Motif ID: Esrrb_Esrra

Z-value: 1.364

Transcription factors associated with Esrrb_Esrra:

Gene SymbolEntrez IDGene Name
Esrra ENSMUSG00000024955.7 Esrra
Esrrb ENSMUSG00000021255.11 Esrrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrrbmm10_v2_chr12_+_86361112_86361131-0.231.8e-01Click!
Esrramm10_v2_chr19_-_6921753_6921803-0.057.7e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrb_Esrra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 14.020 ENSMUST00000119481.1
ENSMUST00000055815.7
Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr11_+_7063423 10.368 ENSMUST00000020706.4
Adcy1
adenylate cyclase 1
chr3_-_54915867 8.331 ENSMUST00000070342.3
Sertm1
serine rich and transmembrane domain containing 1
chr4_+_13751297 8.116 ENSMUST00000105566.2
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr19_-_57314896 7.926 ENSMUST00000111524.1
Ablim1
actin-binding LIM protein 1
chr7_-_74554474 6.926 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
Slco3a1


solute carrier organic anion transporter family, member 3a1


chr15_+_84669565 6.511 ENSMUST00000171460.1
Prr5
proline rich 5 (renal)
chr2_+_121357714 6.507 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr1_-_84696182 6.284 ENSMUST00000049126.6
Dner
delta/notch-like EGF-related receptor
chrX_-_72656135 6.275 ENSMUST00000055966.6
Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr15_-_79804717 6.161 ENSMUST00000023057.8
Nptxr
neuronal pentraxin receptor
chr5_-_110343009 6.087 ENSMUST00000058016.9
ENSMUST00000112478.3
P2rx2

purinergic receptor P2X, ligand-gated ion channel, 2

chr8_+_124793061 6.051 ENSMUST00000041106.7
Trim67
tripartite motif-containing 67
chr8_+_124793013 6.012 ENSMUST00000167588.1
Trim67
tripartite motif-containing 67
chr2_+_121358591 5.359 ENSMUST00000000317.6
ENSMUST00000129130.1
Ckmt1

creatine kinase, mitochondrial 1, ubiquitous

chr11_+_42419729 5.176 ENSMUST00000007797.4
Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr6_+_38663061 5.176 ENSMUST00000114874.3
Clec2l
C-type lectin domain family 2, member L
chr17_-_83631892 4.913 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr6_-_113501818 4.836 ENSMUST00000101059.1
Prrt3
proline-rich transmembrane protein 3
chr19_+_6400523 4.822 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
Rasgrp2



RAS, guanyl releasing protein 2




Gene overrepresentation in biological_process category:

Showing 1 to 20 of 248 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.5 12.1 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.9 11.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.7 10.4 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.2 9.8 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
1.0 8.8 GO:0071420 cellular response to histamine(GO:0071420)
0.1 8.1 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.1 7.7 GO:0032091 negative regulation of protein binding(GO:0032091)
0.1 7.5 GO:0030032 lamellipodium assembly(GO:0030032)
2.5 7.4 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.3 7.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.7 6.5 GO:0038203 TORC2 signaling(GO:0038203)
0.4 6.3 GO:0007220 Notch receptor processing(GO:0007220)
0.3 6.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.7 6.1 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832)
0.5 5.9 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.6 5.1 GO:0019388 galactose catabolic process(GO:0019388)
0.2 5.1 GO:0014003 oligodendrocyte development(GO:0014003)
1.6 4.8 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.3 4.8 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 27.9 GO:0030054 cell junction(GO:0030054)
1.0 15.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 12.8 GO:0043204 perikaryon(GO:0043204)
0.2 11.0 GO:0009925 basal plasma membrane(GO:0009925)
0.1 10.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 9.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.6 9.6 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.2 8.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 7.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.7 6.7 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.4 6.5 GO:0031932 TORC2 complex(GO:0031932)
0.6 6.4 GO:0032426 stereocilium tip(GO:0032426)
0.8 6.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.4 6.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 6.1 GO:0016363 nuclear matrix(GO:0016363)
0.1 5.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 5.4 GO:0005604 basement membrane(GO:0005604)
0.2 5.2 GO:0032590 dendrite membrane(GO:0032590)
0.6 5.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.4 5.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
3.5 14.1 GO:0004111 creatine kinase activity(GO:0004111)
1.7 11.6 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.7 10.4 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.6 9.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.4 8.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 8.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 8.1 GO:0030246 carbohydrate binding(GO:0030246)
0.5 7.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 7.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 6.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
1.6 6.5 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
1.5 6.2 GO:0001847 opsonin receptor activity(GO:0001847)
1.0 6.1 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) mercury ion binding(GO:0045340)
0.0 6.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 5.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 5.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.7 5.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
1.0 4.9 GO:0043532 angiostatin binding(GO:0043532)
0.4 4.8 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.6 10.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 9.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 7.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 7.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 4.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 4.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 4.3 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 3.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 3.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 2.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.4 PID_ARF_3PATHWAY Arf1 pathway
0.2 2.1 PID_ALK2_PATHWAY ALK2 signaling events
0.1 2.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 1.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 18.4 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 17.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.9 14.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
1.4 11.6 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.2 11.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.9 10.4 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.6 10.1 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 8.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 7.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 7.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 7.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.5 6.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 6.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 5.0 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 5.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.6 4.7 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 4.7 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 3.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 3.7 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.2 3.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation