Motif ID: Epas1_Bcl3

Z-value: 2.079

Transcription factors associated with Epas1_Bcl3:

Gene SymbolEntrez IDGene Name
Bcl3 ENSMUSG00000053175.10 Bcl3
Epas1 ENSMUSG00000024140.9 Epas1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Epas1mm10_v2_chr17_+_86753900_867539140.202.5e-01Click!


Activity profile for motif Epas1_Bcl3.

activity profile for motif Epas1_Bcl3


Sorted Z-values histogram for motif Epas1_Bcl3

Sorted Z-values for motif Epas1_Bcl3



Network of associatons between targets according to the STRING database.



First level regulatory network of Epas1_Bcl3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_48932368 23.519 ENSMUST00000046254.2
 Lrfn2
leucine rich repeat and fibronectin type III domain containing 2
chr2_+_169632996 19.749 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr19_+_8664005 17.704 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr2_-_113217051 15.934 ENSMUST00000080673.5
 Ryr3
ryanodine receptor 3
chr6_+_65671590 14.862 ENSMUST00000054351.4
 Ndnf
neuron-derived neurotrophic factor
chr8_-_48555846 14.717 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr5_-_128953303 14.472 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr12_+_61523889 13.913 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr4_+_123183722 13.898 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr12_-_67221221 13.136 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr9_-_29963112 12.728 ENSMUST00000075069.4
 Ntm
neurotrimin
chr7_-_119184374 12.424 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr3_-_152668135 10.234 ENSMUST00000045262.6
 Ak5
adenylate kinase 5
chr14_-_60177482 9.834 ENSMUST00000140924.1
 Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr5_+_27261916 9.228 ENSMUST00000101471.3
 Dpp6
dipeptidylpeptidase 6
chr1_+_75507077 9.206 ENSMUST00000037330.4
 Inha
inhibin alpha
chr8_+_118283719 8.640 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr5_-_67847400 8.385 ENSMUST00000113652.1
ENSMUST00000113651.1
ENSMUST00000037380.8
 Atp8a1


ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1


chr19_+_23758819 8.127 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr15_-_66969616 8.012 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 22.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
3.1 21.6 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
1.3 18.8 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.4 17.2 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
1.8 16.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 16.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
2.5 14.8 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
1.7 13.5 GO:0097264 self proteolysis(GO:0097264)
0.1 13.4 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
2.5 12.7 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.1 11.6 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.4 10.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.3 9.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.2 8.9 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.4 8.8 GO:0016082 synaptic vesicle priming(GO:0016082)
0.2 8.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.5 8.6 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.4 8.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 8.2 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.8 8.0 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 48.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 27.6 GO:0031225 anchored component of membrane(GO:0031225)
0.8 17.2 GO:0032279 asymmetric synapse(GO:0032279)
0.1 16.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
3.2 15.9 GO:0030314 junctional membrane complex(GO:0030314)
4.9 14.8 GO:0043512 inhibin A complex(GO:0043512)
0.1 14.8 GO:0005802 trans-Golgi network(GO:0005802)
0.0 13.8 GO:0005768 endosome(GO:0005768)
0.1 12.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 10.8 GO:0005794 Golgi apparatus(GO:0005794)
0.1 10.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 10.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.9 10.3 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.9 8.8 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 8.8 GO:0097440 apical dendrite(GO:0097440)
0.0 8.8 GO:0043209 myelin sheath(GO:0043209)
0.3 8.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 8.0 GO:0055038 recycling endosome membrane(GO:0055038)
1.0 7.9 GO:0032009 early phagosome(GO:0032009)
0.4 7.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 22.9 GO:0015459 potassium channel regulator activity(GO:0015459)
4.5 22.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.5 22.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.9 21.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 16.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
5.3 15.9 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
1.6 14.8 GO:0034711 inhibin binding(GO:0034711)
2.8 13.8 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.6 12.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 11.3 GO:0008201 heparin binding(GO:0008201)
0.3 10.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 10.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.9 10.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 9.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 9.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.7 8.6 GO:0055100 adiponectin binding(GO:0055100)
0.6 7.6 GO:0004016 adenylate cyclase activity(GO:0004016)
0.4 7.5 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.9 7.3 GO:0032051 clathrin light chain binding(GO:0032051)
0.5 7.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 21.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 8.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 7.2 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.1 7.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 7.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 6.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 6.3 PID_LKB1_PATHWAY LKB1 signaling events
0.1 6.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 6.0 PID_ALK1_PATHWAY ALK1 signaling events
0.2 5.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 5.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 5.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 5.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 4.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 4.1 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 2.3 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 2.2 ST_ADRENERGIC Adrenergic Pathway
0.1 2.1 PID_ARF_3PATHWAY Arf1 pathway
0.6 1.8 PID_REELIN_PATHWAY Reelin signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 22.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.6 21.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.5 16.4 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
3.7 14.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
1.1 14.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.4 13.5 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.4 13.5 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.7 13.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.5 11.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.4 10.2 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 9.0 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 8.8 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.2 7.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 6.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 5.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.2 5.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 5.2 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.4 5.0 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 4.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 4.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events