Motif ID: Evx2

Z-value: 0.843


Transcription factors associated with Evx2:

Gene SymbolEntrez IDGene Name
Evx2 ENSMUSG00000001815.9 Evx2



Activity profile for motif Evx2.

activity profile for motif Evx2


Sorted Z-values histogram for motif Evx2

Sorted Z-values for motif Evx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Evx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_60893430 5.873 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr4_+_109978004 5.727 ENSMUST00000061187.3
Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr13_+_51645232 3.867 ENSMUST00000075853.5
Cks2
CDC28 protein kinase regulatory subunit 2
chr5_-_98030727 3.776 ENSMUST00000031281.9
Antxr2
anthrax toxin receptor 2
chr2_+_119047116 3.257 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5

cancer susceptibility candidate 5

chr2_+_119047129 3.044 ENSMUST00000153300.1
ENSMUST00000028799.5
Casc5

cancer susceptibility candidate 5

chr7_+_51879041 2.964 ENSMUST00000107591.2
Gas2
growth arrest specific 2
chr2_-_168767136 2.887 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chrX_+_58030999 2.638 ENSMUST00000088631.4
ENSMUST00000088629.3
Zic3

zinc finger protein of the cerebellum 3

chr2_+_154548888 2.431 ENSMUST00000045116.4
ENSMUST00000109709.3
1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr14_+_62292475 2.412 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chr18_-_88927447 2.390 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6
chrX_+_58030622 2.046 ENSMUST00000088627.4
Zic3
zinc finger protein of the cerebellum 3
chr9_-_66514567 1.860 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chr2_-_132247747 1.755 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
Tmem230


transmembrane protein 230


chr15_+_34453285 1.727 ENSMUST00000060894.7
BC030476
cDNA sequence BC030476
chr4_-_132075250 1.640 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1

erythrocyte protein band 4.1

chr11_+_60537978 1.583 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr17_+_17402672 1.540 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr4_-_42661893 1.439 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr10_+_80264942 1.350 ENSMUST00000105362.1
ENSMUST00000105361.3
Dazap1

DAZ associated protein 1

chr2_-_168767029 1.325 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr12_+_52699297 1.147 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr4_-_129227883 1.070 ENSMUST00000106051.1
C77080
expressed sequence C77080
chr14_+_73173825 1.012 ENSMUST00000166875.1
Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr10_-_8886033 0.998 ENSMUST00000015449.5
Sash1
SAM and SH3 domain containing 1
chr4_+_140701466 0.975 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr16_-_45724600 0.956 ENSMUST00000096057.4
Tagln3
transgelin 3
chr4_-_132345686 0.913 ENSMUST00000030726.6
Rcc1
regulator of chromosome condensation 1
chr4_-_132345715 0.856 ENSMUST00000084250.4
Rcc1
regulator of chromosome condensation 1
chr5_-_84417359 0.820 ENSMUST00000113401.1
Epha5
Eph receptor A5
chr19_+_5088534 0.817 ENSMUST00000025811.4
Yif1a
Yip1 interacting factor homolog A (S. cerevisiae)
chr17_+_36837123 0.815 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
Trim26





tripartite motif-containing 26





chr11_-_61267177 0.745 ENSMUST00000066277.3
ENSMUST00000074127.7
ENSMUST00000108715.2
Aldh3a2


aldehyde dehydrogenase family 3, subfamily A2


chr9_-_85749308 0.621 ENSMUST00000039213.8
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chrX_-_111536325 0.615 ENSMUST00000156639.1
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr7_-_126800354 0.578 ENSMUST00000106348.1
Aldoa
aldolase A, fructose-bisphosphate
chr11_+_75532099 0.576 ENSMUST00000169547.2
Slc43a2
solute carrier family 43, member 2
chr1_-_24612700 0.548 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr4_+_100478806 0.531 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr6_+_72097561 0.526 ENSMUST00000069994.4
ENSMUST00000114112.1
St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr2_+_91257323 0.484 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr7_-_143460989 0.460 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr2_+_91256813 0.417 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
Pacsin3



protein kinase C and casein kinase substrate in neurons 3



chr12_-_98577940 0.412 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr13_+_38204928 0.408 ENSMUST00000091641.5
ENSMUST00000178564.1
Snrnp48

small nuclear ribonucleoprotein 48 (U11/U12)

chr7_+_27927592 0.392 ENSMUST00000181644.1
Gm26891
predicted gene, 26891
chr14_+_48446128 0.364 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chrM_+_10167 0.340 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr19_+_47067721 0.288 ENSMUST00000026027.5
Taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr14_-_59365410 0.247 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d

PHD finger protein 11D

chr2_-_150255591 0.243 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr7_+_29816061 0.175 ENSMUST00000032796.6
ENSMUST00000178162.1
Zfp790

zinc finger protein 790

chr18_+_9958147 0.174 ENSMUST00000025137.7
Thoc1
THO complex 1
chr11_+_116843278 0.173 ENSMUST00000106370.3
Mettl23
methyltransferase like 23
chr3_+_94837702 0.172 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
Pogz


pogo transposable element with ZNF domain


chrM_+_7759 0.158 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr8_+_14888022 0.152 ENSMUST00000123990.1
ENSMUST00000027554.7
Cln8

ceroid-lipofuscinosis, neuronal 8

chr8_-_31168699 0.140 ENSMUST00000033983.4
Mak16
MAK16 homolog (S. cerevisiae)
chr15_-_58034289 0.125 ENSMUST00000100655.3
9130401M01Rik
RIKEN cDNA 9130401M01 gene
chr5_-_106926245 0.118 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr17_-_36032682 0.078 ENSMUST00000102678.4
H2-T23
histocompatibility 2, T region locus 23
chr8_+_92855319 0.061 ENSMUST00000046290.1
Lpcat2
lysophosphatidylcholine acyltransferase 2
chr6_-_69284319 0.052 ENSMUST00000103349.1
Igkv4-69
immunoglobulin kappa variable 4-69
chr3_-_130709419 0.026 ENSMUST00000043937.7
Ostc
oligosaccharyltransferase complex subunit
chr10_+_70175011 0.021 ENSMUST00000156001.1
ENSMUST00000135607.1
Ccdc6

coiled-coil domain containing 6

chr3_+_121291725 0.007 ENSMUST00000039442.7
Alg14
asparagine-linked glycosylation 14

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.7 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.4 1.6 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.4 5.7 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.3 1.0 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.3 1.1 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.3 5.9 GO:0007530 sex determination(GO:0007530)
0.2 4.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 1.0 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.1 2.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.7 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.1 0.8 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.1 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.1 3.8 GO:1901998 toxin transport(GO:1901998)
0.1 3.9 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1 0.5 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.1 0.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 1.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.2 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.0 0.6 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 1.5 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.9 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.8 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 2.4 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 3.0 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.1 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 1.8 GO:0048489 synaptic vesicle transport(GO:0048489) establishment of synaptic vesicle localization(GO:0097480)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.7 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 5.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.5 GO:0033503 HULC complex(GO:0033503)
0.1 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 1.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 2.4 GO:0001772 immunological synapse(GO:0001772)
0.0 4.8 GO:0000792 heterochromatin(GO:0000792)
0.0 1.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.8 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 4.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.3 GO:0005844 polysome(GO:0005844)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.8 GO:0055037 recycling endosome(GO:0055037)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.4 1.6 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.3 2.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 1.8 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.2 0.7 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 5.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 0.6 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 1.1 GO:0043495 protein anchor(GO:0043495)
0.1 0.9 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 2.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.1 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.5 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 3.9 GO:0008017 microtubule binding(GO:0008017)
0.0 0.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 4.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 9.9 GO:0043565 sequence-specific DNA binding(GO:0043565)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 3.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 4.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 6.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 2.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 0.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 2.1 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.6 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 1.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase