Motif ID: Ebf1

Z-value: 1.275


Transcription factors associated with Ebf1:

Gene SymbolEntrez IDGene Name
Ebf1 ENSMUSG00000078561.3 Ebf1
Ebf1 ENSMUSG00000057098.8 Ebf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ebf1mm10_v2_chr11_+_44617310_446173360.391.8e-02Click!


Activity profile for motif Ebf1.

activity profile for motif Ebf1


Sorted Z-values histogram for motif Ebf1

Sorted Z-values for motif Ebf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ebf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_58313189 6.791 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr2_-_180225812 5.730 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr2_+_172550991 5.644 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr1_+_135729147 4.733 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr19_+_7268296 4.682 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr11_-_98053415 4.644 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr5_-_124095749 4.622 ENSMUST00000031354.4
 Abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr17_-_6782775 4.588 ENSMUST00000064234.6
 Ezr
ezrin
chr17_-_35702040 4.493 ENSMUST00000166980.2
ENSMUST00000145900.1
 Ddr1

discoidin domain receptor family, member 1

chr2_+_79255500 4.408 ENSMUST00000099972.4
 Itga4
integrin alpha 4
chr11_+_115154139 4.142 ENSMUST00000021076.5
 Rab37
RAB37, member of RAS oncogene family
chr19_+_5740885 3.985 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr12_+_112620030 3.847 ENSMUST00000180015.1
ENSMUST00000021726.6
 Adssl1

adenylosuccinate synthetase like 1

chr2_+_172550761 3.723 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr11_-_114795888 3.659 ENSMUST00000000206.3
 Btbd17
BTB (POZ) domain containing 17
chr2_+_130295148 3.549 ENSMUST00000110288.2
 Ebf4
early B cell factor 4
chr2_+_105668888 3.353 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr11_-_101551837 3.319 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr2_+_105668935 3.246 ENSMUST00000142772.1
 Pax6
paired box gene 6
chr10_+_112271123 3.214 ENSMUST00000092175.2
 Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 700 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 13.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.3 10.2 GO:2001198 regulation of dendritic cell differentiation(GO:2001198)
3.1 9.4 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
1.4 7.2 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
1.3 6.6 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.4 6.1 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.2 6.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.7 5.3 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
1.0 5.2 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.6 4.7 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
1.1 4.5 GO:0060857 establishment of glial blood-brain barrier(GO:0060857)
0.6 4.5 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.1 4.4 GO:0050904 diapedesis(GO:0050904)
0.9 4.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.2 4.2 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
1.3 4.0 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.3 4.0 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
1.3 3.9 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.4 3.9 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.3 3.9 GO:0043249 erythrocyte maturation(GO:0043249)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 232 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.8 GO:0005667 transcription factor complex(GO:0005667)
0.1 11.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 7.5 GO:0005604 basement membrane(GO:0005604)
0.4 6.7 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 6.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 5.8 GO:0000790 nuclear chromatin(GO:0000790)
1.4 5.7 GO:0043259 laminin-10 complex(GO:0043259)
0.5 5.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 5.4 GO:0000791 euchromatin(GO:0000791)
0.0 5.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 5.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 4.9 GO:0032993 protein-DNA complex(GO:0032993)
0.2 4.7 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
1.5 4.6 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.5 4.5 GO:0000796 condensin complex(GO:0000796)
0.7 4.3 GO:0031262 Ndc80 complex(GO:0031262)
0.0 4.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 4.0 GO:0005814 centriole(GO:0005814)
1.0 3.9 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.0 3.9 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 407 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 16.2 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
1.5 13.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.6 9.5 GO:0003680 AT DNA binding(GO:0003680)
0.1 9.2 GO:0005178 integrin binding(GO:0005178)
0.6 9.0 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1 7.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 7.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 7.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.5 6.5 GO:0044548 S100 protein binding(GO:0044548)
0.4 6.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 5.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 5.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 5.4 GO:0005080 protein kinase C binding(GO:0005080)
0.1 5.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 5.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 4.9 GO:0050431 transforming growth factor beta binding(GO:0050431)
1.1 4.6 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
1.1 4.5 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.9 4.4 GO:0019960 C-X3-C chemokine binding(GO:0019960)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 14.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 9.2 PID_AURORA_B_PATHWAY Aurora B signaling
1.0 7.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 7.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.3 5.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.5 4.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 4.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 4.4 PID_CDC42_PATHWAY CDC42 signaling events
0.2 4.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.8 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 3.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.4 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 3.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 2.8 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.4 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 8.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 6.7 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.5 6.5 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 5.2 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.2 5.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 4.8 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.3 4.7 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 4.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 4.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 3.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 3.5 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 3.5 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.4 3.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 3.2 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 3.0 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.2 2.9 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 2.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 2.8 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 2.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly