Motif ID: Egr4

Z-value: 0.700


Transcription factors associated with Egr4:

Gene SymbolEntrez IDGene Name
Egr4 ENSMUSG00000071341.3 Egr4



Activity profile for motif Egr4.

activity profile for motif Egr4


Sorted Z-values histogram for motif Egr4

Sorted Z-values for motif Egr4



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_70851189 3.890 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr11_-_19018956 3.722 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
Meis1


Meis homeobox 1


chr18_+_35829798 3.285 ENSMUST00000060722.6
Cxxc5
CXXC finger 5
chr11_-_19018714 2.829 ENSMUST00000177417.1
Meis1
Meis homeobox 1
chr4_+_86748526 2.738 ENSMUST00000082026.7
ENSMUST00000045512.8
Dennd4c

DENN/MADD domain containing 4C

chr11_-_86993682 2.700 ENSMUST00000018571.4
Ypel2
yippee-like 2 (Drosophila)
chr4_+_128883549 2.271 ENSMUST00000035667.8
Trim62
tripartite motif-containing 62
chr2_-_102186322 1.977 ENSMUST00000111222.1
ENSMUST00000058790.5
Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr7_+_35119285 1.916 ENSMUST00000042985.9
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr14_+_84443553 1.910 ENSMUST00000071370.5
Pcdh17
protocadherin 17
chr2_+_124610278 1.757 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr12_+_17690793 1.637 ENSMUST00000071858.3
Hpcal1
hippocalcin-like 1
chr10_-_81350389 1.621 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
Hmg20b



high mobility group 20B



chr10_-_81350191 1.538 ENSMUST00000122993.1
Hmg20b
high mobility group 20B
chrX_-_145505175 1.531 ENSMUST00000143610.1
Amot
angiomotin
chr14_-_54926784 1.523 ENSMUST00000022813.6
Efs
embryonal Fyn-associated substrate
chr6_+_4747306 1.498 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
Peg10


paternally expressed 10


chr19_-_50678642 1.486 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1

VPS10 domain receptor protein SORCS 1

chr19_+_25505618 1.436 ENSMUST00000025755.4
Dmrt1
doublesex and mab-3 related transcription factor 1
chr10_-_81350305 1.400 ENSMUST00000167481.1
Hmg20b
high mobility group 20B
chr12_+_76370266 1.393 ENSMUST00000042779.3
Zbtb1
zinc finger and BTB domain containing 1
chr14_+_79481164 1.380 ENSMUST00000040131.5
Elf1
E74-like factor 1
chr2_+_124610573 1.355 ENSMUST00000103239.3
ENSMUST00000103240.2
Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr10_+_19591949 1.318 ENSMUST00000020188.6
Ifngr1
interferon gamma receptor 1
chr2_+_32535315 1.278 ENSMUST00000133512.1
ENSMUST00000048375.5
Fam102a

family with sequence similarity 102, member A

chrX_+_7762652 1.210 ENSMUST00000077680.3
ENSMUST00000079542.6
ENSMUST00000115679.1
ENSMUST00000137467.1
Tfe3



transcription factor E3



chr11_+_70000578 1.202 ENSMUST00000019362.8
Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr1_-_36939521 1.176 ENSMUST00000027290.5
Tmem131
transmembrane protein 131
chr13_+_48261427 1.175 ENSMUST00000021810.1
Id4
inhibitor of DNA binding 4
chr14_+_56668242 1.169 ENSMUST00000116468.1
Mphosph8
M-phase phosphoprotein 8
chr14_-_79481268 1.160 ENSMUST00000022601.5
Wbp4
WW domain binding protein 4
chr6_-_28261907 1.147 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
Zfp800



zinc finger protein 800



chr19_+_6306456 1.108 ENSMUST00000025681.7
Cdc42bpg
CDC42 binding protein kinase gamma (DMPK-like)
chr2_+_92184106 1.098 ENSMUST00000111294.1
ENSMUST00000111293.2
ENSMUST00000162146.1
ENSMUST00000111292.1
ENSMUST00000162497.1
Phf21a




PHD finger protein 21A




chr13_-_55513427 1.088 ENSMUST00000069929.6
ENSMUST00000069968.6
ENSMUST00000131306.1
ENSMUST00000046246.6
Pdlim7



PDZ and LIM domain 7



chr5_-_96161742 1.077 ENSMUST00000129646.1
ENSMUST00000113005.2
ENSMUST00000154500.1
ENSMUST00000141383.1
Cnot6l



CCR4-NOT transcription complex, subunit 6-like



chr9_+_108306205 1.064 ENSMUST00000007959.8
Rhoa
ras homolog gene family, member A
chr2_-_48949206 1.027 ENSMUST00000090976.3
ENSMUST00000149679.1
ENSMUST00000028098.4
Orc4


origin recognition complex, subunit 4


chr1_-_52500679 0.983 ENSMUST00000069792.7
Nab1
Ngfi-A binding protein 1
chr2_-_119477613 0.932 ENSMUST00000110808.1
ENSMUST00000049920.7
Ino80

INO80 homolog (S. cerevisiae)

chrX_+_36195968 0.835 ENSMUST00000115256.1
Zcchc12
zinc finger, CCHC domain containing 12
chrX_-_20291728 0.834 ENSMUST00000115393.2
Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr11_+_114851814 0.823 ENSMUST00000053361.5
ENSMUST00000021071.7
ENSMUST00000136785.1
Gprc5c


G protein-coupled receptor, family C, group 5, member C


chr10_+_128232065 0.773 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
Timeless




timeless circadian clock 1




chr15_+_58141397 0.743 ENSMUST00000067563.7
Wdyhv1
WDYHV motif containing 1
chr16_+_36071624 0.737 ENSMUST00000164916.1
ENSMUST00000163352.1
Ccdc58

coiled-coil domain containing 58

chr15_+_26309039 0.706 ENSMUST00000140840.1
ENSMUST00000152841.1
March11

membrane-associated ring finger (C3HC4) 11

chr11_-_102407315 0.672 ENSMUST00000149777.1
ENSMUST00000154001.1
Slc25a39

solute carrier family 25, member 39

chr3_+_135438722 0.663 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr17_-_23677432 0.659 ENSMUST00000167059.1
ENSMUST00000024698.8
Tnfrsf12a

tumor necrosis factor receptor superfamily, member 12a

chr11_-_102407899 0.658 ENSMUST00000124755.1
Slc25a39
solute carrier family 25, member 39
chr4_+_130055010 0.614 ENSMUST00000123617.1
Col16a1
collagen, type XVI, alpha 1
chrX_-_153037549 0.594 ENSMUST00000051484.3
Mageh1
melanoma antigen, family H, 1
chr14_+_75845093 0.589 ENSMUST00000110894.2
Tpt1
tumor protein, translationally-controlled 1
chr2_+_48949495 0.585 ENSMUST00000112745.1
Mbd5
methyl-CpG binding domain protein 5
chrX_-_48513518 0.573 ENSMUST00000114945.2
ENSMUST00000037349.7
Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr16_+_64851991 0.564 ENSMUST00000067744.7
Cggbp1
CGG triplet repeat binding protein 1
chr17_+_26138661 0.534 ENSMUST00000074370.3
ENSMUST00000118904.2
ENSMUST00000163421.1
Axin1


axin 1


chr5_-_149051604 0.529 ENSMUST00000093196.4
Hmgb1
high mobility group box 1
chr16_-_4213404 0.528 ENSMUST00000023165.6
Crebbp
CREB binding protein
chr9_+_65630552 0.505 ENSMUST00000055844.8
Rbpms2
RNA binding protein with multiple splicing 2
chrX_+_36195950 0.489 ENSMUST00000115257.1
Zcchc12
zinc finger, CCHC domain containing 12
chr13_-_111490111 0.474 ENSMUST00000047627.7
Gpbp1
GC-rich promoter binding protein 1
chr9_-_95511897 0.474 ENSMUST00000079659.5
ENSMUST00000078374.6
U2surp

U2 snRNP-associated SURP domain containing

chrX_+_36195904 0.471 ENSMUST00000115258.2
Zcchc12
zinc finger, CCHC domain containing 12
chr13_-_111490028 0.470 ENSMUST00000091236.4
Gpbp1
GC-rich promoter binding protein 1
chrX_+_36195938 0.452 ENSMUST00000048067.3
Zcchc12
zinc finger, CCHC domain containing 12
chr2_-_66634952 0.439 ENSMUST00000100064.2
ENSMUST00000100063.2
Scn9a

sodium channel, voltage-gated, type IX, alpha

chr4_-_99120898 0.438 ENSMUST00000075836.5
Dock7
dedicator of cytokinesis 7
chr11_+_114851507 0.437 ENSMUST00000177952.1
Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr8_-_92355764 0.429 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
4933436C20Rik



RIKEN cDNA 4933436C20 gene



chr9_-_59750616 0.423 ENSMUST00000163586.1
ENSMUST00000177963.1
ENSMUST00000051039.4
Senp8


SUMO/sentrin specific peptidase 8


chr15_-_38078842 0.405 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr11_-_102407455 0.388 ENSMUST00000107098.1
ENSMUST00000018821.2
Slc25a39

solute carrier family 25, member 39

chr19_-_50678485 0.382 ENSMUST00000111756.3
Sorcs1
VPS10 domain receptor protein SORCS 1
chr17_+_69383024 0.350 ENSMUST00000112674.1
Zbtb14
zinc finger and BTB domain containing 14
chr8_-_92356103 0.346 ENSMUST00000034183.3
4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr11_-_87987528 0.323 ENSMUST00000020775.2
Dynll2
dynein light chain LC8-type 2
chr7_-_4778141 0.311 ENSMUST00000094892.5
Il11
interleukin 11
chr19_-_21652779 0.306 ENSMUST00000179768.1
ENSMUST00000178523.1
ENSMUST00000038830.3
1110059E24Rik


RIKEN cDNA 1110059E24 gene


chr2_-_121355284 0.297 ENSMUST00000134796.1
ENSMUST00000110628.1
ENSMUST00000110627.1
ENSMUST00000110625.1
Ppip5k1



diphosphoinositol pentakisphosphate kinase 1



chrX_-_20291776 0.284 ENSMUST00000072451.4
Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr1_+_135132693 0.271 ENSMUST00000049449.4
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr9_+_65908967 0.231 ENSMUST00000034949.3
ENSMUST00000154589.1
Csnk1g1

casein kinase 1, gamma 1

chr9_+_114688782 0.194 ENSMUST00000047404.6
Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr6_+_127149389 0.191 ENSMUST00000180811.1
9330179D12Rik
RIKEN cDNA 9330179D12 gene
chr3_+_144570687 0.188 ENSMUST00000106211.1
Sep15
selenoprotein
chr16_+_44173239 0.177 ENSMUST00000119746.1
Gm608
predicted gene 608
chr9_-_44440868 0.170 ENSMUST00000098837.1
Foxr1
forkhead box R1
chr2_-_148045891 0.163 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr6_-_85961631 0.162 ENSMUST00000032071.9
Dusp11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr9_+_118926453 0.147 ENSMUST00000073109.5
Ctdspl
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr15_-_36608959 0.140 ENSMUST00000001809.8
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr17_-_31658729 0.139 ENSMUST00000166526.1
ENSMUST00000014684.4
U2af1

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1

chr19_-_5085483 0.138 ENSMUST00000140389.1
ENSMUST00000151413.1
ENSMUST00000077066.7
Tmem151a


transmembrane protein 151A


chr9_+_108347827 0.130 ENSMUST00000035237.6
Usp4
ubiquitin specific peptidase 4 (proto-oncogene)
chr9_+_59750876 0.100 ENSMUST00000136740.1
ENSMUST00000135298.1
ENSMUST00000128341.1
Myo9a


myosin IXa


chr19_+_6363671 0.084 ENSMUST00000131252.1
Sf1
splicing factor 1
chrX_+_7842056 0.084 ENSMUST00000115667.3
ENSMUST00000115668.3
ENSMUST00000115665.1
Otud5


OTU domain containing 5


chr19_+_6363719 0.076 ENSMUST00000113489.1
ENSMUST00000113488.1
Sf1

splicing factor 1

chr19_-_8786245 0.058 ENSMUST00000177216.1
Taf6l
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
chr16_+_8830093 0.050 ENSMUST00000023150.5
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr7_-_19404082 0.036 ENSMUST00000108458.3
Klc3
kinesin light chain 3
chr19_-_8786272 0.033 ENSMUST00000176610.1
ENSMUST00000177056.1
Taf6l

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

chr16_+_93883895 0.025 ENSMUST00000023666.4
ENSMUST00000117099.1
ENSMUST00000142316.1
Chaf1b


chromatin assembly factor 1, subunit B (p60)


chrX_-_12762069 0.023 ENSMUST00000096495.4
ENSMUST00000076016.5
Med14

mediator complex subunit 14

chr6_-_85451248 0.021 ENSMUST00000113770.1
ENSMUST00000032080.2
Pradc1

protease-associated domain containing 1

chr2_-_9883993 0.011 ENSMUST00000114915.2
9230102O04Rik
RIKEN cDNA 9230102O04 gene
chr18_+_86394952 0.007 ENSMUST00000058829.2
Neto1
neuropilin (NRP) and tolloid (TLL)-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.4 1.5 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.4 1.1 GO:0003100 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.3 1.4 GO:0002572 pro-T cell differentiation(GO:0002572)
0.3 1.2 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.3 6.6 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.3 1.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.3 4.6 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.3 0.8 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.3 5.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.2 1.9 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.2 0.7 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.2 0.6 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.2 0.5 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.6 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.1 1.9 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.1 0.4 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 1.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.5 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.1 0.5 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.1 1.1 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 2.3 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.1 3.1 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 0.9 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 1.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.6 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.1 1.2 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.4 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.5 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 0.2 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.1 0.2 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
0.1 1.7 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 1.1 GO:0001967 suckling behavior(GO:0001967)
0.0 0.1 GO:1905077 negative regulation of interleukin-17 secretion(GO:1905077)
0.0 1.2 GO:0044030 regulation of DNA methylation(GO:0044030)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.3 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 1.0 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.6 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 1.0 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 1.2 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.2 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 1.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 3.3 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 1.1 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.4 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.3 GO:0007601 visual perception(GO:0007601)
0.0 2.0 GO:0032869 cellular response to insulin stimulus(GO:0032869)
0.0 1.1 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.7 GO:0070613 regulation of protein processing(GO:0070613)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.6 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.6 1.9 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.2 2.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 1.0 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.9 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.6 GO:0045298 tubulin complex(GO:0045298)
0.0 1.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.5 GO:1990909 Wnt signalosome(GO:1990909)
0.0 2.0 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 1.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.6 GO:0016235 aggresome(GO:0016235)
0.0 0.6 GO:0010369 chromocenter(GO:0010369)
0.0 1.1 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 6.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.7 GO:0001726 ruffle(GO:0001726)
0.0 3.6 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0005118 sevenless binding(GO:0005118)
0.3 1.5 GO:0043532 angiostatin binding(GO:0043532)
0.2 5.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 0.6 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 3.9 GO:0070410 co-SMAD binding(GO:0070410)
0.2 3.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 1.9 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.1 1.1 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 0.5 GO:0043426 MRF binding(GO:0043426)
0.1 2.2 GO:0032183 SUMO binding(GO:0032183)
0.1 0.3 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 1.0 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 2.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 1.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 6.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.5 GO:0070411 I-SMAD binding(GO:0070411)
0.0 1.2 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.2 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.4 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 1.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 1.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 1.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 4.9 GO:0008134 transcription factor binding(GO:0008134)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 1.1 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 2.0 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 4.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 3.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.6 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.4 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.6 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 3.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.3 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 1.0 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 2.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 5.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides