Motif ID: Egr3

Z-value: 0.726


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_700774450.616.6e-05Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Showing 1 to 20 of 101 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_119184374 4.233 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr6_-_49214954 3.111 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr6_-_144209558 2.851 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr4_+_123183722 2.595 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr17_-_87282793 2.447 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr4_+_123183456 2.345 ENSMUST00000126995.1
 Hpcal4
hippocalcin-like 4
chr17_+_87282880 2.325 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr17_-_87282771 2.310 ENSMUST00000161759.1
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr12_-_67221221 2.290 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr11_+_98937669 1.879 ENSMUST00000107475.2
ENSMUST00000068133.3
 Rara

retinoic acid receptor, alpha

chr8_+_62951361 1.826 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr17_-_83631892 1.674 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr10_+_40883819 1.669 ENSMUST00000105509.1
 Wasf1
WAS protein family, member 1
chrX_+_143664365 1.615 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
 Pak3



p21 protein (Cdc42/Rac)-activated kinase 3



chr7_-_144939823 1.557 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr5_+_77265454 1.521 ENSMUST00000080359.5
 Rest
RE1-silencing transcription factor
chr4_-_41695935 1.500 ENSMUST00000145379.1
 Cntfr
ciliary neurotrophic factor receptor
chrX_+_143664290 1.460 ENSMUST00000112868.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr10_+_40883469 1.394 ENSMUST00000019975.7
 Wasf1
WAS protein family, member 1
chr9_-_58204310 1.329 ENSMUST00000114144.2
 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 3.4 GO:0051028 mRNA transport(GO:0051028)
0.4 3.1 GO:1990416 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 3.1 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.4 2.9 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 2.5 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 2.3 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.6 1.9 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.2 1.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 1.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.4 1.5 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.4 1.5 GO:0003360 brainstem development(GO:0003360)
0.3 1.4 GO:0007403 glial cell fate determination(GO:0007403)
0.0 1.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.2 1.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 1.1 GO:0070166 enamel mineralization(GO:0070166)
0.1 1.0 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 1.0 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.2 0.9 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.1 0.9 GO:1900028 negative regulation of ruffle assembly(GO:1900028)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.1 GO:0031209 SCAR complex(GO:0031209)
0.0 3.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 2.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.5 1.5 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 1.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 1.0 GO:0031430 M band(GO:0031430)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.3 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.3 GO:0042825 TAP complex(GO:0042825)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 4.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.2 4.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 3.4 GO:0030507 spectrin binding(GO:0030507)
0.2 3.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 3.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.2 1.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.6 GO:0070064 proline-rich region binding(GO:0070064)
0.2 1.5 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 1.4 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.3 1.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 1.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 1.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 0.9 GO:0005522 profilin binding(GO:0005522)
0.0 0.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 0.7 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.2 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.1 2.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.9 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.5 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 0.4 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.1 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.1 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters