Motif ID: Ezh2_Atf2_Ikzf1

Z-value: 1.622

Transcription factors associated with Ezh2_Atf2_Ikzf1:

Gene SymbolEntrez IDGene Name
Atf2 ENSMUSG00000027104.12 Atf2
Ezh2 ENSMUSG00000029687.10 Ezh2
Ikzf1 ENSMUSG00000018654.11 Ikzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ezh2mm10_v2_chr6_-_47594967_475950470.758.4e-08Click!
Atf2mm10_v2_chr2_-_73892588_738926160.581.5e-04Click!


Activity profile for motif Ezh2_Atf2_Ikzf1.

activity profile for motif Ezh2_Atf2_Ikzf1


Sorted Z-values histogram for motif Ezh2_Atf2_Ikzf1

Sorted Z-values for motif Ezh2_Atf2_Ikzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ezh2_Atf2_Ikzf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_190170671 22.169 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr6_+_34745952 21.119 ENSMUST00000123823.1
ENSMUST00000136907.1
ENSMUST00000126181.1
 Cald1


caldesmon 1


chr6_+_34746368 17.974 ENSMUST00000142716.1
 Cald1
caldesmon 1
chr14_-_98169542 14.842 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_+_152081529 14.285 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr1_-_190170178 12.756 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr9_-_91365756 10.414 ENSMUST00000034927.6
 Zic1
zinc finger protein of the cerebellum 1
chr3_-_86548268 10.004 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr9_-_91365778 9.525 ENSMUST00000065360.3
 Zic1
zinc finger protein of the cerebellum 1
chr9_-_117252450 9.318 ENSMUST00000111773.3
ENSMUST00000068962.7
ENSMUST00000044901.7
 Rbms3


RNA binding motif, single stranded interacting protein


chr14_+_28504736 8.839 ENSMUST00000063465.4
 Wnt5a
wingless-related MMTV integration site 5A
chr15_-_91191733 8.054 ENSMUST00000069511.6
 Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr4_-_110290884 7.771 ENSMUST00000142722.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr17_-_35704000 7.204 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chr16_-_59555752 7.126 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr4_-_110287479 7.113 ENSMUST00000106598.1
ENSMUST00000102723.4
ENSMUST00000153906.1
 Elavl4


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)


chr11_+_44617310 6.660 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr13_-_78199757 6.583 ENSMUST00000091458.6
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr5_-_106458440 6.472 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr11_-_84525514 5.926 ENSMUST00000018842.7
 Lhx1
LIM homeobox protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 424 entries
Log-likelihood per target Total log-likelihoodTermDescription
12.3 36.8 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.4 25.0 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.4 20.2 GO:0007628 adult walking behavior(GO:0007628)
0.5 19.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 18.1 GO:0043488 regulation of mRNA stability(GO:0043488)
1.0 15.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
4.9 14.8 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
4.9 14.8 GO:0060067 cervix development(GO:0060067)
0.3 14.3 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 12.9 GO:0045727 positive regulation of translation(GO:0045727)
1.0 12.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.9 12.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.5 11.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
1.2 10.6 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
1.5 9.2 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
2.0 8.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.7 7.9 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
2.6 7.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.7 7.3 GO:0060539 diaphragm development(GO:0060539)
0.3 7.1 GO:0035855 megakaryocyte development(GO:0035855)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 134.5 GO:0005634 nucleus(GO:0005634)
4.6 41.7 GO:0030478 actin cap(GO:0030478)
1.4 20.3 GO:0042788 polysomal ribosome(GO:0042788)
0.1 11.9 GO:0032993 protein-DNA complex(GO:0032993)
0.1 9.4 GO:0005814 centriole(GO:0005814)
0.2 8.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 8.2 GO:0051233 spindle midzone(GO:0051233)
0.1 7.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.6 7.0 GO:0032584 growth cone membrane(GO:0032584)
0.0 6.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.6 6.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.3 6.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 5.9 GO:0005657 replication fork(GO:0005657)
0.6 5.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 4.8 GO:0036064 ciliary basal body(GO:0036064)
0.0 4.4 GO:0005813 centrosome(GO:0005813)
0.2 4.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 4.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.9 3.7 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.3 3.7 GO:0000974 Prp19 complex(GO:0000974)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 256 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 40.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
3.1 36.8 GO:0050693 LBD domain binding(GO:0050693)
0.2 33.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.9 20.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.6 20.6 GO:0017091 AU-rich element binding(GO:0017091)
0.0 20.2 GO:0003779 actin binding(GO:0003779)
0.4 16.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.9 15.5 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
1.5 13.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 10.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 10.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 10.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
2.9 8.8 GO:0005110 frizzled-2 binding(GO:0005110)
0.3 8.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 8.4 GO:0001047 core promoter binding(GO:0001047)
0.3 8.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.7 7.9 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 7.4 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3 6.4 GO:0045295 gamma-catenin binding(GO:0045295)
1.0 5.8 GO:0005042 netrin receptor activity(GO:0005042)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 10.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.3 9.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 7.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 7.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.2 5.5 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 4.5 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 4.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 4.1 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 4.1 PID_PLK1_PATHWAY PLK1 signaling events
0.1 3.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.8 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 3.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.3 2.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 40.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 11.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 10.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 7.0 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.6 6.6 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.3 6.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 5.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 5.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 5.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 4.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 3.6 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3 3.4 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 3.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 2.9 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 2.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.6 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 2.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix