Motif ID: Etv6

Z-value: 0.595


Transcription factors associated with Etv6:

Gene SymbolEntrez IDGene Name
Etv6 ENSMUSG00000030199.10 Etv6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv6mm10_v2_chr6_+_134035691_134035717-0.382.0e-02Click!


Activity profile for motif Etv6.

activity profile for motif Etv6


Sorted Z-values histogram for motif Etv6

Sorted Z-values for motif Etv6



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_4546567 1.211 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr1_+_33669816 1.113 ENSMUST00000051203.5
 1700001G17Rik
RIKEN cDNA 1700001G17 gene
chr2_+_168230597 0.827 ENSMUST00000099071.3
 Mocs3
molybdenum cofactor synthesis 3
chr18_+_62548911 0.782 ENSMUST00000055725.4
ENSMUST00000162365.1
 Spink10

serine peptidase inhibitor, Kazal type 10

chr11_-_84819450 0.767 ENSMUST00000018549.7
 Mrm1
mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
chrX_+_7884244 0.655 ENSMUST00000115663.3
 Slc35a2
solute carrier family 35 (UDP-galactose transporter), member A2
chr5_-_31220491 0.646 ENSMUST00000031032.7
 Ppm1g
protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
chr3_+_95217417 0.603 ENSMUST00000181819.1
 Gm16740
predicted gene, 16740
chr17_+_35135463 0.569 ENSMUST00000173535.1
ENSMUST00000173952.1
 Bag6

BCL2-associated athanogene 6

chr6_-_120822680 0.562 ENSMUST00000019354.8
 Atp6v1e1
ATPase, H+ transporting, lysosomal V1 subunit E1
chr11_+_5955693 0.557 ENSMUST00000002818.8
 Ykt6
YKT6 homolog (S. Cerevisiae)
chr1_-_183221529 0.545 ENSMUST00000003035.5
 Disp1
dispatched homolog 1 (Drosophila)
chr17_+_20945311 0.545 ENSMUST00000007708.7
 Ppp2r1a
protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
chrX_+_7884022 0.543 ENSMUST00000115660.4
 Slc35a2
solute carrier family 35 (UDP-galactose transporter), member A2
chr5_-_115348953 0.541 ENSMUST00000040154.8
 Cox6a1
cytochrome c oxidase subunit VIa polypeptide 1
chr15_-_98145625 0.519 ENSMUST00000059112.5
 Asb8
ankyrin repeat and SOCS box-containing 8
chr1_+_58586381 0.515 ENSMUST00000027193.8
 Ndufb3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3
chr1_-_33669745 0.515 ENSMUST00000027312.9
 Prim2
DNA primase, p58 subunit
chr9_+_107563246 0.514 ENSMUST00000010198.3
 Tusc2
tumor suppressor candidate 2
chr3_-_94886945 0.512 ENSMUST00000005923.6
 Psmb4
proteasome (prosome, macropain) subunit, beta type 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 1.9 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 1.7 GO:0008643 carbohydrate transport(GO:0008643)
0.0 1.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.0 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 0.9 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.9 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.9 GO:0032543 mitochondrial translation(GO:0032543)
0.2 0.8 GO:0018307 tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307)
0.1 0.8 GO:0060046 regulation of acrosome reaction(GO:0060046)
0.1 0.8 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.8 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.8 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.1 0.7 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.7 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.7 GO:0044364 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.0 0.7 GO:0045116 protein neddylation(GO:0045116)
0.2 0.6 GO:0019085 early viral transcription(GO:0019085)
0.1 0.6 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.1 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 1.9 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 1.8 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.3 1.2 GO:1990769 proximal neuron projection(GO:1990769)
0.0 1.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 1.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.3 0.9 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.3 0.9 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.1 0.9 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.9 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 0.8 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.8 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.8 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.8 GO:0000502 proteasome complex(GO:0000502)
0.0 0.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.6 GO:0097441 basilar dendrite(GO:0097441)
0.1 0.6 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 1.9 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 1.7 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 1.2 GO:0001786 phosphatidylserine binding(GO:0001786) calcium-dependent phospholipid binding(GO:0005544)
0.0 1.2 GO:0043022 ribosome binding(GO:0043022)
0.1 1.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.0 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 1.0 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 1.0 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.2 0.9 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 0.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 0.8 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.1 0.8 GO:0031386 protein tag(GO:0031386)
0.0 0.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.7 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.7 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.4 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.9 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.9 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 2.0 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.8 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.8 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.0 1.7 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.6 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.1 1.3 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 1.1 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 1.1 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.9 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.1 0.8 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 0.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.8 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.8 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.8 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 0.5 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.5 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing