Motif ID: Emx1_Emx2

Z-value: 0.494

Transcription factors associated with Emx1_Emx2:

Gene SymbolEntrez IDGene Name
Emx1 ENSMUSG00000033726.8 Emx1
Emx2 ENSMUSG00000043969.4 Emx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Emx1mm10_v2_chr6_+_85187438_851875100.221.9e-01Click!
Emx2mm10_v2_chr19_+_59458372_594584500.105.5e-01Click!


Activity profile for motif Emx1_Emx2.

activity profile for motif Emx1_Emx2


Sorted Z-values histogram for motif Emx1_Emx2

Sorted Z-values for motif Emx1_Emx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Emx1_Emx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 160 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_118961578 3.231 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr4_-_82505274 2.127 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr4_-_82505749 2.077 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr3_+_127633134 1.661 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr4_-_82505707 1.658 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr7_-_103827922 1.603 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr17_-_36032682 1.322 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr2_-_160619971 1.293 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr12_-_98577940 1.074 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr13_-_97747373 1.056 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chrX_+_106920618 1.053 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr7_+_126781483 1.012 ENSMUST00000172352.1
ENSMUST00000094037.4
 Tbx6

T-box 6

chr17_-_31636631 0.957 ENSMUST00000135425.1
ENSMUST00000151718.1
ENSMUST00000155814.1
 Cbs


cystathionine beta-synthase


chr13_-_97747399 0.954 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr3_+_90541146 0.905 ENSMUST00000107333.1
ENSMUST00000107331.1
ENSMUST00000098910.2
 S100a16


S100 calcium binding protein A16


chr8_-_21906412 0.841 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr3_-_49757257 0.818 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr5_-_28210022 0.818 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr18_+_57142782 0.806 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr10_+_90071095 0.722 ENSMUST00000183109.1
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 5.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 2.9 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 1.7 GO:0021954 central nervous system neuron development(GO:0021954)
0.2 1.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.4 1.3 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.2 1.3 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.1 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.3 1.0 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.1 1.0 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.2 0.9 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 0.7 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.7 GO:0006749 glutathione metabolic process(GO:0006749)
0.2 0.6 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.1 0.6 GO:0070295 renal water absorption(GO:0070295)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.6 GO:0007528 neuromuscular junction development(GO:0007528)
0.2 0.5 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.1 0.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.4 1.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.4 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.1 3.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 1.7 GO:0070888 E-box binding(GO:0070888)
0.4 1.6 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.2 1.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 1.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 1.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.3 1.0 GO:0098809 nitrite reductase activity(GO:0098809)
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.8 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.7 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 0.6 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.1 0.6 GO:0015288 porin activity(GO:0015288)
0.2 0.5 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.4 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.9 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.2 1.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.0 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 0.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.3 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly