Motif ID: Figla

Z-value: 0.755


Transcription factors associated with Figla:

Gene SymbolEntrez IDGene Name
Figla ENSMUSG00000030001.3 Figla



Activity profile for motif Figla.

activity profile for motif Figla


Sorted Z-values histogram for motif Figla

Sorted Z-values for motif Figla



Network of associatons between targets according to the STRING database.



First level regulatory network of Figla

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 6.935 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr2_+_164769892 6.529 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr15_-_78773452 5.938 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr11_+_99864476 5.279 ENSMUST00000092694.3
 Gm11559
predicted gene 11559
chr1_+_74791516 4.757 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr1_-_119053339 4.718 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr5_+_123749696 4.181 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr13_-_100786402 3.795 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr8_+_127064107 3.355 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr6_+_47244359 3.242 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr12_+_109459843 3.134 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chrX_-_23266751 3.077 ENSMUST00000115316.2
 Klhl13
kelch-like 13
chr15_+_25622525 3.041 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr17_-_35700520 2.874 ENSMUST00000119825.1
 Ddr1
discoidin domain receptor family, member 1
chr7_-_127218390 2.824 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr9_+_91368970 2.781 ENSMUST00000172646.1
 Zic4
zinc finger protein of the cerebellum 4
chr4_+_11156411 2.741 ENSMUST00000029865.3
 Trp53inp1
transformation related protein 53 inducible nuclear protein 1
chr6_+_105677745 2.623 ENSMUST00000113261.2
ENSMUST00000113264.2
 Cntn4

contactin 4

chr7_-_127218303 2.494 ENSMUST00000106313.1
 Sept1
septin 1
chr2_-_62483637 2.435 ENSMUST00000136686.1
ENSMUST00000102733.3
 Gcg

glucagon


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 6.5 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.5 5.9 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.3 5.3 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.4 4.8 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 4.5 GO:0048706 embryonic skeletal system development(GO:0048706)
1.1 4.4 GO:0060032 notochord regression(GO:0060032)
1.3 3.8 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.6 3.4 GO:0003383 apical constriction(GO:0003383)
0.4 3.4 GO:0030035 microspike assembly(GO:0030035)
0.6 3.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.6 3.2 GO:0035063 nuclear speck organization(GO:0035063)
0.2 3.2 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 3.1 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 3.1 GO:0000910 cytokinesis(GO:0000910)
0.0 3.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 2.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.9 2.7 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.2 2.5 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 2.5 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.3 2.4 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 5.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.6 5.3 GO:0072687 meiotic spindle(GO:0072687)
0.0 5.3 GO:0030496 midbody(GO:0030496)
0.3 4.4 GO:0097542 ciliary tip(GO:0097542)
1.4 4.2 GO:1990423 RZZ complex(GO:1990423)
0.1 4.1 GO:0030673 axolemma(GO:0030673)
0.9 3.8 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.4 3.4 GO:0033269 internode region of axon(GO:0033269)
0.0 3.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.7 GO:0005776 autophagosome(GO:0005776)
0.0 2.4 GO:0016459 myosin complex(GO:0016459)
0.0 2.4 GO:0031985 Golgi cisterna(GO:0031985)
0.0 2.4 GO:0016605 PML body(GO:0016605)
0.0 2.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 2.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 2.1 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 1.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.3 1.4 GO:0035189 Rb-E2F complex(GO:0035189)
0.2 1.4 GO:0044305 calyx of Held(GO:0044305)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
2.0 5.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 4.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 4.8 GO:0005109 frizzled binding(GO:0005109)
0.0 4.0 GO:0005525 GTP binding(GO:0005525)
0.9 3.8 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 3.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 3.2 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 3.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 3.0 GO:0030507 spectrin binding(GO:0030507)
0.3 2.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 2.9 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.7 GO:0016209 antioxidant activity(GO:0016209)
0.0 2.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 2.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.4 2.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 2.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 2.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.6 GO:0002020 protease binding(GO:0002020)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 4.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 4.1 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 3.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 3.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.5 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 2.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.3 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 2.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.5 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.2 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.0 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.9 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 0.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 11.3 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.2 5.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 5.1 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 4.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 4.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 3.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 3.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 3.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 2.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.8 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.1 2.4 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.9 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.8 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 1.8 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.0 1.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.4 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.3 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.3 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS Genes involved in RNA Polymerase II Pre-transcription Events