Motif ID: Esrrb_Esrra

Z-value: 1.364

Transcription factors associated with Esrrb_Esrra:

Gene SymbolEntrez IDGene Name
Esrra ENSMUSG00000024955.7 Esrra
Esrrb ENSMUSG00000021255.11 Esrrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrrbmm10_v2_chr12_+_86361112_86361131-0.231.8e-01Click!
Esrramm10_v2_chr19_-_6921753_6921803-0.057.7e-01Click!


Activity profile for motif Esrrb_Esrra.

activity profile for motif Esrrb_Esrra


Sorted Z-values histogram for motif Esrrb_Esrra

Sorted Z-values for motif Esrrb_Esrra



Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrb_Esrra

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 14.020 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr11_+_7063423 10.368 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr3_-_54915867 8.331 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr4_+_13751297 8.116 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr19_-_57314896 7.926 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr7_-_74554474 6.926 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr15_+_84669565 6.511 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr2_+_121357714 6.507 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr1_-_84696182 6.284 ENSMUST00000049126.6
 Dner
delta/notch-like EGF-related receptor
chrX_-_72656135 6.275 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr15_-_79804717 6.161 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr5_-_110343009 6.087 ENSMUST00000058016.9
ENSMUST00000112478.3
 P2rx2

purinergic receptor P2X, ligand-gated ion channel, 2

chr8_+_124793061 6.051 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr8_+_124793013 6.012 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr2_+_121358591 5.359 ENSMUST00000000317.6
ENSMUST00000129130.1
 Ckmt1

creatine kinase, mitochondrial 1, ubiquitous

chr11_+_42419729 5.176 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr6_+_38663061 5.176 ENSMUST00000114874.3
 Clec2l
C-type lectin domain family 2, member L
chr17_-_83631892 4.913 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr6_-_113501818 4.836 ENSMUST00000101059.1
 Prrt3
proline-rich transmembrane protein 3
chr19_+_6400523 4.822 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 248 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.5 12.1 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.9 11.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.7 10.4 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.2 9.8 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
1.0 8.8 GO:0071420 cellular response to histamine(GO:0071420)
0.1 8.1 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.1 7.7 GO:0032091 negative regulation of protein binding(GO:0032091)
0.1 7.5 GO:0030032 lamellipodium assembly(GO:0030032)
2.5 7.4 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.3 7.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.7 6.5 GO:0038203 TORC2 signaling(GO:0038203)
0.4 6.3 GO:0007220 Notch receptor processing(GO:0007220)
0.3 6.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.7 6.1 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832)
0.5 5.9 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.6 5.1 GO:0019388 galactose catabolic process(GO:0019388)
0.2 5.1 GO:0014003 oligodendrocyte development(GO:0014003)
1.6 4.8 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.3 4.8 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 27.9 GO:0030054 cell junction(GO:0030054)
1.0 15.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 12.8 GO:0043204 perikaryon(GO:0043204)
0.2 11.0 GO:0009925 basal plasma membrane(GO:0009925)
0.1 10.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 9.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.6 9.6 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.2 8.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 7.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.7 6.7 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.4 6.5 GO:0031932 TORC2 complex(GO:0031932)
0.6 6.4 GO:0032426 stereocilium tip(GO:0032426)
0.8 6.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.4 6.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 6.1 GO:0016363 nuclear matrix(GO:0016363)
0.1 5.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 5.4 GO:0005604 basement membrane(GO:0005604)
0.2 5.2 GO:0032590 dendrite membrane(GO:0032590)
0.6 5.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.4 5.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
3.5 14.1 GO:0004111 creatine kinase activity(GO:0004111)
1.7 11.6 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.7 10.4 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.6 9.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.4 8.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 8.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 8.1 GO:0030246 carbohydrate binding(GO:0030246)
0.5 7.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 7.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 6.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
1.6 6.5 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
1.5 6.2 GO:0001847 opsonin receptor activity(GO:0001847)
1.0 6.1 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) mercury ion binding(GO:0045340)
0.0 6.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 5.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 5.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.7 5.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
1.0 4.9 GO:0043532 angiostatin binding(GO:0043532)
0.4 4.8 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.6 10.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 9.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 7.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 7.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 4.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 4.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 4.3 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 3.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 3.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 2.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.4 PID_ARF_3PATHWAY Arf1 pathway
0.2 2.1 PID_ALK2_PATHWAY ALK2 signaling events
0.1 2.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 1.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 18.4 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 17.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.9 14.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
1.4 11.6 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.2 11.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.9 10.4 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.6 10.1 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 8.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 7.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 7.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 7.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.5 6.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 6.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 5.0 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 5.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.6 4.7 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 4.7 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 3.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 3.7 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.2 3.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation