Motif ID: Foxa2_Foxa1

Z-value: 1.607

Transcription factors associated with Foxa2_Foxa1:

Gene SymbolEntrez IDGene Name
Foxa1 ENSMUSG00000035451.6 Foxa1
Foxa2 ENSMUSG00000037025.5 Foxa2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa1mm10_v2_chr12_-_57546121_575461410.421.1e-02Click!
Foxa2mm10_v2_chr2_-_148045891_1480459480.163.4e-01Click!


Activity profile for motif Foxa2_Foxa1.

activity profile for motif Foxa2_Foxa1


Sorted Z-values histogram for motif Foxa2_Foxa1

Sorted Z-values for motif Foxa2_Foxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_84086379 21.392 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr14_+_13454010 16.262 ENSMUST00000112656.2
 Synpr
synaptoporin
chr14_+_73237891 15.434 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr2_-_62483637 11.574 ENSMUST00000136686.1
ENSMUST00000102733.3
 Gcg

glucagon

chr18_-_62756275 11.201 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr17_+_29090969 10.051 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr1_-_138619687 9.923 ENSMUST00000027642.2
 Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
chr17_-_70851710 9.780 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr6_+_34709442 9.756 ENSMUST00000115021.1
 Cald1
caldesmon 1
chr2_+_181767283 9.652 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr2_+_181767040 9.513 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr8_+_45628176 9.248 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr6_+_14901344 9.221 ENSMUST00000115477.1
 Foxp2
forkhead box P2
chr6_+_34709610 9.209 ENSMUST00000031775.6
 Cald1
caldesmon 1
chr4_+_97777606 8.481 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr14_+_13453937 8.401 ENSMUST00000153954.1
 Synpr
synaptoporin
chr1_-_97977233 8.199 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chr8_+_45658666 7.916 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr8_+_45658731 7.608 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr8_+_127064022 7.373 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 24.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
7.1 21.4 GO:0060023 soft palate development(GO:0060023)
1.8 19.8 GO:0060539 diaphragm development(GO:0060539)
0.9 19.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.3 19.0 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
1.5 13.2 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.4 13.0 GO:0007129 synapsis(GO:0007129)
0.9 12.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.7 11.6 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.7 10.7 GO:0072189 ureter development(GO:0072189)
0.9 10.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.1 10.1 GO:0071493 cellular response to UV-B(GO:0071493)
0.4 9.9 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.7 8.2 GO:0009404 toxin metabolic process(GO:0009404)
1.2 7.4 GO:0003383 apical constriction(GO:0003383)
0.7 7.3 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 7.0 GO:0043171 peptide catabolic process(GO:0043171)
0.8 6.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.5 5.5 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.6 5.3 GO:0014807 regulation of somitogenesis(GO:0014807)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 24.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
2.1 19.0 GO:0030478 actin cap(GO:0030478)
0.0 18.4 GO:0043025 neuronal cell body(GO:0043025)
0.0 17.8 GO:0016607 nuclear speck(GO:0016607)
4.1 12.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
3.4 10.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.9 9.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 8.2 GO:0030667 secretory granule membrane(GO:0030667)
0.9 7.4 GO:0033269 internode region of axon(GO:0033269)
0.0 5.8 GO:0031965 nuclear membrane(GO:0031965)
0.1 5.2 GO:0005876 spindle microtubule(GO:0005876)
0.1 4.9 GO:0017053 transcriptional repressor complex(GO:0017053)
1.2 4.8 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.8 4.8 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.6 4.2 GO:0001940 male pronucleus(GO:0001940)
0.8 4.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.2 3.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 3.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.3 GO:0005819 spindle(GO:0005819)
0.1 3.2 GO:0030904 retromer complex(GO:0030904)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 55.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.7 18.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 17.1 GO:0019904 protein domain specific binding(GO:0019904)
0.1 16.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 13.8 GO:0003779 actin binding(GO:0003779)
0.0 12.7 GO:0005096 GTPase activator activity(GO:0005096)
0.4 12.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
3.4 10.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 10.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.4 9.8 GO:0070410 co-SMAD binding(GO:0070410)
2.7 8.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
1.9 7.7 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 7.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 7.3 GO:0005521 lamin binding(GO:0005521)
0.4 6.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 6.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 5.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 5.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.8 4.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
1.4 4.1 GO:0016015 morphogen activity(GO:0016015)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
1.2 16.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 13.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.4 13.2 PID_MYC_PATHWAY C-MYC pathway
1.3 10.1 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 7.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 7.4 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 5.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 5.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 4.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 3.2 PID_ALK2_PATHWAY ALK2 signaling events
0.1 3.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.3 3.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 2.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 2.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 18.9 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.5 18.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.6 16.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.4 12.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.6 11.6 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.3 9.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 9.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 8.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 5.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 5.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 5.0 REACTOME_KINESINS Genes involved in Kinesins
0.3 4.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 4.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 4.1 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 2.6 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 2.5 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 2.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 2.3 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.4 2.2 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 1.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha