Motif ID: En2

Z-value: 0.553


Transcription factors associated with En2:

Gene SymbolEntrez IDGene Name
En2 ENSMUSG00000039095.7 En2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En2mm10_v2_chr5_+_28165690_28165717-0.241.6e-01Click!


Activity profile for motif En2.

activity profile for motif En2


Sorted Z-values histogram for motif En2

Sorted Z-values for motif En2



Network of associatons between targets according to the STRING database.



First level regulatory network of En2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_139543889 5.115 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr5_-_53707532 3.887 ENSMUST00000031093.3
Cckar
cholecystokinin A receptor
chr14_-_67715585 3.411 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
Cdca2


cell division cycle associated 2


chr4_+_109978004 2.796 ENSMUST00000061187.3
Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr6_+_8948608 2.624 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chrX_-_60893430 2.365 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr2_+_25372315 2.322 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
Sapcd2


suppressor APC domain containing 2


chr5_+_33658123 2.312 ENSMUST00000074849.6
ENSMUST00000079534.4
Tacc3

transforming, acidic coiled-coil containing protein 3

chr9_+_65890237 2.264 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr6_+_4755327 2.241 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr3_-_27153861 2.122 ENSMUST00000108300.1
ENSMUST00000108298.2
Ect2

ect2 oncogene

chr8_+_83955507 2.003 ENSMUST00000005607.8
Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr3_-_27153844 2.002 ENSMUST00000176242.2
ENSMUST00000176780.1
Ect2

ect2 oncogene

chr13_-_114458720 1.832 ENSMUST00000022287.5
Fst
follistatin
chr5_+_33658567 1.826 ENSMUST00000114426.3
Tacc3
transforming, acidic coiled-coil containing protein 3
chr6_+_146888481 1.802 ENSMUST00000016631.7
ENSMUST00000111623.2
Ppfibp1

PTPRF interacting protein, binding protein 1 (liprin beta 1)

chr2_-_72986716 1.612 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr4_+_62583568 1.598 ENSMUST00000098031.3
Rgs3
regulator of G-protein signaling 3
chr8_-_45382198 1.535 ENSMUST00000093526.6
Fam149a
family with sequence similarity 149, member A
chr10_+_73821857 1.470 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
Pcdh15



















protocadherin 15



















chr5_+_33658550 1.422 ENSMUST00000152847.1
Tacc3
transforming, acidic coiled-coil containing protein 3
chr13_-_47106176 1.384 ENSMUST00000021807.6
ENSMUST00000135278.1
Dek

DEK oncogene (DNA binding)

chr18_+_34625009 1.319 ENSMUST00000166044.1
Kif20a
kinesin family member 20A
chrX_+_134308084 1.284 ENSMUST00000081064.5
ENSMUST00000101251.1
ENSMUST00000129782.1
Cenpi


centromere protein I


chr1_+_110099295 1.238 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr8_-_90908415 1.210 ENSMUST00000098517.1
Gm6658
predicted gene 6658
chr14_+_67716095 1.207 ENSMUST00000078053.6
ENSMUST00000145542.1
ENSMUST00000125212.1
Kctd9


potassium channel tetramerisation domain containing 9


chrM_+_7005 1.202 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr10_+_26772477 1.132 ENSMUST00000039557.7
Arhgap18
Rho GTPase activating protein 18
chr13_+_21717626 1.130 ENSMUST00000091754.2
Hist1h3h
histone cluster 1, H3h
chr18_+_34624621 1.123 ENSMUST00000167161.1
Kif20a
kinesin family member 20A
chr12_+_38780284 1.116 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr18_+_82914632 1.097 ENSMUST00000071233.6
Zfp516
zinc finger protein 516
chr3_+_134236483 1.093 ENSMUST00000181904.1
ENSMUST00000053048.9
Cxxc4

CXXC finger 4

chr12_+_38780817 1.093 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr7_+_27486910 1.079 ENSMUST00000008528.7
Sertad1
SERTA domain containing 1
chrM_+_7759 1.059 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr9_+_45138437 0.924 ENSMUST00000060125.5
Scn4b
sodium channel, type IV, beta
chr12_+_109545390 0.923 ENSMUST00000146701.1
Meg3
maternally expressed 3
chr3_-_116253467 0.914 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr17_+_34039437 0.840 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
Col11a2



collagen, type XI, alpha 2



chr12_+_72441852 0.800 ENSMUST00000162159.1
Lrrc9
leucine rich repeat containing 9
chr9_-_66514567 0.797 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chr12_+_72441933 0.796 ENSMUST00000161284.1
Lrrc9
leucine rich repeat containing 9
chr18_-_61707583 0.793 ENSMUST00000025472.1
Pcyox1l
prenylcysteine oxidase 1 like
chr18_-_88927447 0.781 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6
chr3_+_76075583 0.778 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr13_+_23544052 0.776 ENSMUST00000075558.2
Hist1h3f
histone cluster 1, H3f
chr13_+_44121167 0.772 ENSMUST00000163056.1
ENSMUST00000159595.1
Gm5083

predicted gene 5083

chrM_+_10167 0.761 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr11_-_86993682 0.759 ENSMUST00000018571.4
Ypel2
yippee-like 2 (Drosophila)
chr12_+_52699297 0.685 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr1_+_131527901 0.681 ENSMUST00000068613.4
Fam72a
family with sequence similarity 72, member A
chr6_-_50456085 0.664 ENSMUST00000146341.1
ENSMUST00000071728.4
Osbpl3

oxysterol binding protein-like 3

chrM_+_3906 0.644 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chrX_+_56454871 0.642 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr17_-_35697971 0.597 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr14_+_67716262 0.587 ENSMUST00000150768.1
Kctd9
potassium channel tetramerisation domain containing 9
chr3_+_19188099 0.574 ENSMUST00000130645.1
Mtfr1
mitochondrial fission regulator 1
chr11_-_102946688 0.536 ENSMUST00000057849.5
C1ql1
complement component 1, q subcomponent-like 1
chr3_+_88207308 0.493 ENSMUST00000180582.1
Gm3764
predicted gene 3764
chr5_+_138187485 0.492 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chrM_+_9452 0.487 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr19_+_6046576 0.486 ENSMUST00000138532.1
ENSMUST00000129081.1
ENSMUST00000156550.1
Syvn1


synovial apoptosis inhibitor 1, synoviolin


chrM_+_9870 0.471 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr3_+_159839729 0.468 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr7_+_101896340 0.462 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr4_-_24430838 0.461 ENSMUST00000183964.1
RP23-35K5.2
RP23-35K5.2
chr3_+_96268654 0.456 ENSMUST00000098843.2
Hist2h3b
histone cluster 2, H3b
chrX_-_134111852 0.440 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr7_+_29071597 0.439 ENSMUST00000180926.1
Gm26604
predicted gene, 26604
chr8_-_84662841 0.433 ENSMUST00000060427.4
Ier2
immediate early response 2
chr6_-_71632897 0.429 ENSMUST00000065509.4
Kdm3a
lysine (K)-specific demethylase 3A
chr1_-_79440039 0.425 ENSMUST00000049972.4
Scg2
secretogranin II
chr5_-_138187177 0.421 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chrM_+_2743 0.420 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chrX_+_129749740 0.415 ENSMUST00000167619.2
ENSMUST00000037854.8
Diap2

diaphanous homolog 2 (Drosophila)

chr12_-_91779129 0.405 ENSMUST00000170077.1
Ston2
stonin 2
chr5_-_77115145 0.403 ENSMUST00000081964.5
Hopx
HOP homeobox
chr15_+_80255184 0.397 ENSMUST00000109605.3
Atf4
activating transcription factor 4
chr7_+_25681158 0.396 ENSMUST00000108403.3
B9d2
B9 protein domain 2
chr9_-_107635330 0.392 ENSMUST00000055704.6
Gnai2
guanine nucleotide binding protein (G protein), alpha inhibiting 2
chr8_-_84237042 0.392 ENSMUST00000039480.5
Zswim4
zinc finger SWIM-type containing 4
chr1_+_132298606 0.392 ENSMUST00000046071.4
Klhdc8a
kelch domain containing 8A
chr2_+_71389239 0.373 ENSMUST00000028408.2
Hat1
histone aminotransferase 1
chrX_+_102119447 0.356 ENSMUST00000113627.3
Pin4
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
chr18_+_84851338 0.342 ENSMUST00000160180.1
Cyb5
cytochrome b-5
chr4_+_130047840 0.336 ENSMUST00000044565.8
ENSMUST00000132251.1
Col16a1

collagen, type XVI, alpha 1

chr4_-_129558355 0.335 ENSMUST00000167288.1
ENSMUST00000134336.1
Lck

lymphocyte protein tyrosine kinase

chr6_-_71632651 0.332 ENSMUST00000167220.1
Kdm3a
lysine (K)-specific demethylase 3A
chr9_-_109082372 0.326 ENSMUST00000167504.1
Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr1_-_78968079 0.326 ENSMUST00000049117.5
Gm5830
predicted pseudogene 5830
chr2_+_14873656 0.322 ENSMUST00000114718.1
ENSMUST00000114719.1
Cacnb2

calcium channel, voltage-dependent, beta 2 subunit

chrX_-_136741155 0.319 ENSMUST00000166930.1
ENSMUST00000113095.1
ENSMUST00000155207.1
ENSMUST00000080411.6
ENSMUST00000169418.1
Morf4l2




mortality factor 4 like 2




chr15_-_38300693 0.313 ENSMUST00000074043.5
Klf10
Kruppel-like factor 10
chr3_-_79841729 0.302 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chr2_+_20737306 0.286 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr14_-_55560340 0.279 ENSMUST00000066106.3
A730061H03Rik
RIKEN cDNA A730061H03 gene
chrX_+_75514299 0.277 ENSMUST00000114070.3
ENSMUST00000033540.5
Vbp1

von Hippel-Lindau binding protein 1

chr3_+_61364507 0.258 ENSMUST00000049064.2
Rap2b
RAP2B, member of RAS oncogene family
chr16_+_52031549 0.257 ENSMUST00000114471.1
Cblb
Casitas B-lineage lymphoma b
chr4_-_129261394 0.253 ENSMUST00000145261.1
C77080
expressed sequence C77080
chr11_-_101095367 0.248 ENSMUST00000019447.8
Psmc3ip
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
chr9_+_113930934 0.232 ENSMUST00000084885.5
ENSMUST00000009885.7
Ubp1

upstream binding protein 1

chr2_+_118861954 0.231 ENSMUST00000028807.5
Ivd
isovaleryl coenzyme A dehydrogenase
chrM_+_11734 0.228 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr8_-_107403197 0.223 ENSMUST00000003947.8
Nqo1
NAD(P)H dehydrogenase, quinone 1
chr19_+_25406661 0.222 ENSMUST00000146647.1
Kank1
KN motif and ankyrin repeat domains 1
chr14_+_79515618 0.218 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr7_-_30559828 0.218 ENSMUST00000108164.1
Lin37
lin-37 homolog (C. elegans)
chr5_+_135106881 0.216 ENSMUST00000005507.3
Mlxipl
MLX interacting protein-like
chr15_+_100353149 0.205 ENSMUST00000088142.5
ENSMUST00000176287.1
ENSMUST00000075675.5
Mettl7a2

AB099516
methyltransferase like 7A2

cDNA sequence AB099516
chr14_+_58070547 0.201 ENSMUST00000165526.1
Fgf9
fibroblast growth factor 9
chr2_+_144527718 0.198 ENSMUST00000028914.2
ENSMUST00000110017.2
Polr3f

polymerase (RNA) III (DNA directed) polypeptide F

chr12_+_108605757 0.197 ENSMUST00000109854.2
Evl
Ena-vasodilator stimulated phosphoprotein
chrX_-_37110257 0.189 ENSMUST00000076265.6
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr1_+_66468364 0.174 ENSMUST00000061620.9
Unc80
unc-80 homolog (C. elegans)
chr5_+_81021583 0.169 ENSMUST00000121707.1
Lphn3
latrophilin 3
chr4_+_150853919 0.167 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr6_-_85451248 0.165 ENSMUST00000113770.1
ENSMUST00000032080.2
Pradc1

protease-associated domain containing 1

chr19_-_15924928 0.142 ENSMUST00000025542.3
Psat1
phosphoserine aminotransferase 1
chr3_+_108653931 0.142 ENSMUST00000029483.8
ENSMUST00000124384.1
Clcc1

chloride channel CLIC-like 1

chr1_-_75046639 0.138 ENSMUST00000152855.1
Nhej1
nonhomologous end-joining factor 1
chr16_-_45724600 0.135 ENSMUST00000096057.4
Tagln3
transgelin 3
chr4_+_21848039 0.130 ENSMUST00000098238.2
ENSMUST00000108229.1
Sfrs18

serine/arginine-rich splicing factor 18

chr7_-_30559600 0.130 ENSMUST00000043975.4
ENSMUST00000156241.1
Lin37

lin-37 homolog (C. elegans)

chr6_+_37870786 0.130 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24

chr5_+_88583527 0.128 ENSMUST00000031229.6
Rufy3
RUN and FYVE domain containing 3
chr7_+_64501687 0.122 ENSMUST00000032732.8
Apba2
amyloid beta (A4) precursor protein-binding, family A, member 2
chr7_-_116198487 0.117 ENSMUST00000181981.1
Plekha7
pleckstrin homology domain containing, family A member 7
chrX_-_57338598 0.114 ENSMUST00000033468.4
ENSMUST00000114736.1
Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr11_-_31671863 0.113 ENSMUST00000058060.7
Bod1
biorientation of chromosomes in cell division 1
chr3_-_94436574 0.100 ENSMUST00000029787.4
Oaz3
ornithine decarboxylase antizyme 3
chr16_+_33684538 0.090 ENSMUST00000126532.1
Heg1
HEG homolog 1 (zebrafish)
chr17_+_45734506 0.087 ENSMUST00000180558.1
F630040K05Rik
RIKEN cDNA F630040K05 gene
chr9_+_104063678 0.086 ENSMUST00000047799.5
Acad11
acyl-Coenzyme A dehydrogenase family, member 11
chr18_+_56432116 0.083 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr5_-_137531952 0.082 ENSMUST00000140139.1
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr7_+_144838590 0.077 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chr4_-_42084291 0.073 ENSMUST00000177937.1
Gm21968
predicted gene, 21968
chr3_+_96629919 0.062 ENSMUST00000048915.6
Rbm8a
RNA binding motif protein 8a
chr7_+_64185459 0.061 ENSMUST00000177102.2
ENSMUST00000107519.1
ENSMUST00000137650.1
ENSMUST00000032737.5
ENSMUST00000107515.1
ENSMUST00000144996.1
Trpm1





transient receptor potential cation channel, subfamily M, member 1





chr13_-_23710714 0.060 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
Hfe


hemochromatosis


chr14_+_53324632 0.060 ENSMUST00000178100.1
Trav7n-6
T cell receptor alpha variable 7N-6
chr1_-_172632931 0.059 ENSMUST00000027826.5
Dusp23
dual specificity phosphatase 23
chr7_+_64502090 0.058 ENSMUST00000137732.1
Apba2
amyloid beta (A4) precursor protein-binding, family A, member 2
chr4_-_155056784 0.048 ENSMUST00000131173.2
Plch2
phospholipase C, eta 2
chr3_+_94413244 0.046 ENSMUST00000166032.1
ENSMUST00000045245.5
Tdrkh

tudor and KH domain containing protein

chr11_+_60537978 0.043 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr5_-_131616599 0.043 ENSMUST00000161804.1
Auts2
autism susceptibility candidate 2
chr12_-_56613270 0.041 ENSMUST00000072631.5
Nkx2-9
NK2 homeobox 9
chr6_-_146502141 0.038 ENSMUST00000079573.6
ENSMUST00000139732.1
Itpr2

inositol 1,4,5-triphosphate receptor 2

chr11_-_50292302 0.038 ENSMUST00000059458.4
Maml1
mastermind like 1 (Drosophila)
chr11_-_31671727 0.036 ENSMUST00000109415.1
Bod1
biorientation of chromosomes in cell division 1
chr4_+_116221633 0.035 ENSMUST00000030464.7
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr17_+_35424842 0.033 ENSMUST00000174699.1
H2-Q6
histocompatibility 2, Q region locus 6
chr9_+_21955747 0.030 ENSMUST00000053583.5
Swsap1
SWIM type zinc finger 7 associated protein 1
chr17_+_35424870 0.025 ENSMUST00000113879.3
H2-Q6
histocompatibility 2, Q region locus 6
chr2_-_148045891 0.024 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr5_-_62766153 0.024 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_+_100334929 0.023 ENSMUST00000075420.4
Mettl7a3
methyltransferase like 7A3
chr5_-_106696819 0.012 ENSMUST00000127434.1
ENSMUST00000112696.1
ENSMUST00000112698.1
Zfp644


zinc finger protein 644


chr13_+_5861489 0.011 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr16_+_8830093 0.011 ENSMUST00000023150.5
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr2_+_9882622 0.008 ENSMUST00000114919.1
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr18_+_42511496 0.005 ENSMUST00000025375.7
Tcerg1
transcription elongation regulator 1 (CA150)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.6 5.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.4 1.5 GO:0061743 motor learning(GO:0061743)
0.3 5.6 GO:0030953 astral microtubule organization(GO:0030953)
0.3 0.8 GO:0060023 soft palate development(GO:0060023)
0.3 1.4 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.3 0.8 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.3 0.8 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.2 4.1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.2 1.8 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.2 2.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 1.5 GO:0050957 equilibrioception(GO:0050957)
0.2 2.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.2 0.7 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.2 0.5 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.4 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.1 2.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 4.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 2.6 GO:0007530 sex determination(GO:0007530)
0.1 0.3 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 0.4 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 0.7 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.1 0.3 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1 0.4 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.1 1.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.2 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.2 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.1 0.4 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.1 0.9 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307)
0.1 3.4 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
0.1 0.2 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1 0.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 1.8 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.3 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.0 1.3 GO:0034508 centromere complex assembly(GO:0034508)
0.0 0.4 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 1.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.5 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.2 GO:0006551 leucine metabolic process(GO:0006551)
0.0 0.1 GO:0002725 negative regulation of T cell cytokine production(GO:0002725)
0.0 0.1 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 1.1 GO:0009409 response to cold(GO:0009409)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.3 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.3 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.5 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 1.3 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.4 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.9 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.3 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.0 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.0 0.3 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 0.5 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.0 GO:0003162 atrioventricular node development(GO:0003162)
0.0 0.0 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.0 0.6 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.0 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0097149 centralspindlin complex(GO:0097149)
0.1 0.4 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.5 GO:0044301 climbing fiber(GO:0044301)
0.1 0.4 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.1 1.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 3.0 GO:0070469 respiratory chain(GO:0070469)
0.0 2.4 GO:0005871 kinesin complex(GO:0005871)
0.0 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 1.5 GO:0032420 stereocilium(GO:0032420)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.4 GO:0031045 dense core granule(GO:0031045)
0.0 0.3 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 1.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 3.6 GO:0043195 terminal bouton(GO:0043195)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.8 GO:0005774 vacuolar membrane(GO:0005774)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:1990357 terminal web(GO:1990357)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.2 1.8 GO:0048185 activin binding(GO:0048185)
0.1 0.4 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 3.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.8 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 0.4 GO:0003681 bent DNA binding(GO:0003681)
0.1 0.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 0.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.7 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 2.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 3.1 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 0.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 1.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 2.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.7 GO:0043495 protein anchor(GO:0043495)
0.0 0.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.8 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 2.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.4 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.9 GO:0003774 motor activity(GO:0003774)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 1.1 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.2 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.7 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.0 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.0 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 1.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.2 GO:0001056 RNA polymerase III activity(GO:0001056)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 6.1 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.4 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 2.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME_KINESINS Genes involved in Kinesins
0.1 0.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.8 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 3.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.4 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 1.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions