Motif ID: E2f8

Z-value: 0.825


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.841.1e-10Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_123749696 4.895 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr7_-_115824699 4.639 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr17_+_56303321 4.000 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr17_+_56303396 3.694 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr7_+_110122299 3.542 ENSMUST00000033326.8
 Wee1
WEE 1 homolog 1 (S. pombe)
chr9_-_36726374 3.528 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr2_+_145785980 3.389 ENSMUST00000110005.1
ENSMUST00000094480.4
 Rin2

Ras and Rab interactor 2

chr8_+_40926220 3.319 ENSMUST00000034004.9
 Pdgfrl
platelet-derived growth factor receptor-like
chr12_+_24708984 3.202 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr6_-_88898664 2.960 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr7_-_48881032 2.873 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr16_-_18811615 2.765 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr2_+_163054682 2.689 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr12_+_24708241 2.663 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr11_+_98907801 2.584 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr7_-_48881596 2.541 ENSMUST00000119223.1
 E2f8
E2F transcription factor 8
chr1_-_128359610 2.327 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr15_+_55557399 2.150 ENSMUST00000022998.7
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr19_+_38931008 2.110 ENSMUST00000145051.1
 Hells
helicase, lymphoid specific
chr19_+_38930909 2.034 ENSMUST00000025965.5
 Hells
helicase, lymphoid specific
chr17_+_56040350 1.924 ENSMUST00000002914.8
 Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr2_-_157204483 1.802 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr2_-_34913976 1.686 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr15_+_55557575 1.622 ENSMUST00000170046.1
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr2_-_18048784 1.613 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr8_+_75109528 1.610 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr13_+_44731265 1.537 ENSMUST00000173246.1
 Jarid2
jumonji, AT rich interactive domain 2
chr2_-_154569720 1.430 ENSMUST00000000894.5
 E2f1
E2F transcription factor 1
chr10_-_21160925 1.414 ENSMUST00000020158.6
 Myb
myeloblastosis oncogene
chr2_-_84743655 1.375 ENSMUST00000181711.1
 Gm19426
predicted gene, 19426
chr5_-_123749393 1.266 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
 Rsrc2


arginine/serine-rich coiled-coil 2


chr5_-_123749371 1.246 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
 Rsrc2


arginine/serine-rich coiled-coil 2


chr11_+_79993062 1.223 ENSMUST00000017692.8
ENSMUST00000163272.1
 Suz12

suppressor of zeste 12 homolog (Drosophila)

chr2_-_154569845 1.212 ENSMUST00000103145.4
 E2f1
E2F transcription factor 1
chr10_+_19356558 1.193 ENSMUST00000053225.5
 Olig3
oligodendrocyte transcription factor 3
chr16_+_10835046 1.116 ENSMUST00000037913.8
 Rmi2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr5_+_137787769 1.070 ENSMUST00000035852.7
 Zcwpw1
zinc finger, CW type with PWWP domain 1
chr7_-_44548733 1.060 ENSMUST00000145956.1
ENSMUST00000049343.8
 Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr13_+_94875600 1.036 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr13_+_44731281 1.008 ENSMUST00000174086.1
 Jarid2
jumonji, AT rich interactive domain 2
chr5_-_33652296 0.865 ENSMUST00000151081.1
ENSMUST00000101354.3
 Slbp

stem-loop binding protein

chr6_+_38551786 0.846 ENSMUST00000161227.1
 Luc7l2
LUC7-like 2 (S. cerevisiae)
chr6_-_94700137 0.833 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr7_+_102065713 0.794 ENSMUST00000094129.2
ENSMUST00000094130.2
ENSMUST00000084843.3
 Trpc2


transient receptor potential cation channel, subfamily C, member 2


chr11_+_77462325 0.775 ENSMUST00000102493.1
 Coro6
coronin 6
chr4_+_132768325 0.768 ENSMUST00000102561.4
 Rpa2
replication protein A2
chrX_+_73716577 0.713 ENSMUST00000002084.7
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chrX_-_70477170 0.667 ENSMUST00000101506.3
ENSMUST00000114630.2
 BC023829

cDNA sequence BC023829

chr5_+_129020069 0.651 ENSMUST00000031383.7
ENSMUST00000111343.1
 Ran

RAN, member RAS oncogene family

chr12_+_110279228 0.639 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr6_+_117917281 0.564 ENSMUST00000180020.1
ENSMUST00000177570.1
 Hnrnpf

heterogeneous nuclear ribonucleoprotein F

chrX_-_41911877 0.564 ENSMUST00000047037.8
 Thoc2
THO complex 2
chr16_+_20733104 0.500 ENSMUST00000115423.1
ENSMUST00000007171.6
 Chrd

chordin

chrX_+_73716712 0.488 ENSMUST00000114461.2
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr16_+_15637844 0.486 ENSMUST00000023352.8
 Prkdc
protein kinase, DNA activated, catalytic polypeptide
chr16_-_18248697 0.481 ENSMUST00000115645.3
 Ranbp1
RAN binding protein 1
chr10_+_128015157 0.481 ENSMUST00000178041.1
ENSMUST00000026461.7
 Prim1

DNA primase, p49 subunit

chr10_+_42860348 0.474 ENSMUST00000063063.7
 Scml4
sex comb on midleg-like 4 (Drosophila)
chr1_+_42229726 0.457 ENSMUST00000066196.1
 Gm9915
predicted gene 9915
chr6_+_117916981 0.443 ENSMUST00000179478.1
 Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr5_+_150673739 0.442 ENSMUST00000016569.4
ENSMUST00000038900.8
 Pds5b

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

chr19_+_4756557 0.426 ENSMUST00000036744.7
 Rbm4b
RNA binding motif protein 4B
chr9_-_50659780 0.410 ENSMUST00000034567.3
 Dlat
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
chr9_+_103305156 0.347 ENSMUST00000035164.3
 Topbp1
topoisomerase (DNA) II binding protein 1
chr15_-_55557748 0.347 ENSMUST00000172387.1
 Mrpl13
mitochondrial ribosomal protein L13
chr5_-_65335597 0.341 ENSMUST00000172660.1
ENSMUST00000172732.1
ENSMUST00000031092.8
 Rfc1


replication factor C (activator 1) 1


chr5_+_135187251 0.341 ENSMUST00000002825.5
 Baz1b
bromodomain adjacent to zinc finger domain, 1B
chr7_+_102065485 0.317 ENSMUST00000106950.1
ENSMUST00000146450.1
 Trpc2

transient receptor potential cation channel, subfamily C, member 2

chr11_+_88047693 0.252 ENSMUST00000079866.4
 Srsf1
serine/arginine-rich splicing factor 1
chr3_-_127553233 0.252 ENSMUST00000029588.5
 Larp7
La ribonucleoprotein domain family, member 7
chr5_-_33652339 0.224 ENSMUST00000075670.6
 Slbp
stem-loop binding protein
chr10_+_84917616 0.204 ENSMUST00000038523.7
ENSMUST00000095385.3
 Ric8b

resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)

chr18_-_9726670 0.161 ENSMUST00000171339.1
 Gm17430
predicted gene, 17430
chr15_+_78926720 0.154 ENSMUST00000089377.5
 Lgals1
lectin, galactose binding, soluble 1
chr5_-_65335564 0.117 ENSMUST00000172780.1
 Rfc1
replication factor C (activator 1) 1
chrX_+_153498202 0.087 ENSMUST00000060714.8
 Ubqln2
ubiquilin 2
chr13_+_19623163 0.058 ENSMUST00000002883.5
 Sfrp4
secreted frizzled-related protein 4
chr11_+_69991061 0.048 ENSMUST00000018711.8
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr6_+_29348069 0.023 ENSMUST00000173216.1
ENSMUST00000031779.10
ENSMUST00000090481.7
 Calu


calumenin


chr9_+_100643605 0.011 ENSMUST00000041418.6
 Stag1
stromal antigen 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.9 2.8 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.9 2.6 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.8 11.8 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.8 3.8 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.5 5.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.4 4.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.4 4.0 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.4 1.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.4 1.1 GO:0045004 DNA replication proofreading(GO:0045004)
0.3 5.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 4.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.3 0.8 GO:0032474 otolith morphogenesis(GO:0032474)
0.2 1.7 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.2 1.2 GO:0097476 spinal cord motor neuron migration(GO:0097476)
0.2 1.1 GO:0002121 inter-male aggressive behavior(GO:0002121) response to pheromone(GO:0019236)
0.2 4.5 GO:0006270 DNA replication initiation(GO:0006270)
0.2 0.5 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 1.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 1.2 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 0.5 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 0.6 GO:0046549 phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549)
0.1 0.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.5 GO:0002326 B cell lineage commitment(GO:0002326) ectopic germ cell programmed cell death(GO:0035234)
0.1 1.0 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 0.6 GO:0010793 regulation of mRNA export from nucleus(GO:0010793) regulation of ribonucleoprotein complex localization(GO:2000197)
0.1 1.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.4 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 5.7 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.0 2.7 GO:0090307 mitotic spindle assembly(GO:0090307)
0.0 1.8 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.1 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 1.1 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.0 0.2 GO:0002317 plasma cell differentiation(GO:0002317) positive regulation of viral entry into host cell(GO:0046598)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.1 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
0.0 0.4 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 2.9 GO:0030010 establishment of cell polarity(GO:0030010)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:1990423 RZZ complex(GO:1990423)
1.2 5.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.9 2.8 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.6 1.9 GO:0033186 CAF-1 complex(GO:0033186)
0.5 2.7 GO:0031523 Myb complex(GO:0031523)
0.5 2.6 GO:0035189 Rb-E2F complex(GO:0035189)
0.4 6.5 GO:0042555 MCM complex(GO:0042555)
0.4 1.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 5.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 0.7 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.2 13.3 GO:0005657 replication fork(GO:0005657)
0.2 1.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.2 4.1 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.4 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.5 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1 2.4 GO:0051233 spindle midzone(GO:0051233)
0.1 0.6 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.8 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.5 GO:1904115 axon cytoplasm(GO:1904115)
0.0 1.1 GO:0032590 dendrite membrane(GO:0032590)
0.0 10.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.9 GO:0000776 kinetochore(GO:0000776)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.7 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.2 3.5 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.2 5.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5 7.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 4.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.4 1.1 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.2 1.9 GO:0070087 chromo shadow domain binding(GO:0070087)
0.2 1.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.2 1.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 0.5 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.1 1.1 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 0.7 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 1.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 0.5 GO:0045545 syndecan binding(GO:0045545)
0.1 0.4 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 3.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.8 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 2.5 GO:0032452 histone demethylase activity(GO:0032452)
0.1 2.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 10.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 1.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 4.1 GO:0004386 helicase activity(GO:0004386)
0.0 0.2 GO:0005534 galactose binding(GO:0005534)
0.0 1.0 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 1.1 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.5 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 2.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 6.7 PID_ATR_PATHWAY ATR signaling pathway
0.1 4.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 6.4 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.4 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.5 PID_FAS_PATHWAY FAS (CD95) signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 13.9 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.7 7.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.5 6.8 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 3.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 1.8 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 0.5 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.1 1.1 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.2 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.4 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 3.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.7 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.5 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS Genes involved in Host Interactions of HIV factors
0.0 0.5 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.0 1.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production