Motif ID: Esr2

Z-value: 1.837


Transcription factors associated with Esr2:

Gene SymbolEntrez IDGene Name
Esr2 ENSMUSG00000021055.7 Esr2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr2mm10_v2_chr12_-_76177251_76177265-0.019.7e-01Click!


Activity profile for motif Esr2.

activity profile for motif Esr2


Sorted Z-values histogram for motif Esr2

Sorted Z-values for motif Esr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78499087 9.242 ENSMUST00000017488.4
 Vtn
vitronectin
chr18_+_20665250 9.190 ENSMUST00000075312.3
 Ttr
transthyretin
chr2_-_25470031 8.833 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr2_-_25469742 8.032 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr4_-_136892867 7.636 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr6_+_90550789 6.223 ENSMUST00000130418.1
ENSMUST00000032175.8
 Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr7_-_79386943 4.906 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr6_-_35308110 4.499 ENSMUST00000031868.4
 Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr11_+_101246960 4.176 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr8_+_70501116 4.138 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr5_-_116422858 4.084 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr7_-_126625676 3.998 ENSMUST00000032961.3
 Nupr1
nuclear protein transcription regulator 1
chr19_+_8591254 3.943 ENSMUST00000010251.3
ENSMUST00000170817.1
 Slc22a8

solute carrier family 22 (organic anion transporter), member 8

chr5_+_35056813 3.861 ENSMUST00000101298.2
ENSMUST00000114270.1
ENSMUST00000133381.1
 Dok7


docking protein 7


chr13_+_38345716 3.828 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr7_-_19698206 3.814 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr7_-_19698383 3.799 ENSMUST00000173739.1
 Apoe
apolipoprotein E
chr11_-_6065538 3.674 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr9_-_54661870 3.617 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr15_-_66801577 3.478 ENSMUST00000168589.1
 Sla
src-like adaptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 809 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 17.6 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.0 10.7 GO:0097421 liver regeneration(GO:0097421)
1.9 9.6 GO:0070327 thyroid hormone transport(GO:0070327)
2.5 7.6 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
1.1 7.6 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
1.3 7.5 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.9 7.2 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.6 6.7 GO:0043589 skin morphogenesis(GO:0043589)
0.2 6.3 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
2.1 6.2 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.7 6.0 GO:0043129 surfactant homeostasis(GO:0043129)
1.0 5.9 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.7 5.9 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
1.9 5.8 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430)
0.6 5.8 GO:1900426 positive regulation of defense response to bacterium(GO:1900426)
0.1 5.6 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.9 5.2 GO:0045919 positive regulation of cytolysis(GO:0045919)
1.2 4.8 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.3 4.7 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
1.5 4.6 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 288 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 30.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 28.6 GO:0005615 extracellular space(GO:0005615)
0.1 23.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 14.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.9 11.2 GO:0005796 Golgi lumen(GO:0005796)
0.1 10.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.6 8.3 GO:0005614 interstitial matrix(GO:0005614)
2.5 7.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 7.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.6 7.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 7.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 6.8 GO:0031594 neuromuscular junction(GO:0031594)
2.2 6.6 GO:0005584 collagen type I trimer(GO:0005584)
0.1 6.4 GO:0005581 collagen trimer(GO:0005581)
0.1 6.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 6.1 GO:0034707 chloride channel complex(GO:0034707)
0.7 5.9 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.2 5.7 GO:0031231 intrinsic component of peroxisomal membrane(GO:0031231)
0.1 5.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 5.4 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 497 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 17.1 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.6 13.5 GO:0005044 scavenger receptor activity(GO:0005044)
1.5 13.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 12.1 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.2 9.6 GO:0005158 insulin receptor binding(GO:0005158)
0.0 9.5 GO:0005096 GTPase activator activity(GO:0005096)
0.2 8.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 7.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.6 7.8 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.4 7.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
2.5 7.6 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 7.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
2.1 6.2 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.6 6.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.5 6.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.0 5.9 GO:0019841 retinol binding(GO:0019841)
0.8 5.9 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.2 5.6 GO:0043274 phospholipase binding(GO:0043274)
0.1 5.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 5.4 GO:0030742 GTP-dependent protein binding(GO:0030742)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 16.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5 15.7 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 8.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 6.1 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 5.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 5.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 5.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 5.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 5.1 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 4.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.8 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 4.2 PID_INSULIN_PATHWAY Insulin Pathway
0.2 4.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 3.7 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.3 3.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 3.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.2 3.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.3 PID_BMP_PATHWAY BMP receptor signaling
0.1 3.2 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 13.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 11.5 REACTOME_AMYLOIDS Genes involved in Amyloids
0.3 8.7 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.6 8.4 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.6 8.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 8.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 7.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
1.3 7.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.3 7.5 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.3 7.1 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 6.9 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.2 6.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 5.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 4.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 4.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 4.3 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 4.1 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 3.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules