11.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
2.2 11.0 GO:0043515 kinetochore binding(GO:0043515)
0.1 10.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 80.2 PID_E2F_PATHWAY E2F transcription factor network
1.2 55.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.8 31.7 PID_ATR_PATHWAY ATR signaling pathway
1.6 22.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.6 19.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 14.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
1.2 10.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 10.2 NABA_COLLAGENS Genes encoding collagen proteins
0.3 9.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.3 8.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.2 7.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 6.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 5.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 5.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.2 5.3 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 5.2 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 5.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 4.6 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 44.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.8 36.0 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
2.0 33.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.3 23.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 19.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 15.9 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.8 15.1 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.5 14.8 REACTOME_KINESINS Genes involved in Kinesins
0.4 14.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 12.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras
0.9 11.6 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.5 11.6 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.5 11.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.4 11.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
1.0 10.9 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 10.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 10.4 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.7 9.4 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.6 8.6 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
1.2 8.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway