Motif ID: Ets2

Z-value: 1.141


Transcription factors associated with Ets2:

Gene SymbolEntrez IDGene Name
Ets2 ENSMUSG00000022895.8 Ets2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ets2mm10_v2_chr16_+_95702044_957020940.771.9e-08Click!


Activity profile for motif Ets2.

activity profile for motif Ets2


Sorted Z-values histogram for motif Ets2

Sorted Z-values for motif Ets2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ets2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 12.024 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr6_+_5725812 10.476 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr15_-_66969616 7.915 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr5_-_44799643 6.838 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr11_-_55419898 6.737 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr9_-_29411736 6.598 ENSMUST00000115236.1
 Ntm
neurotrimin
chr1_-_56969864 6.391 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 6.135 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr17_+_3397189 5.810 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr11_-_67922136 5.729 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr10_+_85386813 5.516 ENSMUST00000105307.1
ENSMUST00000020231.3
 Btbd11

BTB (POZ) domain containing 11

chr17_-_68004075 4.919 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr7_-_4546567 4.339 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr15_-_37458523 4.311 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr7_+_30413744 3.984 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr2_-_5714490 3.948 ENSMUST00000044009.7
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr4_+_128058962 3.891 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr19_+_47854970 3.645 ENSMUST00000026050.7
 Gsto1
glutathione S-transferase omega 1
chr4_+_103313806 3.596 ENSMUST00000035780.3
 Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chr3_-_87768932 3.588 ENSMUST00000173184.1
ENSMUST00000172621.1
ENSMUST00000174759.1
ENSMUST00000172590.1
ENSMUST00000079083.5
 Pear1




platelet endothelial aggregation receptor 1





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 215 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 22.5 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 13.7 GO:0007266 Rho protein signal transduction(GO:0007266)
0.8 12.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.7 7.9 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.2 6.7 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.1 5.5 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.6 5.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.2 4.9 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 4.5 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 4.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 4.2 GO:0010669 epithelial structure maintenance(GO:0010669)
0.6 3.9 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.4 3.8 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.3 3.8 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.9 3.6 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.7 3.6 GO:0010637 diet induced thermogenesis(GO:0002024) negative regulation of mitochondrial fusion(GO:0010637)
0.6 3.6 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.4 3.6 GO:0030259 lipid glycosylation(GO:0030259)
0.5 3.3 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.3 3.3 GO:0000185 activation of MAPKKK activity(GO:0000185)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.5 22.5 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.2 7.9 GO:0055038 recycling endosome membrane(GO:0055038)
1.7 6.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 6.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 5.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 5.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 5.3 GO:0031430 M band(GO:0031430)
0.0 4.9 GO:0000139 Golgi membrane(GO:0000139)
1.1 4.3 GO:1990769 proximal neuron projection(GO:1990769)
0.3 4.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 4.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 3.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 3.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 3.6 GO:0001891 phagocytic cup(GO:0001891)
0.0 3.6 GO:0005604 basement membrane(GO:0005604)
0.5 3.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.2 3.2 GO:0000421 autophagosome membrane(GO:0000421)
0.5 3.1 GO:0097443 sorting endosome(GO:0097443)
0.1 3.0 GO:0005605 basal lamina(GO:0005605)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 22.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 17.8 GO:0005096 GTPase activator activity(GO:0005096)
0.2 14.2 GO:0030276 clathrin binding(GO:0030276)
0.1 7.6 GO:0005518 collagen binding(GO:0005518)
0.2 7.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 7.2 GO:0008013 beta-catenin binding(GO:0008013)
0.1 6.5 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 6.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 6.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.2 6.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.4 5.3 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 4.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 3.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
1.2 3.6 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.4 3.3 GO:0030274 LIM domain binding(GO:0030274)
0.1 3.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.6 3.0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 2.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 2.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.8 GO:0008432 JUN kinase binding(GO:0008432)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 9.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 4.3 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 4.2 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 3.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 2.9 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 2.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 2.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.5 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 2.3 PID_INSULIN_PATHWAY Insulin Pathway
0.0 2.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.2 PID_ARF_3PATHWAY Arf1 pathway
0.1 2.1 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 2.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 1.9 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 1.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.6 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 24.4 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 7.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 7.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 7.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 6.1 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 5.6 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.4 5.0 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 4.9 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 4.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 4.1 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.1 3.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 3.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 3.0 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 2.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 2.9 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 2.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.2 2.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.2 2.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 2.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 2.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines