Motif ID: Fosb

Z-value: 0.375


Transcription factors associated with Fosb:

Gene SymbolEntrez IDGene Name
Fosb ENSMUSG00000003545.2 Fosb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosbmm10_v2_chr7_-_19310035_19310050-0.153.8e-01Click!


Activity profile for motif Fosb.

activity profile for motif Fosb


Sorted Z-values histogram for motif Fosb

Sorted Z-values for motif Fosb



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosb

PNG image of the network

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Top targets:


Showing 1 to 20 of 71 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_78930940 1.769 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin


chr10_-_64090241 1.614 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr6_+_17463927 1.312 ENSMUST00000115442.1
 Met
met proto-oncogene
chr8_+_36489191 1.222 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr10_-_64090265 1.190 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr13_-_113663670 1.081 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr8_-_8639363 1.000 ENSMUST00000152698.1
 Efnb2
ephrin B2
chr17_+_35841668 0.884 ENSMUST00000174124.1
 Mdc1
mediator of DNA damage checkpoint 1
chr14_+_80000292 0.708 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr15_-_102257306 0.699 ENSMUST00000135466.1
 Rarg
retinoic acid receptor, gamma
chr3_+_123267445 0.630 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr2_+_118663235 0.627 ENSMUST00000099557.3
 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr6_-_113934679 0.565 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr15_-_102257449 0.564 ENSMUST00000043172.8
 Rarg
retinoic acid receptor, gamma
chr9_+_114978507 0.560 ENSMUST00000183104.1
 Osbpl10
oxysterol binding protein-like 10
chr2_-_45110241 0.520 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr14_+_27622433 0.508 ENSMUST00000090302.5
 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr3_+_55461758 0.498 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr9_+_104566677 0.487 ENSMUST00000157006.1
 Cpne4
copine IV
chr2_-_151632471 0.461 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin







Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.3 1.3 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.2 1.3 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 1.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 1.0 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 0.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.6 GO:0048840 otolith development(GO:0048840)
0.0 0.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.5 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.4 GO:0035937 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.1 0.4 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.4 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.4 GO:0033198 response to ATP(GO:0033198)
0.0 0.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.1 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.2 GO:0090472 dibasic protein processing(GO:0090472)
0.0 0.2 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 0.1 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.3 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.7 GO:0042581 specific granule(GO:0042581)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 0.4 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.2 GO:0045298 tubulin complex(GO:0045298)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0031597 cytosolic proteasome complex(GO:0031597)

Gene overrepresentation in molecular_function category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 1.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 1.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 1.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.4 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 0.4 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.3 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.2 PID_ATM_PATHWAY ATM pathway
0.0 1.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.0 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.4 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.6 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation