Motif ID: En1

Z-value: 0.535


Transcription factors associated with En1:

Gene SymbolEntrez IDGene Name
En1 ENSMUSG00000058665.7 En1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En1mm10_v2_chr1_+_120602405_120602418-0.125.0e-01Click!


Activity profile for motif En1.

activity profile for motif En1


Sorted Z-values histogram for motif En1

Sorted Z-values for motif En1



Network of associatons between targets according to the STRING database.



First level regulatory network of En1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 3.242 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr14_+_67234620 2.822 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr1_+_6487231 2.248 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr16_-_26989974 2.123 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr15_-_56694525 1.606 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr12_+_109453455 1.500 ENSMUST00000109844.4
ENSMUST00000109842.2
ENSMUST00000109843.1
ENSMUST00000109846.4
ENSMUST00000173539.1
ENSMUST00000109841.2
 Dlk1





delta-like 1 homolog (Drosophila)





chr19_+_47014672 1.350 ENSMUST00000037636.3
 Ina
internexin neuronal intermediate filament protein, alpha
chr6_+_4755327 1.346 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr3_+_141465564 1.159 ENSMUST00000106236.2
ENSMUST00000075282.3
 Unc5c

unc-5 homolog C (C. elegans)

chr1_+_72824482 1.129 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr9_+_65587187 1.053 ENSMUST00000047099.5
ENSMUST00000131483.1
ENSMUST00000141046.1
 Pif1


PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)


chr9_+_65587149 1.051 ENSMUST00000134538.1
ENSMUST00000136205.1
 Pif1

PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)

chr12_+_109452833 1.039 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr1_-_158814469 0.994 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr11_-_77725281 0.984 ENSMUST00000078623.4
 Cryba1
crystallin, beta A1
chr16_-_59555752 0.983 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr19_+_60144682 0.980 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr16_-_45953565 0.962 ENSMUST00000134802.1
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr11_-_28583995 0.927 ENSMUST00000146385.2
 Ccdc85a
coiled-coil domain containing 85A
chr3_+_141465592 0.921 ENSMUST00000130636.1
 Unc5c
unc-5 homolog C (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 2.8 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.4 2.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 2.2 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.3 2.1 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.3 2.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 2.1 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.8 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.4 1.6 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 1.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 1.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.2 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 1.2 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 1.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 1.0 GO:2000210 positive regulation of anoikis(GO:2000210)
0.2 0.8 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.8 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 0.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.8 GO:0045773 positive regulation of axon extension(GO:0045773)
0.2 0.7 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.5 GO:0045180 basal cortex(GO:0045180)
0.0 2.2 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.1 GO:0005657 replication fork(GO:0005657)
0.0 1.5 GO:0005814 centriole(GO:0005814)
0.1 1.3 GO:0005883 neurofilament(GO:0005883)
0.1 1.0 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.9 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.8 GO:0000242 pericentriolar material(GO:0000242)
0.1 0.6 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1 0.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.6 GO:0043034 costamere(GO:0043034)
0.1 0.5 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.4 GO:1990357 terminal web(GO:1990357)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 2.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.2 GO:0001047 core promoter binding(GO:0001047)
0.7 2.1 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680)
0.3 2.1 GO:0005042 netrin receptor activity(GO:0005042)
0.5 1.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 1.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 0.8 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.6 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.6 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.6 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.6 GO:0015172 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 2.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.6 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 0.6 PID_ATM_PATHWAY ATM pathway
0.0 0.6 PID_LKB1_PATHWAY LKB1 signaling events
0.1 0.4 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.3 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.3 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.1 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 2.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.1 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.6 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.8 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.7 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 0.6 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 0.6 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 0.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 0.3 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 0.3 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.3 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome