Motif ID: Ebf3

Z-value: 1.395


Transcription factors associated with Ebf3:

Gene SymbolEntrez IDGene Name
Ebf3 ENSMUSG00000010476.7 Ebf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ebf3mm10_v2_chr7_-_137314394_137314445-0.651.2e-05Click!


Activity profile for motif Ebf3.

activity profile for motif Ebf3


Sorted Z-values histogram for motif Ebf3

Sorted Z-values for motif Ebf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Ebf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66812593 19.927 ENSMUST00000100572.3
 Sla
src-like adaptor
chr1_-_56969827 9.660 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969864 9.408 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr7_+_123982799 8.626 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr8_+_70493156 7.390 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr1_-_193370260 6.074 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr5_+_117781017 6.031 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr1_-_193370225 6.024 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr1_+_75400070 5.990 ENSMUST00000113589.1
 Speg
SPEG complex locus
chr15_-_98677451 5.829 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
 Rnd1


Rho family GTPase 1


chr11_+_104231465 5.708 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr15_-_45114926 5.657 ENSMUST00000022967.5
 Kcnv1
potassium channel, subfamily V, member 1
chr11_+_104231573 5.577 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr11_+_104231515 5.505 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr2_-_118703963 5.370 ENSMUST00000104937.1
 Ankrd63
ankyrin repeat domain 63
chr11_+_104231390 5.149 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr3_+_26331150 5.139 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr19_+_43440404 4.946 ENSMUST00000165311.1
 Cnnm1
cyclin M1
chr2_+_170731807 4.789 ENSMUST00000029075.4
 Dok5
docking protein 5
chr9_-_110743653 4.778 ENSMUST00000166716.1
 Pth1r
parathyroid hormone 1 receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 21.9 GO:1900034 regulation of cellular response to heat(GO:1900034)
1.2 19.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 12.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 12.1 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.7 8.8 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.2 7.4 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
2.2 6.7 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
2.0 6.0 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 6.0 GO:0055013 cardiac muscle cell development(GO:0055013)
0.8 5.8 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.2 5.6 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.9 5.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
1.0 4.8 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.4 4.8 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.3 4.8 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.2 4.8 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.7 4.6 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.9 4.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.5 4.3 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.3 4.3 GO:0001553 luteinization(GO:0001553)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 21.9 GO:0045298 tubulin complex(GO:0045298)
0.1 19.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 15.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 12.7 GO:0005794 Golgi apparatus(GO:0005794)
0.1 10.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.7 8.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 7.5 GO:0043025 neuronal cell body(GO:0043025)
2.5 7.4 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.5 6.7 GO:0044327 dendritic spine head(GO:0044327)
0.1 6.4 GO:0031941 filamentous actin(GO:0031941)
0.1 6.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.5 6.0 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 5.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
1.1 5.3 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.2 4.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
1.5 4.4 GO:0045160 myosin I complex(GO:0045160)
1.1 4.2 GO:1990769 proximal neuron projection(GO:1990769)
0.2 3.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 3.9 GO:0031526 brush border membrane(GO:0031526)
0.2 3.8 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 21.9 GO:0099609 microtubule lateral binding(GO:0099609)
0.5 19.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 12.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 10.7 GO:0003682 chromatin binding(GO:0003682)
0.8 8.8 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.1 7.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
2.0 6.0 GO:0004517 nitric-oxide synthase activity(GO:0004517)
1.2 5.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.6 5.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.4 5.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.1 5.3 GO:0097643 amylin receptor activity(GO:0097643)
0.1 5.0 GO:0070888 E-box binding(GO:0070888)
0.6 4.6 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.2 4.5 GO:0017046 peptide hormone binding(GO:0017046)
0.2 4.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 4.4 GO:0044325 ion channel binding(GO:0044325)
0.1 4.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.8 4.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 4.1 GO:0003924 GTPase activity(GO:0003924)
1.3 4.0 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.5 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
1.2 21.9 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 10.4 ST_ADRENERGIC Adrenergic Pathway
0.1 10.0 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.3 5.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 5.5 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 4.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.4 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.9 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.5 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.2 2.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.6 PID_MYC_PATHWAY C-MYC pathway
0.1 1.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.5 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.0 PID_S1P_S1P1_PATHWAY S1P1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 15.1 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6 11.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 10.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 8.8 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 8.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 7.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 6.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 6.0 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.8 5.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 5.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 4.2 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.2 3.8 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 3.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.3 3.1 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 3.1 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 2.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 2.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 2.2 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand