Motif ID: Erg

Z-value: 0.967


Transcription factors associated with Erg:

Gene SymbolEntrez IDGene Name
Erg ENSMUSG00000040732.12 Erg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ergmm10_v2_chr16_-_95459245_954593840.633.5e-05Click!


Activity profile for motif Erg.

activity profile for motif Erg


Sorted Z-values histogram for motif Erg

Sorted Z-values for motif Erg



Network of associatons between targets according to the STRING database.



First level regulatory network of Erg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 6.579 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr1_-_56969864 5.726 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56972437 5.515 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 4.994 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr4_+_144893077 4.842 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr12_+_75308308 4.367 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr4_+_144893127 4.071 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr2_+_32646586 3.695 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr11_-_55419898 3.480 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr8_+_70501116 3.426 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr11_-_101785252 3.385 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr7_-_27181149 3.355 ENSMUST00000071986.6
ENSMUST00000121848.1
 Mia

melanoma inhibitory activity

chr13_-_41487306 3.277 ENSMUST00000021794.6
 Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
chr7_+_30413744 3.236 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr17_-_68004075 3.228 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr16_+_43363855 3.123 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr13_-_37050237 3.011 ENSMUST00000164727.1
 F13a1
coagulation factor XIII, A1 subunit
chr3_+_68869563 2.976 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr3_-_146781351 2.803 ENSMUST00000005164.7
 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr3_+_95526777 2.757 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 208 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 16.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.4 15.5 GO:0042572 retinol metabolic process(GO:0042572)
0.1 9.0 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.6 7.7 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.1 6.1 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.2 5.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.9 4.5 GO:0061438 renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439)
0.4 4.4 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
1.2 3.7 GO:1905072 detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072)
0.3 3.6 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.5 3.3 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.8 3.2 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.5 3.2 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
1.0 3.0 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.2 3.0 GO:0030574 collagen catabolic process(GO:0030574)
0.6 2.9 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.3 2.9 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.2 2.9 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 2.9 GO:0034340 response to type I interferon(GO:0034340)
0.3 2.8 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 35.6 GO:0016021 integral component of membrane(GO:0016021)
0.2 22.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 9.8 GO:0009986 cell surface(GO:0009986)
0.1 4.9 GO:0072562 blood microparticle(GO:0072562)
0.1 4.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 4.5 GO:0031225 anchored component of membrane(GO:0031225)
0.9 3.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
1.1 3.4 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.8 3.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 3.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 2.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.5 2.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 2.5 GO:0000139 Golgi membrane(GO:0000139)
0.4 2.4 GO:0097443 sorting endosome(GO:0097443)
0.2 2.4 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.4 2.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 2.3 GO:0005902 microvillus(GO:0005902)
0.0 2.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 15.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 10.3 GO:0003682 chromatin binding(GO:0003682)
0.2 5.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.3 5.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 4.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 4.8 GO:0017124 SH3 domain binding(GO:0017124)
0.9 4.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 4.4 GO:0005518 collagen binding(GO:0005518)
0.7 3.7 GO:0005534 galactose binding(GO:0005534)
0.1 3.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.5 3.4 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 3.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 3.1 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.8 3.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 3.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 2.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 2.9 GO:0008083 growth factor activity(GO:0008083)
0.2 2.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.6 2.5 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 9.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 5.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.8 PID_ALK1_PATHWAY ALK1 signaling events
0.1 3.5 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.1 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 2.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 2.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.2 2.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 2.3 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1 2.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 1.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.3 PID_INSULIN_PATHWAY Insulin Pathway
0.0 1.3 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 6.1 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 5.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 4.6 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 4.3 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.5 3.0 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.2 3.0 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 2.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.9 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 2.9 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.9 2.8 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 2.3 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.2 2.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.2 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.9 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.4 1.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 1.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation