Motif ID: Esrrg

Z-value: 0.291


Transcription factors associated with Esrrg:

Gene SymbolEntrez IDGene Name
Esrrg ENSMUSG00000026610.7 Esrrg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrrgmm10_v2_chr1_+_187997821_187997834-0.563.2e-04Click!


Activity profile for motif Esrrg.

activity profile for motif Esrrg


Sorted Z-values histogram for motif Esrrg

Sorted Z-values for motif Esrrg



Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrg

PNG image of the network

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Top targets:


Showing 1 to 20 of 173 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_68869563 1.883 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr10_+_79716588 1.312 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr19_+_6400523 1.248 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr9_-_107668967 1.150 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr19_+_6399857 0.967 ENSMUST00000146601.1
ENSMUST00000150713.1
 Rasgrp2

RAS, guanyl releasing protein 2

chr19_+_6400611 0.852 ENSMUST00000113467.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr19_+_6399746 0.810 ENSMUST00000113468.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr17_-_81649607 0.801 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr13_-_51567084 0.779 ENSMUST00000021898.5
 Shc3
src homology 2 domain-containing transforming protein C3
chr8_-_46294592 0.775 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr1_+_104768510 0.775 ENSMUST00000062528.8
 Cdh20
cadherin 20
chr15_-_79285502 0.765 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr7_-_105482197 0.699 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein
chr2_+_164785823 0.661 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
 Snx21


sorting nexin family member 21


chr19_-_43674844 0.593 ENSMUST00000046038.7
 Slc25a28
solute carrier family 25, member 28
chr1_+_75546522 0.577 ENSMUST00000138814.1
 Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr2_+_164785994 0.533 ENSMUST00000152471.1
 Snx21
sorting nexin family member 21
chr11_+_69088490 0.533 ENSMUST00000021273.6
ENSMUST00000117780.1
 Vamp2

vesicle-associated membrane protein 2

chr11_+_98741805 0.481 ENSMUST00000064187.5
 Thra
thyroid hormone receptor alpha
chr8_-_105295934 0.476 ENSMUST00000057855.3
 Exoc3l
exocyst complex component 3-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.3 1.3 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.2 1.1 GO:0015817 glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365)
0.2 1.0 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.8 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.0 0.8 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2 0.5 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.2 0.5 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.2 0.5 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.1 0.5 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.5 GO:0051601 exocyst localization(GO:0051601)
0.0 0.5 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.1 0.4 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.4 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.4 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.0 0.4 GO:1900244 positive regulation of synaptic vesicle endocytosis(GO:1900244)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.3 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.1 0.3 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 0.3 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0031901 early endosome membrane(GO:0031901)
0.4 1.3 GO:0098855 HCN channel complex(GO:0098855)
0.0 1.1 GO:0030315 T-tubule(GO:0030315)
0.1 0.8 GO:0071439 clathrin complex(GO:0071439)
0.1 0.5 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.5 GO:0000145 exocyst(GO:0000145)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0031430 M band(GO:0031430)
0.1 0.3 GO:0044316 cone cell pedicle(GO:0044316)
0.1 0.3 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.3 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.2 GO:0005745 m-AAA complex(GO:0005745)
0.0 0.2 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.3 1.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 1.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.4 1.1 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.1 1.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 0.8 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.0 0.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.6 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.2 0.5 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.1 0.5 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.5 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.4 GO:0015288 porin activity(GO:0015288)
0.0 0.4 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.3 GO:0030172 troponin C binding(GO:0030172)
0.1 0.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 1.6 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 1.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 0.8 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.8 REACTOME_SHC_MEDIATED_SIGNALLING Genes involved in SHC-mediated signalling
0.1 0.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection