Motif ID: E2f4

Z-value: 2.212


Transcription factors associated with E2f4:

Gene SymbolEntrez IDGene Name
E2f4 ENSMUSG00000014859.8 E2f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.764.8e-08Click!


Activity profile for motif E2f4.

activity profile for motif E2f4


Sorted Z-values histogram for motif E2f4

Sorted Z-values for motif E2f4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 168 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_34751502 19.794 ENSMUST00000060710.7
 Cdc25c
cell division cycle 25C
chr8_-_53638945 19.337 ENSMUST00000047768.4
 Neil3
nei like 3 (E. coli)
chr19_+_6084983 18.547 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr11_-_101551837 18.183 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr14_-_47418407 16.270 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr1_-_169531343 15.276 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr6_+_124830217 15.227 ENSMUST00000131847.1
ENSMUST00000151674.1
 Cdca3

cell division cycle associated 3

chr1_-_189688074 14.603 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr9_+_72438534 13.368 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr4_+_134510999 13.124 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr9_+_72438519 13.078 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr1_-_169531447 13.035 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr2_+_163054682 10.668 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr2_-_26503814 10.127 ENSMUST00000028288.4
 Notch1
notch 1
chr4_-_133967296 10.077 ENSMUST00000105893.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr18_+_34751803 10.024 ENSMUST00000181453.1
ENSMUST00000181641.1
 2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr4_-_133967235 9.719 ENSMUST00000123234.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr10_+_79997463 9.687 ENSMUST00000171637.1
ENSMUST00000043866.7
 Abca7

ATP-binding cassette, sub-family A (ABC1), member 7

chr15_+_57912199 9.579 ENSMUST00000022992.6
 Tbc1d31
TBC1 domain family, member 31
chr4_-_116123618 9.363 ENSMUST00000102704.3
ENSMUST00000102705.3
 Rad54l

RAD54 like (S. cerevisiae)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 32.4 GO:0040034 regulation of development, heterochronic(GO:0040034)
2.2 31.0 GO:0070986 left/right axis specification(GO:0070986)
0.8 28.3 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.7 19.8 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.4 19.3 GO:0006284 base-excision repair(GO:0006284)
6.2 18.5 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
6.1 18.2 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.6 16.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.3 16.6 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 16.1 GO:0051301 cell division(GO:0051301)
0.4 14.6 GO:0051310 metaphase plate congression(GO:0051310)
1.6 14.1 GO:0055059 asymmetric neuroblast division(GO:0055059)
1.0 13.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.3 10.7 GO:0090307 mitotic spindle assembly(GO:0090307)
3.4 10.1 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
0.1 9.8 GO:0007051 spindle organization(GO:0007051)
1.9 9.7 GO:1902995 apolipoprotein A-I-mediated signaling pathway(GO:0038027) regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of apoptotic cell clearance(GO:2000427)
0.6 9.4 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
2.2 8.7 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
2.8 8.3 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 28.3 GO:0031262 Ndc80 complex(GO:0031262)
0.4 26.3 GO:0005882 intermediate filament(GO:0005882)
0.0 22.3 GO:0005654 nucleoplasm(GO:0005654)
2.6 18.5 GO:0008278 cohesin complex(GO:0008278)
3.0 18.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.8 16.3 GO:0031616 spindle pole centrosome(GO:0031616)
1.2 14.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 13.6 GO:0016607 nuclear speck(GO:0016607)
0.2 13.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 13.4 GO:0043198 dendritic shaft(GO:0043198)
0.1 13.1 GO:0000922 spindle pole(GO:0000922)
0.0 13.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 13.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 12.8 GO:0000786 nucleosome(GO:0000786)
2.1 10.7 GO:0031523 Myb complex(GO:0031523)
2.0 10.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.4 9.7 GO:0001891 phagocytic cup(GO:0001891)
0.1 9.4 GO:0005814 centriole(GO:0005814)
0.1 7.3 GO:0030315 T-tubule(GO:0030315)
0.8 7.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 19.8 GO:0050699 WW domain binding(GO:0050699)
0.1 19.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
3.9 19.3 GO:0000405 bubble DNA binding(GO:0000405)
0.3 16.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 14.8 GO:0003682 chromatin binding(GO:0003682)
0.1 14.7 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.4 14.6 GO:0070840 dynein complex binding(GO:0070840)
0.3 12.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.8 11.0 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
1.3 10.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 10.1 GO:0005112 Notch binding(GO:0005112)
3.2 9.7 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.9 9.4 GO:0036310 annealing helicase activity(GO:0036310)
1.3 9.1 GO:0015616 DNA translocase activity(GO:0015616)
0.3 8.9 GO:0070182 DNA polymerase binding(GO:0070182)
1.2 8.7 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.3 8.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
1.5 7.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.6 7.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 5.6 GO:0008139 nuclear localization sequence binding(GO:0008139)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 44.2 PID_ATM_PATHWAY ATM pathway
0.4 20.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.5 16.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 13.9 PID_E2F_PATHWAY E2F transcription factor network
0.1 12.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 8.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 8.7 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 8.3 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 7.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 5.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.5 5.4 PID_ALK2_PATHWAY ALK2 signaling events
0.1 4.9 NABA_COLLAGENS Genes encoding collagen proteins
0.1 4.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.1 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 3.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.9 PID_FGF_PATHWAY FGF signaling pathway
0.1 2.7 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.8 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 1.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 31.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.2 25.2 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.9 21.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
2.0 19.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.5 14.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 12.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 10.7 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.5 9.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 8.7 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.2 7.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 6.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 5.4 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 5.2 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.5 5.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 5.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 3.6 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.5 3.2 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.3 2.9 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.2 2.9 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.9 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression