Motif ID: Egr1

Z-value: 2.831


Transcription factors associated with Egr1:

Gene SymbolEntrez IDGene Name
Egr1 ENSMUSG00000038418.7 Egr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr1mm10_v2_chr18_+_34861200_34861215-0.124.6e-01Click!


Activity profile for motif Egr1.

activity profile for motif Egr1


Sorted Z-values histogram for motif Egr1

Sorted Z-values for motif Egr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_6065538 26.070 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr11_-_67922136 21.491 ENSMUST00000021288.3
ENSMUST00000108677.1
Usp43

ubiquitin specific peptidase 43

chr4_+_125490688 18.272 ENSMUST00000030676.7
Grik3
glutamate receptor, ionotropic, kainate 3
chr4_+_127169131 16.369 ENSMUST00000046659.7
Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr11_+_119942763 15.589 ENSMUST00000026436.3
ENSMUST00000106231.1
ENSMUST00000075180.5
ENSMUST00000103021.3
ENSMUST00000106233.1
Baiap2




brain-specific angiogenesis inhibitor 1-associated protein 2




chr11_+_98348404 13.101 ENSMUST00000078694.6
Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr3_+_54156039 12.498 ENSMUST00000029311.6
Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr9_-_102354685 11.592 ENSMUST00000035129.7
ENSMUST00000085169.5
Ephb1

Eph receptor B1

chr7_+_73740277 11.399 ENSMUST00000107456.2
Fam174b
family with sequence similarity 174, member B
chr5_-_139129662 10.670 ENSMUST00000026973.7
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr5_+_32136458 10.481 ENSMUST00000031017.9
Fosl2
fos-like antigen 2
chr15_-_45114926 10.323 ENSMUST00000022967.5
Kcnv1
potassium channel, subfamily V, member 1
chr2_-_167188787 10.315 ENSMUST00000059826.8
Kcnb1
potassium voltage gated channel, Shab-related subfamily, member 1
chr7_-_27396542 10.077 ENSMUST00000108363.1
Sptbn4
spectrin beta, non-erythrocytic 4
chr12_+_108334341 9.979 ENSMUST00000021684.4
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr5_-_139130159 9.626 ENSMUST00000129851.1
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr8_+_104170513 9.584 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
Bean1



brain expressed, associated with Nedd4, 1



chr3_-_89322883 9.455 ENSMUST00000029673.5
Efna3
ephrin A3
chr10_-_54075730 9.451 ENSMUST00000105469.1
ENSMUST00000003843.8
Man1a

mannosidase 1, alpha

chr4_+_42917234 9.423 ENSMUST00000107976.2
ENSMUST00000069184.2
N28178

expressed sequence N28178

chr5_+_137288273 9.406 ENSMUST00000024099.4
ENSMUST00000085934.3
Ache

acetylcholinesterase

chr7_+_82175156 9.095 ENSMUST00000180243.1
Sh3gl3
SH3-domain GRB2-like 3
chr9_-_37552904 9.083 ENSMUST00000065668.5
Nrgn
neurogranin
chr14_-_102982630 8.976 ENSMUST00000184744.1
KCTD12
mmu-mir-5130
chr17_-_83631892 8.843 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr11_-_6065737 8.721 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr9_-_107710475 8.669 ENSMUST00000080560.3
Sema3f
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr13_-_68999518 8.659 ENSMUST00000022013.7
Adcy2
adenylate cyclase 2
chr7_-_47132698 8.535 ENSMUST00000033142.5
Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chrX_-_20920911 8.324 ENSMUST00000081893.6
ENSMUST00000115345.1
Syn1

synapsin I

chr7_+_5057161 8.220 ENSMUST00000045543.5
Ccdc106
coiled-coil domain containing 106
chr9_-_56418023 8.194 ENSMUST00000061552.8
C230081A13Rik
RIKEN cDNA C230081A13 gene
chr7_+_5056856 8.124 ENSMUST00000131368.1
ENSMUST00000123956.1
Ccdc106

coiled-coil domain containing 106

chr3_+_117575268 8.063 ENSMUST00000039564.6
4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr10_-_54075702 7.968 ENSMUST00000105470.1
Man1a
mannosidase 1, alpha
chr5_+_138995038 7.806 ENSMUST00000100518.2
6330403L08Rik
RIKEN cDNA 6330403L08 gene
chr9_+_60712989 7.789 ENSMUST00000038407.5
Larp6
La ribonucleoprotein domain family, member 6
chr9_-_110742577 7.772 ENSMUST00000006005.7
Pth1r
parathyroid hormone 1 receptor
chr7_+_82174796 7.677 ENSMUST00000032874.7
Sh3gl3
SH3-domain GRB2-like 3
chr1_-_56969864 7.645 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 7.573 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr11_-_75796048 7.369 ENSMUST00000021209.7
Doc2b
double C2, beta
chr7_+_5056706 7.366 ENSMUST00000144802.1
Ccdc106
coiled-coil domain containing 106
chrX_+_36195968 7.310 ENSMUST00000115256.1
Zcchc12
zinc finger, CCHC domain containing 12
chr15_-_60824942 7.190 ENSMUST00000100635.3
Fam84b
family with sequence similarity 84, member B
chr9_-_112187766 7.187 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr1_+_75382114 7.074 ENSMUST00000113590.1
ENSMUST00000148515.1
Speg

SPEG complex locus

chr2_-_32312162 6.976 ENSMUST00000155269.1
Dnm1
dynamin 1
chr7_+_122671378 6.963 ENSMUST00000182563.1
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr13_-_107890059 6.753 ENSMUST00000105097.2
Zswim6
zinc finger SWIM-type containing 6
chr7_-_45370559 6.751 ENSMUST00000003971.7
Lin7b
lin-7 homolog B (C. elegans)
chr5_+_9266097 6.677 ENSMUST00000134991.1
ENSMUST00000069538.7
ENSMUST00000115348.2
9330182L06Rik


RIKEN cDNA 9330182L06 gene


chr4_+_42949814 6.643 ENSMUST00000037872.3
ENSMUST00000098112.2
Dnajb5

DnaJ (Hsp40) homolog, subfamily B, member 5

chr9_+_21032038 6.619 ENSMUST00000019616.4
Icam5
intercellular adhesion molecule 5, telencephalin
chr5_+_137553517 6.540 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
Actl6b




actin-like 6B




chr5_-_138994935 6.521 ENSMUST00000046901.7
ENSMUST00000076095.7
Pdgfa

platelet derived growth factor, alpha

chr11_-_37235882 6.470 ENSMUST00000102801.1
Tenm2
teneurin transmembrane protein 2
chr9_-_112187898 6.463 ENSMUST00000178410.1
ENSMUST00000172380.3
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr6_-_126645784 6.445 ENSMUST00000055168.3
Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr5_+_137030275 6.367 ENSMUST00000041543.8
Vgf
VGF nerve growth factor inducible
chr19_+_27217357 6.338 ENSMUST00000047645.6
ENSMUST00000167487.1
Vldlr

very low density lipoprotein receptor

chr11_-_89302545 6.271 ENSMUST00000061728.3
Nog
noggin
chr2_-_24763047 6.256 ENSMUST00000100348.3
ENSMUST00000041342.5
ENSMUST00000114447.1
ENSMUST00000102939.2
ENSMUST00000070864.7
Cacna1b




calcium channel, voltage-dependent, N type, alpha 1B subunit




chr19_+_27217011 6.178 ENSMUST00000164746.1
ENSMUST00000172302.1
Vldlr

very low density lipoprotein receptor

chr6_-_60828889 6.144 ENSMUST00000114268.3
Snca
synuclein, alpha
chr7_+_122671401 6.142 ENSMUST00000182095.1
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr3_+_96596628 6.132 ENSMUST00000058943.7
Ankrd34a
ankyrin repeat domain 34A
chr11_+_75193783 6.123 ENSMUST00000102514.3
Rtn4rl1
reticulon 4 receptor-like 1
chr11_-_108343917 5.904 ENSMUST00000059595.4
Prkca
protein kinase C, alpha
chr9_+_59680144 5.895 ENSMUST00000123914.1
Gramd2
GRAM domain containing 2
chr16_+_20589471 5.822 ENSMUST00000100074.3
ENSMUST00000096197.4
Vwa5b2

von Willebrand factor A domain containing 5B2

chr10_+_93160824 5.787 ENSMUST00000069965.7
Cdk17
cyclin-dependent kinase 17
chr16_-_22439570 5.785 ENSMUST00000170393.1
Etv5
ets variant gene 5
chr19_+_37550397 5.779 ENSMUST00000066439.6
Exoc6
exocyst complex component 6
chr9_-_107231816 5.775 ENSMUST00000044532.4
Dock3
dedicator of cyto-kinesis 3
chr2_-_25319095 5.693 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chrX_-_73660047 5.680 ENSMUST00000114472.1
Pnck
pregnancy upregulated non-ubiquitously expressed CaM kinase
chr13_-_54749627 5.596 ENSMUST00000099506.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr10_-_116473875 5.595 ENSMUST00000068233.4
Kcnmb4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr11_+_42419729 5.493 ENSMUST00000007797.4
Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr14_-_33447142 5.470 ENSMUST00000111944.3
ENSMUST00000022504.5
ENSMUST00000111945.2
Mapk8


mitogen-activated protein kinase 8


chr15_-_79834323 5.418 ENSMUST00000177316.2
ENSMUST00000175858.2
Nptxr

neuronal pentraxin receptor

chr10_-_116473418 5.368 ENSMUST00000087965.4
ENSMUST00000164271.1
Kcnmb4

potassium large conductance calcium-activated channel, subfamily M, beta member 4

chr12_-_76709997 5.348 ENSMUST00000166101.1
Sptb
spectrin beta, erythrocytic
chr15_+_89499598 5.344 ENSMUST00000109309.1
Shank3
SH3/ankyrin domain gene 3
chr13_-_54749849 5.338 ENSMUST00000135343.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr2_+_143546144 5.300 ENSMUST00000028905.9
Pcsk2
proprotein convertase subtilisin/kexin type 2
chr14_-_55585250 5.278 ENSMUST00000022828.8
Emc9
ER membrane protein complex subunit 9
chr7_-_126704816 5.159 ENSMUST00000032949.7
Coro1a
coronin, actin binding protein 1A
chr10_+_79716588 5.128 ENSMUST00000099513.1
ENSMUST00000020581.2
Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr14_-_76556662 5.088 ENSMUST00000064517.7
Serp2
stress-associated endoplasmic reticulum protein family member 2
chr1_-_189343704 5.052 ENSMUST00000180044.1
ENSMUST00000110920.1
Kcnk2

potassium channel, subfamily K, member 2

chr11_+_97415527 5.032 ENSMUST00000121799.1
Arhgap23
Rho GTPase activating protein 23
chr11_-_101785252 4.908 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr19_+_6399857 4.900 ENSMUST00000146601.1
ENSMUST00000150713.1
Rasgrp2

RAS, guanyl releasing protein 2

chr19_-_4698315 4.887 ENSMUST00000096325.3
Gm960
predicted gene 960
chr12_+_78226627 4.877 ENSMUST00000110388.2
ENSMUST00000052472.4
Gphn

gephyrin

chr1_-_174921813 4.849 ENSMUST00000055294.3
Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chrX_+_36195938 4.816 ENSMUST00000048067.3
Zcchc12
zinc finger, CCHC domain containing 12
chr10_-_127666673 4.744 ENSMUST00000026469.2
Nab2
Ngfi-A binding protein 2
chr5_+_30588078 4.705 ENSMUST00000066295.2
Kcnk3
potassium channel, subfamily K, member 3
chr17_+_69156791 4.681 ENSMUST00000112680.1
ENSMUST00000080208.5
Epb4.1l3

erythrocyte protein band 4.1-like 3

chr13_+_118714678 4.668 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chrX_+_36195904 4.645 ENSMUST00000115258.2
Zcchc12
zinc finger, CCHC domain containing 12
chr8_-_70234097 4.633 ENSMUST00000130319.1
Armc6
armadillo repeat containing 6
chr9_+_21165714 4.613 ENSMUST00000039413.8
Pde4a
phosphodiesterase 4A, cAMP specific
chrX_+_36195950 4.573 ENSMUST00000115257.1
Zcchc12
zinc finger, CCHC domain containing 12
chr6_-_85502858 4.547 ENSMUST00000161546.1
ENSMUST00000161078.1
Fbxo41

F-box protein 41

chr2_-_118703963 4.542 ENSMUST00000104937.1
Ankrd63
ankyrin repeat domain 63
chr2_-_25319187 4.541 ENSMUST00000114312.1
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr1_-_152766323 4.511 ENSMUST00000111857.1
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr3_-_141931523 4.500 ENSMUST00000106232.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr1_+_42952872 4.470 ENSMUST00000179766.1
Gpr45
G protein-coupled receptor 45
chr10_-_127666598 4.456 ENSMUST00000099157.3
Nab2
Ngfi-A binding protein 2
chr19_-_5098418 4.455 ENSMUST00000025805.6
Cnih2
cornichon homolog 2 (Drosophila)
chr4_-_126753372 4.453 ENSMUST00000030637.7
ENSMUST00000106116.1
Ncdn

neurochondrin

chr7_-_126704179 4.450 ENSMUST00000106364.1
Coro1a
coronin, actin binding protein 1A
chr6_-_85502980 4.445 ENSMUST00000159062.1
Fbxo41
F-box protein 41
chr8_+_95678085 4.438 ENSMUST00000041318.7
Ndrg4
N-myc downstream regulated gene 4
chr12_+_5375870 4.406 ENSMUST00000037953.6
2810032G03Rik
RIKEN cDNA 2810032G03 gene
chr9_-_86695897 4.390 ENSMUST00000034989.8
Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chrX_+_152144240 4.389 ENSMUST00000168786.1
ENSMUST00000112605.1
ENSMUST00000112604.1
Iqsec2


IQ motif and Sec7 domain 2


chr16_-_20621255 4.365 ENSMUST00000052939.2
Camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr7_+_40899278 4.314 ENSMUST00000044705.9
Vstm2b
V-set and transmembrane domain containing 2B
chr8_-_70234401 4.313 ENSMUST00000019679.5
Armc6
armadillo repeat containing 6
chr11_+_79660532 4.264 ENSMUST00000155381.1
Rab11fip4
RAB11 family interacting protein 4 (class II)
chr1_-_189343342 4.253 ENSMUST00000079451.6
Kcnk2
potassium channel, subfamily K, member 2
chr11_+_70540260 4.252 ENSMUST00000018429.5
ENSMUST00000108557.3
ENSMUST00000108556.1
Pld2


phospholipase D2


chr1_-_152766281 4.223 ENSMUST00000111859.1
ENSMUST00000148865.1
Rgl1

ral guanine nucleotide dissociation stimulator,-like 1

chr19_-_5085483 4.209 ENSMUST00000140389.1
ENSMUST00000151413.1
ENSMUST00000077066.7
Tmem151a


transmembrane protein 151A


chr7_-_126704522 4.209 ENSMUST00000135087.1
Coro1a
coronin, actin binding protein 1A
chr3_-_152668135 4.187 ENSMUST00000045262.6
Ak5
adenylate kinase 5
chr4_+_43046014 4.184 ENSMUST00000180426.1
Gm26881
predicted gene, 26881
chr19_+_42255704 4.127 ENSMUST00000087123.5
Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr8_-_122551316 4.059 ENSMUST00000067252.7
Piezo1
piezo-type mechanosensitive ion channel component 1
chr6_+_85431970 4.046 ENSMUST00000045693.7
Smyd5
SET and MYND domain containing 5
chr9_+_58582397 4.045 ENSMUST00000176557.1
ENSMUST00000114121.4
ENSMUST00000177064.1
Nptn


neuroplastin


chr16_-_18629864 4.044 ENSMUST00000096987.5
Sept5
septin 5
chr10_-_80139347 3.975 ENSMUST00000105369.1
Dos
downstream of Stk11
chr2_+_127336152 3.973 ENSMUST00000028846.6
Dusp2
dual specificity phosphatase 2
chr4_-_124850473 3.967 ENSMUST00000137769.2
1110065P20Rik
RIKEN cDNA 1110065P20 gene
chr17_+_26414820 3.963 ENSMUST00000182897.1
ENSMUST00000183077.1
ENSMUST00000053020.7
Neurl1b


neuralized homolog 1b (Drosophila)


chr5_-_77408034 3.961 ENSMUST00000163898.1
ENSMUST00000046746.6
Igfbp7

insulin-like growth factor binding protein 7

chr1_-_22805994 3.946 ENSMUST00000097808.4
Rims1
regulating synaptic membrane exocytosis 1
chr5_+_100039990 3.928 ENSMUST00000169390.1
ENSMUST00000031268.6
Enoph1

enolase-phosphatase 1

chr17_+_86167777 3.869 ENSMUST00000097275.2
Prkce
protein kinase C, epsilon
chr14_-_30353468 3.863 ENSMUST00000112249.1
Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr16_-_4880284 3.854 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr13_-_43304153 3.829 ENSMUST00000055341.5
Gfod1
glucose-fructose oxidoreductase domain containing 1
chr12_+_36157124 3.805 ENSMUST00000041640.3
Ankmy2
ankyrin repeat and MYND domain containing 2
chr2_+_59160884 3.792 ENSMUST00000037903.8
Pkp4
plakophilin 4
chr4_+_138250403 3.779 ENSMUST00000105818.1
ENSMUST00000105824.1
ENSMUST00000124239.1
Kif17
Sh2d5

kinesin family member 17
SH2 domain containing 5

chr4_+_136286061 3.737 ENSMUST00000069195.4
ENSMUST00000130658.1
Zfp46

zinc finger protein 46

chr2_-_168741898 3.713 ENSMUST00000109176.1
ENSMUST00000178504.1
Atp9a

ATPase, class II, type 9A

chr5_-_24842579 3.707 ENSMUST00000030787.8
Rheb
Ras homolog enriched in brain
chr19_+_6399746 3.688 ENSMUST00000113468.1
Rasgrp2
RAS, guanyl releasing protein 2
chr10_-_80577285 3.613 ENSMUST00000038558.8
Klf16
Kruppel-like factor 16
chr4_-_124850670 3.604 ENSMUST00000163946.1
ENSMUST00000106190.3
1110065P20Rik

RIKEN cDNA 1110065P20 gene

chr8_-_73353477 3.591 ENSMUST00000119826.1
Large
like-glycosyltransferase
chr7_-_126704736 3.587 ENSMUST00000131415.1
Coro1a
coronin, actin binding protein 1A
chr18_+_74779190 3.550 ENSMUST00000041053.9
Acaa2
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
chr5_-_31295862 3.544 ENSMUST00000041266.7
ENSMUST00000172435.1
Fndc4

fibronectin type III domain containing 4

chr4_-_124850652 3.522 ENSMUST00000125776.1
1110065P20Rik
RIKEN cDNA 1110065P20 gene
chr7_-_142659482 3.496 ENSMUST00000121128.1
Igf2
insulin-like growth factor 2
chr11_+_121702393 3.465 ENSMUST00000036742.7
Metrnl
meteorin, glial cell differentiation regulator-like
chrX_-_59134421 3.462 ENSMUST00000033473.5
Fgf13
fibroblast growth factor 13
chr12_-_112929415 3.455 ENSMUST00000075827.3
Jag2
jagged 2
chr11_-_72135721 3.432 ENSMUST00000108508.2
ENSMUST00000075258.6
Pitpnm3

PITPNM family member 3

chr2_+_118111876 3.364 ENSMUST00000039559.8
Thbs1
thrombospondin 1
chr14_-_20546512 3.350 ENSMUST00000022355.4
ENSMUST00000161445.1
ENSMUST00000159027.1
Ppp3cb


protein phosphatase 3, catalytic subunit, beta isoform


chr8_+_83972951 3.345 ENSMUST00000005606.6
Prkaca
protein kinase, cAMP dependent, catalytic, alpha
chr19_+_5568002 3.294 ENSMUST00000096318.3
Ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr6_-_4747019 3.269 ENSMUST00000126151.1
ENSMUST00000133306.1
ENSMUST00000123907.1
Sgce


sarcoglycan, epsilon


chr2_+_150749036 3.242 ENSMUST00000094467.5
Entpd6
ectonucleoside triphosphate diphosphohydrolase 6
chr15_-_76660108 3.185 ENSMUST00000066677.8
ENSMUST00000177359.1
Cyhr1

cysteine and histidine rich 1

chr10_-_75932468 3.162 ENSMUST00000120281.1
ENSMUST00000000924.6
Mmp11

matrix metallopeptidase 11

chr13_+_100107997 3.130 ENSMUST00000142155.1
ENSMUST00000022145.8
ENSMUST00000132053.1
Serf1


small EDRK-rich factor 1


chr3_-_89089955 3.086 ENSMUST00000166687.1
Rusc1
RUN and SH3 domain containing 1
chr2_+_157914618 3.084 ENSMUST00000109523.1
Vstm2l
V-set and transmembrane domain containing 2-like
chr15_-_64922290 3.080 ENSMUST00000023007.5
Adcy8
adenylate cyclase 8
chrX_-_7574120 3.015 ENSMUST00000045924.7
ENSMUST00000115742.2
ENSMUST00000150787.1
Ppp1r3f


protein phosphatase 1, regulatory (inhibitor) subunit 3F


chr13_-_100108337 2.969 ENSMUST00000180822.1
BC001981
cDNA sequence BC001981
chr17_+_87282880 2.956 ENSMUST00000041110.5
ENSMUST00000125875.1
Ttc7

tetratricopeptide repeat domain 7

chr12_+_85599047 2.951 ENSMUST00000177587.1
Jdp2
Jun dimerization protein 2
chr3_+_136670679 2.943 ENSMUST00000056758.8
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr13_+_100108155 2.938 ENSMUST00000129014.1
Serf1
small EDRK-rich factor 1
chr15_-_76243401 2.904 ENSMUST00000165738.1
ENSMUST00000075689.6
Parp10

poly (ADP-ribose) polymerase family, member 10

chr7_-_45366714 2.889 ENSMUST00000107779.1
Ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr15_+_78935177 2.871 ENSMUST00000145157.1
ENSMUST00000123013.1
Nol12

nucleolar protein 12

chrX_-_160994665 2.829 ENSMUST00000087104.4
Cdkl5
cyclin-dependent kinase-like 5
chr11_-_106779483 2.824 ENSMUST00000021060.5
Polg2
polymerase (DNA directed), gamma 2, accessory subunit
chr7_-_25250720 2.823 ENSMUST00000116343.2
ENSMUST00000045847.8
Erf

Ets2 repressor factor

chr10_-_81472859 2.810 ENSMUST00000147524.1
ENSMUST00000119060.1
Celf5

CUGBP, Elav-like family member 5

chr12_-_69582985 2.805 ENSMUST00000058639.9
Mettl21d
methyltransferase like 21D
chr6_-_82652856 2.794 ENSMUST00000160281.1
ENSMUST00000095786.5
Pole4

polymerase (DNA-directed), epsilon 4 (p12 subunit)

chr6_-_4747157 2.791 ENSMUST00000090686.4
ENSMUST00000115579.1
ENSMUST00000115577.2
ENSMUST00000101677.3
ENSMUST00000004750.8
Sgce




sarcoglycan, epsilon




chr2_-_94157881 2.772 ENSMUST00000028619.4
Hsd17b12
hydroxysteroid (17-beta) dehydrogenase 12
chr6_-_83831736 2.770 ENSMUST00000058383.8
Paip2b
poly(A) binding protein interacting protein 2B
chr4_-_151861762 2.759 ENSMUST00000097774.2
Camta1
calmodulin binding transcription activator 1
chr3_+_121723515 2.694 ENSMUST00000029771.8
F3
coagulation factor III

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
11.6 34.8 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
4.4 13.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
4.3 21.3 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
3.4 10.2 GO:1900673 olefin metabolic process(GO:1900673)
3.1 9.3 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
2.9 17.4 GO:0032796 uropod organization(GO:0032796)
2.7 2.7 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
2.5 12.5 GO:0034436 glycoprotein transport(GO:0034436)
2.3 11.6 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
2.3 6.8 GO:0010360 negative regulation of anion channel activity(GO:0010360)
2.2 6.5 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
2.1 6.4 GO:0050975 sensory perception of touch(GO:0050975)
1.9 9.5 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
1.8 5.3 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
1.8 8.9 GO:2001025 positive regulation of response to drug(GO:2001025)
1.8 5.3 GO:0030070 insulin processing(GO:0030070)
1.7 20.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.7 8.5 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
1.7 10.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.7 18.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
1.6 6.3 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
1.6 9.4 GO:0019695 choline metabolic process(GO:0019695)
1.6 4.7 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
1.5 6.1 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468)
1.5 2.9 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
1.4 4.3 GO:0072720 response to sorbitol(GO:0072708) response to dithiothreitol(GO:0072720)
1.4 8.7 GO:0097491 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
1.4 5.5 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
1.4 4.1 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
1.4 6.8 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
1.3 9.2 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
1.3 16.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.2 6.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.2 4.9 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
1.2 3.6 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
1.1 4.5 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
1.1 3.4 GO:0010752 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752) negative regulation of endothelial cell chemotaxis(GO:2001027)
1.1 3.3 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
1.1 6.5 GO:0097264 self proteolysis(GO:0097264)
1.1 8.6 GO:0005513 detection of calcium ion(GO:0005513)
1.0 5.1 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
1.0 10.0 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
1.0 7.0 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
1.0 20.9 GO:0006491 N-glycan processing(GO:0006491)
1.0 4.0 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.0 3.9 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
1.0 3.9 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
1.0 2.9 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
1.0 4.9 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
1.0 3.9 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
1.0 15.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.9 17.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.9 10.3 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.9 2.7 GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641)
0.9 4.4 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.9 6.1 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.9 2.6 GO:0006597 spermine biosynthetic process(GO:0006597)
0.9 11.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.8 4.9 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.8 2.3 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
0.8 13.6 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.8 1.5 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.7 2.2 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.7 2.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.7 4.3 GO:0070314 G1 to G0 transition(GO:0070314)
0.7 3.5 GO:0007256 activation of JNKK activity(GO:0007256)
0.7 4.8 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.7 2.1 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.7 7.4 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.7 8.7 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.7 0.7 GO:0007521 muscle cell fate determination(GO:0007521)
0.6 5.5 GO:0071420 cellular response to histamine(GO:0071420)
0.6 2.4 GO:1990034 calcium ion export from cell(GO:1990034)
0.6 14.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.6 4.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.6 3.5 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.6 1.7 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.6 3.5 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.6 8.5 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.6 2.8 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.6 2.8 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.6 2.8 GO:0006842 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.5 1.6 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.5 6.5 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.5 2.2 GO:0031133 regulation of axon diameter(GO:0031133)
0.5 6.4 GO:0043084 penile erection(GO:0043084)
0.5 2.1 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.5 2.6 GO:0015871 choline transport(GO:0015871) negative regulation of RIG-I signaling pathway(GO:0039536)
0.5 3.5 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.5 6.3 GO:0001956 positive regulation of neurotransmitter secretion(GO:0001956)
0.5 3.8 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.5 3.7 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.5 1.4 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.5 1.8 GO:0060437 lung growth(GO:0060437)
0.5 2.3 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.4 1.3 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.4 3.0 GO:0060137 maternal process involved in parturition(GO:0060137)
0.4 2.1 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.4 6.1 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.4 4.4 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.4 2.8 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.4 1.6 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.4 1.2 GO:0032532 regulation of microvillus length(GO:0032532)
0.4 7.3 GO:0002076 osteoblast development(GO:0002076)
0.4 2.6 GO:0015862 uridine transport(GO:0015862)
0.4 2.6 GO:0061092 involuntary skeletal muscle contraction(GO:0003011) detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.4 0.7 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.4 6.5 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.4 1.8 GO:0006543 glutamine catabolic process(GO:0006543)
0.4 1.4 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.4 1.4 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.4 16.8 GO:0034605 cellular response to heat(GO:0034605)
0.3 4.4 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.3 1.3 GO:0009597 detection of virus(GO:0009597)
0.3 1.0 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.3 1.5 GO:0006706 steroid catabolic process(GO:0006706)
0.3 1.2 GO:0090365 regulation of mRNA modification(GO:0090365)
0.3 4.5 GO:0051639 actin filament network formation(GO:0051639)
0.3 3.9 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.3 1.8 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.3 1.8 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.3 1.6 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.3 0.5 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.3 3.0 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.3 0.8 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.3 5.3 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.2 7.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.2 10.5 GO:0032355 response to estradiol(GO:0032355)
0.2 1.2 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.2 1.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 2.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.2 1.6 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 2.0 GO:1900016 negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.2 8.7 GO:2001222 regulation of neuron migration(GO:2001222)
0.2 2.8 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.2 0.9 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.2 0.4 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 0.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.2 1.0 GO:0001923 B-1 B cell differentiation(GO:0001923)
0.2 1.3 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.2 3.2 GO:0032026 response to magnesium ion(GO:0032026)
0.2 1.9 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.2 5.1 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.2 4.9 GO:0061157 mRNA destabilization(GO:0061157)
0.2 1.9 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 4.0 GO:0071711 basement membrane organization(GO:0071711)
0.2 1.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.2 2.0 GO:0072643 interferon-gamma secretion(GO:0072643)
0.2 1.6 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.2 1.9 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.2 2.5 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.2 0.6 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.2 0.9 GO:0009169 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.1 5.9 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.1 1.0 GO:0097501 stress response to metal ion(GO:0097501)
0.1 1.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 3.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 3.1 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.1 3.6 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 1.1 GO:0009408 response to heat(GO:0009408)
0.1 2.0 GO:0060074 synapse maturation(GO:0060074)
0.1 5.4 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.1 0.8 GO:0009405 pathogenesis(GO:0009405)
0.1 5.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 2.8 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.1 0.4 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.1 3.2 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 14.7 GO:0016579 protein deubiquitination(GO:0016579)
0.1 4.0 GO:0001706 endoderm formation(GO:0001706)
0.1 0.5 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.1 1.8 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.1 0.9 GO:0001771 immunological synapse formation(GO:0001771)
0.1 2.0 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 1.2 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 2.7 GO:0045453 bone resorption(GO:0045453)
0.1 0.6 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 1.8 GO:0061462 protein localization to lysosome(GO:0061462)
0.1 2.4 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.1 2.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.4 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.1 3.0 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 0.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.7 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 1.0 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 2.2 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.1 0.4 GO:0090292 nuclear migration along microfilament(GO:0031022) nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 2.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 0.9 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.1 2.4 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 3.6 GO:0046326 positive regulation of glucose import(GO:0046326)
0.1 0.2 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.1 0.4 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 9.3 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 0.8 GO:0010452 histone H3-K36 methylation(GO:0010452)
0.1 2.2 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 1.1 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.1 1.7 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.1 0.4 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.6 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 4.7 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.1 0.5 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.1 0.6 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 0.4 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 0.3 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 2.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.4 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.9 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.4 GO:0043011 negative regulation of interferon-beta production(GO:0032688) myeloid dendritic cell differentiation(GO:0043011)
0.0 0.3 GO:0048680 positive regulation of axon regeneration(GO:0048680)
0.0 1.0 GO:0006829 zinc II ion transport(GO:0006829)
0.0 6.0 GO:0006457 protein folding(GO:0006457)
0.0 0.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 2.4 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 0.9 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.5 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.8 GO:0098927 vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 1.0 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.0 1.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.2 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.1 GO:0030578 PML body organization(GO:0030578)
0.0 1.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 10.4 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 2.8 GO:0001764 neuron migration(GO:0001764)
0.0 0.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.6 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.0 0.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.8 GO:0050810 regulation of steroid biosynthetic process(GO:0050810)
0.0 0.1 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.6 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.7 GO:0042073 intraciliary transport(GO:0042073)
0.0 1.1 GO:1901214 regulation of neuron death(GO:1901214)
0.0 1.2 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.0 0.3 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.0 0.5 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.2 GO:0044804 nucleophagy(GO:0044804)
0.0 1.1 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.9 GO:0006909 phagocytosis(GO:0006909)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 15.4 GO:0008091 spectrin(GO:0008091)
2.6 10.2 GO:0044307 dendritic branch(GO:0044307)
1.9 3.8 GO:1990075 periciliary membrane compartment(GO:1990075)
1.8 23.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.7 5.1 GO:0098855 HCN channel complex(GO:0098855)
1.6 9.7 GO:0005955 calcineurin complex(GO:0005955)
1.6 17.4 GO:0032426 stereocilium tip(GO:0032426)
1.6 9.3 GO:0044305 calyx of Held(GO:0044305)
1.5 6.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
1.5 6.1 GO:0016012 sarcoglycan complex(GO:0016012)
1.4 5.8 GO:0090537 CERF complex(GO:0090537)
1.1 3.4 GO:0005577 fibrinogen complex(GO:0005577)
1.1 16.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.1 36.0 GO:0051233 spindle midzone(GO:0051233)
1.0 12.5 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
1.0 3.9 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
1.0 6.8 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.9 2.8 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.9 9.4 GO:0043083 synaptic cleft(GO:0043083)
0.8 9.8 GO:0044327 dendritic spine head(GO:0044327)
0.8 3.3 GO:0032127 dense core granule membrane(GO:0032127)
0.8 11.6 GO:0032433 filopodium tip(GO:0032433)
0.7 9.7 GO:1990635 proximal dendrite(GO:1990635)
0.7 23.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.7 2.0 GO:0044194 cytolytic granule(GO:0044194)
0.6 11.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.6 17.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.6 6.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.6 16.6 GO:0032590 dendrite membrane(GO:0032590)
0.6 2.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.6 2.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.5 2.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.5 0.5 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.5 5.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.5 5.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.5 1.9 GO:0016461 unconventional myosin complex(GO:0016461)
0.4 1.3 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.4 28.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.4 6.9 GO:0043196 varicosity(GO:0043196)
0.4 20.8 GO:0034704 calcium channel complex(GO:0034704)
0.4 3.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.3 1.7 GO:0031523 Myb complex(GO:0031523)
0.3 4.1 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.3 0.7 GO:0016011 dystroglycan complex(GO:0016011)
0.3 4.0 GO:0031105 septin complex(GO:0031105)
0.3 1.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.3 2.3 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.3 5.8 GO:0000145 exocyst(GO:0000145)
0.3 8.3 GO:0000795 synaptonemal complex(GO:0000795)
0.3 1.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.3 17.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2 3.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.2 7.5 GO:0032420 stereocilium(GO:0032420)
0.2 1.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.2 5.4 GO:0071565 nBAF complex(GO:0071565)
0.2 2.8 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.2 0.6 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.2 15.5 GO:0043198 dendritic shaft(GO:0043198)
0.2 1.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 13.4 GO:0031526 brush border membrane(GO:0031526)
0.2 5.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 1.5 GO:0089701 U2AF(GO:0089701)
0.2 2.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 1.5 GO:0014704 intercalated disc(GO:0014704)
0.2 7.9 GO:0030667 secretory granule membrane(GO:0030667)
0.2 7.4 GO:0031201 SNARE complex(GO:0031201)
0.1 1.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.3 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 13.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 1.6 GO:0031209 SCAR complex(GO:0031209)
0.1 1.7 GO:0031143 pseudopodium(GO:0031143)
0.1 5.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.3 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.8 GO:0070695 FHF complex(GO:0070695)
0.1 3.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 25.2 GO:0005769 early endosome(GO:0005769)
0.1 1.2 GO:0097542 ciliary tip(GO:0097542)
0.1 1.3 GO:0016342 catenin complex(GO:0016342)
0.1 1.8 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 2.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 2.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.8 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 3.0 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 3.7 GO:0005902 microvillus(GO:0005902)
0.1 0.9 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 5.1 GO:0030175 filopodium(GO:0030175)
0.1 0.5 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 1.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 1.7 GO:0030125 clathrin vesicle coat(GO:0030125)
0.1 4.7 GO:0043204 perikaryon(GO:0043204)
0.1 3.2 GO:0005871 kinesin complex(GO:0005871)
0.1 14.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 1.0 GO:0042555 MCM complex(GO:0042555)
0.1 1.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 2.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 28.8 GO:0043025 neuronal cell body(GO:0043025)
0.1 0.4 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 3.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 1.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.7 GO:0001891 phagocytic cup(GO:0001891)
0.1 2.0 GO:0035869 ciliary transition zone(GO:0035869)
0.1 4.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.5 GO:0031970 organelle envelope lumen(GO:0031970)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 6.4 GO:0030424 axon(GO:0030424)
0.0 1.3 GO:0055037 recycling endosome(GO:0055037)
0.0 0.1 GO:0043293 apoptosome(GO:0043293)
0.0 1.1 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 2.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)
0.0 1.3 GO:0005643 nuclear pore(GO:0005643)
0.0 2.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.0 GO:0072562 blood microparticle(GO:0072562)
0.0 1.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.4 GO:0030018 Z disc(GO:0030018)
0.0 2.6 GO:0005635 nuclear envelope(GO:0005635)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.1 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
4.2 12.5 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
3.7 18.3 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
2.4 9.4 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
2.0 5.9 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
1.9 15.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.9 17.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
1.9 5.8 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
1.8 20.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.7 3.4 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
1.7 10.2 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
1.6 17.4 GO:0032036 myosin heavy chain binding(GO:0032036)
1.5 39.4 GO:0043274 phospholipase binding(GO:0043274)
1.5 4.4 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
1.5 8.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
1.4 25.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.4 5.5 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
1.4 5.5 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.4 5.4 GO:0001847 opsonin receptor activity(GO:0001847)
1.4 4.1 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
1.3 5.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
1.3 7.8 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
1.3 5.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
1.3 14.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
1.2 4.9 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
1.2 4.9 GO:0043546 molybdopterin cofactor binding(GO:0043546)
1.2 4.7 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
1.1 6.8 GO:0097016 L27 domain binding(GO:0097016)
1.1 3.4 GO:0070052 collagen V binding(GO:0070052)
1.1 6.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
1.0 11.7 GO:0004016 adenylate cyclase activity(GO:0004016)
0.9 12.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.9 10.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.9 3.6 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.9 4.4 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.9 7.0 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.8 2.4 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.8 6.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.8 3.0 GO:2001069 glycogen binding(GO:2001069)
0.7 2.8 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.7 11.0 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.7 6.1 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.7 8.7 GO:0038191 neuropilin binding(GO:0038191)
0.6 4.8 GO:0036122 BMP binding(GO:0036122)
0.6 2.3 GO:0031762 alpha-1A adrenergic receptor binding(GO:0031691) alpha-1B adrenergic receptor binding(GO:0031692) follicle-stimulating hormone receptor binding(GO:0031762)
0.6 2.8 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.5 1.6 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.5 1.6 GO:0019002 GMP binding(GO:0019002)
0.5 14.8 GO:0032183 SUMO binding(GO:0032183)
0.5 13.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.5 4.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.5 2.9 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.5 2.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.5 10.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.4 6.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 4.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.4 4.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.4 1.9 GO:0016018 cyclosporin A binding(GO:0016018)
0.4 1.5 GO:0070012 oligopeptidase activity(GO:0070012)
0.4 1.8 GO:0004359 glutaminase activity(GO:0004359)
0.4 1.4 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.3 8.3 GO:0030506 ankyrin binding(GO:0030506)
0.3 3.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.3 1.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.3 1.0 GO:0019966 C-X-C chemokine binding(GO:0019958) interleukin-1 binding(GO:0019966) tumor necrosis factor binding(GO:0043120)
0.3 6.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 4.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 4.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.3 3.6 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.3 1.8 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.3 1.4 GO:0042610 CD8 receptor binding(GO:0042610)
0.3 3.9 GO:0017166 vinculin binding(GO:0017166)
0.3 2.5 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.3 3.3 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.3 1.3 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.3 4.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 7.8 GO:0017046 peptide hormone binding(GO:0017046)
0.3 0.8 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924)
0.3 6.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 13.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 1.2 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.2 10.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 1.8 GO:1990405 protein antigen binding(GO:1990405)
0.2 9.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 0.8 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.2 2.3 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.2 5.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 3.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 0.6 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.2 18.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 2.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 8.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 3.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 5.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 2.4 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.2 5.1 GO:0030552 cAMP binding(GO:0030552)
0.2 3.6 GO:0031489 myosin V binding(GO:0031489)
0.2 1.3 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.1 3.2 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 1.5 GO:0050733 RS domain binding(GO:0050733)
0.1 2.9 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 4.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 1.8 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.1 7.6 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 0.8 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 0.9 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.8 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 7.0 GO:0019003 GDP binding(GO:0019003)
0.1 2.7 GO:0008143 poly(A) binding(GO:0008143)
0.1 4.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.4 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 1.9 GO:0070403 NAD+ binding(GO:0070403)
0.1 7.4 GO:0030276 clathrin binding(GO:0030276)
0.1 9.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 2.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 17.3 GO:0005516 calmodulin binding(GO:0005516)
0.1 1.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 3.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.2 GO:0005522 profilin binding(GO:0005522)
0.1 1.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 2.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 1.9 GO:0030332 cyclin binding(GO:0030332)
0.1 2.3 GO:0071617 lysophospholipid acyltransferase activity(GO:0071617)
0.1 2.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 7.7 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.7 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 4.8 GO:0016247 channel regulator activity(GO:0016247)
0.1 1.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.2 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 1.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.5 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 5.7 GO:0005178 integrin binding(GO:0005178)
0.1 1.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.9 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 1.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 0.5 GO:0070097 delta-catenin binding(GO:0070097)
0.1 3.9 GO:0019843 rRNA binding(GO:0019843)
0.1 0.9 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 1.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 0.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.3 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 1.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 5.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.4 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 0.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 2.8 GO:0008083 growth factor activity(GO:0008083)
0.0 0.6 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769)
0.0 2.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 5.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 1.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.9 GO:0000049 tRNA binding(GO:0000049)
0.0 1.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.3 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.0 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.0 0.8 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0003746 translation elongation factor activity(GO:0003746)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 35.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
1.1 19.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.7 20.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.5 24.5 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.5 12.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.5 20.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.4 12.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.4 8.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.4 9.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.4 19.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.3 14.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.3 13.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 25.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 1.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.2 7.5 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.2 3.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 2.0 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 9.6 PID_BMP_PATHWAY BMP receptor signaling
0.2 1.2 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.2 9.7 PID_LKB1_PATHWAY LKB1 signaling events
0.2 5.9 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 2.1 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.9 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 0.7 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 4.5 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 13.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.0 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.1 3.5 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 1.8 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.1 2.7 PID_ATM_PATHWAY ATM pathway
0.1 1.8 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.1 9.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 1.1 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.1 2.2 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.8 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.0 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 2.8 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.8 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 0.4 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.3 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.0 PID_P73PATHWAY p73 transcription factor network
0.0 0.6 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.7 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 14.0 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
1.8 45.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.6 35.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
1.4 10.0 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
1.3 18.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.1 11.7 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
1.0 14.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.9 24.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.8 6.1 REACTOME_AMYLOIDS Genes involved in Amyloids
0.7 5.9 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.7 30.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.7 8.7 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.5 16.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.5 11.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.5 15.4 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.4 3.6 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling
0.4 11.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.4 9.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.4 4.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.4 6.1 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.4 5.9 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.4 3.9 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.3 5.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.3 8.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.3 2.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.3 2.3 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.2 18.1 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
0.2 3.7 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 3.7 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.2 1.8 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.2 3.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 3.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 6.2 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 1.8 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 4.2 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 3.2 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 2.2 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.0 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.9 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.1 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 3.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 5.7 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 8.6 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.1 0.9 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 3.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.3 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 1.6 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.1 5.3 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.1 1.2 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.1 3.0 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 1.8 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 1.7 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 3.3 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.2 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 3.7 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.1 0.5 REACTOME_CTLA4_INHIBITORY_SIGNALING Genes involved in CTLA4 inhibitory signaling
0.1 0.7 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 2.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 5.1 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 1.6 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 1.1 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.2 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.9 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 1.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.4 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.0 1.6 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.6 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 1.6 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells