Motif ID: Egr1

Z-value: 2.831


Transcription factors associated with Egr1:

Gene SymbolEntrez IDGene Name
Egr1 ENSMUSG00000038418.7 Egr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr1mm10_v2_chr18_+_34861200_34861215-0.124.6e-01Click!


Activity profile for motif Egr1.

activity profile for motif Egr1


Sorted Z-values histogram for motif Egr1

Sorted Z-values for motif Egr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065538 26.070 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr11_-_67922136 21.491 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr4_+_125490688 18.272 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr4_+_127169131 16.369 ENSMUST00000046659.7
 Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr11_+_119942763 15.589 ENSMUST00000026436.3
ENSMUST00000106231.1
ENSMUST00000075180.5
ENSMUST00000103021.3
ENSMUST00000106233.1
 Baiap2




brain-specific angiogenesis inhibitor 1-associated protein 2




chr11_+_98348404 13.101 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr3_+_54156039 12.498 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr9_-_102354685 11.592 ENSMUST00000035129.7
ENSMUST00000085169.5
 Ephb1

Eph receptor B1

chr7_+_73740277 11.399 ENSMUST00000107456.2
 Fam174b
family with sequence similarity 174, member B
chr5_-_139129662 10.670 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr5_+_32136458 10.481 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr15_-_45114926 10.323 ENSMUST00000022967.5
 Kcnv1
potassium channel, subfamily V, member 1
chr2_-_167188787 10.315 ENSMUST00000059826.8
 Kcnb1
potassium voltage gated channel, Shab-related subfamily, member 1
chr7_-_27396542 10.077 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr12_+_108334341 9.979 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr5_-_139130159 9.626 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr8_+_104170513 9.584 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
 Bean1



brain expressed, associated with Nedd4, 1



chr3_-_89322883 9.455 ENSMUST00000029673.5
 Efna3
ephrin A3
chr10_-_54075730 9.451 ENSMUST00000105469.1
ENSMUST00000003843.8
 Man1a

mannosidase 1, alpha

chr4_+_42917234 9.423 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 239 entries
Log-likelihood per target Total log-likelihoodTermDescription
11.6 34.8 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
4.3 21.3 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
1.0 20.9 GO:0006491 N-glycan processing(GO:0006491)
1.7 20.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.7 18.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
2.9 17.4 GO:0032796 uropod organization(GO:0032796)
0.9 17.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.4 16.8 GO:0034605 cellular response to heat(GO:0034605)
1.3 16.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.0 15.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 14.7 GO:0016579 protein deubiquitination(GO:0016579)
0.6 14.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.8 13.6 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
4.4 13.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
2.5 12.5 GO:0034436 glycoprotein transport(GO:0034436)
2.3 11.6 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.9 11.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 10.5 GO:0032355 response to estradiol(GO:0032355)
0.0 10.4 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.9 10.3 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 36.0 GO:0051233 spindle midzone(GO:0051233)
0.1 28.8 GO:0043025 neuronal cell body(GO:0043025)
0.4 28.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 25.2 GO:0005769 early endosome(GO:0005769)
0.7 23.8 GO:0032839 dendrite cytoplasm(GO:0032839)
1.8 23.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 20.8 GO:0034704 calcium channel complex(GO:0034704)
0.3 17.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.6 17.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.6 17.4 GO:0032426 stereocilium tip(GO:0032426)
0.6 16.6 GO:0032590 dendrite membrane(GO:0032590)
1.1 16.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 15.5 GO:0043198 dendritic shaft(GO:0043198)
2.6 15.4 GO:0008091 spectrin(GO:0008091)
0.1 14.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 13.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 13.4 GO:0031526 brush border membrane(GO:0031526)
1.0 12.5 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.6 11.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.8 11.6 GO:0032433 filopodium tip(GO:0032433)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 39.4 GO:0043274 phospholipase binding(GO:0043274)
1.4 25.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.8 20.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 18.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
3.7 18.3 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
1.9 17.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
1.6 17.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 17.3 GO:0005516 calmodulin binding(GO:0005516)
1.9 15.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.5 14.8 GO:0032183 SUMO binding(GO:0032183)
1.3 14.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 13.3 GO:0001540 beta-amyloid binding(GO:0001540)
4.4 13.1 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.5 13.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.9 12.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
4.2 12.5 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
1.0 11.7 GO:0004016 adenylate cyclase activity(GO:0004016)
0.7 11.0 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.9 10.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 10.7 GO:0001784 phosphotyrosine binding(GO:0001784)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 35.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 25.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.5 24.5 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.7 20.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.5 20.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.4 19.9 PID_RAC1_PATHWAY RAC1 signaling pathway
1.1 19.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 14.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 13.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 13.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 12.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.4 12.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.2 9.7 PID_LKB1_PATHWAY LKB1 signaling events
0.2 9.6 PID_BMP_PATHWAY BMP receptor signaling
0.4 9.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 9.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 8.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 7.5 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.2 5.9 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 4.5 PID_CERAMIDE_PATHWAY Ceramide signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 45.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.6 35.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.7 30.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.9 24.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
1.3 18.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 18.1 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
0.5 16.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.5 15.4 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
1.0 14.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
2.0 14.0 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
1.1 11.7 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.4 11.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.5 11.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
1.4 10.0 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.4 9.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.7 8.7 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.3 8.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 8.6 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.2 6.2 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.8 6.1 REACTOME_AMYLOIDS Genes involved in Amyloids