Motif ID: E2f3

Z-value: 1.340


Transcription factors associated with E2f3:

Gene SymbolEntrez IDGene Name
E2f3 ENSMUSG00000016477.11 E2f3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f3mm10_v2_chr13_-_29984219_299843530.464.4e-03Click!


Activity profile for motif E2f3.

activity profile for motif E2f3


Sorted Z-values histogram for motif E2f3

Sorted Z-values for motif E2f3



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_137314394 12.182 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr11_-_101551837 8.700 ENSMUST00000017290.4
Brca1
breast cancer 1
chr2_-_127133909 6.658 ENSMUST00000110387.3
Ncaph
non-SMC condensin I complex, subunit H
chr4_+_46450892 5.845 ENSMUST00000102926.4
Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr5_+_114568016 5.590 ENSMUST00000043650.7
Fam222a
family with sequence similarity 222, member A
chr2_+_109280738 5.468 ENSMUST00000028527.7
Kif18a
kinesin family member 18A
chr12_+_24708241 5.406 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr2_-_180225812 5.169 ENSMUST00000015791.5
Lama5
laminin, alpha 5
chr11_-_100759942 5.135 ENSMUST00000107363.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr15_+_102296256 5.114 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr3_+_69004969 5.026 ENSMUST00000136502.1
ENSMUST00000107803.1
Smc4

structural maintenance of chromosomes 4

chr19_+_41482632 4.996 ENSMUST00000067795.5
Lcor
ligand dependent nuclear receptor corepressor
chr6_+_7555053 4.978 ENSMUST00000090679.2
ENSMUST00000184986.1
Tac1

tachykinin 1

chr1_-_134079114 4.834 ENSMUST00000020692.6
Btg2
B cell translocation gene 2, anti-proliferative
chr16_-_78376758 4.749 ENSMUST00000023570.7
Btg3
B cell translocation gene 3
chr18_+_11657349 4.726 ENSMUST00000047322.6
Rbbp8
retinoblastoma binding protein 8
chr3_+_69004711 4.654 ENSMUST00000042901.8
Smc4
structural maintenance of chromosomes 4
chr4_+_115000156 4.599 ENSMUST00000030490.6
Stil
Scl/Tal1 interrupting locus
chr10_+_20347788 4.417 ENSMUST00000169712.1
Mtfr2
mitochondrial fission regulator 2
chr3_+_41742615 4.310 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr19_+_21778325 4.288 ENSMUST00000096194.2
ENSMUST00000025663.6
Tmem2

transmembrane protein 2

chr6_+_85187438 3.853 ENSMUST00000045942.8
Emx1
empty spiracles homeobox 1
chr4_+_115000174 3.828 ENSMUST00000129957.1
Stil
Scl/Tal1 interrupting locus
chr11_-_100759740 3.646 ENSMUST00000107361.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr10_-_61147659 3.617 ENSMUST00000092498.5
ENSMUST00000137833.1
ENSMUST00000155919.1
Sgpl1


sphingosine phosphate lyase 1


chr4_-_133967235 3.571 ENSMUST00000123234.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr1_+_187609028 3.558 ENSMUST00000110939.1
Esrrg
estrogen-related receptor gamma
chr19_+_40894692 3.533 ENSMUST00000050092.6
Zfp518a
zinc finger protein 518A
chr2_+_102659213 3.361 ENSMUST00000111213.1
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr10_-_61147625 3.355 ENSMUST00000122259.1
Sgpl1
sphingosine phosphate lyase 1
chr7_+_13278778 3.354 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
Lig1


ligase I, DNA, ATP-dependent


chr8_+_34807287 3.227 ENSMUST00000033930.4
Dusp4
dual specificity phosphatase 4
chr10_+_50895651 3.180 ENSMUST00000020071.3
Sim1
single-minded homolog 1 (Drosophila)
chr5_-_100719675 2.809 ENSMUST00000112908.1
ENSMUST00000045617.8
Hpse

heparanase

chr3_+_59006978 2.764 ENSMUST00000040325.7
ENSMUST00000164225.1
ENSMUST00000040846.8
ENSMUST00000029393.8
Med12l



mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)-like



chrX_-_53269786 2.755 ENSMUST00000114841.1
ENSMUST00000071023.5
Fam122b

family with sequence similarity 122, member B

chr16_-_4719148 2.694 ENSMUST00000115851.3
Nmral1
NmrA-like family domain containing 1
chr2_+_144556229 2.671 ENSMUST00000143573.1
ENSMUST00000028916.8
ENSMUST00000155258.1
Sec23b


SEC23B (S. cerevisiae)


chr17_+_26917091 2.653 ENSMUST00000078961.4
Kifc5b
kinesin family member C5B
chr16_+_17489600 2.646 ENSMUST00000115685.1
Aifm3
apoptosis-inducing factor, mitochondrion-associated 3
chr6_+_47454320 2.623 ENSMUST00000031697.8
Cul1
cullin 1
chr17_-_67354459 2.617 ENSMUST00000037974.8
Ptprm
protein tyrosine phosphatase, receptor type, M
chr3_-_95217690 2.544 ENSMUST00000107209.1
Gabpb2
GA repeat binding protein, beta 2
chr16_-_4719078 2.525 ENSMUST00000120056.1
ENSMUST00000074970.7
Nmral1

NmrA-like family domain containing 1

chr9_-_79793507 2.510 ENSMUST00000120690.1
Tmem30a
transmembrane protein 30A
chr7_-_75309262 2.380 ENSMUST00000165175.1
Sv2b
synaptic vesicle glycoprotein 2 b
chr9_-_79793378 2.327 ENSMUST00000034878.5
Tmem30a
transmembrane protein 30A
chr5_-_65697856 2.283 ENSMUST00000031104.6
Pds5a
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr12_+_4917376 2.252 ENSMUST00000045664.5
Atad2b
ATPase family, AAA domain containing 2B
chr11_+_21239279 2.230 ENSMUST00000006221.7
ENSMUST00000109578.1
Vps54

vacuolar protein sorting 54 (yeast)

chr10_+_17723220 2.185 ENSMUST00000038107.7
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr3_-_95217877 2.162 ENSMUST00000136139.1
Gabpb2
GA repeat binding protein, beta 2
chr4_-_130275523 2.158 ENSMUST00000146478.1
Serinc2
serine incorporator 2
chr19_+_53600377 2.156 ENSMUST00000025930.9
Smc3
structural maintenance of chromosomes 3
chr1_+_44147847 2.137 ENSMUST00000027214.3
Ercc5
excision repair cross-complementing rodent repair deficiency, complementation group 5
chr2_-_168590191 2.095 ENSMUST00000029057.6
ENSMUST00000074618.3
Nfatc2

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2

chr14_+_8214135 2.042 ENSMUST00000022272.6
Kctd6
potassium channel tetramerisation domain containing 6
chr5_+_32611171 1.967 ENSMUST00000072311.6
ENSMUST00000168707.2
Yes1

Yamaguchi sarcoma viral (v-yes) oncogene homolog 1

chr8_+_128685654 1.967 ENSMUST00000090006.5
Itgb1
integrin beta 1 (fibronectin receptor beta)
chr13_-_21531084 1.957 ENSMUST00000045228.5
Zkscan8
zinc finger with KRAB and SCAN domains 8
chr2_+_144556306 1.954 ENSMUST00000155876.1
ENSMUST00000149697.1
Sec23b

SEC23B (S. cerevisiae)

chr5_-_45857473 1.920 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
Lcorl


ligand dependent nuclear receptor corepressor-like


chr3_+_81932601 1.881 ENSMUST00000029649.2
Ctso
cathepsin O
chr3_-_41742471 1.863 ENSMUST00000026866.8
Sclt1
sodium channel and clathrin linker 1
chr12_-_69228167 1.845 ENSMUST00000021359.5
Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr13_+_84222286 1.790 ENSMUST00000057495.8
Tmem161b
transmembrane protein 161B
chr12_-_21373550 1.747 ENSMUST00000101551.3
Adam17
a disintegrin and metallopeptidase domain 17
chr4_+_33031371 1.744 ENSMUST00000124992.1
Ube2j1
ubiquitin-conjugating enzyme E2J 1
chr12_-_21373606 1.737 ENSMUST00000064536.6
Adam17
a disintegrin and metallopeptidase domain 17
chr16_+_43889896 1.735 ENSMUST00000122014.1
ENSMUST00000178400.1
2610015P09Rik

RIKEN cDNA 2610015P09 gene

chr1_+_127774164 1.715 ENSMUST00000027587.8
ENSMUST00000112570.1
Ccnt2

cyclin T2

chr15_-_79605084 1.700 ENSMUST00000023065.6
Dmc1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
chr2_-_37703845 1.673 ENSMUST00000155237.1
Strbp
spermatid perinuclear RNA binding protein
chr16_+_43889800 1.649 ENSMUST00000132859.1
2610015P09Rik
RIKEN cDNA 2610015P09 gene
chr14_-_13961202 1.648 ENSMUST00000065865.8
Thoc7
THO complex 7 homolog (Drosophila)
chr1_+_139422196 1.646 ENSMUST00000039867.7
Zbtb41
zinc finger and BTB domain containing 41 homolog
chr6_-_51469869 1.645 ENSMUST00000114459.1
ENSMUST00000069949.6
Hnrnpa2b1

heterogeneous nuclear ribonucleoprotein A2/B1

chr9_-_105495130 1.640 ENSMUST00000038118.7
Atp2c1
ATPase, Ca++-sequestering
chr2_+_128818104 1.624 ENSMUST00000110325.1
Tmem87b
transmembrane protein 87B
chr1_-_191575534 1.596 ENSMUST00000027933.5
Dtl
denticleless homolog (Drosophila)
chr13_-_55329723 1.576 ENSMUST00000021941.7
Mxd3
Max dimerization protein 3
chr8_-_57487801 1.564 ENSMUST00000034022.3
Sap30
sin3 associated polypeptide
chr13_+_117220584 1.547 ENSMUST00000022242.7
Emb
embigin
chrX_-_49288229 1.518 ENSMUST00000114918.2
ENSMUST00000033437.8
ENSMUST00000114912.1
ENSMUST00000114911.1
Enox2



ecto-NOX disulfide-thiol exchanger 2



chr5_+_108132885 1.478 ENSMUST00000047677.7
Ccdc18
coiled-coil domain containing 18
chr12_-_11265768 1.436 ENSMUST00000166117.1
Gen1
Gen homolog 1, endonuclease (Drosophila)
chr10_-_7780866 1.432 ENSMUST00000124838.1
ENSMUST00000039763.7
Ginm1

glycoprotein integral membrane 1

chr19_+_53944870 1.424 ENSMUST00000025932.7
Shoc2
soc-2 (suppressor of clear) homolog (C. elegans)
chr3_-_69004565 1.404 ENSMUST00000169064.1
Ift80
intraflagellar transport 80
chr12_-_4874341 1.401 ENSMUST00000137337.1
ENSMUST00000045921.7
Mfsd2b

major facilitator superfamily domain containing 2B

chrX_+_101274198 1.349 ENSMUST00000117203.1
ENSMUST00000087948.4
ENSMUST00000087956.5
Med12


mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)


chrX_+_103356464 1.341 ENSMUST00000116547.2
Chic1
cysteine-rich hydrophobic domain 1
chr3_-_69004503 1.339 ENSMUST00000107812.1
Ift80
intraflagellar transport 80
chr4_+_34614940 1.337 ENSMUST00000029968.7
ENSMUST00000148519.1
Rars2

arginyl-tRNA synthetase 2, mitochondrial

chr6_-_51469836 1.331 ENSMUST00000090002.7
Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr5_-_108132541 1.329 ENSMUST00000119437.1
ENSMUST00000118036.1
Tmed5

transmembrane emp24 protein transport domain containing 5

chrX_+_101274023 1.319 ENSMUST00000117706.1
Med12
mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
chr7_-_6730412 1.290 ENSMUST00000051209.4
Peg3
paternally expressed 3
chr4_+_117096049 1.288 ENSMUST00000030443.5
Ptch2
patched homolog 2
chr7_+_100372224 1.287 ENSMUST00000051777.8
ENSMUST00000098259.4
C2cd3

C2 calcium-dependent domain containing 3

chr1_-_95667555 1.284 ENSMUST00000043336.4
St8sia4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr3_+_88607742 1.252 ENSMUST00000175903.1
Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr3_-_69004475 1.233 ENSMUST00000154741.1
ENSMUST00000148031.1
Ift80

intraflagellar transport 80

chr9_-_72985344 1.224 ENSMUST00000124565.2
Gm5918
predicted gene 5918
chr7_-_142372210 1.208 ENSMUST00000084412.5
Ifitm10
interferon induced transmembrane protein 10
chr16_+_43889936 1.200 ENSMUST00000151183.1
2610015P09Rik
RIKEN cDNA 2610015P09 gene
chr9_-_96631487 1.154 ENSMUST00000128346.1
ENSMUST00000034984.6
Rasa2

RAS p21 protein activator 2

chr4_-_148159838 1.130 ENSMUST00000151127.1
ENSMUST00000105705.2
Fbxo44

F-box protein 44

chr9_-_105495037 1.130 ENSMUST00000176190.1
ENSMUST00000163879.2
ENSMUST00000112558.2
ENSMUST00000176390.1
Atp2c1



ATPase, Ca++-sequestering



chr9_+_64281575 1.110 ENSMUST00000034964.6
Tipin
timeless interacting protein
chrX_-_49288195 1.106 ENSMUST00000114914.1
Enox2
ecto-NOX disulfide-thiol exchanger 2
chr11_+_94741782 1.086 ENSMUST00000021240.6
Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr8_+_57488053 1.079 ENSMUST00000180690.1
2500002B13Rik
RIKEN cDNA 2500002B13 gene
chr17_-_74294834 1.068 ENSMUST00000078459.6
Memo1
mediator of cell motility 1
chr13_-_21402688 1.067 ENSMUST00000117721.1
ENSMUST00000070785.8
ENSMUST00000116433.1
ENSMUST00000116434.3
Zkscan3



zinc finger with KRAB and SCAN domains 3



chr6_-_71440623 1.046 ENSMUST00000002292.8
Rmnd5a
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr4_+_32615473 1.030 ENSMUST00000178925.1
ENSMUST00000029950.3
Casp8ap2

caspase 8 associated protein 2

chr9_+_56041857 1.025 ENSMUST00000114276.2
Rcn2
reticulocalbin 2
chr9_-_39603635 1.022 ENSMUST00000119722.1
AW551984
expressed sequence AW551984
chr10_-_61784014 0.985 ENSMUST00000020283.4
H2afy2
H2A histone family, member Y2
chr14_-_30626196 0.982 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
Prkcd


protein kinase C, delta


chr4_+_140701466 0.982 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr16_+_34690548 0.981 ENSMUST00000023532.6
Ccdc14
coiled-coil domain containing 14
chr3_-_95217741 0.960 ENSMUST00000107204.1
Gabpb2
GA repeat binding protein, beta 2
chr17_-_80062333 0.956 ENSMUST00000061331.7
Hnrnpll
heterogeneous nuclear ribonucleoprotein L-like
chr5_-_137333561 0.955 ENSMUST00000039991.7
Slc12a9
solute carrier family 12 (potassium/chloride transporters), member 9
chr12_+_11265867 0.950 ENSMUST00000020931.5
Smc6
structural maintenance of chromosomes 6
chr5_+_74535449 0.908 ENSMUST00000080164.5
ENSMUST00000113536.1
ENSMUST00000122245.1
ENSMUST00000120618.1
ENSMUST00000113535.2
ENSMUST00000113534.2
Fip1l1





FIP1 like 1 (S. cerevisiae)





chr8_+_105860634 0.884 ENSMUST00000008594.7
Nutf2
nuclear transport factor 2
chr5_-_143315360 0.878 ENSMUST00000046418.2
E130309D02Rik
RIKEN cDNA E130309D02 gene
chr16_+_36875119 0.870 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chr7_+_28808795 0.849 ENSMUST00000172529.1
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr13_-_21531032 0.833 ENSMUST00000156674.2
ENSMUST00000110481.2
Zkscan8

zinc finger with KRAB and SCAN domains 8

chr5_+_74535535 0.829 ENSMUST00000121950.1
Fip1l1
FIP1 like 1 (S. cerevisiae)
chr5_-_33936301 0.827 ENSMUST00000030993.6
Nelfa
negative elongation factor complex member A, Whsc2
chr9_-_62980874 0.826 ENSMUST00000098651.4
Pias1
protein inhibitor of activated STAT 1
chr11_+_101552188 0.803 ENSMUST00000147239.1
Nbr1
neighbor of Brca1 gene 1
chr9_+_109875541 0.785 ENSMUST00000094324.3
Cdc25a
cell division cycle 25A
chr11_-_120796369 0.784 ENSMUST00000143139.1
ENSMUST00000129955.1
ENSMUST00000026151.4
ENSMUST00000167023.1
ENSMUST00000106133.1
ENSMUST00000106135.1
Dus1l





dihydrouridine synthase 1-like (S. cerevisiae)





chr17_-_80062199 0.766 ENSMUST00000184635.1
Hnrnpll
heterogeneous nuclear ribonucleoprotein L-like
chr3_+_33800158 0.762 ENSMUST00000139880.1
ENSMUST00000076916.6
ENSMUST00000142280.1
ENSMUST00000117915.1
ENSMUST00000108210.2
Ttc14




tetratricopeptide repeat domain 14




chr14_+_73143564 0.758 ENSMUST00000110952.3
Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr9_+_108854024 0.746 ENSMUST00000098376.3
Slc26a6
solute carrier family 26, member 6
chr2_+_76675265 0.746 ENSMUST00000111920.1
Plekha3
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
chrX_-_51205773 0.741 ENSMUST00000114875.1
Mbnl3
muscleblind-like 3 (Drosophila)
chr14_+_73143099 0.737 ENSMUST00000169513.1
ENSMUST00000165727.1
ENSMUST00000165567.1
ENSMUST00000022702.6
Rcbtb2



regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2



chr14_+_30716377 0.731 ENSMUST00000112177.1
Sfmbt1
Scm-like with four mbt domains 1
chr9_+_102717668 0.634 ENSMUST00000035121.7
Amotl2
angiomotin-like 2
chr11_-_86544754 0.600 ENSMUST00000138810.1
ENSMUST00000058286.2
ENSMUST00000154617.1
Rps6kb1


ribosomal protein S6 kinase, polypeptide 1


chr5_+_72914554 0.593 ENSMUST00000143829.1
Slain2
SLAIN motif family, member 2
chr3_-_84155762 0.591 ENSMUST00000047368.6
Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr7_+_90130227 0.583 ENSMUST00000049537.7
Picalm
phosphatidylinositol binding clathrin assembly protein
chrX_-_51205990 0.577 ENSMUST00000114876.2
Mbnl3
muscleblind-like 3 (Drosophila)
chr2_+_115581667 0.562 ENSMUST00000166472.1
ENSMUST00000110918.2
BC052040

cDNA sequence BC052040

chr1_+_191906743 0.561 ENSMUST00000044954.6
Slc30a1
solute carrier family 30 (zinc transporter), member 1
chrX_-_105929397 0.547 ENSMUST00000113573.1
ENSMUST00000130980.1
Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr3_-_51340555 0.544 ENSMUST00000091144.4
Elf2
E74-like factor 2
chr18_+_44380479 0.542 ENSMUST00000025350.8
Dcp2
DCP2 decapping enzyme homolog (S. cerevisiae)
chr13_+_45078692 0.534 ENSMUST00000054395.6
Gm9817
predicted gene 9817
chr8_-_119605199 0.527 ENSMUST00000093099.6
Taf1c
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, C
chr3_-_51340628 0.523 ENSMUST00000062009.7
Elf2
E74-like factor 2
chr6_+_29768443 0.517 ENSMUST00000166718.1
ENSMUST00000102995.2
ENSMUST00000115242.2
Ahcyl2


S-adenosylhomocysteine hydrolase-like 2


chr14_-_54864055 0.516 ENSMUST00000142283.2
Homez
homeodomain leucine zipper-encoding gene
chr4_+_3938888 0.513 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr14_-_60251473 0.506 ENSMUST00000041905.6
Nupl1
nucleoporin like 1
chr16_-_43889669 0.490 ENSMUST00000023387.7
Qtrtd1
queuine tRNA-ribosyltransferase domain containing 1
chr11_+_101552135 0.486 ENSMUST00000103099.1
Nbr1
neighbor of Brca1 gene 1
chr5_-_108132577 0.471 ENSMUST00000061203.6
ENSMUST00000002837.4
Tmed5

transmembrane emp24 protein transport domain containing 5

chr10_-_91123955 0.469 ENSMUST00000164505.1
ENSMUST00000170810.1
ENSMUST00000076694.6
Slc25a3


solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3


chr17_+_29032664 0.469 ENSMUST00000130216.1
Srsf3
serine/arginine-rich splicing factor 3
chr17_-_56584585 0.467 ENSMUST00000075510.5
Safb2
scaffold attachment factor B2
chrX_-_102189371 0.449 ENSMUST00000033683.7
Rps4x
ribosomal protein S4, X-linked
chr7_+_113513854 0.449 ENSMUST00000067929.8
ENSMUST00000129087.1
ENSMUST00000164745.1
ENSMUST00000136158.1
Far1



fatty acyl CoA reductase 1



chrX_+_47912387 0.445 ENSMUST00000001202.8
ENSMUST00000115020.1
Ocrl

oculocerebrorenal syndrome of Lowe

chr18_-_65939048 0.444 ENSMUST00000025396.3
Rax
retina and anterior neural fold homeobox
chr6_+_57580992 0.438 ENSMUST00000031817.8
Herc6
hect domain and RLD 6
chr7_+_133637686 0.432 ENSMUST00000128901.2
2700050L05Rik
RIKEN cDNA 2700050L05 gene
chr5_-_92505518 0.432 ENSMUST00000031377.7
Scarb2
scavenger receptor class B, member 2
chr3_-_127553233 0.424 ENSMUST00000029588.5
Larp7
La ribonucleoprotein domain family, member 7
chr12_-_69681795 0.423 ENSMUST00000183277.1
ENSMUST00000035773.7
Sos2

son of sevenless homolog 2 (Drosophila)

chr16_+_91647859 0.420 ENSMUST00000119368.1
ENSMUST00000114037.2
ENSMUST00000114036.2
ENSMUST00000122302.1
Son



Son DNA binding protein



chr12_+_80945520 0.420 ENSMUST00000110354.1
ENSMUST00000110352.3
ENSMUST00000110351.1
ENSMUST00000110356.2
Srsf5



serine/arginine-rich splicing factor 5



chrX_-_105929206 0.402 ENSMUST00000134381.1
ENSMUST00000154866.1
Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr5_-_39644597 0.394 ENSMUST00000152057.1
Hs3st1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr16_+_13109682 0.393 ENSMUST00000023206.7
Ercc4
excision repair cross-complementing rodent repair deficiency, complementation group 4
chr8_+_13287887 0.376 ENSMUST00000045229.5
Tmco3
transmembrane and coiled-coil domains 3
chr9_+_103112072 0.375 ENSMUST00000035155.6
Rab6b
RAB6B, member RAS oncogene family
chr2_-_103797617 0.355 ENSMUST00000028607.6
Caprin1
cell cycle associated protein 1
chr7_+_113513829 0.349 ENSMUST00000033018.8
Far1
fatty acyl CoA reductase 1
chr11_+_55213783 0.332 ENSMUST00000108867.1
Slc36a1
solute carrier family 36 (proton/amino acid symporter), member 1
chr9_-_20976762 0.328 ENSMUST00000054197.5
S1pr2
sphingosine-1-phosphate receptor 2
chr9_+_57076343 0.307 ENSMUST00000168678.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr19_+_56874249 0.304 ENSMUST00000026068.7
Vwa2
von Willebrand factor A domain containing 2
chr9_+_44240668 0.302 ENSMUST00000092426.3
Ccdc153
coiled-coil domain containing 153
chr1_+_156558759 0.291 ENSMUST00000173929.1
Abl2
v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
chr10_-_62449738 0.289 ENSMUST00000020273.9
Supv3l1
suppressor of var1, 3-like 1 (S. cerevisiae)
chr4_-_34614886 0.285 ENSMUST00000140334.1
ENSMUST00000108142.1
ENSMUST00000048706.3
Orc3


origin recognition complex, subunit 3


chr4_+_131843459 0.283 ENSMUST00000030742.4
ENSMUST00000137321.1
Mecr

mitochondrial trans-2-enoyl-CoA reductase

chr2_+_103969528 0.282 ENSMUST00000123437.1
ENSMUST00000163256.1
Lmo2

LIM domain only 2

chr4_+_155812489 0.279 ENSMUST00000030944.4
Ccnl2
cyclin L2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.7 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
2.2 6.7 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
1.7 5.0 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
1.4 9.7 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.9 4.7 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.9 2.8 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.9 3.5 GO:0035624 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) response to high density lipoprotein particle(GO:0055099)
0.8 2.5 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.8 7.2 GO:0033504 floor plate development(GO:0033504)
0.8 2.3 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.7 4.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.7 2.8 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.7 4.8 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.6 1.7 GO:0019085 early viral transcription(GO:0019085)
0.5 2.2 GO:0061428 embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.5 3.4 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.5 3.4 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.4 4.0 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.4 7.0 GO:0033327 Leydig cell differentiation(GO:0033327)
0.4 5.1 GO:0051307 meiotic chromosome separation(GO:0051307)
0.4 3.0 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.4 2.7 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702) axis elongation involved in somitogenesis(GO:0090245)
0.4 6.7 GO:0072520 seminiferous tubule development(GO:0072520)
0.3 1.3 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.3 1.3 GO:0009957 epidermal cell fate specification(GO:0009957)
0.3 3.9 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.3 1.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 2.2 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.3 1.8 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.3 4.8 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.3 5.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 0.9 GO:0090204 protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046)
0.3 2.2 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.3 5.8 GO:0043486 histone exchange(GO:0043486)
0.3 1.3 GO:0061511 centriole elongation(GO:0061511)
0.3 1.0 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.3 4.1 GO:0006312 mitotic recombination(GO:0006312)
0.2 0.7 GO:0035672 transepithelial chloride transport(GO:0030321) oligopeptide transmembrane transport(GO:0035672)
0.2 1.6 GO:0019985 translesion synthesis(GO:0019985)
0.2 3.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 2.3 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.2 1.0 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.2 1.0 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.2 1.7 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 0.6 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.2 1.1 GO:0048478 replication fork protection(GO:0048478)
0.2 0.5 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.2 1.7 GO:1904152 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) regulation of retrograde protein transport, ER to cytosol(GO:1904152) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.2 1.0 GO:0036337 Fas signaling pathway(GO:0036337)
0.2 1.0 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.2 0.8 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.2 1.3 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.2 1.5 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 0.6 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 1.6 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.1 0.6 GO:1905245 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) negative regulation of metalloendopeptidase activity(GO:1904684) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1 3.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.1 1.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.3 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.1 2.1 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 2.0 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.1 5.2 GO:0001755 neural crest cell migration(GO:0001755)
0.1 2.6 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.1 1.1 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.1 0.3 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.5 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 0.8 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 0.8 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.1 0.4 GO:2000973 regulation of pro-B cell differentiation(GO:2000973)
0.1 1.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 1.6 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 0.8 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 4.4 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.3 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) mitochondrial RNA 3'-end processing(GO:0000965)
0.1 2.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 3.6 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.3 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.1 0.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.2 GO:0060406 positive regulation of penile erection(GO:0060406)
0.1 0.1 GO:0003134 heart induction(GO:0003129) BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) cell-cell signaling involved in cell fate commitment(GO:0045168)
0.1 1.7 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 1.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.3 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.4 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 2.2 GO:0050879 multicellular organismal movement(GO:0050879) musculoskeletal movement(GO:0050881)
0.0 2.1 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.0 1.4 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.0 0.1 GO:1904179 positive regulation of adipose tissue development(GO:1904179)
0.0 0.6 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 1.0 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 2.6 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 3.2 GO:0072164 ureteric bud development(GO:0001657) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164)
0.0 0.4 GO:0021854 hypothalamus development(GO:0021854)
0.0 1.2 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 0.3 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 2.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.5 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.0 0.3 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 1.3 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.2 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0 0.5 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 3.8 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 1.6 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 2.2 GO:0048511 rhythmic process(GO:0048511)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.7 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 0.6 GO:0035329 hippo signaling(GO:0035329)
0.0 0.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.8 GO:0034644 cellular response to UV(GO:0034644)
0.0 0.3 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.3 GO:0001706 endoderm formation(GO:0001706)
0.0 0.3 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.6 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.5 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.1 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555) initiation of neural tube closure(GO:0021993)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:0000799 nuclear condensin complex(GO:0000799)
1.4 8.7 GO:0070531 BRCA1-A complex(GO:0070531)
1.4 9.7 GO:0000796 condensin complex(GO:0000796)
1.3 5.2 GO:0043259 laminin-10 complex(GO:0043259)
1.1 5.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.8 5.5 GO:0005828 kinetochore microtubule(GO:0005828)
0.7 2.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.7 2.0 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)
0.5 2.2 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.4 2.2 GO:0000938 GARP complex(GO:0000938)
0.4 1.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.3 1.0 GO:0034657 GID complex(GO:0034657)
0.3 0.9 GO:0035061 interchromatin granule(GO:0035061)
0.3 4.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.3 1.2 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.3 0.3 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.2 3.0 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.2 1.6 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 0.8 GO:0032021 NELF complex(GO:0032021)
0.2 0.6 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.2 1.9 GO:0071439 clathrin complex(GO:0071439)
0.2 1.6 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 1.1 GO:0031298 replication fork protection complex(GO:0031298)
0.2 1.7 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.2 2.1 GO:0005675 holo TFIIH complex(GO:0005675)
0.1 1.0 GO:0001740 Barr body(GO:0001740)
0.1 5.4 GO:0016592 mediator complex(GO:0016592)
0.1 0.4 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 1.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.9 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.4 GO:0043202 lysosomal lumen(GO:0043202)
0.1 2.0 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 0.5 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 2.1 GO:0016580 Sin3 complex(GO:0016580)
0.1 9.7 GO:0005814 centriole(GO:0005814)
0.1 3.4 GO:0030673 axolemma(GO:0030673)
0.1 1.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 1.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 1.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 4.2 GO:0072686 mitotic spindle(GO:0072686)
0.1 4.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 4.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.8 GO:0045120 pronucleus(GO:0045120)
0.0 1.0 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.5 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.8 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 3.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 1.7 GO:0016605 PML body(GO:0016605)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.0 0.6 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 2.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.7 GO:0031526 brush border membrane(GO:0031526)
0.0 1.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 1.0 GO:0005913 cell-cell adherens junction(GO:0005913)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
1.1 6.7 GO:0044547 DNA topoisomerase binding(GO:0044547)
1.1 5.4 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.1 4.3 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.9 2.6 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.7 2.8 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.6 3.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.6 3.4 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.5 2.2 GO:0036033 mediator complex binding(GO:0036033)
0.5 7.0 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.5 3.0 GO:0001069 regulatory region RNA binding(GO:0001069)
0.5 2.0 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.5 2.8 GO:0045545 syndecan binding(GO:0045545)
0.4 3.5 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.4 1.3 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.4 2.1 GO:0000405 bubble DNA binding(GO:0000405)
0.4 5.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.3 1.3 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.3 5.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 0.8 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.2 5.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 1.0 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.2 1.7 GO:0000150 recombinase activity(GO:0000150)
0.2 1.4 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.2 3.6 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 1.7 GO:0097322 7SK snRNA binding(GO:0097322)
0.2 1.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 0.6 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.2 2.2 GO:0050693 LBD domain binding(GO:0050693)
0.2 0.7 GO:0015563 uptake transmembrane transporter activity(GO:0015563)
0.2 0.5 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.2 1.2 GO:0070087 DNA translocase activity(GO:0015616) chromo shadow domain binding(GO:0070087)
0.2 0.8 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.2 2.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 1.0 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 8.6 GO:0003684 damaged DNA binding(GO:0003684)
0.1 1.0 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 2.6 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.8 GO:0050733 RS domain binding(GO:0050733)
0.1 0.8 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.3 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 8.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 0.8 GO:0097157 pre-mRNA intronic binding(GO:0097157) mRNA CDS binding(GO:1990715)
0.1 5.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 2.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.3 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1 2.0 GO:0030506 ankyrin binding(GO:0030506)
0.1 8.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 1.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 6.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.2 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.1 0.5 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.4 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.1 2.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 1.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 1.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.5 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 1.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 1.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 13.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.6 GO:0003690 double-stranded DNA binding(GO:0003690)
0.0 0.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 6.0 GO:0042393 histone binding(GO:0042393)
0.0 0.4 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.9 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.3 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.2 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.0 20.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 1.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.0 GO:0005178 integrin binding(GO:0005178)
0.0 1.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 3.8 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0008430 selenium binding(GO:0008430)
0.0 0.4 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.4 15.3 PID_ATM_PATHWAY ATM pathway
0.3 16.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 7.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.3 9.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.0 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 4.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 2.6 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 3.2 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 3.5 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 1.0 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 2.2 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 0.8 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.1 1.0 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 4.7 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.0 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 3.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 4.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 2.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.1 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.1 PID_ATR_PATHWAY ATR signaling pathway
0.0 3.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID_ILK_PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.8 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.3 6.2 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 3.5 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.2 2.6 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 3.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.2 8.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 5.1 REACTOME_KINESINS Genes involved in Kinesins
0.2 1.8 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2 7.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 2.0 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.2 2.0 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 0.1 REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.1 2.5 REACTOME_GLOBAL_GENOMIC_NER_GG_NER Genes involved in Global Genomic NER (GG-NER)
0.1 2.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 7.0 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.8 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 5.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.2 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.1 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.1 3.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.7 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 1.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.6 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.5 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.5 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.8 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 2.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 0.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions