Motif ID: E2f2_E2f5

Z-value: 3.657

Transcription factors associated with E2f2_E2f5:

Gene SymbolEntrez IDGene Name
E2f2 ENSMUSG00000018983.9 E2f2
E2f5 ENSMUSG00000027552.8 E2f5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f2mm10_v2_chr4_+_136172367_1361723950.956.3e-19Click!
E2f5mm10_v2_chr3_+_14578609_145786870.796.6e-09Click!


Activity profile for motif E2f2_E2f5.

activity profile for motif E2f2_E2f5


Sorted Z-values histogram for motif E2f2_E2f5

Sorted Z-values for motif E2f2_E2f5



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f2_E2f5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 55.388 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr10_-_69352886 43.567 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr7_-_137314394 42.178 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr4_+_126556935 40.255 ENSMUST00000048391.8
 Clspn
claspin
chr4_+_136172367 39.378 ENSMUST00000061721.5
 E2f2
E2F transcription factor 2
chr2_-_157204483 37.165 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr9_+_122951051 30.374 ENSMUST00000040717.5
 Kif15
kinesin family member 15
chr2_-_113848655 29.955 ENSMUST00000102545.1
ENSMUST00000110948.1
 Arhgap11a

Rho GTPase activating protein 11A

chr12_+_24708241 29.021 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr2_-_113848601 28.341 ENSMUST00000110949.2
 Arhgap11a
Rho GTPase activating protein 11A
chr17_+_56304313 26.796 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr13_-_24761861 26.634 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr13_-_24761440 26.069 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr15_-_58135047 25.779 ENSMUST00000038194.3
 Atad2
ATPase family, AAA domain containing 2
chr4_+_126556994 25.404 ENSMUST00000147675.1
 Clspn
claspin
chr4_+_115000156 23.731 ENSMUST00000030490.6
 Stil
Scl/Tal1 interrupting locus
chr6_-_88898664 20.949 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr13_-_55329723 20.861 ENSMUST00000021941.7
 Mxd3
Max dimerization protein 3
chr7_+_110122299 20.023 ENSMUST00000033326.8
 Wee1
WEE 1 homolog 1 (S. pombe)
chr4_+_115000174 19.409 ENSMUST00000129957.1
 Stil
Scl/Tal1 interrupting locus

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 69.3 GO:0006270 DNA replication initiation(GO:0006270)
6.8 67.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
9.1 63.6 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
1.0 56.4 GO:0008156 negative regulation of DNA replication(GO:0008156)
6.9 55.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
2.8 48.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
3.2 45.0 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
4.8 43.1 GO:0033504 floor plate development(GO:0033504)
4.7 42.0 GO:0090166 Golgi disassembly(GO:0090166)
0.8 36.2 GO:0043550 regulation of lipid kinase activity(GO:0043550)
10.9 32.8 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
4.3 25.8 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 24.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
2.7 24.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
4.5 18.0 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
1.1 17.6 GO:0006312 mitotic recombination(GO:0006312)
1.7 16.7 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
3.3 16.5 GO:0034421 post-translational protein acetylation(GO:0034421)
1.0 15.6 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.3 15.2 GO:0019985 translesion synthesis(GO:0019985)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 114.0 GO:0005634 nucleus(GO:0005634)
0.1 99.7 GO:0005694 chromosome(GO:0005694)
0.5 66.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 64.7 GO:0005667 transcription factor complex(GO:0005667)
1.1 59.2 GO:0005657 replication fork(GO:0005657)
3.8 57.7 GO:0042555 MCM complex(GO:0042555)
0.9 48.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 48.4 GO:0005814 centriole(GO:0005814)
9.6 48.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.5 34.8 GO:0005871 kinesin complex(GO:0005871)
0.5 32.3 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
4.8 24.2 GO:0035189 Rb-E2F complex(GO:0035189)
3.3 23.3 GO:0031298 replication fork protection complex(GO:0031298)
1.8 16.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 15.8 GO:0005819 spindle(GO:0005819)
0.2 15.6 GO:0017053 transcriptional repressor complex(GO:0017053)
1.2 15.0 GO:0000800 lateral element(GO:0000800)
0.6 13.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
2.4 12.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 11.0 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 90.6 GO:0001047 core promoter binding(GO:0001047)
10.9 65.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 56.1 GO:0005096 GTPase activator activity(GO:0005096)
12.3 49.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
3.3 48.9 GO:0035173 histone kinase activity(GO:0035173)
9.6 48.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
3.2 45.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 40.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 39.0 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.4 34.8 GO:0003777 microtubule motor activity(GO:0003777)
1.1 32.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 32.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.5 30.8 GO:0000975 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
0.2 30.5 GO:0004386 helicase activity(GO:0004386)
0.2 29.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 21.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 21.3 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
2.9 20.0 GO:0000150 recombinase activity(GO:0000150)
0.4 20.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 19.0 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 140.5 PID_E2F_PATHWAY E2F transcription factor network
2.8 121.3 PID_ATR_PATHWAY ATR signaling pathway
8.2 74.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
5.2 73.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.3 43.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.7 34.3 PID_PLK1_PATHWAY PLK1 signaling events
0.3 29.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.4 18.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.6 15.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 11.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.2 10.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 8.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 8.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.2 7.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.3 4.9 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 4.7 PID_ATM_PATHWAY ATM pathway
0.1 4.3 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.2 3.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 2.7 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 2.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.8 175.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
8.4 92.1 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
4.5 63.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 57.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
2.5 41.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.6 33.0 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
3.5 31.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.1 30.4 REACTOME_KINESINS Genes involved in Kinesins
1.7 23.4 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
1.5 17.9 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 13.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.8 12.9 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.4 11.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 10.8 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.3 9.1 REACTOME_RNA_POL_I_TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
2.1 8.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.4 8.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.4 7.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 5.9 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
1.0 5.8 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation