Motif ID: Etv1_Etv5_Gabpa

Z-value: 1.419

Transcription factors associated with Etv1_Etv5_Gabpa:

Gene SymbolEntrez IDGene Name
Etv1 ENSMUSG00000004151.10 Etv1
Etv5 ENSMUSG00000013089.9 Etv5
Gabpa ENSMUSG00000008976.10 Gabpa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv5mm10_v2_chr16_-_22439719_22439733-0.725.7e-07Click!
Etv1mm10_v2_chr12_+_38783455_387834820.202.2e-01Click!
Gabpamm10_v2_chr16_+_84834901_848349410.076.6e-01Click!


Activity profile for motif Etv1_Etv5_Gabpa.

activity profile for motif Etv1_Etv5_Gabpa


Sorted Z-values histogram for motif Etv1_Etv5_Gabpa

Sorted Z-values for motif Etv1_Etv5_Gabpa



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv1_Etv5_Gabpa

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_127042420 8.205 ENSMUST00000032915.6
 Kif22
kinesin family member 22
chr16_-_22161450 7.653 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr2_+_5845243 7.271 ENSMUST00000127116.1
 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr1_+_187215501 6.955 ENSMUST00000097443.3
ENSMUST00000065573.7
ENSMUST00000110943.2
ENSMUST00000044812.5
 Gpatch2



G patch domain containing 2



chr2_+_152847961 6.773 ENSMUST00000164120.1
ENSMUST00000178997.1
ENSMUST00000109816.1
 Tpx2


TPX2, microtubule-associated protein homolog (Xenopus laevis)


chr2_+_118814237 6.486 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr2_+_152847993 6.411 ENSMUST00000028969.8
 Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr19_+_6084983 6.004 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr4_-_43499608 5.977 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr16_+_48994185 5.900 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr2_+_118814195 5.875 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr2_+_73312601 5.595 ENSMUST00000090811.4
ENSMUST00000112050.1
 Scrn3

secernin 3

chr2_+_105682463 5.457 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr2_+_118813995 5.330 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chrX_+_100625737 5.213 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr11_-_94653964 5.146 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr9_-_96889381 5.125 ENSMUST00000112951.2
ENSMUST00000126411.1
ENSMUST00000078478.1
ENSMUST00000119141.1
ENSMUST00000120101.1
 Acpl2




acid phosphatase-like 2




chr1_+_187215737 4.912 ENSMUST00000160471.1
 Gpatch2
G patch domain containing 2
chr2_-_113848601 4.629 ENSMUST00000110949.2
 Arhgap11a
Rho GTPase activating protein 11A
chr19_+_5366764 4.610 ENSMUST00000025759.7
 Eif1ad
eukaryotic translation initiation factor 1A domain containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 669 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.4 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.7 23.2 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
1.3 22.6 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.2 15.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
3.4 13.6 GO:0019323 pentose catabolic process(GO:0019323)
0.6 13.0 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.1 12.1 GO:0051028 mRNA transport(GO:0051028)
0.1 11.6 GO:0006413 translational initiation(GO:0006413)
0.1 11.6 GO:0008360 regulation of cell shape(GO:0008360)
0.1 9.7 GO:0007059 chromosome segregation(GO:0007059)
0.2 9.4 GO:0010965 regulation of mitotic sister chromatid separation(GO:0010965)
2.8 8.3 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.6 7.7 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.5 7.6 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.4 7.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.3 6.9 GO:0045116 protein neddylation(GO:0045116)
0.3 6.5 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.4 6.4 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
2.0 6.0 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.4 5.8 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 292 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 23.6 GO:0005871 kinesin complex(GO:0005871)
0.6 20.5 GO:0035371 microtubule plus-end(GO:0035371)
0.8 15.3 GO:0031616 spindle pole centrosome(GO:0031616)
1.8 14.6 GO:0005818 aster(GO:0005818)
0.1 11.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 10.4 GO:0016607 nuclear speck(GO:0016607)
1.5 9.0 GO:0031262 Ndc80 complex(GO:0031262)
0.0 8.9 GO:0005667 transcription factor complex(GO:0005667)
0.3 8.6 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 7.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 7.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 6.7 GO:0031965 nuclear membrane(GO:0031965)
0.4 6.6 GO:0017119 Golgi transport complex(GO:0017119)
0.1 6.5 GO:0005814 centriole(GO:0005814)
0.0 6.3 GO:0016604 nuclear body(GO:0016604)
1.2 6.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.6 5.9 GO:0031595 nuclear proteasome complex(GO:0031595)
0.4 5.7 GO:0030008 TRAPP complex(GO:0030008)
1.1 5.4 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.8 5.3 GO:0008278 cohesin complex(GO:0008278)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 412 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 23.8 GO:0003777 microtubule motor activity(GO:0003777)
1.5 13.5 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 12.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 11.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
3.5 10.5 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.2 10.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.7 9.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 9.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.3 8.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.3 8.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 7.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.5 7.3 GO:0003680 AT DNA binding(GO:0003680)
0.2 7.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 6.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.8 6.5 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 6.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 6.2 GO:0070513 death domain binding(GO:0070513)
0.4 6.2 GO:0016805 dipeptidase activity(GO:0016805)
0.4 5.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 5.7 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 21.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 12.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 12.4 PID_ATR_PATHWAY ATR signaling pathway
0.2 9.4 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 7.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 7.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 7.1 PID_MYC_PATHWAY C-MYC pathway
0.2 6.2 PID_PLK1_PATHWAY PLK1 signaling events
0.2 5.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.2 5.1 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 5.1 PID_CDC42_PATHWAY CDC42 signaling events
0.1 4.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 4.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 4.3 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 4.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 3.4 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 3.3 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 3.2 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 3.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 25.4 REACTOME_KINESINS Genes involved in Kinesins
0.3 23.6 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.2 21.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 17.4 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.1 15.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.7 7.8 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3 7.6 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.3 6.8 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 6.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.4 6.1 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 6.0 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 5.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.3 5.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 5.5 REACTOME_INFLUENZA_LIFE_CYCLE Genes involved in Influenza Life Cycle
0.1 5.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 5.0 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 4.8 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.3 3.9 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.3 3.8 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex