Motif ID: Fli1

Z-value: 1.016


Transcription factors associated with Fli1:

Gene SymbolEntrez IDGene Name
Fli1 ENSMUSG00000016087.7 Fli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fli1mm10_v2_chr9_-_32541589_32541602-0.271.0e-01Click!


Activity profile for motif Fli1.

activity profile for motif Fli1


Sorted Z-values histogram for motif Fli1

Sorted Z-values for motif Fli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Fli1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_175491130 26.105 ENSMUST00000027812.5
Rgs7
regulator of G protein signaling 7
chr10_+_26229707 23.384 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr7_-_140082489 8.620 ENSMUST00000026541.7
Caly
calcyon neuron-specific vesicular protein
chr9_+_74848437 6.748 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
Gm16551


Gm20649
predicted gene 16551


predicted gene 20649
chr5_-_36398090 5.066 ENSMUST00000037370.7
ENSMUST00000070720.6
Sorcs2

sortilin-related VPS10 domain containing receptor 2

chr8_+_23035116 4.912 ENSMUST00000117296.1
ENSMUST00000141784.2
Ank1

ankyrin 1, erythroid

chr11_-_100759942 4.846 ENSMUST00000107363.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr11_-_100759740 4.584 ENSMUST00000107361.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr17_+_79051906 4.224 ENSMUST00000040789.4
Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr8_+_23035099 3.944 ENSMUST00000117662.1
Ank1
ankyrin 1, erythroid
chr11_-_68927049 3.587 ENSMUST00000038932.7
Odf4
outer dense fiber of sperm tails 4
chr4_+_43406435 3.322 ENSMUST00000098106.2
ENSMUST00000139198.1
Rusc2

RUN and SH3 domain containing 2

chr1_-_126492900 3.141 ENSMUST00000161954.1
Nckap5
NCK-associated protein 5
chrX_-_136868537 3.071 ENSMUST00000058814.6
Rab9b
RAB9B, member RAS oncogene family
chrX_-_72656135 3.045 ENSMUST00000055966.6
Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr15_-_76126538 2.766 ENSMUST00000054022.5
ENSMUST00000089654.3
BC024139

cDNA sequence BC024139

chr16_-_42340595 2.726 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr1_+_182763961 2.725 ENSMUST00000153348.1
Susd4
sushi domain containing 4
chr8_+_106870827 2.660 ENSMUST00000176144.1
ENSMUST00000175987.1
Has3

hyaluronan synthase 3

chr4_-_41697040 2.516 ENSMUST00000102962.3
ENSMUST00000084701.5
Cntfr

ciliary neurotrophic factor receptor

chr17_-_53539411 2.511 ENSMUST00000056198.3
Pp2d1
protein phosphatase 2C-like domain containing 1
chr15_-_76521902 2.466 ENSMUST00000164703.1
ENSMUST00000096365.3
Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr2_+_65845767 2.383 ENSMUST00000122912.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr2_+_65845833 2.193 ENSMUST00000053910.3
Csrnp3
cysteine-serine-rich nuclear protein 3
chr15_-_97020322 1.963 ENSMUST00000166223.1
Slc38a4
solute carrier family 38, member 4
chr5_-_106458440 1.922 ENSMUST00000086795.6
Barhl2
BarH-like 2 (Drosophila)
chr1_+_42952872 1.848 ENSMUST00000179766.1
Gpr45
G protein-coupled receptor 45
chr7_+_24862193 1.490 ENSMUST00000052897.4
ENSMUST00000170837.2
Gm9844
Gm9844
predicted pseudogene 9844
predicted pseudogene 9844
chr6_-_77979652 1.489 ENSMUST00000161846.1
ENSMUST00000160894.1
Ctnna2

catenin (cadherin associated protein), alpha 2

chr1_-_180330550 1.469 ENSMUST00000050581.3
Gm5069
predicted pseudogene 5069
chr12_+_3807076 1.442 ENSMUST00000174817.1
Dnmt3a
DNA methyltransferase 3A
chr12_+_3807017 1.426 ENSMUST00000020991.8
ENSMUST00000172509.1
Dnmt3a

DNA methyltransferase 3A

chr7_+_3390629 1.416 ENSMUST00000182222.1
Cacng8
calcium channel, voltage-dependent, gamma subunit 8
chr6_-_77979515 1.395 ENSMUST00000159626.1
ENSMUST00000075340.5
ENSMUST00000162273.1
Ctnna2


catenin (cadherin associated protein), alpha 2


chr6_-_120822680 1.366 ENSMUST00000019354.8
Atp6v1e1
ATPase, H+ transporting, lysosomal V1 subunit E1
chr3_+_159839729 1.364 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr11_-_106998483 1.318 ENSMUST00000124541.1
Kpna2
karyopherin (importin) alpha 2
chr14_+_70077375 1.206 ENSMUST00000035908.1
Egr3
early growth response 3
chr4_+_109280266 1.191 ENSMUST00000102729.3
Eps15
epidermal growth factor receptor pathway substrate 15
chr9_+_111439063 1.131 ENSMUST00000111879.3
Dclk3
doublecortin-like kinase 3
chr9_+_104569754 1.128 ENSMUST00000077190.6
Cpne4
copine IV
chr9_+_104569671 1.099 ENSMUST00000057742.8
Cpne4
copine IV
chr5_+_117133567 1.067 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
Taok3


TAO kinase 3


chr2_-_6951680 1.067 ENSMUST00000076071.2
Gm10115
predicted gene 10115
chrX_+_123793665 1.027 ENSMUST00000178148.1
Gm5167
predicted gene 5167
chr18_-_75697639 0.997 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor
chr10_-_85957775 0.961 ENSMUST00000001834.3
Rtcb
RNA 2',3'-cyclic phosphate and 5'-OH ligase
chr13_-_51203065 0.942 ENSMUST00000091708.4
Hist1h2al
histone cluster 1, H2al
chr13_+_55464237 0.930 ENSMUST00000046533.7
Prr7
proline rich 7 (synaptic)
chrX_+_123581700 0.929 ENSMUST00000178457.1
Gm6604
predicted gene 6604
chr10_+_21993890 0.906 ENSMUST00000092673.4
Sgk1
serum/glucocorticoid regulated kinase 1
chr1_+_134182404 0.865 ENSMUST00000153856.1
ENSMUST00000082060.3
ENSMUST00000133701.1
ENSMUST00000132873.1
Chi3l1



chitinase 3-like 1



chr10_-_71285234 0.793 ENSMUST00000020085.6
Ube2d1
ubiquitin-conjugating enzyme E2D 1
chr5_+_127632238 0.760 ENSMUST00000118139.1
Glt1d1
glycosyltransferase 1 domain containing 1
chr6_-_28831747 0.748 ENSMUST00000062304.5
Lrrc4
leucine rich repeat containing 4
chr1_+_42953106 0.739 ENSMUST00000179655.1
Gpr45
G protein-coupled receptor 45
chr18_+_35536539 0.723 ENSMUST00000081864.3
Gm5239
predicted pseudogene 5239
chr2_-_137116624 0.715 ENSMUST00000028735.7
Jag1
jagged 1
chr1_+_44551483 0.708 ENSMUST00000074525.3
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr7_-_141214080 0.698 ENSMUST00000026573.5
ENSMUST00000170841.1
1600016N20Rik

RIKEN cDNA 1600016N20 gene

chr10_+_78393298 0.646 ENSMUST00000072739.4
Gm10146
predicted gene 10146
chr11_-_5915124 0.638 ENSMUST00000109823.2
ENSMUST00000109822.1
Gck

glucokinase

chr2_+_152962485 0.615 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9

tubulin tyrosine ligase-like family, member 9

chr11_+_17257558 0.597 ENSMUST00000000594.2
ENSMUST00000156784.1
C1d

C1D nuclear receptor co-repressor

chr15_-_98763195 0.564 ENSMUST00000053183.9
Arf3
ADP-ribosylation factor 3
chr12_+_3806513 0.552 ENSMUST00000172719.1
Dnmt3a
DNA methyltransferase 3A
chr8_+_83997613 0.546 ENSMUST00000095228.3
Samd1
sterile alpha motif domain containing 1
chrX_-_167209149 0.545 ENSMUST00000112176.1
Tmsb4x
thymosin, beta 4, X chromosome
chr2_-_165287755 0.540 ENSMUST00000109298.1
ENSMUST00000109299.1
ENSMUST00000130393.1
ENSMUST00000017808.7
ENSMUST00000131409.1
ENSMUST00000156134.1
ENSMUST00000133961.1
Slc35c2






solute carrier family 35, member C2






chr4_+_109280365 0.537 ENSMUST00000177089.1
ENSMUST00000175776.1
ENSMUST00000132165.2
Eps15


epidermal growth factor receptor pathway substrate 15


chr7_+_110772604 0.467 ENSMUST00000005829.6
Ampd3
adenosine monophosphate deaminase 3
chr2_+_91082362 0.457 ENSMUST00000169852.1
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
chr7_-_4445637 0.453 ENSMUST00000008579.7
Rdh13
retinol dehydrogenase 13 (all-trans and 9-cis)
chr8_-_106893581 0.441 ENSMUST00000176437.1
ENSMUST00000177068.1
ENSMUST00000169312.1
ENSMUST00000176515.1
Chtf8



CTF8, chromosome transmission fidelity factor 8



chr4_+_40723084 0.436 ENSMUST00000149794.1
Dnaja1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr18_-_56975333 0.420 ENSMUST00000139243.2
ENSMUST00000025488.8
C330018D20Rik

RIKEN cDNA C330018D20 gene

chr8_-_106893515 0.420 ENSMUST00000176090.1
Chtf8
CTF8, chromosome transmission fidelity factor 8
chr2_+_131186942 0.417 ENSMUST00000028804.8
ENSMUST00000079857.8
Cdc25b

cell division cycle 25B

chr2_-_51934644 0.406 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr6_+_142414012 0.400 ENSMUST00000141548.1
B230216G23Rik
RIKEN cDNA B230216G23 gene
chr7_+_35186370 0.395 ENSMUST00000135452.1
ENSMUST00000001854.5
Slc7a10

solute carrier family 7 (cationic amino acid transporter, y+ system), member 10

chr8_+_106893616 0.381 ENSMUST00000047629.5
Cirh1a
cirrhosis, autosomal recessive 1A (human)
chr15_-_98762992 0.380 ENSMUST00000156572.1
Arf3
ADP-ribosylation factor 3
chr11_+_87595646 0.373 ENSMUST00000134216.1
Mtmr4
myotubularin related protein 4
chr13_+_42709482 0.373 ENSMUST00000066928.5
ENSMUST00000148891.1
Phactr1

phosphatase and actin regulator 1

chr11_-_74723829 0.350 ENSMUST00000102520.2
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr4_+_40722912 0.345 ENSMUST00000164233.1
ENSMUST00000137246.1
ENSMUST00000125442.1
Dnaja1


DnaJ (Hsp40) homolog, subfamily A, member 1


chr10_+_69533761 0.344 ENSMUST00000182884.1
Ank3
ankyrin 3, epithelial
chr2_+_181520485 0.337 ENSMUST00000072334.5
Dnajc5
DnaJ (Hsp40) homolog, subfamily C, member 5
chr15_-_73184840 0.314 ENSMUST00000044113.10
Ago2
argonaute RISC catalytic subunit 2
chr5_-_136198908 0.310 ENSMUST00000149151.1
ENSMUST00000151786.1
Prkrip1

Prkr interacting protein 1 (IL11 inducible)

chr18_+_61953048 0.306 ENSMUST00000051720.5
Sh3tc2
SH3 domain and tetratricopeptide repeats 2
chr6_-_145250177 0.306 ENSMUST00000111710.1
ENSMUST00000155145.1
ENSMUST00000032399.5
Kras


v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog


chr11_+_32000496 0.289 ENSMUST00000093219.3
Nsg2
neuron specific gene family member 2
chr12_+_100199435 0.281 ENSMUST00000110082.3
Calm1
calmodulin 1
chr4_-_149454971 0.261 ENSMUST00000030848.2
Rbp7
retinol binding protein 7, cellular
chr1_+_44551650 0.258 ENSMUST00000160854.1
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr4_+_42158092 0.254 ENSMUST00000098122.2
Gm13306
predicted gene 13306
chr7_+_28440927 0.252 ENSMUST00000078845.6
Gmfg
glia maturation factor, gamma
chr3_-_122619442 0.248 ENSMUST00000162947.1
Fnbp1l
formin binding protein 1-like
chr7_+_116093296 0.243 ENSMUST00000032899.5
1110004F10Rik
RIKEN cDNA 1110004F10 gene
chr12_-_75596195 0.239 ENSMUST00000021447.7
Ppp2r5e
protein phosphatase 2, regulatory subunit B (B56), epsilon isoform
chr3_+_89136572 0.234 ENSMUST00000107482.3
ENSMUST00000127058.1
Pklr

pyruvate kinase liver and red blood cell

chr19_-_46044914 0.231 ENSMUST00000026252.7
Ldb1
LIM domain binding 1
chr4_+_42655251 0.220 ENSMUST00000177785.1
Ccl27b
chemokine (C-C motif) ligand 27b
chr8_-_107439585 0.215 ENSMUST00000077208.4
Rps26-ps1
ribosomal protein S26, pseudogene 1
chr14_-_52305056 0.205 ENSMUST00000174853.1
ENSMUST00000022767.9
Mettl3

methyltransferase like 3

chr7_+_110773658 0.203 ENSMUST00000143786.1
Ampd3
adenosine monophosphate deaminase 3
chr17_+_48346465 0.197 ENSMUST00000113237.3
Trem2
triggering receptor expressed on myeloid cells 2
chr10_+_84756055 0.161 ENSMUST00000060397.6
Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr5_+_92137896 0.139 ENSMUST00000031355.6
Uso1
USO1 vesicle docking factor
chr19_+_8735808 0.135 ENSMUST00000049424.9
Wdr74
WD repeat domain 74
chr17_+_48346401 0.134 ENSMUST00000024791.8
Trem2
triggering receptor expressed on myeloid cells 2
chr9_+_70678950 0.124 ENSMUST00000067880.6
Adam10
a disintegrin and metallopeptidase domain 10
chr6_-_88446491 0.123 ENSMUST00000165242.1
Eefsec
eukaryotic elongation factor, selenocysteine-tRNA-specific
chr19_-_46045194 0.121 ENSMUST00000156585.1
ENSMUST00000152946.1
Ldb1

LIM domain binding 1

chr6_-_12109583 0.104 ENSMUST00000080891.5
Gm6578
predicted gene 6578
chr4_+_115057410 0.102 ENSMUST00000136946.1
Tal1
T cell acute lymphocytic leukemia 1
chr9_-_106789130 0.099 ENSMUST00000046502.5
Rad54l2
RAD54 like 2 (S. cerevisiae)
chrX_-_8175890 0.075 ENSMUST00000143984.1
Tbc1d25
TBC1 domain family, member 25
chr3_+_122245557 0.072 ENSMUST00000029769.7
Gclm
glutamate-cysteine ligase, modifier subunit
chr9_-_62811592 0.071 ENSMUST00000034775.8
Fem1b
feminization 1 homolog b (C. elegans)
chr14_+_54883377 0.067 ENSMUST00000022806.3
ENSMUST00000172844.1
ENSMUST00000133397.2
ENSMUST00000134077.1
Bcl2l2


Gm20521
BCL2-like 2


predicted gene 20521
chr10_+_84917616 0.049 ENSMUST00000038523.7
ENSMUST00000095385.3
Ric8b

resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)

chr16_-_36666067 0.046 ENSMUST00000089620.4
Cd86
CD86 antigen
chr13_+_109260481 0.041 ENSMUST00000153234.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr9_+_72532609 0.039 ENSMUST00000183372.1
ENSMUST00000184015.1
Rfx7

regulatory factor X, 7

chr1_-_181183739 0.038 ENSMUST00000159290.1
Wdr26
WD repeat domain 26
chr11_-_100354040 0.030 ENSMUST00000173630.1
Hap1
huntingtin-associated protein 1
chr4_+_145585166 0.014 ENSMUST00000105739.1
ENSMUST00000119718.1
Gm13212

predicted gene 13212

chr9_+_44107286 0.009 ENSMUST00000152956.1
ENSMUST00000114815.1
C1qtnf5

C1q and tumor necrosis factor related protein 5

chr13_+_118714678 0.007 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chr10_+_24595434 0.006 ENSMUST00000020171.5
Ctgf
connective tissue growth factor
chrX_+_109095359 0.005 ENSMUST00000033598.8
Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr5_-_120711927 0.003 ENSMUST00000031607.6
Dtx1
deltex 1 homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.9 2.7 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.7 2.7 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.6 2.5 GO:0003360 brainstem development(GO:0003360)
0.5 3.9 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.5 1.4 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.4 10.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 2.7 GO:0016198 axon choice point recognition(GO:0016198)
0.2 2.9 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.2 8.9 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.2 0.6 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.2 26.1 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 0.7 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.5 GO:0015786 UDP-glucose transport(GO:0015786)
0.1 0.3 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499)
0.1 1.2 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 3.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.4 GO:0015825 L-serine transport(GO:0015825)
0.1 0.7 GO:0032261 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.1 0.9 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.4 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.1 0.8 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 0.3 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 1.0 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.9 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 1.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 0.3 GO:2000774 positive regulation of Rac protein signal transduction(GO:0035022) positive regulation of cellular senescence(GO:2000774)
0.1 0.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 0.4 GO:0007144 female meiosis I(GO:0007144)
0.1 2.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 4.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.4 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.7 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.0 2.5 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.2 GO:1904690 adenosine to inosine editing(GO:0006382) regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.0 0.2 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.2 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 3.1 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.1 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.0 0.1 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.9 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 1.0 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.0 0.3 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 1.9 GO:0030516 regulation of axon extension(GO:0030516)
0.0 0.6 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.0 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 6.3 GO:0042391 regulation of membrane potential(GO:0042391)
0.0 0.8 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 2.6 GO:0006470 protein dephosphorylation(GO:0006470)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 26.1 GO:0044292 dendrite terminus(GO:0044292)
0.8 2.5 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.4 3.6 GO:0001520 outer dense fiber(GO:0001520)
0.4 8.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 3.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 3.4 GO:0001741 XY body(GO:0001741)
0.1 1.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.9 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 2.1 GO:0031527 filopodium membrane(GO:0031527)
0.1 1.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 1.4 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.1 0.4 GO:0000235 astral microtubule(GO:0000235)
0.0 3.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.6 GO:0045180 basal cortex(GO:0045180)
0.0 0.2 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 1.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.3 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.1 GO:0033193 Lsd1/2 complex(GO:0033193)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.6 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 13.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.5 GO:0005801 cis-Golgi network(GO:0005801)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 25.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
1.1 8.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.1 8.7 GO:0032051 clathrin light chain binding(GO:0032051)
0.9 2.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.4 3.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.4 2.5 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.3 4.2 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.3 1.4 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 3.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 0.8 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 9.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 1.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.9 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 0.6 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.1 0.3 GO:0019002 GMP binding(GO:0019002)
0.1 1.0 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.1 0.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.3 GO:0070891 peptidoglycan binding(GO:0042834) lipoteichoic acid binding(GO:0070891)
0.1 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.5 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.3 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.1 2.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.2 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.1 0.9 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 0.4 GO:0030274 LIM domain binding(GO:0030274)
0.0 3.1 GO:0019003 GDP binding(GO:0019003)
0.0 0.3 GO:0019841 retinol binding(GO:0019841)
0.0 1.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 2.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.3 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340) siRNA binding(GO:0035197)
0.0 0.4 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 2.0 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.7 GO:0005112 Notch binding(GO:0005112)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 0.9 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 2.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.2 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.2 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.9 PID_INSULIN_PATHWAY Insulin Pathway
0.0 1.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.7 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 8.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 3.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 26.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 2.7 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 2.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 0.8 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 0.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.8 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.7 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.3 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.8 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.2 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.3 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.2 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions