Motif ID: Ets1

Z-value: 0.764


Transcription factors associated with Ets1:

Gene SymbolEntrez IDGene Name
Ets1 ENSMUSG00000032035.9 Ets1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ets1mm10_v2_chr9_+_32696005_32696121-0.231.7e-01Click!


Activity profile for motif Ets1.

activity profile for motif Ets1


Sorted Z-values histogram for motif Ets1

Sorted Z-values for motif Ets1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ets1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 4.474 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr4_-_63403330 3.663 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr7_-_127218390 3.513 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr7_-_127218303 3.295 ENSMUST00000106313.1
 Sept1
septin 1
chr11_-_20112876 2.903 ENSMUST00000000137.7
 Actr2
ARP2 actin-related protein 2
chr6_-_115994953 2.419 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr11_-_76509419 2.137 ENSMUST00000094012.4
 Abr
active BCR-related gene
chr11_+_96464587 2.076 ENSMUST00000103154.4
ENSMUST00000100521.3
ENSMUST00000100519.4
ENSMUST00000071510.7
ENSMUST00000107662.2
 Skap1




src family associated phosphoprotein 1




chr10_-_6980376 2.034 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr7_+_62348277 2.012 ENSMUST00000038775.4
 Ndn
necdin
chr11_-_105944412 1.899 ENSMUST00000019734.4
ENSMUST00000184269.1
ENSMUST00000150563.1
 Cyb561


cytochrome b-561


chr17_+_29090969 1.841 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr9_-_66514567 1.813 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr18_+_50030977 1.783 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr1_+_107511489 1.728 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr9_+_110476985 1.723 ENSMUST00000084948.4
ENSMUST00000061155.6
ENSMUST00000140686.1
ENSMUST00000084952.5
 Kif9



kinesin family member 9



chr1_+_107511416 1.608 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr14_-_19977040 1.558 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr14_-_19977151 1.518 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr4_-_129573637 1.515 ENSMUST00000102596.1
 Lck
lymphocyte protein tyrosine kinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 401 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 7.5 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.5 3.8 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.0 3.7 GO:0000398 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
1.0 2.9 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.2 2.9 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.1 2.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 2.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 2.9 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.1 2.7 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.5 2.6 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 2.5 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.5 2.4 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.4 2.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.2 2.4 GO:0042989 sequestering of actin monomers(GO:0042989)
0.6 2.3 GO:0030576 Cajal body organization(GO:0030576)
0.1 2.3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 2.3 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 2.2 GO:0007413 axonal fasciculation(GO:0007413)
0.1 2.2 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.7 2.1 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 202 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 7.3 GO:0072687 meiotic spindle(GO:0072687)
0.1 6.0 GO:0002102 podosome(GO:0002102)
0.1 4.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 4.2 GO:0000242 pericentriolar material(GO:0000242)
0.1 4.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.3 2.9 GO:0030478 actin cap(GO:0030478)
0.1 2.8 GO:0035371 microtubule plus-end(GO:0035371)
0.0 2.8 GO:0001650 fibrillar center(GO:0001650)
0.2 2.6 GO:0030008 TRAPP complex(GO:0030008)
0.3 2.5 GO:0005818 aster(GO:0005818)
0.2 2.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.3 2.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.3 2.4 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 2.3 GO:0070069 cytochrome complex(GO:0070069)
0.1 2.3 GO:0015030 Cajal body(GO:0015030)
0.0 2.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 2.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.1 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 253 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0005525 GTP binding(GO:0005525)
0.3 4.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 4.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.8 3.8 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 3.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 3.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 3.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 3.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 3.4 GO:0019003 GDP binding(GO:0019003)
0.1 3.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 3.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 3.0 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 3.0 GO:0002039 p53 binding(GO:0002039)
0.1 2.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 2.9 GO:0042169 SH2 domain binding(GO:0042169)
0.0 2.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 2.5 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.2 2.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.3 2.4 GO:0061133 endopeptidase activator activity(GO:0061133)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 7.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 5.8 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 5.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.4 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.3 4.1 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 3.4 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 3.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.3 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 2.1 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 1.8 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 1.8 PID_ARF6_PATHWAY Arf6 signaling events
0.1 1.6 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.2 1.4 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.1 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.0 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 0.9 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 0.9 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.2 5.9 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 4.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 4.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 4.1 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.3 4.0 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 3.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 3.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 3.2 REACTOME_KINESINS Genes involved in Kinesins
0.1 3.2 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.0 2.7 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 2.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.3 2.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.0 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 2.0 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 1.7 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 1.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 1.6 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.3 1.5 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G