Motif ID: E2f7

Z-value: 1.061


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.261.3e-01Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_3013140 8.561 ENSMUST00000143083.2
Gm10721
predicted gene 10721
chr9_+_3037111 7.796 ENSMUST00000177969.1
Gm10715
predicted gene 10715
chr9_+_3025417 6.930 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr9_+_3017408 6.422 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr9_+_3015654 6.171 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr10_-_69352886 5.080 ENSMUST00000119827.1
ENSMUST00000020099.5
Cdk1

cyclin-dependent kinase 1

chr15_+_102296256 3.409 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr12_+_24708984 3.295 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr12_+_24708241 2.999 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr11_+_102248842 2.998 ENSMUST00000100392.4
BC030867
cDNA sequence BC030867
chr3_+_108383829 2.676 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
Psrc1


proline/serine-rich coiled-coil 1


chr4_+_126556935 2.344 ENSMUST00000048391.8
Clspn
claspin
chr7_+_110122299 2.336 ENSMUST00000033326.8
Wee1
WEE 1 homolog 1 (S. pombe)
chr11_-_101466222 2.309 ENSMUST00000040430.7
Vat1
vesicle amine transport protein 1 homolog (T californica)
chr2_-_157204483 2.291 ENSMUST00000029170.7
Rbl1
retinoblastoma-like 1 (p107)
chr6_-_67037399 2.118 ENSMUST00000043098.6
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr4_+_126556994 2.114 ENSMUST00000147675.1
Clspn
claspin
chr17_-_35516780 2.078 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19


transcription factor 19


chr13_-_100775844 2.011 ENSMUST00000075550.3
Cenph
centromere protein H
chr4_+_136172367 1.968 ENSMUST00000061721.5
E2f2
E2F transcription factor 2
chr6_-_88898664 1.919 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr13_+_23581563 1.898 ENSMUST00000102968.1
Hist1h4d
histone cluster 1, H4d
chr11_-_6444352 1.701 ENSMUST00000093346.5
ENSMUST00000109737.2
H2afv

H2A histone family, member V

chr2_+_72476159 1.604 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr19_-_41206774 1.597 ENSMUST00000025986.7
ENSMUST00000169941.1
Tll2

tolloid-like 2

chr2_+_72476225 1.576 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr13_-_21783391 1.526 ENSMUST00000099704.3
Hist1h3i
histone cluster 1, H3i
chr13_-_21716143 1.372 ENSMUST00000091756.1
Hist1h2bl
histone cluster 1, H2bl
chr13_+_21754067 1.244 ENSMUST00000091709.2
Hist1h2bn
histone cluster 1, H2bn
chr14_-_54641347 1.202 ENSMUST00000067784.6
Cdh24
cadherin-like 24
chr8_+_75109528 1.132 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr11_-_77513335 1.123 ENSMUST00000060417.4
Trp53i13
transformation related protein 53 inducible protein 13
chr13_-_55329723 1.098 ENSMUST00000021941.7
Mxd3
Max dimerization protein 3
chr7_-_44816586 1.065 ENSMUST00000047356.8
Atf5
activating transcription factor 5
chr13_+_21833736 1.054 ENSMUST00000180288.1
ENSMUST00000110467.1
Hist1h2br

histone cluster 1 H2br

chr13_-_22042949 1.026 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr7_+_35802593 1.006 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr13_+_22043189 0.967 ENSMUST00000110452.1
Hist1h2bj
histone cluster 1, H2bj
chr12_+_73286868 0.965 ENSMUST00000153941.1
ENSMUST00000122920.1
ENSMUST00000101313.3
Slc38a6


solute carrier family 38, member 6


chr13_-_21833575 0.946 ENSMUST00000081342.5
Hist1h2ap
histone cluster 1, H2ap
chr5_+_129020069 0.924 ENSMUST00000031383.7
ENSMUST00000111343.1
Ran

RAN, member RAS oncogene family

chr7_-_44548733 0.895 ENSMUST00000145956.1
ENSMUST00000049343.8
Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr7_-_116308241 0.878 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
Plekha7


pleckstrin homology domain containing, family A member 7


chr4_+_108579445 0.865 ENSMUST00000102744.3
Orc1
origin recognition complex, subunit 1
chr14_+_54254124 0.826 ENSMUST00000180359.1
Abhd4
abhydrolase domain containing 4
chr12_-_11265768 0.784 ENSMUST00000166117.1
Gen1
Gen homolog 1, endonuclease (Drosophila)
chr9_-_87255536 0.770 ENSMUST00000093802.4
4922501C03Rik
RIKEN cDNA 4922501C03 gene
chr10_+_11281304 0.719 ENSMUST00000129456.1
Fbxo30
F-box protein 30
chr4_+_132768325 0.704 ENSMUST00000102561.4
Rpa2
replication protein A2
chr13_+_21810428 0.695 ENSMUST00000091745.5
Hist1h2ao
histone cluster 1, H2ao
chr13_-_21810190 0.692 ENSMUST00000110469.1
ENSMUST00000091749.2
Hist1h2bq

histone cluster 1, H2bq

chr17_-_24960620 0.663 ENSMUST00000024981.7
Hn1l
hematological and neurological expressed 1-like
chr1_+_180568913 0.661 ENSMUST00000027777.6
Parp1
poly (ADP-ribose) polymerase family, member 1
chr9_-_121277160 0.658 ENSMUST00000051479.6
ENSMUST00000171923.1
Ulk4

unc-51-like kinase 4

chr10_-_117376922 0.578 ENSMUST00000177145.1
ENSMUST00000176670.1
Cpsf6

cleavage and polyadenylation specific factor 6

chr1_+_172521044 0.571 ENSMUST00000085894.5
ENSMUST00000161140.1
ENSMUST00000162988.1
Ccdc19


coiled-coil domain containing 19


chr5_+_9100681 0.563 ENSMUST00000115365.1
Tmem243
transmembrane protein 243, mitochondrial
chr14_-_20388822 0.560 ENSMUST00000022345.6
Dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr13_+_22035821 0.516 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr1_-_128359610 0.512 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr13_+_23555023 0.512 ENSMUST00000045301.6
Hist1h1d
histone cluster 1, H1d
chr11_-_87404380 0.500 ENSMUST00000067692.6
Rad51c
RAD51 homolog C
chr1_-_180813591 0.490 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
H3f3a


H3 histone, family 3A


chrX_+_153006461 0.476 ENSMUST00000095755.3
Usp51
ubiquitin specific protease 51
chr9_+_64281575 0.459 ENSMUST00000034964.6
Tipin
timeless interacting protein
chr12_+_112146187 0.447 ENSMUST00000128402.2
Kif26a
kinesin family member 26A
chr3_+_60501252 0.425 ENSMUST00000099087.2
Mbnl1
muscleblind-like 1 (Drosophila)
chr2_-_180920925 0.417 ENSMUST00000037299.8
ENSMUST00000108876.2
Ythdf1

YTH domain family 1

chr16_+_38346986 0.414 ENSMUST00000050273.8
ENSMUST00000120495.1
ENSMUST00000119704.1
Cox17

Gm21987
cytochrome c oxidase assembly protein 17

predicted gene 21987
chr13_+_21716385 0.403 ENSMUST00000070124.3
Hist1h2ai
histone cluster 1, H2ai
chr17_-_35046726 0.388 ENSMUST00000097338.4
Msh5
mutS homolog 5 (E. coli)
chr15_+_79030874 0.353 ENSMUST00000171999.1
ENSMUST00000006544.7
Gcat

glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)

chr3_+_152396664 0.333 ENSMUST00000089982.4
ENSMUST00000106101.1
Zzz3

zinc finger, ZZ domain containing 3

chr11_-_61762040 0.330 ENSMUST00000004955.7
ENSMUST00000168115.1
Prpsap2

phosphoribosyl pyrophosphate synthetase-associated protein 2

chr13_-_21753851 0.328 ENSMUST00000074752.2
Hist1h2ak
histone cluster 1, H2ak
chr4_+_124714776 0.319 ENSMUST00000030734.4
Sf3a3
splicing factor 3a, subunit 3
chr10_+_11281583 0.312 ENSMUST00000070300.4
Fbxo30
F-box protein 30
chr12_-_73286698 0.306 ENSMUST00000116420.2
Trmt5
TRM5 tRNA methyltransferase 5
chr10_+_19934472 0.298 ENSMUST00000095806.3
ENSMUST00000120259.1
Map3k5

mitogen-activated protein kinase kinase kinase 5

chr11_+_88047693 0.297 ENSMUST00000079866.4
Srsf1
serine/arginine-rich splicing factor 1
chr10_-_117376955 0.294 ENSMUST00000069168.6
ENSMUST00000176686.1
Cpsf6

cleavage and polyadenylation specific factor 6

chr3_+_152395991 0.287 ENSMUST00000106100.2
Zzz3
zinc finger, ZZ domain containing 3
chr18_+_56707725 0.262 ENSMUST00000025486.8
Lmnb1
lamin B1
chr6_-_149101674 0.252 ENSMUST00000111557.1
Dennd5b
DENN/MADD domain containing 5B
chr6_+_15721087 0.247 ENSMUST00000120512.1
Mdfic
MyoD family inhibitor domain containing
chr11_+_71019859 0.242 ENSMUST00000155236.1
ENSMUST00000143762.1
ENSMUST00000136137.1
Mis12


MIS12 homolog (yeast)


chr17_+_28691342 0.236 ENSMUST00000114758.1
ENSMUST00000004990.6
ENSMUST00000062694.8
ENSMUST00000114754.1
Mapk14



mitogen-activated protein kinase 14



chrX_-_37085402 0.231 ENSMUST00000115231.3
Rpl39
ribosomal protein L39
chr3_+_14533867 0.220 ENSMUST00000163660.1
Lrrcc1
leucine rich repeat and coiled-coil domain containing 1
chr3_+_14533817 0.212 ENSMUST00000169079.1
ENSMUST00000091325.3
Lrrcc1

leucine rich repeat and coiled-coil domain containing 1

chr14_-_37135126 0.189 ENSMUST00000042564.9
Ghitm
growth hormone inducible transmembrane protein
chr3_+_14533788 0.188 ENSMUST00000108370.2
Lrrcc1
leucine rich repeat and coiled-coil domain containing 1
chr10_+_91083036 0.183 ENSMUST00000020149.5
Ikbip
IKBKB interacting protein
chr5_-_65697856 0.179 ENSMUST00000031104.6
Pds5a
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr4_+_108459389 0.178 ENSMUST00000106673.1
ENSMUST00000043368.5
Zcchc11

zinc finger, CCHC domain containing 11

chr17_+_34850373 0.171 ENSMUST00000097343.4
ENSMUST00000173357.1
ENSMUST00000173065.1
ENSMUST00000165953.2
Nelfe



negative elongation factor complex member E, Rdbp



chr2_+_11172080 0.166 ENSMUST00000114853.1
Prkcq
protein kinase C, theta
chr4_+_108619925 0.165 ENSMUST00000030320.6
Cc2d1b
coiled-coil and C2 domain containing 1B
chr11_+_71019593 0.164 ENSMUST00000133413.1
ENSMUST00000164220.1
ENSMUST00000048807.5
Mis12


MIS12 homolog (yeast)


chr17_-_25792284 0.157 ENSMUST00000072735.7
Fam173a
family with sequence similarity 173, member A
chr9_+_44334685 0.150 ENSMUST00000052686.2
H2afx
H2A histone family, member X
chr12_+_11265867 0.141 ENSMUST00000020931.5
Smc6
structural maintenance of chromosomes 6
chr2_+_130667610 0.135 ENSMUST00000103193.4
Itpa
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
chr13_-_23574196 0.118 ENSMUST00000105106.1
Hist1h2bf
histone cluster 1, H2bf
chr7_-_142578139 0.118 ENSMUST00000136359.1
H19
H19 fetal liver mRNA
chr11_+_88047788 0.116 ENSMUST00000107920.3
Srsf1
serine/arginine-rich splicing factor 1
chr17_+_33524170 0.114 ENSMUST00000087623.6
Adamts10
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10
chr11_+_43682038 0.102 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chr1_-_156474249 0.095 ENSMUST00000051396.6
Soat1
sterol O-acyltransferase 1
chr1_-_135167606 0.093 ENSMUST00000027682.8
Gpr37l1
G protein-coupled receptor 37-like 1
chr11_+_43681998 0.090 ENSMUST00000061070.5
Pwwp2a
PWWP domain containing 2A
chr7_-_28598140 0.083 ENSMUST00000108283.1
ENSMUST00000040531.8
Pak4
Samd4b
p21 protein (Cdc42/Rac)-activated kinase 4
sterile alpha motif domain containing 4B
chr5_+_135187251 0.079 ENSMUST00000002825.5
Baz1b
bromodomain adjacent to zinc finger domain, 1B
chr7_+_66109474 0.078 ENSMUST00000036372.6
Chsy1
chondroitin sulfate synthase 1
chr3_-_57847478 0.074 ENSMUST00000120289.1
ENSMUST00000066882.8
Pfn2

profilin 2

chr11_+_88047302 0.053 ENSMUST00000139129.2
Srsf1
serine/arginine-rich splicing factor 1
chr1_+_118389058 0.050 ENSMUST00000049404.6
ENSMUST00000070989.7
ENSMUST00000165223.1
ENSMUST00000178710.1
Clasp1



CLIP associating protein 1



chr17_-_35121990 0.043 ENSMUST00000173915.1
ENSMUST00000172765.2
Csnk2b

casein kinase 2, beta polypeptide

chr1_+_86526688 0.042 ENSMUST00000045897.8
Ptma
prothymosin alpha
chr7_-_35802968 0.035 ENSMUST00000061586.4
Zfp507
zinc finger protein 507
chr7_+_28169744 0.022 ENSMUST00000042405.6
Fbl
fibrillarin
chr1_+_74506044 0.008 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.6 GO:0090166 Golgi disassembly(GO:0090166)
0.5 2.3 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.4 4.5 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.3 6.3 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 1.6 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.3 0.9 GO:0045004 DNA replication proofreading(GO:0045004)
0.3 2.0 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.2 3.4 GO:0000212 meiotic spindle organization(GO:0000212)
0.2 2.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 0.7 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.2 0.9 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.2 2.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 2.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 2.4 GO:0051382 kinetochore assembly(GO:0051382)
0.1 0.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.4 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.1 0.5 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.1 0.5 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.1 0.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 3.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.4 GO:0051026 chiasma assembly(GO:0051026)
0.1 0.5 GO:0000076 DNA replication checkpoint(GO:0000076)
0.1 0.3 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.1 0.8 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.1 2.6 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.1 0.2 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.3 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 0.5 GO:0016584 nucleosome positioning(GO:0016584)
0.1 2.1 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 0.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.2 GO:2000569 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.1 1.2 GO:0021924 cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930)
0.0 1.8 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 1.1 GO:0006270 DNA replication initiation(GO:0006270)
0.0 4.1 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.4 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.7 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 1.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 1.0 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.4 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.1 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.0 0.1 GO:0009146 purine nucleoside triphosphate catabolic process(GO:0009146)
0.0 0.3 GO:1904707 cellular response to reactive nitrogen species(GO:1902170) positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0 0.1 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 1.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.5 GO:0016578 histone deubiquitination(GO:0016578)
0.0 2.4 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 0.1 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.2 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.0 0.6 GO:0032781 positive regulation of ATPase activity(GO:0032781)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 2.8 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 0.9 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.3 0.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 7.8 GO:0005876 spindle microtubule(GO:0005876)
0.1 3.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.9 GO:0042382 paraspeckles(GO:0042382)
0.1 0.4 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.1 0.5 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.1 1.3 GO:0042555 MCM complex(GO:0042555)
0.1 3.2 GO:0000786 nucleosome(GO:0000786)
0.1 0.3 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 0.9 GO:0005915 zonula adherens(GO:0005915)
0.1 0.5 GO:0031298 replication fork protection complex(GO:0031298)
0.1 0.3 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.2 GO:0032021 NELF complex(GO:0032021)
0.0 3.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 3.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.0 GO:0000776 kinetochore(GO:0000776)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 2.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.4 GO:0005871 kinesin complex(GO:0005871)
0.0 0.7 GO:0032993 protein-DNA complex(GO:0032993)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.7 4.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 2.1 GO:0043515 kinetochore binding(GO:0043515)
0.3 5.2 GO:0035173 histone kinase activity(GO:0035173)
0.2 3.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 2.1 GO:0070097 delta-catenin binding(GO:0070097)
0.2 1.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.2 0.9 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 0.7 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 0.9 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 0.3 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.5 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 0.4 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 2.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.4 GO:0016531 copper chaperone activity(GO:0016531)
0.0 2.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 2.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.3 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 2.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.2 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.4 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.2 GO:0030957 Tat protein binding(GO:0030957)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 3.2 GO:0001047 core promoter binding(GO:0001047)
0.0 0.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 2.9 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.3 GO:0008432 JUN kinase binding(GO:0008432) phospholipase binding(GO:0043274)
0.0 0.5 GO:0031490 chromatin DNA binding(GO:0031490)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 2.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 7.5 PID_ATR_PATHWAY ATR signaling pathway
0.1 9.4 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.1 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 1.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 7.4 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 7.2 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 2.0 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.3 3.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 1.6 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 6.1 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 2.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.9 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.9 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.5 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway