Motif ID: Esr1

Z-value: 1.027


Transcription factors associated with Esr1:

Gene SymbolEntrez IDGene Name
Esr1 ENSMUSG00000019768.10 Esr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr1mm10_v2_chr10_+_4710119_47101660.363.0e-02Click!


Activity profile for motif Esr1.

activity profile for motif Esr1


Sorted Z-values histogram for motif Esr1

Sorted Z-values for motif Esr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_66860458 3.587 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr1_+_34579693 3.234 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr16_-_76373827 3.059 ENSMUST00000121927.1
 Nrip1
nuclear receptor interacting protein 1
chr3_+_117575268 2.935 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr4_-_141598206 2.911 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1


chr18_-_38211957 2.645 ENSMUST00000159405.1
ENSMUST00000160721.1
 Pcdh1

protocadherin 1

chr10_-_125308809 2.600 ENSMUST00000105257.2
 Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr19_-_57182293 2.593 ENSMUST00000133369.1
 Ablim1
actin-binding LIM protein 1
chr1_-_87573825 2.564 ENSMUST00000068681.5
 Ngef
neuronal guanine nucleotide exchange factor
chr4_+_152199805 2.544 ENSMUST00000105652.2
 Acot7
acyl-CoA thioesterase 7
chr13_+_31806627 2.259 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr8_-_68735058 2.198 ENSMUST00000136060.1
ENSMUST00000130214.1
ENSMUST00000078350.6
 Csgalnact1


chondroitin sulfate N-acetylgalactosaminyltransferase 1


chr7_+_45699843 2.190 ENSMUST00000003360.7
 Car11
carbonic anhydrase 11
chr2_-_104257400 2.175 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr1_-_43163891 2.170 ENSMUST00000008280.7
 Fhl2
four and a half LIM domains 2
chr11_+_32286946 2.127 ENSMUST00000101387.3
 Hbq1b
hemoglobin, theta 1B
chr5_-_77408034 2.126 ENSMUST00000163898.1
ENSMUST00000046746.6
 Igfbp7

insulin-like growth factor binding protein 7

chrX_-_104857228 2.007 ENSMUST00000033575.5
 Magee2
melanoma antigen, family E, 2
chr5_-_143909782 1.887 ENSMUST00000031613.4
ENSMUST00000100483.2
 Aimp2

aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

chr11_+_7063423 1.872 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 230 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.6 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.7 3.6 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 3.5 GO:0030032 lamellipodium assembly(GO:0030032)
1.0 3.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.1 3.0 GO:0033014 tetrapyrrole biosynthetic process(GO:0033014)
0.6 2.6 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.3 2.6 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.2 2.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.8 2.3 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.0 2.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.5 2.2 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.5 2.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.2 2.2 GO:0060347 heart trabecula formation(GO:0060347)
0.3 2.0 GO:0032439 endosome localization(GO:0032439)
0.1 2.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.6 1.9 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632)
0.6 1.9 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.0 1.9 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.4 1.8 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 1.8 GO:0046959 habituation(GO:0046959)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 5.1 GO:0031430 M band(GO:0031430)
0.0 3.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 2.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 2.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.2 2.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.3 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) cell-substrate junction(GO:0030055)
0.0 2.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 2.0 GO:0045179 apical cortex(GO:0045179)
0.0 2.0 GO:0005911 cell-cell junction(GO:0005911)
0.4 1.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 1.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.9 GO:0030027 lamellipodium(GO:0030027)
0.2 1.8 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.4 1.7 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 1.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 1.7 GO:0061574 ASAP complex(GO:0061574)
0.5 1.6 GO:0098855 HCN channel complex(GO:0098855)
0.5 1.5 GO:0072534 perineuronal net(GO:0072534)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 176 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 3.6 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.3 3.6 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 3.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 3.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 3.0 GO:0015485 cholesterol binding(GO:0015485)
0.1 2.8 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.6 2.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 2.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 2.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.8 2.3 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.2 2.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 2.3 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.5 2.2 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.3 2.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 2.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 2.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.1 GO:0050699 WW domain binding(GO:0050699)
0.0 2.1 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.3 2.0 GO:0048495 Roundabout binding(GO:0048495)
0.3 1.9 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 3.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 3.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 2.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.6 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.2 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.1 1.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.5 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 1.4 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.3 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.2 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.1 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 3.4 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.2 3.1 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 3.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 2.6 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.5 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 2.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.3 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 2.3 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 2.2 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.2 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 2.1 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 2.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.0 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 1.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.6 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.5 1.4 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 1.4 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression