Motif ID: Evx2

Z-value: 0.843


Transcription factors associated with Evx2:

Gene SymbolEntrez IDGene Name
Evx2 ENSMUSG00000001815.9 Evx2



Activity profile for motif Evx2.

activity profile for motif Evx2


Sorted Z-values histogram for motif Evx2

Sorted Z-values for motif Evx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Evx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 67 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 5.873 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr4_+_109978004 5.727 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr13_+_51645232 3.867 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr5_-_98030727 3.776 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr2_+_119047116 3.257 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr2_+_119047129 3.044 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr7_+_51879041 2.964 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr2_-_168767136 2.887 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chrX_+_58030999 2.638 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr2_+_154548888 2.431 ENSMUST00000045116.4
ENSMUST00000109709.3
 1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr14_+_62292475 2.412 ENSMUST00000166879.1
 Rnaseh2b
ribonuclease H2, subunit B
chr18_-_88927447 2.390 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6
chrX_+_58030622 2.046 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr9_-_66514567 1.860 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr2_-_132247747 1.755 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
 Tmem230


transmembrane protein 230


chr15_+_34453285 1.727 ENSMUST00000060894.7
 BC030476
cDNA sequence BC030476
chr4_-_132075250 1.640 ENSMUST00000105970.1
ENSMUST00000105975.1
 Epb4.1

erythrocyte protein band 4.1

chr11_+_60537978 1.583 ENSMUST00000044250.3
 Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr17_+_17402672 1.540 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr4_-_42661893 1.439 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.9 GO:0007530 sex determination(GO:0007530)
0.4 5.7 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.8 4.7 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.2 4.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 3.9 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1 3.8 GO:1901998 toxin transport(GO:1901998)
0.0 3.0 GO:0007050 cell cycle arrest(GO:0007050)
0.1 2.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 2.4 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 1.8 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 1.8 GO:0048489 synaptic vesicle transport(GO:0048489) establishment of synaptic vesicle localization(GO:0097480)
0.4 1.6 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.0 1.5 GO:0097352 autophagosome maturation(GO:0097352)
0.1 1.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3 1.1 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.3 1.0 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.2 1.0 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.9 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.8 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 4.8 GO:0000792 heterochromatin(GO:0000792)
0.0 4.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 2.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 2.4 GO:0001772 immunological synapse(GO:0001772)
0.0 1.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 1.8 GO:0055037 recycling endosome(GO:0055037)
0.0 1.3 GO:0005844 polysome(GO:0005844)
0.1 1.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.8 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.7 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.5 GO:0033503 HULC complex(GO:0033503)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 5.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 4.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.0 3.9 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 3.9 GO:0008017 microtubule binding(GO:0008017)
0.3 2.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 2.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.3 1.8 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.4 1.6 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 1.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 1.1 GO:0043495 protein anchor(GO:0043495)
0.0 1.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 0.9 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 0.7 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 0.6 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.5 GO:0008373 sialyltransferase activity(GO:0008373)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 3.8 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 3.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.8 PID_EPHA_FWDPATHWAY EPHA forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 3.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 2.1 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.6 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 0.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels