ISMARA results: E2f8

Motif ID: E2f8

Z-value: 0.825

Transcription factors associated with E2f8:

Gene Symbol	Entrez ID	Gene Name
E2f8	ENSMUSG00000046179.11	E2f8

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
E2f8	mm10_v2_chr7_-_48881596_48881619	0.84	1.1e-10	Click!

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Showing 1 to 20 of 80 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr5_+_123749696	4.895	ENSMUST00000031366.7	Kntc1	kinetochore associated 1
chr7_-_115824699	4.639	ENSMUST00000169129.1	Sox6	SRY-box containing gene 6
chr17_+_56303321	4.000	ENSMUST00000001258.8	Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1
chr17_+_56303396	3.694	ENSMUST00000113038.1	Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1
chr7_+_110122299	3.542	ENSMUST00000033326.8	Wee1	WEE 1 homolog 1 (S. pombe)
chr9_-_36726374	3.528	ENSMUST00000172702.2 ENSMUST00000172742.1 ENSMUST00000034625.5	Chek1	checkpoint kinase 1
chr2_+_145785980	3.389	ENSMUST00000110005.1 ENSMUST00000094480.4	Rin2	Ras and Rab interactor 2
chr8_+_40926220	3.319	ENSMUST00000034004.9	Pdgfrl	platelet-derived growth factor receptor-like
chr12_+_24708984	3.202	ENSMUST00000154588.1	Rrm2	ribonucleotide reductase M2
chr6_-_88898664	2.960	ENSMUST00000058011.6	Mcm2	minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr7_-_48881032	2.873	ENSMUST00000058745.8	E2f8	E2F transcription factor 8
chr16_-_18811615	2.765	ENSMUST00000096990.3	Cdc45	cell division cycle 45
chr2_+_163054682	2.689	ENSMUST00000018005.3	Mybl2	myeloblastosis oncogene-like 2
chr12_+_24708241	2.663	ENSMUST00000020980.5	Rrm2	ribonucleotide reductase M2
chr11_+_98907801	2.584	ENSMUST00000092706.6	Cdc6	cell division cycle 6
chr7_-_48881596	2.541	ENSMUST00000119223.1	E2f8	E2F transcription factor 8
chr1_-_128359610	2.327	ENSMUST00000027601.4	Mcm6	minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr15_+_55557399	2.150	ENSMUST00000022998.7	Mtbp	Mdm2, transformed 3T3 cell double minute p53 binding protein
chr19_+_38931008	2.110	ENSMUST00000145051.1	Hells	helicase, lymphoid specific
chr19_+_38930909	2.034	ENSMUST00000025965.5	Hells	helicase, lymphoid specific

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 40 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	11.8	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.3	5.9	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
0.0	5.7	GO:0007093	mitotic cell cycle checkpoint(GO:0007093)
1.8	5.4	GO:0032877	positive regulation of DNA endoreduplication(GO:0032877)
0.5	5.1	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.4	4.6	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2	4.5	GO:0006270	DNA replication initiation(GO:0006270)
0.4	4.0	GO:0046602	regulation of mitotic centrosome separation(GO:0046602)
0.3	4.0	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.8	3.8	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
0.0	2.9	GO:0030010	establishment of cell polarity(GO:0030010)
0.9	2.8	GO:0036388	pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0	2.7	GO:0090307	mitotic spindle assembly(GO:0090307)
0.9	2.6	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.1	1.9	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	1.8	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.2	1.7	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
0.4	1.2	GO:0015910	peroxisomal long-chain fatty acid import(GO:0015910)
0.2	1.2	GO:0097476	spinal cord motor neuron migration(GO:0097476)
0.1	1.2	GO:0098532	histone H3-K27 trimethylation(GO:0098532)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 24 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	13.3	GO:0005657	replication fork(GO:0005657)
0.0	10.1	GO:0005667	transcription factor complex(GO:0005667)
0.4	6.5	GO:0042555	MCM complex(GO:0042555)
1.2	5.9	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2	5.5	GO:0035098	ESC/E(Z) complex(GO:0035098)
1.6	4.9	GO:1990423	RZZ complex(GO:1990423)
0.2	4.1	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	2.9	GO:0000776	kinetochore(GO:0000776)
0.9	2.8	GO:0036387	nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.5	2.7	GO:0031523	Myb complex(GO:0031523)
0.5	2.6	GO:0035189	Rb-E2F complex(GO:0035189)
0.1	2.4	GO:0051233	spindle midzone(GO:0051233)
0.6	1.9	GO:0033186	CAF-1 complex(GO:0033186)
0.0	1.2	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.4	1.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.2	1.1	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	1.1	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.8	GO:0071004	U2-type prespliceosome(GO:0071004)
0.2	0.7	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.1	0.6	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 29 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.1	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.9	7.7	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
0.5	7.3	GO:0003688	DNA replication origin binding(GO:0003688)
1.2	5.9	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5	4.1	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	4.1	GO:0004386	helicase activity(GO:0004386)
0.1	3.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
1.2	3.5	GO:0035402	histone kinase activity (H3-T11 specific)(GO:0035402)
0.1	2.5	GO:0032452	histone demethylase activity(GO:0032452)
0.1	2.2	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.2	1.9	GO:0070087	chromo shadow domain binding(GO:0070087)
0.1	1.8	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.2	1.2	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.2	1.2	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	1.2	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.4	1.1	GO:0071207	histone pre-mRNA stem-loop binding(GO:0071207)
0.1	1.1	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1	1.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	1.1	GO:0035064	methylated histone binding(GO:0035064)
0.0	1.0	GO:0017025	TBP-class protein binding(GO:0017025)

Gene overrepresentation in C2:CP category:

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Showing 1 to 11 of 11 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	7.1	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	6.7	PID_ATR_PATHWAY	ATR signaling pathway
0.1	6.4	PID_E2F_PATHWAY	E2F transcription factor network
0.1	4.1	PID_DELTA_NP63_PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	3.4	PID_AJDISS_2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	2.6	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	1.4	PID_HES_HEY_PATHWAY	Notch-mediated HES/HEY network
0.0	0.8	PID_ERBB4_PATHWAY	ErbB4 signaling events
0.0	0.7	PID_RANBP2_PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.5	PID_DNA_PK_PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.5	PID_FAS_PATHWAY	FAS (CD95) signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 15 of 15 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	13.9	REACTOME_G1_S_SPECIFIC_TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.7	7.1	REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.5	6.8	REACTOME_UNWINDING_OF_DNA	Genes involved in Unwinding of DNA
0.2	3.9	REACTOME_G0_AND_EARLY_G1	Genes involved in G0 and Early G1
0.0	3.3	REACTOME_MITOTIC_PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	1.8	REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	1.4	REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	1.2	REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.1	1.1	REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.7	REACTOME_MICRORNA_MIRNA_BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.1	0.6	REACTOME_AMINE_DERIVED_HORMONES	Genes involved in Amine-derived hormones
0.1	0.5	REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND	Genes involved in Processive synthesis on the lagging strand
0.0	0.5	REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS	Genes involved in Host Interactions of HIV factors
0.0	0.5	REACTOME_DOUBLE_STRAND_BREAK_REPAIR	Genes involved in Double-Strand Break Repair
0.0	0.4	REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex