Motif ID: E2f6

Z-value: 0.541


Transcription factors associated with E2f6:

Gene SymbolEntrez IDGene Name
E2f6 ENSMUSG00000057469.7 E2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f6mm10_v2_chr12_+_16810940_168109780.651.4e-05Click!


Activity profile for motif E2f6.

activity profile for motif E2f6


Sorted Z-values histogram for motif E2f6

Sorted Z-values for motif E2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 3.143 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr10_-_127534540 2.374 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr5_+_139543889 2.366 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_-_23248264 1.952 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_-_98004634 1.789 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chrX_-_141725181 1.779 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr15_-_98004695 1.695 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr2_-_64097994 1.594 ENSMUST00000131615.2
 Fign
fidgetin
chr9_+_65890237 1.569 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr13_+_112987802 1.535 ENSMUST00000038404.4
 Ccno
cyclin O
chr11_+_82388900 1.473 ENSMUST00000054245.4
ENSMUST00000092852.2
 Tmem132e

transmembrane protein 132E

chr12_-_46818749 1.423 ENSMUST00000021438.6
 Nova1
neuro-oncological ventral antigen 1
chr14_-_67715585 1.372 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr2_-_117342709 1.325 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr4_+_126556935 1.208 ENSMUST00000048391.8
 Clspn
claspin
chr19_-_58454435 1.197 ENSMUST00000169850.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr19_-_58454580 1.169 ENSMUST00000129100.1
ENSMUST00000123957.1
 Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr4_+_8691303 1.122 ENSMUST00000051558.3
 Chd7
chromodomain helicase DNA binding protein 7
chr7_-_81706905 1.121 ENSMUST00000026922.7
 Homer2
homer homolog 2 (Drosophila)
chr18_+_35829798 1.088 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 321 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.9 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.2 3.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 3.0 GO:0007530 sex determination(GO:0007530)
0.0 2.7 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.1 2.6 GO:0021516 dorsal spinal cord development(GO:0021516)
0.6 2.5 GO:0003360 brainstem development(GO:0003360)
0.2 2.3 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.1 2.2 GO:0051383 kinetochore organization(GO:0051383)
0.2 2.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.7 2.0 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.4 2.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 1.9 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.1 1.6 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 1.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 1.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 1.5 GO:0006284 base-excision repair(GO:0006284)
0.0 1.5 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.4 1.4 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.1 1.4 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.3 3.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 3.3 GO:0000791 euchromatin(GO:0000791)
0.6 2.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 2.8 GO:0016363 nuclear matrix(GO:0016363)
0.8 2.4 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 2.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.8 GO:0005844 polysome(GO:0005844)
0.1 1.7 GO:0097470 ribbon synapse(GO:0097470)
0.1 1.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.5 GO:0000776 kinetochore(GO:0000776)
0.0 1.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.2 GO:0016592 mediator complex(GO:0016592)
0.1 1.1 GO:0032426 stereocilium tip(GO:0032426)
0.1 1.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 1.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 1.0 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 1.0 GO:0000796 condensin complex(GO:0000796)
0.1 1.0 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 166 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.7 3.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 3.4 GO:0042393 histone binding(GO:0042393)
0.0 3.1 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.6 2.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.4 2.4 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 2.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 2.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 2.0 GO:0005178 integrin binding(GO:0005178)
0.1 1.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.8 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 1.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 1.6 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.4 1.5 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.1 1.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.4 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.2 1.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 PID_E2F_PATHWAY E2F transcription factor network
0.0 3.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.5 PID_PLK1_PATHWAY PLK1 signaling events
0.1 3.1 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.2 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 2.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.0 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 1.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.2 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 1.1 PID_ALK2_PATHWAY ALK2 signaling events
0.1 1.1 ST_STAT3_PATHWAY STAT3 Pathway
0.1 0.9 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.7 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.2 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 3.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.5 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 1.5 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 1.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.1 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 1.0 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.8 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.1 0.8 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 0.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.8 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha