Motif ID: Fosl2_Bach2

Z-value: 0.652

Transcription factors associated with Fosl2_Bach2:

Gene SymbolEntrez IDGene Name
Bach2 ENSMUSG00000040270.10 Bach2
Fosl2 ENSMUSG00000029135.9 Fosl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosl2mm10_v2_chr5_+_32136458_321365050.797.6e-09Click!
Bach2mm10_v2_chr4_+_32238950_322389640.411.1e-02Click!


Activity profile for motif Fosl2_Bach2.

activity profile for motif Fosl2_Bach2


Sorted Z-values histogram for motif Fosl2_Bach2

Sorted Z-values for motif Fosl2_Bach2



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosl2_Bach2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_33907721 7.967 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr6_+_17463927 5.595 ENSMUST00000115442.1
 Met
met proto-oncogene
chr14_+_65968483 4.009 ENSMUST00000022616.6
 Clu
clusterin
chr10_-_64090241 3.376 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr18_+_32938955 3.299 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chrY_-_1286563 2.910 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr10_-_64090265 2.877 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr9_+_60712989 2.850 ENSMUST00000038407.5
 Larp6
La ribonucleoprotein domain family, member 6
chr6_-_124769548 2.825 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr9_-_20728219 2.777 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr2_+_156475803 2.771 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr16_-_22439719 2.732 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr14_+_101840602 2.697 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr2_+_156475844 2.657 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr2_-_151632471 2.635 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr14_+_101840501 2.621 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr3_+_55461758 2.521 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr2_-_45110241 2.310 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr7_-_105482197 2.200 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein
chr4_-_42034726 2.068 ENSMUST00000084677.2
 Gm21093
predicted gene, 21093

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 10.3 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
1.3 9.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.2 8.0 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 4.3 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
1.0 4.0 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.3 3.8 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.7 3.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.5 3.3 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 3.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 3.0 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.2 2.9 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.6 2.8 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.5 2.7 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 2.5 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.3 2.0 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.3 2.0 GO:0015862 uridine transport(GO:0015862)
0.0 2.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 1.9 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.6 1.8 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.1 1.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.9 GO:0009925 basal plasma membrane(GO:0009925)
0.0 9.2 GO:0016324 apical plasma membrane(GO:0016324)
0.0 6.3 GO:0001650 fibrillar center(GO:0001650)
0.1 5.7 GO:0042734 presynaptic membrane(GO:0042734)
0.6 4.0 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.3 3.7 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 3.4 GO:0005604 basement membrane(GO:0005604)
0.5 3.3 GO:0005638 lamin filament(GO:0005638)
0.0 3.3 GO:0014069 postsynaptic density(GO:0014069)
0.0 3.0 GO:0055037 recycling endosome(GO:0055037)
0.1 2.9 GO:0032279 asymmetric synapse(GO:0032279)
0.1 2.9 GO:0031985 Golgi cisterna(GO:0031985)
0.0 2.9 GO:0031253 cell projection membrane(GO:0031253)
0.3 2.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 2.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 2.1 GO:0005581 collagen trimer(GO:0005581)
0.1 1.8 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.7 GO:0043034 costamere(GO:0043034)
0.0 1.7 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 9.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 8.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 7.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 5.3 GO:0042805 actinin binding(GO:0042805)
0.2 4.0 GO:0051787 misfolded protein binding(GO:0051787)
0.1 3.9 GO:0070412 R-SMAD binding(GO:0070412)
0.3 3.7 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 3.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.3 3.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 3.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 3.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 3.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 2.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 2.8 GO:0005543 phospholipid binding(GO:0005543)
0.3 2.7 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 2.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 2.0 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 2.0 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 2.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 2.0 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.7 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.1 PID_ARF_3PATHWAY Arf1 pathway
0.1 3.6 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 3.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 3.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.8 PID_ATM_PATHWAY ATM pathway
0.0 1.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.6 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 1.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.8 PID_IGF1_PATHWAY IGF1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 3.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 3.4 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 3.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.3 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.1 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 2.0 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.9 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.8 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 1.7 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.7 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.4 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.3 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.2 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.2 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 1.2 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.0 1.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides