Motif ID: Elf1_Elf2_Etv2_Elf4

Z-value: 2.772

Transcription factors associated with Elf1_Elf2_Etv2_Elf4:

Gene SymbolEntrez IDGene Name
Elf1 ENSMUSG00000036461.9 Elf1
Elf2 ENSMUSG00000037174.12 Elf2
Elf4 ENSMUSG00000031103.6 Elf4
Etv2 ENSMUSG00000006311.8 Etv2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elf1mm10_v2_chr14_+_79515618_795156940.464.5e-03Click!
Elf2mm10_v2_chr3_-_51277470_512775140.261.3e-01Click!
Elf4mm10_v2_chrX_-_48454152_48454193-0.183.0e-01Click!


Activity profile for motif Elf1_Elf2_Etv2_Elf4.

activity profile for motif Elf1_Elf2_Etv2_Elf4


Sorted Z-values histogram for motif Elf1_Elf2_Etv2_Elf4

Sorted Z-values for motif Elf1_Elf2_Etv2_Elf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Elf1_Elf2_Etv2_Elf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_63403330 17.515 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr7_-_127042420 15.910 ENSMUST00000032915.6
 Kif22
kinesin family member 22
chr19_+_6084983 14.783 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr11_+_61485431 13.746 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chrX_+_100625737 13.244 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr16_+_48994185 13.241 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr2_+_105682463 11.964 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr6_-_23248264 11.759 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_+_5845243 11.488 ENSMUST00000127116.1
 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr10_-_83648713 11.403 ENSMUST00000020500.7
 Appl2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr4_-_118437331 10.628 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr2_+_156840077 10.572 ENSMUST00000081335.6
ENSMUST00000073352.3
 Tgif2

TGFB-induced factor homeobox 2

chr5_-_28210022 10.232 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr7_+_51879041 10.116 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr11_-_12037391 9.895 ENSMUST00000093321.5
 Grb10
growth factor receptor bound protein 10
chr16_-_18811972 9.826 ENSMUST00000000028.7
ENSMUST00000115585.1
 Cdc45

cell division cycle 45

chr2_-_5012716 9.788 ENSMUST00000027980.7
 Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
chr15_+_85859689 9.661 ENSMUST00000170629.1
 Gtse1
G two S phase expressed protein 1
chr13_-_103920508 9.623 ENSMUST00000053927.5
ENSMUST00000091269.4
ENSMUST00000022222.5
 Erbb2ip


Erbb2 interacting protein


chr19_-_9899450 9.356 ENSMUST00000025562.7
 Incenp
inner centromere protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,036 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 46.0 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.2 45.8 GO:0008380 RNA splicing(GO:0008380)
2.0 33.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
2.9 28.9 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
6.2 25.0 GO:0019323 pentose catabolic process(GO:0019323)
1.6 22.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.8 21.8 GO:0006270 DNA replication initiation(GO:0006270)
0.2 21.8 GO:0007059 chromosome segregation(GO:0007059)
0.5 21.5 GO:0035411 catenin import into nucleus(GO:0035411)
2.2 20.1 GO:0048251 elastic fiber assembly(GO:0048251)
5.0 19.9 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.2 18.8 GO:0007050 cell cycle arrest(GO:0007050)
2.6 18.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.8 18.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
2.6 17.9 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
3.0 17.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.5 17.0 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.4 16.9 GO:0006284 base-excision repair(GO:0006284)
0.8 16.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
4.1 16.4 GO:0044565 dendritic cell proliferation(GO:0044565)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 359 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 166.9 GO:0005634 nucleus(GO:0005634)
0.1 101.3 GO:0005654 nucleoplasm(GO:0005654)
1.1 64.1 GO:0005871 kinesin complex(GO:0005871)
0.2 49.9 GO:0016607 nuclear speck(GO:0016607)
0.1 44.0 GO:0005694 chromosome(GO:0005694)
0.1 35.5 GO:0005813 centrosome(GO:0005813)
0.3 29.6 GO:0032587 ruffle membrane(GO:0032587)
1.5 25.8 GO:0031616 spindle pole centrosome(GO:0031616)
1.0 24.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 22.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.3 21.9 GO:0005814 centriole(GO:0005814)
2.6 21.1 GO:0005818 aster(GO:0005818)
0.1 19.0 GO:0016604 nuclear body(GO:0016604)
0.8 18.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 18.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.8 18.3 GO:0005682 U5 snRNP(GO:0005682)
0.6 18.1 GO:0035371 microtubule plus-end(GO:0035371)
0.4 17.9 GO:0000922 spindle pole(GO:0000922)
0.3 17.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 16.8 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 570 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 93.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.8 55.3 GO:0003777 microtubule motor activity(GO:0003777)
0.1 51.2 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.4 47.7 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 36.0 GO:0003735 structural constituent of ribosome(GO:0003735)
2.0 28.6 GO:0003688 DNA replication origin binding(GO:0003688)
3.8 22.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.5 22.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 21.8 GO:0042393 histone binding(GO:0042393)
0.5 21.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 19.1 GO:0004386 helicase activity(GO:0004386)
2.2 17.9 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.7 17.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.4 17.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.2 17.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
5.7 17.2 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.1 16.4 GO:0003714 transcription corepressor activity(GO:0003714)
1.6 15.6 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
1.4 15.5 GO:0070990 snRNP binding(GO:0070990)
0.6 14.3 GO:0070182 DNA polymerase binding(GO:0070182)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 93.7 PID_PLK1_PATHWAY PLK1 signaling events
1.0 40.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.5 34.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.7 29.2 PID_ATR_PATHWAY ATR signaling pathway
0.9 27.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.5 27.1 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.6 21.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 19.1 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.6 16.0 PID_MYC_PATHWAY C-MYC pathway
0.2 15.1 PID_E2F_PATHWAY E2F transcription factor network
0.4 13.2 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.2 12.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 12.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.3 11.1 PID_IL1_PATHWAY IL1-mediated signaling events
0.6 10.4 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.3 9.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 8.9 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 8.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 8.5 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.2 8.4 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 76.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
2.2 58.6 REACTOME_KINESINS Genes involved in Kinesins
1.4 51.5 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.2 37.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5 26.1 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE Genes involved in Regulation of mitotic cell cycle
1.3 24.3 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 24.1 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
1.1 22.6 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.4 20.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.9 20.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6 19.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
1.0 19.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.6 19.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 18.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 17.4 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.6 16.8 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.4 15.0 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
1.0 13.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.8 13.3 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.4 12.4 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter