Motif ID: Fli1

Z-value: 1.016


Transcription factors associated with Fli1:

Gene SymbolEntrez IDGene Name
Fli1 ENSMUSG00000016087.7 Fli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fli1mm10_v2_chr9_-_32541589_32541602-0.271.0e-01Click!


Activity profile for motif Fli1.

activity profile for motif Fli1


Sorted Z-values histogram for motif Fli1

Sorted Z-values for motif Fli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Fli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 135 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_175491130 26.105 ENSMUST00000027812.5
 Rgs7
regulator of G protein signaling 7
chr10_+_26229707 23.384 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr7_-_140082489 8.620 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr9_+_74848437 6.748 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
 Gm16551


Gm20649
predicted gene 16551


predicted gene 20649
chr5_-_36398090 5.066 ENSMUST00000037370.7
ENSMUST00000070720.6
 Sorcs2

sortilin-related VPS10 domain containing receptor 2

chr8_+_23035116 4.912 ENSMUST00000117296.1
ENSMUST00000141784.2
 Ank1

ankyrin 1, erythroid

chr11_-_100759942 4.846 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr11_-_100759740 4.584 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr17_+_79051906 4.224 ENSMUST00000040789.4
 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr8_+_23035099 3.944 ENSMUST00000117662.1
 Ank1
ankyrin 1, erythroid
chr11_-_68927049 3.587 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr4_+_43406435 3.322 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr1_-_126492900 3.141 ENSMUST00000161954.1
 Nckap5
NCK-associated protein 5
chrX_-_136868537 3.071 ENSMUST00000058814.6
 Rab9b
RAB9B, member RAS oncogene family
chrX_-_72656135 3.045 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr15_-_76126538 2.766 ENSMUST00000054022.5
ENSMUST00000089654.3
 BC024139

cDNA sequence BC024139

chr16_-_42340595 2.726 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr1_+_182763961 2.725 ENSMUST00000153348.1
 Susd4
sushi domain containing 4
chr8_+_106870827 2.660 ENSMUST00000176144.1
ENSMUST00000175987.1
 Has3

hyaluronan synthase 3

chr4_-_41697040 2.516 ENSMUST00000102962.3
ENSMUST00000084701.5
 Cntfr

ciliary neurotrophic factor receptor


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.1 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.4 10.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.2 8.9 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.0 6.3 GO:0042391 regulation of membrane potential(GO:0042391)
0.1 4.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.4 4.2 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.5 3.9 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.0 3.1 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 3.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 2.9 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.9 2.7 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.7 2.7 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.3 2.7 GO:0016198 axon choice point recognition(GO:0016198)
0.0 2.6 GO:0006470 protein dephosphorylation(GO:0006470)
0.6 2.5 GO:0003360 brainstem development(GO:0003360)
0.0 2.5 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 2.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 1.9 GO:0030516 regulation of axon extension(GO:0030516)
0.5 1.4 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.1 1.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 26.1 GO:0044292 dendrite terminus(GO:0044292)
0.0 13.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.4 8.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.4 3.6 GO:0001520 outer dense fiber(GO:0001520)
0.1 3.4 GO:0001741 XY body(GO:0001741)
0.0 3.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 3.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.8 2.5 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 2.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.1 GO:0031527 filopodium membrane(GO:0031527)
0.1 1.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 1.4 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 1.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.1 1.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.9 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.6 GO:0045180 basal cortex(GO:0045180)
0.0 0.6 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.5 GO:0005801 cis-Golgi network(GO:0005801)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 25.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 9.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
1.1 8.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.1 8.7 GO:0032051 clathrin light chain binding(GO:0032051)
0.3 4.2 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.4 3.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 3.1 GO:0019003 GDP binding(GO:0019003)
0.2 3.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 2.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.9 2.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 2.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.4 2.5 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 2.0 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 1.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.3 1.4 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 1.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 1.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 1.0 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.1 0.9 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.7 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.2 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.2 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 0.9 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.9 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 0.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 9.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 8.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 3.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 2.7 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 2.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.2 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 0.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 0.8 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.8 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.8 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.7 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.3 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions