Motif ID: E2f2_E2f5

Z-value: 3.657

Transcription factors associated with E2f2_E2f5:

Gene SymbolEntrez IDGene Name
E2f2 ENSMUSG00000018983.9 E2f2
E2f5 ENSMUSG00000027552.8 E2f5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f2mm10_v2_chr4_+_136172367_1361723950.956.3e-19Click!
E2f5mm10_v2_chr3_+_14578609_145786870.796.6e-09Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of E2f2_E2f5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_139543889 55.388 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr10_-_69352886 43.567 ENSMUST00000119827.1
ENSMUST00000020099.5
Cdk1

cyclin-dependent kinase 1

chr7_-_137314394 42.178 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr4_+_126556935 40.255 ENSMUST00000048391.8
Clspn
claspin
chr4_+_136172367 39.378 ENSMUST00000061721.5
E2f2
E2F transcription factor 2
chr2_-_157204483 37.165 ENSMUST00000029170.7
Rbl1
retinoblastoma-like 1 (p107)
chr9_+_122951051 30.374 ENSMUST00000040717.5
Kif15
kinesin family member 15
chr2_-_113848655 29.955 ENSMUST00000102545.1
ENSMUST00000110948.1
Arhgap11a

Rho GTPase activating protein 11A

chr12_+_24708241 29.021 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr2_-_113848601 28.341 ENSMUST00000110949.2
Arhgap11a
Rho GTPase activating protein 11A
chr17_+_56304313 26.796 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr13_-_24761861 26.634 ENSMUST00000006898.3
ENSMUST00000110382.2
Gmnn

geminin

chr13_-_24761440 26.069 ENSMUST00000176890.1
ENSMUST00000175689.1
Gmnn

geminin

chr15_-_58135047 25.779 ENSMUST00000038194.3
Atad2
ATPase family, AAA domain containing 2
chr4_+_126556994 25.404 ENSMUST00000147675.1
Clspn
claspin
chr4_+_115000156 23.731 ENSMUST00000030490.6
Stil
Scl/Tal1 interrupting locus
chr6_-_88898664 20.949 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr13_-_55329723 20.861 ENSMUST00000021941.7
Mxd3
Max dimerization protein 3
chr7_+_110122299 20.023 ENSMUST00000033326.8
Wee1
WEE 1 homolog 1 (S. pombe)
chr4_+_115000174 19.409 ENSMUST00000129957.1
Stil
Scl/Tal1 interrupting locus
chr1_-_20820213 18.549 ENSMUST00000053266.9
Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr10_-_5805412 18.034 ENSMUST00000019907.7
Fbxo5
F-box protein 5
chr15_-_55090422 16.454 ENSMUST00000110231.1
ENSMUST00000023059.6
Dscc1

defective in sister chromatid cohesion 1 homolog (S. cerevisiae)

chr2_+_72476159 16.185 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr2_+_72476225 16.103 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr14_+_51984826 15.232 ENSMUST00000093813.5
Arhgef40
Rho guanine nucleotide exchange factor (GEF) 40
chr6_+_4747306 15.022 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
Peg10


paternally expressed 10


chr2_+_119112793 14.980 ENSMUST00000140939.1
ENSMUST00000028795.3
Rad51

RAD51 homolog

chr13_+_92354783 14.810 ENSMUST00000022218.4
Dhfr
dihydrofolate reductase
chr17_+_56303396 14.701 ENSMUST00000113038.1
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr14_+_51984857 14.356 ENSMUST00000100639.4
ENSMUST00000182909.1
ENSMUST00000182760.1
ENSMUST00000182061.1
ENSMUST00000182193.1
Arhgef40




Rho guanine nucleotide exchange factor (GEF) 40




chr12_+_24708984 13.844 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr2_-_154569845 13.467 ENSMUST00000103145.4
E2f1
E2F transcription factor 1
chr9_+_65890237 13.069 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr8_-_53638945 12.306 ENSMUST00000047768.4
Neil3
nei like 3 (E. coli)
chr7_-_48881032 12.129 ENSMUST00000058745.8
E2f8
E2F transcription factor 8
chr13_+_113035111 11.350 ENSMUST00000180543.1
ENSMUST00000181568.1
ENSMUST00000109244.2
ENSMUST00000181117.1
ENSMUST00000181741.1
Cdc20b




cell division cycle 20B




chr15_+_102296256 11.060 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr8_+_87472805 10.803 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
Gm2694


predicted gene 2694


chr13_-_64153194 10.780 ENSMUST00000059817.4
ENSMUST00000117241.1
Zfp367

zinc finger protein 367

chr2_-_154569720 10.756 ENSMUST00000000894.5
E2f1
E2F transcription factor 1
chr7_-_48881596 10.511 ENSMUST00000119223.1
E2f8
E2F transcription factor 8
chr12_+_116405397 10.267 ENSMUST00000084828.3
Ncapg2
non-SMC condensin II complex, subunit G2
chr8_+_87472838 10.201 ENSMUST00000180806.2
Gm2694
predicted gene 2694
chr10_+_110745433 10.171 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
E2f7



E2F transcription factor 7



chr8_+_75109528 9.754 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chrX_-_93632113 9.586 ENSMUST00000006856.2
Pola1
polymerase (DNA directed), alpha 1
chr3_-_95217877 9.463 ENSMUST00000136139.1
Gabpb2
GA repeat binding protein, beta 2
chr8_+_87473116 9.289 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
Gm2694


predicted gene 2694


chr11_-_6444352 9.282 ENSMUST00000093346.5
ENSMUST00000109737.2
H2afv

H2A histone family, member V

chr4_-_133967953 9.215 ENSMUST00000102553.4
Hmgn2
high mobility group nucleosomal binding domain 2
chr19_+_5406815 9.095 ENSMUST00000174412.1
ENSMUST00000153017.2
4930481A15Rik

RIKEN cDNA 4930481A15 gene

chr3_-_95217690 9.089 ENSMUST00000107209.1
Gabpb2
GA repeat binding protein, beta 2
chr12_+_71016658 8.994 ENSMUST00000125125.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr11_+_80089385 8.785 ENSMUST00000108239.1
ENSMUST00000017694.5
Atad5

ATPase family, AAA domain containing 5

chr1_-_191575534 8.777 ENSMUST00000027933.5
Dtl
denticleless homolog (Drosophila)
chr15_-_9140374 8.666 ENSMUST00000096482.3
ENSMUST00000110585.2
Skp2

S-phase kinase-associated protein 2 (p45)

chr5_+_75574916 8.421 ENSMUST00000144270.1
ENSMUST00000005815.6
Kit

kit oncogene

chr6_+_113531675 8.409 ENSMUST00000036340.5
ENSMUST00000101051.2
Fancd2

Fanconi anemia, complementation group D2

chr8_-_122678072 8.346 ENSMUST00000006525.7
ENSMUST00000064674.6
Cbfa2t3

core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)

chr12_-_11265768 8.195 ENSMUST00000166117.1
Gen1
Gen homolog 1, endonuclease (Drosophila)
chr2_+_53192067 8.182 ENSMUST00000028336.6
Arl6ip6
ADP-ribosylation factor-like 6 interacting protein 6
chr1_+_184034381 8.120 ENSMUST00000048655.7
Dusp10
dual specificity phosphatase 10
chr14_-_104467984 8.047 ENSMUST00000053016.8
Pou4f1
POU domain, class 4, transcription factor 1
chr9_-_72491939 7.940 ENSMUST00000185151.1
ENSMUST00000085358.5
ENSMUST00000184125.1
ENSMUST00000183574.1
ENSMUST00000184831.1
Tex9




testis expressed gene 9




chr17_+_56303321 7.828 ENSMUST00000001258.8
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr1_-_128359610 7.806 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr6_-_47594967 7.780 ENSMUST00000081721.6
ENSMUST00000114618.1
ENSMUST00000114616.1
Ezh2


enhancer of zeste homolog 2 (Drosophila)


chr9_-_97018823 7.704 ENSMUST00000055433.4
Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
chr15_-_8444449 7.562 ENSMUST00000052965.6
Nipbl
Nipped-B homolog (Drosophila)
chr1_+_175880775 7.514 ENSMUST00000039725.6
Exo1
exonuclease 1
chrX_+_42151002 7.465 ENSMUST00000123245.1
Stag2
stromal antigen 2
chrX_+_42150672 7.448 ENSMUST00000069619.7
Stag2
stromal antigen 2
chr16_-_18811615 7.429 ENSMUST00000096990.3
Cdc45
cell division cycle 45
chr2_-_5012716 7.367 ENSMUST00000027980.7
Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
chr4_+_97777780 7.307 ENSMUST00000107062.2
ENSMUST00000052018.5
ENSMUST00000107057.1
Nfia


nuclear factor I/A


chr14_-_76010863 7.071 ENSMUST00000088922.4
Gtf2f2
general transcription factor IIF, polypeptide 2
chr4_+_97777606 6.995 ENSMUST00000075448.6
ENSMUST00000092532.6
Nfia

nuclear factor I/A

chr2_+_132816141 6.786 ENSMUST00000028831.8
ENSMUST00000066559.5
Mcm8

minichromosome maintenance deficient 8 (S. cerevisiae)

chr6_+_85187438 6.751 ENSMUST00000045942.8
Emx1
empty spiracles homeobox 1
chr11_-_100759740 6.694 ENSMUST00000107361.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr6_+_14901344 6.618 ENSMUST00000115477.1
Foxp2
forkhead box P2
chr5_+_110839973 6.561 ENSMUST00000066160.1
Chek2
checkpoint kinase 2
chr1_-_9700209 6.544 ENSMUST00000088658.4
Mybl1
myeloblastosis oncogene-like 1
chr2_-_30474199 6.336 ENSMUST00000065134.2
Ier5l
immediate early response 5-like
chr10_-_7956223 6.262 ENSMUST00000146444.1
Tab2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr8_+_95633500 6.250 ENSMUST00000034094.9
Gins3
GINS complex subunit 3 (Psf3 homolog)
chr10_-_60219260 6.198 ENSMUST00000135158.2
Chst3
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
chr12_-_69228167 5.960 ENSMUST00000021359.5
Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr19_+_53600377 5.945 ENSMUST00000025930.9
Smc3
structural maintenance of chromosomes 3
chr15_+_55557399 5.849 ENSMUST00000022998.7
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr14_+_59625281 5.724 ENSMUST00000053949.5
Shisa2
shisa homolog 2 (Xenopus laevis)
chr3_+_96104498 5.633 ENSMUST00000132980.1
ENSMUST00000138206.1
ENSMUST00000090785.2
ENSMUST00000035519.5
Otud7b



OTU domain containing 7B



chr19_+_16956110 5.611 ENSMUST00000087689.4
Prune2
prune homolog 2 (Drosophila)
chr1_+_157412352 5.458 ENSMUST00000061537.5
2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr4_+_11191354 5.423 ENSMUST00000170901.1
Ccne2
cyclin E2
chr11_+_79993062 5.383 ENSMUST00000017692.8
ENSMUST00000163272.1
Suz12

suppressor of zeste 12 homolog (Drosophila)

chr7_+_102441685 5.335 ENSMUST00000033283.9
Rrm1
ribonucleotide reductase M1
chr9_-_36726374 5.320 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
Chek1


checkpoint kinase 1


chr9_+_109875541 5.206 ENSMUST00000094324.3
Cdc25a
cell division cycle 25A
chr16_-_18248697 5.201 ENSMUST00000115645.3
Ranbp1
RAN binding protein 1
chr13_-_21783391 5.200 ENSMUST00000099704.3
Hist1h3i
histone cluster 1, H3i
chr2_+_119325784 5.196 ENSMUST00000102517.3
Dll4
delta-like 4 (Drosophila)
chr9_+_64281575 5.176 ENSMUST00000034964.6
Tipin
timeless interacting protein
chr8_+_34807287 5.144 ENSMUST00000033930.4
Dusp4
dual specificity phosphatase 4
chrX_+_112311334 5.096 ENSMUST00000026599.3
ENSMUST00000113415.1
Apool

apolipoprotein O-like

chr5_+_88764983 4.983 ENSMUST00000031311.9
Dck
deoxycytidine kinase
chr4_+_32615473 4.896 ENSMUST00000178925.1
ENSMUST00000029950.3
Casp8ap2

caspase 8 associated protein 2

chr17_-_35046726 4.845 ENSMUST00000097338.4
Msh5
mutS homolog 5 (E. coli)
chr13_+_22043189 4.832 ENSMUST00000110452.1
Hist1h2bj
histone cluster 1, H2bj
chr7_-_44548733 4.783 ENSMUST00000145956.1
ENSMUST00000049343.8
Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr15_+_55557575 4.732 ENSMUST00000170046.1
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr13_-_22042949 4.651 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr18_-_46198810 4.650 ENSMUST00000167364.1
Trim36
tripartite motif-containing 36
chr7_+_13278778 4.601 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
Lig1


ligase I, DNA, ATP-dependent


chrX_-_51205773 4.454 ENSMUST00000114875.1
Mbnl3
muscleblind-like 3 (Drosophila)
chr3_+_127553462 4.413 ENSMUST00000043108.4
4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr12_+_11265867 4.394 ENSMUST00000020931.5
Smc6
structural maintenance of chromosomes 6
chr15_-_91049823 4.391 ENSMUST00000088614.5
ENSMUST00000100304.4
ENSMUST00000067205.8
ENSMUST00000109288.2
ENSMUST00000109287.2
Kif21a




kinesin family member 21A




chr11_-_118569910 4.390 ENSMUST00000136551.1
Rbfox3
RNA binding protein, fox-1 homolog (C. elegans) 3
chr2_+_146221921 4.306 ENSMUST00000089257.4
Insm1
insulinoma-associated 1
chr7_-_38107490 4.298 ENSMUST00000108023.3
Ccne1
cyclin E1
chr8_+_72135247 4.294 ENSMUST00000003575.9
Tpm4
tropomyosin 4
chr3_+_116594959 4.281 ENSMUST00000029571.8
Sass6
spindle assembly 6 homolog (C. elegans)
chr10_+_58323466 4.263 ENSMUST00000020078.7
Lims1
LIM and senescent cell antigen-like domains 1
chr10_+_13090788 4.246 ENSMUST00000121646.1
ENSMUST00000121325.1
ENSMUST00000121766.1
Plagl1


pleiomorphic adenoma gene-like 1


chr7_+_79392305 4.181 ENSMUST00000117227.1
ENSMUST00000118959.1
ENSMUST00000036865.6
Fanci


Fanconi anemia, complementation group I


chr19_+_48206025 4.140 ENSMUST00000078880.5
Sorcs3
sortilin-related VPS10 domain containing receptor 3
chr11_+_98907801 4.075 ENSMUST00000092706.6
Cdc6
cell division cycle 6
chr5_+_114130386 4.064 ENSMUST00000031587.6
Ung
uracil DNA glycosylase
chr13_-_23745511 4.062 ENSMUST00000091752.2
Hist1h3c
histone cluster 1, H3c
chr13_-_21716143 4.048 ENSMUST00000091756.1
Hist1h2bl
histone cluster 1, H2bl
chr7_-_126396715 4.038 ENSMUST00000075671.4
Nfatc2ip
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
chr6_+_51470633 4.024 ENSMUST00000114445.1
ENSMUST00000114446.1
ENSMUST00000141711.1
Cbx3


chromobox 3


chr2_-_170142673 3.908 ENSMUST00000109155.1
Zfp217
zinc finger protein 217
chr17_+_29490812 3.761 ENSMUST00000024811.6
Pim1
proviral integration site 1
chr5_+_110286306 3.683 ENSMUST00000007296.5
ENSMUST00000112482.1
Pole

polymerase (DNA directed), epsilon

chr13_-_23622502 3.657 ENSMUST00000062045.2
Hist1h1e
histone cluster 1, H1e
chr13_+_21787461 3.641 ENSMUST00000110473.2
ENSMUST00000102982.1
Hist1h2bp

histone cluster 1, H2bp

chr4_-_107683576 3.541 ENSMUST00000131776.1
Dmrtb1
DMRT-like family B with proline-rich C-terminal, 1
chr5_+_137745730 3.515 ENSMUST00000100540.3
Tsc22d4
TSC22 domain family, member 4
chr7_+_82867327 3.513 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr14_-_20388822 3.513 ENSMUST00000022345.6
Dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr5_+_137745967 3.462 ENSMUST00000100539.3
Tsc22d4
TSC22 domain family, member 4
chrX_-_51205990 3.441 ENSMUST00000114876.2
Mbnl3
muscleblind-like 3 (Drosophila)
chr15_-_79605084 3.428 ENSMUST00000023065.6
Dmc1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
chrX_+_50841434 3.418 ENSMUST00000114887.2
2610018G03Rik
RIKEN cDNA 2610018G03 gene
chr10_+_11281583 3.418 ENSMUST00000070300.4
Fbxo30
F-box protein 30
chr13_-_47106176 3.404 ENSMUST00000021807.6
ENSMUST00000135278.1
Dek

DEK oncogene (DNA binding)

chr4_-_126968124 3.377 ENSMUST00000106108.2
Zmym4
zinc finger, MYM-type 4
chr4_-_133967893 3.343 ENSMUST00000100472.3
ENSMUST00000136327.1
Hmgn2

high mobility group nucleosomal binding domain 2

chr19_-_10203880 3.326 ENSMUST00000142241.1
ENSMUST00000116542.2
ENSMUST00000025651.5
ENSMUST00000156291.1
Fen1



flap structure specific endonuclease 1



chrX_+_20364481 3.312 ENSMUST00000033372.6
ENSMUST00000115391.1
ENSMUST00000115387.1
Rp2h


retinitis pigmentosa 2 homolog (human)


chrX_-_73458990 3.311 ENSMUST00000033737.8
ENSMUST00000077243.4
Haus7

HAUS augmin-like complex, subunit 7

chr8_-_120589304 3.287 ENSMUST00000034278.5
Gins2
GINS complex subunit 2 (Psf2 homolog)
chr4_+_84884276 3.255 ENSMUST00000047023.6
Cntln
centlein, centrosomal protein
chr3_-_95217741 3.250 ENSMUST00000107204.1
Gabpb2
GA repeat binding protein, beta 2
chr7_+_126781483 3.217 ENSMUST00000172352.1
ENSMUST00000094037.4
Tbx6

T-box 6

chr7_-_133122615 3.193 ENSMUST00000167218.1
Ctbp2
C-terminal binding protein 2
chr14_+_31019125 3.182 ENSMUST00000112095.1
ENSMUST00000112098.3
ENSMUST00000112106.1
ENSMUST00000146325.1
Pbrm1



polybromo 1



chr6_-_148946146 3.158 ENSMUST00000132696.1
Fam60a
family with sequence similarity 60, member A
chr6_+_51470510 3.121 ENSMUST00000031862.7
Cbx3
chromobox 3
chr10_+_128232065 3.091 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
Timeless




timeless circadian clock 1




chr1_+_91298334 3.057 ENSMUST00000027532.6
Scly
selenocysteine lyase
chr14_+_21499770 3.048 ENSMUST00000182855.1
ENSMUST00000069648.7
ENSMUST00000182405.1
Kat6b


K(lysine) acetyltransferase 6B


chr17_+_28801090 3.027 ENSMUST00000004985.9
Brpf3
bromodomain and PHD finger containing, 3
chr10_-_128891674 3.025 ENSMUST00000026408.6
Gdf11
growth differentiation factor 11
chr13_-_21787218 3.022 ENSMUST00000091751.2
Hist1h2an
histone cluster 1, H2an
chr7_+_64287665 3.015 ENSMUST00000032736.4
Mtmr10
myotubularin related protein 10
chr3_+_88532314 3.012 ENSMUST00000172699.1
Mex3a
mex3 homolog A (C. elegans)
chr9_+_120933400 2.999 ENSMUST00000007130.8
ENSMUST00000178812.1
Ctnnb1

catenin (cadherin associated protein), beta 1

chr10_-_21160925 2.942 ENSMUST00000020158.6
Myb
myeloblastosis oncogene
chr9_+_44334685 2.873 ENSMUST00000052686.2
H2afx
H2A histone family, member X
chr1_+_91298354 2.853 ENSMUST00000142488.1
ENSMUST00000124832.1
ENSMUST00000147523.1
Scly


selenocysteine lyase


chr6_+_21949571 2.844 ENSMUST00000031680.3
ENSMUST00000115389.1
ENSMUST00000151473.1
Ing3


inhibitor of growth family, member 3


chr9_+_96196246 2.825 ENSMUST00000165120.2
ENSMUST00000034982.9
Tfdp2

transcription factor Dp 2

chr11_+_88068242 2.777 ENSMUST00000018521.4
Vezf1
vascular endothelial zinc finger 1
chr4_+_84884418 2.771 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr18_-_53744509 2.766 ENSMUST00000049811.6
Cep120
centrosomal protein 120
chr4_-_143299498 2.745 ENSMUST00000030317.7
Pdpn
podoplanin
chr11_-_77607812 2.674 ENSMUST00000058496.7
Taok1
TAO kinase 1
chr13_-_96132568 2.648 ENSMUST00000161263.1
Sv2c
synaptic vesicle glycoprotein 2c
chr7_-_6730412 2.619 ENSMUST00000051209.4
Peg3
paternally expressed 3
chr13_-_43480973 2.586 ENSMUST00000144326.2
Ranbp9
RAN binding protein 9
chr4_-_107684228 2.569 ENSMUST00000069271.4
Dmrtb1
DMRT-like family B with proline-rich C-terminal, 1
chr5_-_88675190 2.567 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1

G-rich RNA sequence binding factor 1

chr9_-_108452377 2.530 ENSMUST00000035232.7
Klhdc8b
kelch domain containing 8B
chr1_+_15805639 2.452 ENSMUST00000027057.6
Terf1
telomeric repeat binding factor 1
chr13_+_21754067 2.394 ENSMUST00000091709.2
Hist1h2bn
histone cluster 1, H2bn
chr19_-_5964132 2.380 ENSMUST00000025752.7
ENSMUST00000165143.1
Pola2

polymerase (DNA directed), alpha 2

chr12_+_70453095 2.367 ENSMUST00000021471.6
Tmx1
thioredoxin-related transmembrane protein 1
chr8_+_8689666 2.349 ENSMUST00000179702.1
B930078G14Rik
RIKEN cDNA B930078G14 gene
chr14_+_31019183 2.347 ENSMUST00000052239.5
Pbrm1
polybromo 1
chr3_+_41563356 2.342 ENSMUST00000163764.1
Phf17
PHD finger protein 17
chr4_+_132768325 2.336 ENSMUST00000102561.4
Rpa2
replication protein A2
chr9_-_21291124 2.305 ENSMUST00000086374.6
Cdkn2d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr5_+_52741569 2.282 ENSMUST00000031081.4
ENSMUST00000031082.6
Pi4k2b

phosphatidylinositol 4-kinase type 2 beta

chr7_-_44816586 2.204 ENSMUST00000047356.8
Atf5
activating transcription factor 5
chr17_+_28691342 2.200 ENSMUST00000114758.1
ENSMUST00000004990.6
ENSMUST00000062694.8
ENSMUST00000114754.1
Mapk14



mitogen-activated protein kinase 14



chr4_-_151057933 2.180 ENSMUST00000030797.3
Vamp3
vesicle-associated membrane protein 3

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
10.9 32.8 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
9.1 63.6 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
6.9 55.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
6.8 67.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
5.0 15.0 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
4.8 43.1 GO:0033504 floor plate development(GO:0033504)
4.8 4.8 GO:0045004 DNA replication proofreading(GO:0045004)
4.7 42.0 GO:0090166 Golgi disassembly(GO:0090166)
4.5 18.0 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
4.3 25.8 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
3.7 14.8 GO:0046655 glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655)
3.6 14.5 GO:0006272 leading strand elongation(GO:0006272)
3.3 16.5 GO:0034421 post-translational protein acetylation(GO:0034421)
3.2 45.0 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
2.8 48.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
2.8 8.4 GO:1904347 intestine smooth muscle contraction(GO:0014827) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) regulation of small intestine smooth muscle contraction(GO:1904347) small intestine smooth muscle contraction(GO:1990770)
2.7 24.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
2.6 7.8 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
2.5 7.5 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
2.5 69.3 GO:0006270 DNA replication initiation(GO:0006270)
2.1 10.6 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
1.9 7.6 GO:0061010 gall bladder development(GO:0061010)
1.9 5.6 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
1.7 12.2 GO:1902969 mitotic DNA replication(GO:1902969)
1.7 5.2 GO:0072554 blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
1.7 16.7 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
1.6 8.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
1.6 8.0 GO:0019230 proprioception(GO:0019230)
1.5 9.0 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
1.5 5.9 GO:0001887 selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259)
1.4 8.3 GO:1903715 regulation of aerobic respiration(GO:1903715)
1.4 4.1 GO:0006285 base-excision repair, AP site formation(GO:0006285)
1.3 5.2 GO:0000076 DNA replication checkpoint(GO:0000076)
1.3 15.2 GO:0019985 translesion synthesis(GO:0019985)
1.3 3.8 GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
1.2 5.0 GO:0046125 pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
1.2 12.4 GO:0000212 meiotic spindle organization(GO:0000212)
1.2 8.4 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
1.1 9.0 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
1.1 17.6 GO:0006312 mitotic recombination(GO:0006312)
1.1 4.3 GO:0003357 noradrenergic neuron differentiation(GO:0003357)
1.1 4.3 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
1.0 56.4 GO:0008156 negative regulation of DNA replication(GO:0008156)
1.0 15.6 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.0 3.1 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
1.0 14.3 GO:0072189 ureter development(GO:0072189)
1.0 3.0 GO:0060423 limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023) negative regulation of mitotic cell cycle, embryonic(GO:0045976) foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
1.0 4.8 GO:0051026 chiasma assembly(GO:0051026)
0.9 0.9 GO:0060382 regulation of DNA strand elongation(GO:0060382)
0.9 4.3 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.9 8.7 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.8 3.3 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.8 4.9 GO:0036337 Fas signaling pathway(GO:0036337)
0.8 7.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.8 36.2 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.8 8.8 GO:0033260 nuclear DNA replication(GO:0033260)
0.8 7.0 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.7 2.2 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.7 2.1 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.7 7.6 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.7 3.4 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.7 2.0 GO:0090204 protein localization to nuclear pore(GO:0090204) positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.6 2.5 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.6 7.7 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.6 7.9 GO:0060013 righting reflex(GO:0060013)
0.5 12.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.5 3.5 GO:0072697 protein localization to cell cortex(GO:0072697)
0.5 1.9 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.5 2.3 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.4 1.3 GO:0070375 ERK5 cascade(GO:0070375)
0.4 4.7 GO:0002227 innate immune response in mucosa(GO:0002227)
0.4 1.3 GO:0048369 neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) lateral mesoderm morphogenesis(GO:0048369) lateral mesoderm formation(GO:0048370) lateral mesodermal cell differentiation(GO:0048371) lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) regulation of cardiac ventricle development(GO:1904412) positive regulation of cardiac ventricle development(GO:1904414)
0.4 14.9 GO:0006284 base-excision repair(GO:0006284)
0.4 3.2 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.4 1.8 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.4 2.9 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.4 3.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.4 1.1 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.3 1.7 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.3 5.1 GO:0042407 cristae formation(GO:0042407)
0.3 4.8 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.3 2.9 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.3 1.6 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.3 1.2 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.3 0.3 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.3 1.1 GO:0010826 negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.3 8.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 5.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.3 2.7 GO:0008063 Toll signaling pathway(GO:0008063)
0.3 4.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.3 0.8 GO:0070602 regulation of chondrocyte development(GO:0061181) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.3 7.5 GO:0002455 humoral immune response mediated by circulating immunoglobulin(GO:0002455)
0.2 0.7 GO:0019389 glucuronoside metabolic process(GO:0019389)
0.2 2.2 GO:1902750 negative regulation of cell cycle G2/M phase transition(GO:1902750)
0.2 0.7 GO:0043686 co-translational protein modification(GO:0043686)
0.2 5.7 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.2 2.1 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.2 14.4 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.2 2.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 1.3 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.2 2.8 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.2 4.1 GO:1900452 regulation of long term synaptic depression(GO:1900452)
0.2 0.6 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.2 5.2 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 14.2 GO:0006342 chromatin silencing(GO:0006342)
0.2 1.7 GO:0034501 protein localization to kinetochore(GO:0034501)
0.2 1.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.2 2.3 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 0.6 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.2 1.6 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.2 4.6 GO:0007340 acrosome reaction(GO:0007340)
0.2 0.4 GO:0033484 nitric oxide homeostasis(GO:0033484)
0.2 5.9 GO:0006260 DNA replication(GO:0006260)
0.2 0.8 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 0.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 24.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 2.6 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 3.0 GO:0021511 spinal cord patterning(GO:0021511)
0.1 0.4 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.1 0.7 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.1 3.4 GO:0007099 centriole replication(GO:0007099)
0.1 1.3 GO:0030238 male sex determination(GO:0030238)
0.1 2.1 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 2.4 GO:0097150 removal of superoxide radicals(GO:0019430) neuronal stem cell population maintenance(GO:0097150)
0.1 2.0 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.1 0.8 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 5.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 1.0 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.1 0.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.8 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.1 1.8 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 0.7 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.1 0.6 GO:1904251 regulation of bile acid metabolic process(GO:1904251)
0.1 0.2 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.1 2.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 2.6 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.1 3.5 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 0.5 GO:0009249 protein lipoylation(GO:0009249)
0.1 3.9 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.1 0.9 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.1 0.9 GO:0007130 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.1 2.4 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.2 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 0.9 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 3.3 GO:0051225 spindle assembly(GO:0051225)
0.0 2.8 GO:0001885 endothelial cell development(GO:0001885)
0.0 4.7 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.1 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0 2.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.5 GO:0006816 calcium ion transport(GO:0006816)
0.0 0.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.2 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.6 GO:0007032 endosome organization(GO:0007032)
0.0 1.8 GO:0019827 stem cell population maintenance(GO:0019827)
0.0 8.4 GO:0007017 microtubule-based process(GO:0007017)
0.0 1.2 GO:0007507 heart development(GO:0007507)
0.0 2.0 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.3 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 3.0 GO:0008380 RNA splicing(GO:0008380)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 48.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
4.8 24.2 GO:0035189 Rb-E2F complex(GO:0035189)
3.8 57.7 GO:0042555 MCM complex(GO:0042555)
3.3 23.3 GO:0031298 replication fork protection complex(GO:0031298)
2.4 12.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.8 16.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
1.8 5.4 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
1.6 4.8 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.5 5.9 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
1.5 4.4 GO:0035061 interchromatin granule(GO:0035061)
1.3 9.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
1.2 15.0 GO:0000800 lateral element(GO:0000800)
1.1 5.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.1 59.2 GO:0005657 replication fork(GO:0005657)
1.1 1.1 GO:0001740 Barr body(GO:0001740)
1.0 1.0 GO:0000811 GINS complex(GO:0000811)
1.0 10.3 GO:0000796 condensin complex(GO:0000796)
1.0 7.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.9 48.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.7 4.3 GO:0098536 deuterosome(GO:0098536)
0.7 2.0 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.6 8.8 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.6 13.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.6 2.8 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.6 5.1 GO:0061617 MICOS complex(GO:0061617)
0.5 34.8 GO:0005871 kinesin complex(GO:0005871)
0.5 4.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.5 5.8 GO:0000795 synaptonemal complex(GO:0000795)
0.5 32.3 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.5 1.9 GO:0001673 male germ cell nucleus(GO:0001673)
0.5 48.4 GO:0005814 centriole(GO:0005814)
0.5 66.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.5 2.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.4 1.7 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.4 3.3 GO:0070652 HAUS complex(GO:0070652)
0.4 2.5 GO:0070187 telosome(GO:0070187)
0.4 3.2 GO:0016580 Sin3 complex(GO:0016580)
0.3 4.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.3 5.2 GO:1904115 axon cytoplasm(GO:1904115)
0.3 0.9 GO:0031251 PAN complex(GO:0031251)
0.2 64.7 GO:0005667 transcription factor complex(GO:0005667)
0.2 1.1 GO:0001652 granular component(GO:0001652)
0.2 2.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 1.0 GO:0005683 U7 snRNP(GO:0005683)
0.2 15.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 10.3 GO:0072686 mitotic spindle(GO:0072686)
0.2 2.7 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 1.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 0.8 GO:0033503 HULC complex(GO:0033503)
0.2 3.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 2.2 GO:0070938 contractile ring(GO:0070938)
0.1 99.7 GO:0005694 chromosome(GO:0005694)
0.1 15.8 GO:0005819 spindle(GO:0005819)
0.1 0.4 GO:0018444 translation release factor complex(GO:0018444)
0.1 11.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.8 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.6 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 1.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 2.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 2.2 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 4.9 GO:0016605 PML body(GO:0016605)
0.1 0.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 1.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.1 GO:0036038 MKS complex(GO:0036038)
0.1 1.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 2.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.4 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 1.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.4 GO:0001772 immunological synapse(GO:0001772)
0.0 2.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.9 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 1.3 GO:0005901 caveola(GO:0005901)
0.0 0.2 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.0 114.0 GO:0005634 nucleus(GO:0005634)
0.0 0.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
12.3 49.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
10.9 65.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
9.6 48.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
4.9 14.8 GO:0051870 methotrexate binding(GO:0051870)
3.3 48.9 GO:0035173 histone kinase activity(GO:0035173)
3.2 45.5 GO:0003688 DNA replication origin binding(GO:0003688)
2.9 20.0 GO:0000150 recombinase activity(GO:0000150)
2.6 18.0 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
2.5 12.3 GO:0000405 bubble DNA binding(GO:0000405)
2.3 9.3 GO:0036033 mediator complex binding(GO:0036033)
2.0 5.9 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
1.9 13.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.9 7.5 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
1.5 6.2 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
1.5 16.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.5 5.9 GO:0070279 vitamin B6 binding(GO:0070279)
1.4 8.5 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
1.4 8.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
1.2 5.0 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
1.1 3.3 GO:0048256 flap endonuclease activity(GO:0048256)
1.1 8.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.1 32.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.1 8.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
1.0 4.1 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.8 7.1 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.8 4.6 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.8 12.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.7 2.1 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.7 5.6 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.7 4.9 GO:0032184 SUMO polymer binding(GO:0032184)
0.7 10.3 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.6 13.8 GO:0070182 DNA polymerase binding(GO:0070182)
0.6 8.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.6 13.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.5 4.8 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.5 3.7 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.5 6.0 GO:0031996 thioesterase binding(GO:0031996)
0.5 40.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.5 6.0 GO:0031386 protein tag(GO:0031386)
0.5 30.8 GO:0000975 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
0.5 2.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.5 3.2 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.5 90.6 GO:0001047 core promoter binding(GO:0001047)
0.4 4.3 GO:0008517 folic acid transporter activity(GO:0008517)
0.4 20.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.4 34.8 GO:0003777 microtubule motor activity(GO:0003777)
0.4 2.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.4 4.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.4 1.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.4 2.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.3 1.0 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.3 13.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.3 3.8 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.3 11.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 1.3 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.3 0.3 GO:1990715 mRNA CDS binding(GO:1990715)
0.3 6.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.3 2.9 GO:0050733 RS domain binding(GO:0050733)
0.3 11.3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 29.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 8.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 1.6 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 1.7 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.2 30.5 GO:0004386 helicase activity(GO:0004386)
0.2 56.1 GO:0005096 GTPase activator activity(GO:0005096)
0.2 2.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 1.3 GO:0098821 BMP receptor activity(GO:0098821)
0.2 3.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 0.5 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2 2.6 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.2 5.2 GO:0005112 Notch binding(GO:0005112)
0.1 3.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.8 GO:0097016 L27 domain binding(GO:0097016)
0.1 32.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 4.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.9 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.1 19.0 GO:0042393 histone binding(GO:0042393)
0.1 9.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 1.0 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 1.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.6 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 2.4 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 21.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 17.5 GO:0003682 chromatin binding(GO:0003682)
0.1 39.0 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 0.6 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 1.1 GO:0031005 filamin binding(GO:0031005)
0.1 2.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 3.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 21.3 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 2.0 GO:0030332 cyclin binding(GO:0030332)
0.1 1.9 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 1.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.7 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 5.1 GO:0051087 chaperone binding(GO:0051087)
0.1 0.4 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 1.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.0 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 1.6 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 3.6 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 1.1 GO:0002039 p53 binding(GO:0002039)
0.0 1.1 GO:0016887 ATPase activity(GO:0016887)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 8.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 9.0 GO:0003677 DNA binding(GO:0003677)
0.0 1.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 2.4 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.5 GO:0019842 vitamin binding(GO:0019842)
0.0 0.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
8.2 74.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
5.2 73.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
2.8 121.3 PID_ATR_PATHWAY ATR signaling pathway
1.8 140.5 PID_E2F_PATHWAY E2F transcription factor network
1.3 43.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.7 34.3 PID_PLK1_PATHWAY PLK1 signaling events
0.6 15.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 18.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.3 4.9 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3 29.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 11.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.2 10.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 4.7 PID_ATM_PATHWAY ATM pathway
0.2 3.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.2 2.0 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 8.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.2 8.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 7.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 1.6 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.2 2.0 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 2.7 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 2.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 2.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 4.3 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.8 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 2.2 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.4 PID_BMP_PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
8.8 175.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
8.4 92.1 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
4.5 63.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
3.5 31.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
2.5 41.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
2.1 8.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.8 12.9 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
1.7 23.4 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
1.5 17.9 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
1.1 30.4 REACTOME_KINESINS Genes involved in Kinesins
1.0 5.8 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.6 33.0 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.5 2.5 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.4 3.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.4 11.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.4 5.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.4 7.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.4 8.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.3 5.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.3 57.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 5.2 REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4
0.3 10.8 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.3 5.0 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.3 9.1 REACTOME_RNA_POL_I_TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.2 2.7 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.2 1.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 5.3 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 2.2 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.2 2.0 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.2 4.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 2.6 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.2 1.3 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2 4.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 5.9 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 4.3 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 2.1 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.0 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ Genes involved in Cleavage of Growing Transcript in the Termination Region
0.1 5.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.8 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 13.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.7 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.6 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 3.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.0 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 2.6 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 0.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane