Motif ID: Etv3_Erf_Fev_Elk4_Elk1_Elk3

Z-value: 0.714

Transcription factors associated with Etv3_Erf_Fev_Elk4_Elk1_Elk3:

Gene SymbolEntrez IDGene Name
Elk1 ENSMUSG00000009406.7 Elk1
Elk3 ENSMUSG00000008398.8 Elk3
Elk4 ENSMUSG00000026436.9 Elk4
Erf ENSMUSG00000040857.9 Erf
Etv3 ENSMUSG00000003382.12 Etv3
Fev ENSMUSG00000055197.4 Fev

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elk4mm10_v2_chr1_+_132008285_1320083160.633.3e-05Click!
Etv3mm10_v2_chr3_+_87525572_875256430.372.6e-02Click!
Elk1mm10_v2_chrX_-_20950597_209506130.325.6e-02Click!
Elk3mm10_v2_chr10_-_93310963_93310989-0.192.6e-01Click!
Erfmm10_v2_chr7_-_25250720_252507610.115.3e-01Click!


Activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3.

activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3


Sorted Z-values histogram for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3

Sorted Z-values for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv3_Erf_Fev_Elk4_Elk1_Elk3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_163602331 2.599 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr12_-_64965496 2.474 ENSMUST00000021331.7
 Klhl28
kelch-like 28
chr11_+_54522872 2.395 ENSMUST00000108895.1
ENSMUST00000101206.3
 Rapgef6

Rap guanine nucleotide exchange factor (GEF) 6

chr9_+_27299205 2.099 ENSMUST00000115247.1
ENSMUST00000133213.1
 Igsf9b

immunoglobulin superfamily, member 9B

chr19_-_28011138 1.987 ENSMUST00000174850.1
 Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr16_-_87432597 1.822 ENSMUST00000039449.7
 Ltn1
listerin E3 ubiquitin protein ligase 1
chrX_-_12762069 1.771 ENSMUST00000096495.4
ENSMUST00000076016.5
 Med14

mediator complex subunit 14

chr9_+_65908967 1.753 ENSMUST00000034949.3
ENSMUST00000154589.1
 Csnk1g1

casein kinase 1, gamma 1

chr9_-_44965519 1.713 ENSMUST00000125642.1
ENSMUST00000117506.1
ENSMUST00000117549.1
 Ube4a


ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)


chr11_+_83299005 1.704 ENSMUST00000176944.1
 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr11_-_104550392 1.701 ENSMUST00000106962.2
 Cdc27
cell division cycle 27
chr12_+_80644212 1.684 ENSMUST00000085245.5
 Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr1_-_133025330 1.671 ENSMUST00000067429.3
ENSMUST00000067398.6
 Mdm4

transformed mouse 3T3 cell double minute 4

chr5_-_3803081 1.580 ENSMUST00000043551.6
 Ankib1
ankyrin repeat and IBR domain containing 1
chr7_+_127876796 1.568 ENSMUST00000131000.1
 Zfp646
zinc finger protein 646
chr1_-_121327776 1.507 ENSMUST00000160688.1
 Insig2
insulin induced gene 2
chr6_-_120364344 1.498 ENSMUST00000146667.1
 Ccdc77
coiled-coil domain containing 77
chr2_+_164805082 1.497 ENSMUST00000052107.4
 Zswim3
zinc finger SWIM-type containing 3
chr6_+_86849488 1.481 ENSMUST00000089519.6
ENSMUST00000113668.1
 Aak1

AP2 associated kinase 1

chr16_+_78301673 1.453 ENSMUST00000114229.2
 Cxadr
coxsackie virus and adenovirus receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 362 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.9 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.2 3.7 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.1 3.4 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.1 2.9 GO:0030033 microvillus assembly(GO:0030033)
0.1 2.5 GO:0006829 zinc II ion transport(GO:0006829)
0.8 2.4 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.8 2.3 GO:0019085 early viral transcription(GO:0019085)
0.4 2.3 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 2.3 GO:0000209 protein polyubiquitination(GO:0000209)
0.2 2.1 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151)
0.1 2.1 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 2.1 GO:0046777 protein autophosphorylation(GO:0046777)
0.5 2.0 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.5 2.0 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042)
0.6 1.9 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
0.4 1.9 GO:0021764 amygdala development(GO:0021764)
0.1 1.9 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 1.9 GO:0002076 osteoblast development(GO:0002076)
0.0 1.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.6 1.8 GO:0060003 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 183 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 4.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.5 3.7 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 2.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.6 2.8 GO:1990745 EARP complex(GO:1990745)
0.1 2.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 2.6 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.4 2.5 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 2.5 GO:0016324 apical plasma membrane(GO:0016324)
0.2 2.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 2.2 GO:0005802 trans-Golgi network(GO:0005802)
0.1 2.1 GO:0060077 inhibitory synapse(GO:0060077)
0.0 2.0 GO:0031965 nuclear membrane(GO:0031965)
0.2 1.9 GO:0097427 microtubule bundle(GO:0097427)
0.1 1.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 1.8 GO:0071439 clathrin complex(GO:0071439)
0.3 1.7 GO:0070847 core mediator complex(GO:0070847)
0.1 1.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 1.6 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.3 1.5 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 230 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.8 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 7.4 GO:0008270 zinc ion binding(GO:0008270)
0.0 4.9 GO:0000149 SNARE binding(GO:0000149)
0.1 4.6 GO:0070063 RNA polymerase binding(GO:0070063)
0.2 3.9 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 3.7 GO:0030276 clathrin binding(GO:0030276)
0.2 3.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 3.1 GO:0051018 protein kinase A binding(GO:0051018)
0.1 2.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 2.3 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 2.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 2.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.4 2.0 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 2.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.6 1.8 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.4 1.8 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.1 1.6 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 1.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 2.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 2.6 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 2.0 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 1.6 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.5 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.4 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.3 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.3 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 1.1 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.1 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.0 PID_INSULIN_PATHWAY Insulin Pathway
0.0 1.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.7 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 0.6 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.3 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 4.0 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 3.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.2 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.1 2.2 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 2.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.0 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1 2.0 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.0 2.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.9 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.8 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.6 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 1.5 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 1.5 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 1.5 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.4 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.1 1.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.4 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.1 1.3 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC