Motif ID: Etv4

Z-value: 0.811


Transcription factors associated with Etv4:

Gene SymbolEntrez IDGene Name
Etv4 ENSMUSG00000017724.8 Etv4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv4mm10_v2_chr11_-_101785252_1017853710.554.2e-04Click!


Activity profile for motif Etv4.

activity profile for motif Etv4


Sorted Z-values histogram for motif Etv4

Sorted Z-values for motif Etv4



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66969616 5.881 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr6_+_5725639 5.338 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr9_+_107935876 4.787 ENSMUST00000035700.8
 Camkv
CaM kinase-like vesicle-associated
chr15_-_66812593 4.724 ENSMUST00000100572.3
 Sla
src-like adaptor
chr9_-_29411736 4.457 ENSMUST00000115236.1
 Ntm
neurotrimin
chr17_-_56133817 4.109 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr13_+_83504032 3.961 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr3_+_95526777 3.635 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr11_-_76509419 3.524 ENSMUST00000094012.4
 Abr
active BCR-related gene
chr1_-_56969864 3.493 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr8_+_70501116 3.460 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr1_-_56969827 3.295 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr6_+_8259288 3.183 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr7_+_45627482 3.125 ENSMUST00000057927.7
 Rasip1
Ras interacting protein 1
chr6_+_125552948 2.983 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr7_+_30413744 2.818 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr9_-_29412204 2.657 ENSMUST00000115237.1
 Ntm
neurotrimin
chr2_+_14229390 2.562 ENSMUST00000028045.2
 Mrc1
mannose receptor, C type 1
chr3_-_141982224 2.490 ENSMUST00000029948.8
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr9_+_56418624 2.454 ENSMUST00000034879.3
 Hmg20a
high mobility group 20A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 283 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5 5.4 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.5 5.3 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.3 4.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 4.4 GO:0001570 vasculogenesis(GO:0001570)
0.7 4.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
1.3 4.0 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.0 4.0 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.3 3.8 GO:0010447 response to acidic pH(GO:0010447)
0.7 3.5 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.6 3.5 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 3.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 3.4 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.4 3.3 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645)
0.2 3.1 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 3.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.5 2.8 GO:2001204 regulation of osteoclast development(GO:2001204)
0.4 2.8 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.5 2.7 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.4 2.6 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 8.3 GO:0031225 anchored component of membrane(GO:0031225)
1.8 5.3 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.0 5.3 GO:0009986 cell surface(GO:0009986)
0.1 4.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.9 4.3 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
1.2 3.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 3.3 GO:0000139 Golgi membrane(GO:0000139)
0.1 3.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 3.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.6 3.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 2.8 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2 2.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 2.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 2.7 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) cell-substrate junction(GO:0030055)
0.1 2.4 GO:0031430 M band(GO:0031430)
0.0 2.4 GO:0009925 basal plasma membrane(GO:0009925)
0.1 2.0 GO:0005614 interstitial matrix(GO:0005614)
0.4 1.8 GO:1990745 EARP complex(GO:1990745)
0.2 1.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 188 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 6.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 5.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 5.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.9 4.3 GO:0097643 amylin receptor activity(GO:0097643)
0.2 4.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 4.1 GO:0000149 SNARE binding(GO:0000149)
0.2 4.0 GO:0035198 miRNA binding(GO:0035198)
0.0 3.8 GO:0017124 SH3 domain binding(GO:0017124)
0.3 3.7 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.5 3.5 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 3.5 GO:0043236 laminin binding(GO:0043236)
0.3 3.4 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 3.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 3.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 2.8 GO:0015643 toxic substance binding(GO:0015643)
0.0 2.8 GO:0051015 actin filament binding(GO:0051015)
0.0 2.7 GO:0008083 growth factor activity(GO:0008083)
0.0 2.7 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.9 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 4.8 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 4.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.0 PID_ARF_3PATHWAY Arf1 pathway
0.1 3.7 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 3.5 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.1 3.0 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 2.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.4 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 2.3 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 2.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.0 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 2.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 1.9 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 4.3 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.1 4.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 4.1 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.2 3.7 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
1.2 3.6 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 3.6 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 3.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 3.1 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ Genes involved in Formation of RNA Pol II elongation complex
0.3 3.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 2.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 2.5 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 2.5 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.2 2.4 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 2.4 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 2.2 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 2.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 2.0 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 2.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.8 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation