Motif ID: Elf3

Z-value: 0.998


Transcription factors associated with Elf3:

Gene SymbolEntrez IDGene Name
Elf3 ENSMUSG00000003051.7 Elf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elf3mm10_v2_chr1_-_135258449_1352584720.271.0e-01Click!


Activity profile for motif Elf3.

activity profile for motif Elf3


Sorted Z-values histogram for motif Elf3

Sorted Z-values for motif Elf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Elf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_169685191 5.581 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr4_-_53159885 5.062 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr5_+_17574268 4.898 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr10_-_83648713 4.329 ENSMUST00000020500.7
 Appl2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr19_+_5740885 3.714 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr17_+_35049966 3.528 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr14_-_70207637 3.290 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr13_-_103920508 3.084 ENSMUST00000053927.5
ENSMUST00000091269.4
ENSMUST00000022222.5
 Erbb2ip


Erbb2 interacting protein


chr1_+_138963709 2.974 ENSMUST00000168527.1
 Dennd1b
DENN/MADD domain containing 1B
chr12_-_65172560 2.945 ENSMUST00000052201.8
 Mis18bp1
MIS18 binding protein 1
chr3_-_52104891 2.933 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr11_+_115163333 2.816 ENSMUST00000021077.3
 Slc9a3r1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr1_-_128592284 2.768 ENSMUST00000052172.6
ENSMUST00000142893.1
 Cxcr4

chemokine (C-X-C motif) receptor 4

chr7_-_102250086 2.708 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr13_-_103920295 2.552 ENSMUST00000169083.1
 Erbb2ip
Erbb2 interacting protein
chr15_+_55557399 2.326 ENSMUST00000022998.7
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr10_-_83648631 2.040 ENSMUST00000146876.2
ENSMUST00000176294.1
 Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr14_-_57890242 2.009 ENSMUST00000089473.3
 Zdhhc20
zinc finger, DHHC domain containing 20
chr5_-_43981757 1.907 ENSMUST00000061299.7
 Fgfbp1
fibroblast growth factor binding protein 1
chr9_+_91368811 1.877 ENSMUST00000173054.1
 Zic4
zinc finger protein of the cerebellum 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 5.6 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.6 5.6 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 5.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.8 4.9 GO:0003350 pulmonary myocardium development(GO:0003350)
0.8 3.9 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
1.2 3.7 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.4 3.5 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743)
0.1 3.3 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.3 2.9 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 2.9 GO:0016601 Rac protein signal transduction(GO:0016601)
0.9 2.8 GO:0042939 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.7 2.8 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.1 2.4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.1 2.0 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.2 1.9 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.6 1.8 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.2 1.7 GO:0051461 regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 1.7 GO:0018345 protein palmitoylation(GO:0018345)
0.2 1.6 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.2 1.6 GO:0042730 fibrinolysis(GO:0042730)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.6 GO:0016607 nuclear speck(GO:0016607)
0.1 6.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 6.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 5.2 GO:0034707 chloride channel complex(GO:0034707)
0.3 5.1 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 3.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.3 GO:0000776 kinetochore(GO:0000776)
0.2 2.9 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.3 2.8 GO:0032426 stereocilium tip(GO:0032426)
0.0 2.8 GO:0031965 nuclear membrane(GO:0031965)
0.1 2.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 2.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 2.4 GO:0072562 blood microparticle(GO:0072562)
0.3 2.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 1.7 GO:0051286 cell tip(GO:0051286)
0.1 1.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.5 1.6 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.1 1.6 GO:0005682 U5 snRNP(GO:0005682)
0.4 1.5 GO:0031092 platelet alpha granule membrane(GO:0031092)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0051219 phosphoprotein binding(GO:0051219)
1.7 5.1 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.4 4.9 GO:0038191 neuropilin binding(GO:0038191)
0.0 4.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 3.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 3.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.9 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.9 2.8 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.2 2.8 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 2.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.3 GO:0017166 vinculin binding(GO:0017166)
0.1 1.9 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 1.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.9 GO:0030165 PDZ domain binding(GO:0030165)
0.2 1.7 GO:0030911 TPR domain binding(GO:0030911)
0.1 1.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.5 1.6 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.4 1.6 GO:0035877 death effector domain binding(GO:0035877)
0.0 1.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 5.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.8 PID_S1P_S1P3_PATHWAY S1P3 pathway
0.0 2.8 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 2.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 1.6 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 1.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.3 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.2 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 0.8 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.6 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 3.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 2.9 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 2.8 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle
0.1 2.1 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.8 REACTOME_SIGNALING_BY_SCF_KIT Genes involved in Signaling by SCF-KIT
0.3 1.6 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 1.6 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.4 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.3 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.3 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.1 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 0.9 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 0.9 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 0.9 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER