Motif ID: En2

Z-value: 0.553


Transcription factors associated with En2:

Gene SymbolEntrez IDGene Name
En2 ENSMUSG00000039095.7 En2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En2mm10_v2_chr5_+_28165690_28165717-0.241.6e-01Click!


Activity profile for motif En2.

activity profile for motif En2


Sorted Z-values histogram for motif En2

Sorted Z-values for motif En2



Network of associatons between targets according to the STRING database.



First level regulatory network of En2

PNG image of the network

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Top targets:


Showing 1 to 20 of 166 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 5.115 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr5_-_53707532 3.887 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr14_-_67715585 3.411 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr4_+_109978004 2.796 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr6_+_8948608 2.624 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chrX_-_60893430 2.365 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr2_+_25372315 2.322 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr5_+_33658123 2.312 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr9_+_65890237 2.264 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr6_+_4755327 2.241 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr3_-_27153861 2.122 ENSMUST00000108300.1
ENSMUST00000108298.2
 Ect2

ect2 oncogene

chr8_+_83955507 2.003 ENSMUST00000005607.8
 Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr3_-_27153844 2.002 ENSMUST00000176242.2
ENSMUST00000176780.1
 Ect2

ect2 oncogene

chr13_-_114458720 1.832 ENSMUST00000022287.5
 Fst
follistatin
chr5_+_33658567 1.826 ENSMUST00000114426.3
 Tacc3
transforming, acidic coiled-coil containing protein 3
chr6_+_146888481 1.802 ENSMUST00000016631.7
ENSMUST00000111623.2
 Ppfibp1

PTPRF interacting protein, binding protein 1 (liprin beta 1)

chr2_-_72986716 1.612 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr4_+_62583568 1.598 ENSMUST00000098031.3
 Rgs3
regulator of G-protein signaling 3
chr8_-_45382198 1.535 ENSMUST00000093526.6
 Fam149a
family with sequence similarity 149, member A
chr10_+_73821857 1.470 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
 Pcdh15



















protocadherin 15




















Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.6 GO:0030953 astral microtubule organization(GO:0030953)
0.6 5.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 4.1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 4.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.3 3.9 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.1 3.4 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
0.2 2.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 2.6 GO:0007530 sex determination(GO:0007530)
0.1 2.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.2 2.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 1.8 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.0 1.8 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.4 1.5 GO:0061743 motor learning(GO:0061743)
0.2 1.5 GO:0050957 equilibrioception(GO:0050957)
0.3 1.4 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.1 1.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.3 GO:0034508 centromere complex assembly(GO:0034508)
0.0 1.3 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 1.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.1 GO:0009409 response to cold(GO:0009409)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.1 GO:0097149 centralspindlin complex(GO:0097149)
0.0 3.6 GO:0043195 terminal bouton(GO:0043195)
0.0 3.0 GO:0070469 respiratory chain(GO:0070469)
0.0 2.4 GO:0005871 kinesin complex(GO:0005871)
0.0 1.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.5 GO:0032420 stereocilium(GO:0032420)
0.1 1.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.1 GO:0001772 immunological synapse(GO:0001772)
0.1 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.8 GO:0005774 vacuolar membrane(GO:0005774)
0.0 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.5 GO:0044301 climbing fiber(GO:0044301)
0.0 0.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.4 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.4 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.0 0.4 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 3.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 2.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 2.4 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 1.8 GO:0048185 activin binding(GO:0048185)
0.1 1.7 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.1 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 1.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 0.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.9 GO:0003774 motor activity(GO:0003774)
0.1 0.8 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 0.8 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0043495 protein anchor(GO:0043495)
0.0 0.7 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 PID_PLK1_PATHWAY PLK1 signaling events
0.1 3.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.4 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.4 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.8 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 0.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.3 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.2 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules