Motif ID: Foxa2_Foxa1

Z-value: 1.607

Transcription factors associated with Foxa2_Foxa1:

Gene SymbolEntrez IDGene Name
Foxa1 ENSMUSG00000035451.6 Foxa1
Foxa2 ENSMUSG00000037025.5 Foxa2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa1mm10_v2_chr12_-_57546121_575461410.421.1e-02Click!
Foxa2mm10_v2_chr2_-_148045891_1480459480.163.4e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_84086379 21.392 ENSMUST00000060303.8
Tshz1
teashirt zinc finger family member 1
chr14_+_13454010 16.262 ENSMUST00000112656.2
Synpr
synaptoporin
chr14_+_73237891 15.434 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr2_-_62483637 11.574 ENSMUST00000136686.1
ENSMUST00000102733.3
Gcg

glucagon

chr18_-_62756275 11.201 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr17_+_29090969 10.051 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr1_-_138619687 9.923 ENSMUST00000027642.2
Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
chr17_-_70851710 9.780 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr6_+_34709442 9.756 ENSMUST00000115021.1
Cald1
caldesmon 1
chr2_+_181767283 9.652 ENSMUST00000108757.2
Myt1
myelin transcription factor 1
chr2_+_181767040 9.513 ENSMUST00000108756.1
Myt1
myelin transcription factor 1
chr8_+_45628176 9.248 ENSMUST00000130850.1
Sorbs2
sorbin and SH3 domain containing 2
chr6_+_14901344 9.221 ENSMUST00000115477.1
Foxp2
forkhead box P2
chr6_+_34709610 9.209 ENSMUST00000031775.6
Cald1
caldesmon 1
chr4_+_97777606 8.481 ENSMUST00000075448.6
ENSMUST00000092532.6
Nfia

nuclear factor I/A

chr14_+_13453937 8.401 ENSMUST00000153954.1
Synpr
synaptoporin
chr1_-_97977233 8.199 ENSMUST00000161567.1
Pam
peptidylglycine alpha-amidating monooxygenase
chr8_+_45658666 7.916 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
Sorbs2


sorbin and SH3 domain containing 2


chr8_+_45658731 7.608 ENSMUST00000143820.1
ENSMUST00000132139.1
Sorbs2

sorbin and SH3 domain containing 2

chr8_+_127064022 7.373 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr2_+_26973416 7.038 ENSMUST00000014996.7
ENSMUST00000102891.3
Adamts13

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

chr4_+_11191726 6.798 ENSMUST00000029866.9
ENSMUST00000108324.3
Ccne2

cyclin E2

chr10_-_128180265 6.616 ENSMUST00000099139.1
Rbms2
RNA binding motif, single stranded interacting protein 2
chr3_-_101836223 6.053 ENSMUST00000061831.4
Mab21l3
mab-21-like 3 (C. elegans)
chr7_+_67655414 5.780 ENSMUST00000107470.1
Ttc23
tetratricopeptide repeat domain 23
chr2_+_25180737 5.638 ENSMUST00000104999.2
Nrarp
Notch-regulated ankyrin repeat protein
chr12_-_99883429 5.619 ENSMUST00000046485.3
Efcab11
EF-hand calcium binding domain 11
chr3_-_52104891 5.483 ENSMUST00000121440.1
Maml3
mastermind like 3 (Drosophila)
chr4_+_11191354 5.387 ENSMUST00000170901.1
Ccne2
cyclin E2
chr15_-_84855093 5.380 ENSMUST00000016768.5
Phf21b
PHD finger protein 21B
chr7_+_29071597 5.230 ENSMUST00000180926.1
Gm26604
predicted gene, 26604
chr18_-_47333311 5.218 ENSMUST00000126684.1
ENSMUST00000156422.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr19_+_37376359 5.205 ENSMUST00000012587.3
Kif11
kinesin family member 11
chr14_-_48662740 5.114 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr12_-_31950210 5.060 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chr6_+_8948608 5.044 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr12_-_31950170 5.030 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr12_+_71016658 4.860 ENSMUST00000125125.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr2_-_18048784 4.792 ENSMUST00000142856.1
Skida1
SKI/DACH domain containing 1
chr10_-_49783259 4.790 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr9_+_74848437 4.733 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
Gm16551


Gm20649
predicted gene 16551


predicted gene 20649
chr10_-_93311073 4.548 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr1_-_156034826 4.522 ENSMUST00000141878.1
ENSMUST00000123705.1
Tor1aip1

torsin A interacting protein 1

chr4_-_24430838 4.260 ENSMUST00000183964.1
RP23-35K5.2
RP23-35K5.2
chr2_+_52072823 4.237 ENSMUST00000112693.2
ENSMUST00000069794.5
Rif1

Rap1 interacting factor 1 homolog (yeast)

chr4_-_82885148 4.072 ENSMUST00000048430.3
Cer1
cerberus 1 homolog (Xenopus laevis)
chr3_+_5218546 4.043 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr7_-_132813799 3.908 ENSMUST00000097998.2
Fam53b
family with sequence similarity 53, member B
chr6_-_3494587 3.853 ENSMUST00000049985.8
Hepacam2
HEPACAM family member 2
chr2_-_113848655 3.505 ENSMUST00000102545.1
ENSMUST00000110948.1
Arhgap11a

Rho GTPase activating protein 11A

chrX_+_106920618 3.504 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr11_-_48826655 3.469 ENSMUST00000104959.1
Gm12184
predicted gene 12184
chr14_+_46832127 3.449 ENSMUST00000068532.8
Cgrrf1
cell growth regulator with ring finger domain 1
chr3_+_5218516 3.448 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr11_-_48826500 3.447 ENSMUST00000161192.2
Gm12184
predicted gene 12184
chr9_+_53850243 3.425 ENSMUST00000048485.5
Sln
sarcolipin
chr3_+_131112785 3.415 ENSMUST00000098611.3
Lef1
lymphoid enhancer binding factor 1
chr14_+_84443553 3.413 ENSMUST00000071370.5
Pcdh17
protocadherin 17
chr5_+_92809372 3.346 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr2_-_172940299 3.231 ENSMUST00000009143.7
Bmp7
bone morphogenetic protein 7
chr12_-_31950535 3.144 ENSMUST00000172314.2
Hbp1
high mobility group box transcription factor 1
chr10_-_93310963 3.124 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr6_+_92940572 3.099 ENSMUST00000181145.1
ENSMUST00000181840.1
9530026P05Rik

RIKEN cDNA 9530026P05 gene

chr6_-_23248264 3.089 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr8_-_122699066 3.075 ENSMUST00000127984.1
Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr7_-_37773555 3.034 ENSMUST00000176534.1
Zfp536
zinc finger protein 536
chr19_+_55741810 3.030 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr12_-_73113407 2.979 ENSMUST00000175693.1
Six4
sine oculis-related homeobox 4
chr16_-_63864114 2.963 ENSMUST00000064405.6
Epha3
Eph receptor A3
chr13_-_83729544 2.947 ENSMUST00000181705.1
Gm26803
predicted gene, 26803
chr3_+_76075583 2.899 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr1_-_156034800 2.759 ENSMUST00000169241.1
Tor1aip1
torsin A interacting protein 1
chr10_+_88091070 2.744 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr2_-_160859601 2.682 ENSMUST00000103112.1
Zhx3
zinc fingers and homeoboxes 3
chr18_-_88927447 2.610 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6
chr14_+_55853997 2.607 ENSMUST00000100529.3
Nynrin
NYN domain and retroviral integrase containing
chr10_+_128909866 2.588 ENSMUST00000026407.7
Cd63
CD63 antigen
chr14_+_55854115 2.550 ENSMUST00000168479.1
Nynrin
NYN domain and retroviral integrase containing
chr4_+_98546919 2.548 ENSMUST00000030290.7
Inadl
InaD-like (Drosophila)
chr11_-_49712674 2.518 ENSMUST00000020624.6
ENSMUST00000145353.1
Cnot6

CCR4-NOT transcription complex, subunit 6

chrX_+_35888808 2.487 ENSMUST00000033419.6
Dock11
dedicator of cytokinesis 11
chr4_+_98546710 2.465 ENSMUST00000102792.3
Inadl
InaD-like (Drosophila)
chr2_-_70825726 2.456 ENSMUST00000038584.8
Tlk1
tousled-like kinase 1
chr2_-_168601620 2.426 ENSMUST00000171689.1
ENSMUST00000137451.1
Nfatc2

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2

chr19_-_58455398 2.424 ENSMUST00000026076.7
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr2_-_170427828 2.416 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
Bcas1


breast carcinoma amplified sequence 1


chr2_-_18048347 2.352 ENSMUST00000066885.5
Skida1
SKI/DACH domain containing 1
chr3_+_5218589 2.327 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chrX_-_108834303 2.282 ENSMUST00000101283.3
ENSMUST00000150434.1
Brwd3

bromodomain and WD repeat domain containing 3

chr4_+_97777780 2.257 ENSMUST00000107062.2
ENSMUST00000052018.5
ENSMUST00000107057.1
Nfia


nuclear factor I/A


chr19_-_58455903 2.247 ENSMUST00000131877.1
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr10_+_128908907 2.236 ENSMUST00000105229.1
Cd63
CD63 antigen
chr8_-_31918203 2.232 ENSMUST00000073884.4
Nrg1
neuregulin 1
chr14_-_101609033 2.225 ENSMUST00000161991.1
ENSMUST00000100340.3
Tbc1d4

TBC1 domain family, member 4

chr18_-_7626809 2.225 ENSMUST00000115869.2
Mpp7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr18_-_6136057 2.212 ENSMUST00000182559.1
Arhgap12
Rho GTPase activating protein 12
chr2_-_154569720 2.165 ENSMUST00000000894.5
E2f1
E2F transcription factor 1
chr15_+_4375462 2.163 ENSMUST00000061925.4
Plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chrX_+_109095359 2.151 ENSMUST00000033598.8
Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr4_+_11123950 2.104 ENSMUST00000142297.1
Gm11827
predicted gene 11827
chr19_-_58455161 2.100 ENSMUST00000135730.1
ENSMUST00000152507.1
Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chrX_-_94123087 2.093 ENSMUST00000113925.1
Zfx
zinc finger protein X-linked
chr18_-_6135888 2.051 ENSMUST00000182383.1
ENSMUST00000062584.7
ENSMUST00000077128.6
ENSMUST00000182038.1
ENSMUST00000182213.1
Arhgap12




Rho GTPase activating protein 12




chr6_+_14901440 2.016 ENSMUST00000128567.1
Foxp2
forkhead box P2
chr8_-_125492710 1.977 ENSMUST00000108775.1
Sipa1l2
signal-induced proliferation-associated 1 like 2
chr5_+_120431770 1.932 ENSMUST00000031591.7
Lhx5
LIM homeobox protein 5
chr2_-_154569845 1.908 ENSMUST00000103145.4
E2f1
E2F transcription factor 1
chr1_-_128592284 1.891 ENSMUST00000052172.6
ENSMUST00000142893.1
Cxcr4

chemokine (C-X-C motif) receptor 4

chr1_-_170867761 1.879 ENSMUST00000027974.6
Atf6
activating transcription factor 6
chr1_+_156838915 1.877 ENSMUST00000111720.1
Angptl1
angiopoietin-like 1
chr3_+_76593550 1.872 ENSMUST00000162471.1
Fstl5
follistatin-like 5
chr12_+_76370266 1.838 ENSMUST00000042779.3
Zbtb1
zinc finger and BTB domain containing 1
chr13_+_44840686 1.828 ENSMUST00000173906.1
Jarid2
jumonji, AT rich interactive domain 2
chr19_+_55741884 1.765 ENSMUST00000111658.3
ENSMUST00000111654.1
Tcf7l2

transcription factor 7 like 2, T cell specific, HMG box

chr15_-_50890396 1.725 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr1_+_132298606 1.708 ENSMUST00000046071.4
Klhdc8a
kelch domain containing 8A
chr11_-_68386821 1.705 ENSMUST00000021284.3
Ntn1
netrin 1
chr16_+_43364145 1.665 ENSMUST00000148775.1
Zbtb20
zinc finger and BTB domain containing 20
chr7_-_109960461 1.611 ENSMUST00000080437.6
Dennd5a
DENN/MADD domain containing 5A
chr12_+_38781093 1.603 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr15_-_89170688 1.599 ENSMUST00000060808.9
Plxnb2
plexin B2
chr4_+_11579647 1.591 ENSMUST00000180239.1
Fsbp
fibrinogen silencer binding protein
chr4_+_140701466 1.584 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr16_+_43363855 1.575 ENSMUST00000156367.1
Zbtb20
zinc finger and BTB domain containing 20
chr1_-_13374072 1.567 ENSMUST00000068304.6
ENSMUST00000006037.6
Ncoa2

nuclear receptor coactivator 2

chr7_-_109960385 1.542 ENSMUST00000106722.1
Dennd5a
DENN/MADD domain containing 5A
chr4_+_43669610 1.538 ENSMUST00000107866.1
Tmem8b
transmembrane protein 8B
chr17_+_28858411 1.525 ENSMUST00000114737.1
ENSMUST00000056866.5
Pnpla1

patatin-like phospholipase domain containing 1

chr7_-_84679346 1.521 ENSMUST00000069537.2
ENSMUST00000178385.1
Zfand6

zinc finger, AN1-type domain 6

chr7_-_34655500 1.504 ENSMUST00000032709.1
Kctd15
potassium channel tetramerisation domain containing 15
chr2_+_18064645 1.492 ENSMUST00000114680.2
Mllt10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr2_+_110597298 1.480 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr12_+_38780817 1.477 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr1_+_10056922 1.407 ENSMUST00000149214.1
Cspp1
centrosome and spindle pole associated protein 1
chr2_+_14873656 1.370 ENSMUST00000114718.1
ENSMUST00000114719.1
Cacnb2

calcium channel, voltage-dependent, beta 2 subunit

chr11_+_46235460 1.368 ENSMUST00000060185.2
Fndc9
fibronectin type III domain containing 9
chr6_+_8520008 1.356 ENSMUST00000162567.1
ENSMUST00000161217.1
Glcci1

glucocorticoid induced transcript 1

chr9_+_96196246 1.354 ENSMUST00000165120.2
ENSMUST00000034982.9
Tfdp2

transcription factor Dp 2

chr7_-_133123409 1.351 ENSMUST00000170459.1
ENSMUST00000166400.1
Ctbp2

C-terminal binding protein 2

chr17_-_24163668 1.336 ENSMUST00000040735.5
Amdhd2
amidohydrolase domain containing 2
chr2_+_164403194 1.311 ENSMUST00000017151.1
Rbpjl
recombination signal binding protein for immunoglobulin kappa J region-like
chr10_+_111506286 1.307 ENSMUST00000164773.1
Phlda1
pleckstrin homology-like domain, family A, member 1
chr2_-_170194033 1.301 ENSMUST00000180625.1
Gm17619
predicted gene, 17619
chr19_+_55742056 1.287 ENSMUST00000111659.2
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chrX_+_159303266 1.279 ENSMUST00000112491.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr7_-_133123770 1.273 ENSMUST00000164896.1
ENSMUST00000171968.1
Ctbp2

C-terminal binding protein 2

chr11_+_29463735 1.272 ENSMUST00000155854.1
Ccdc88a
coiled coil domain containing 88A
chr16_+_20611585 1.269 ENSMUST00000115522.2
ENSMUST00000119224.1
ENSMUST00000079600.4
ENSMUST00000120394.1
Ece2



endothelin converting enzyme 2



chr14_+_32599922 1.245 ENSMUST00000068938.5
Prrxl1
paired related homeobox protein-like 1
chr6_+_147032528 1.241 ENSMUST00000036194.4
Rep15
RAB15 effector protein
chrX_+_96455359 1.174 ENSMUST00000033553.7
Heph
hephaestin
chr3_+_32397671 1.167 ENSMUST00000108243.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr11_-_17008647 1.164 ENSMUST00000102881.3
Plek
pleckstrin
chr5_-_20951769 1.161 ENSMUST00000036489.5
Rsbn1l
round spermatid basic protein 1-like
chr17_-_45474839 1.156 ENSMUST00000024731.8
Spats1
spermatogenesis associated, serine-rich 1
chr7_-_65371210 1.142 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr7_+_24907618 1.140 ENSMUST00000151121.1
Arhgef1
Rho guanine nucleotide exchange factor (GEF) 1
chrX_+_169685191 1.089 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr3_-_116614587 1.059 ENSMUST00000041524.4
Trmt13
tRNA methyltransferase 13
chr3_-_123672321 1.058 ENSMUST00000172537.1
ENSMUST00000029602.6
Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr12_+_38780284 1.046 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr8_+_69300776 1.045 ENSMUST00000078257.6
D130040H23Rik
RIKEN cDNA D130040H23 gene
chr9_+_53537021 1.044 ENSMUST00000035850.7
Npat
nuclear protein in the AT region
chr15_-_55548164 1.006 ENSMUST00000165356.1
Mrpl13
mitochondrial ribosomal protein L13
chr16_+_37868383 1.005 ENSMUST00000078717.6
Lrrc58
leucine rich repeat containing 58
chr2_+_4718145 0.978 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chrX_+_74424534 0.968 ENSMUST00000135165.1
ENSMUST00000114128.1
ENSMUST00000114133.2
ENSMUST00000004330.3
Ikbkg



inhibitor of kappaB kinase gamma



chr13_+_23531044 0.960 ENSMUST00000102972.3
Hist1h4h
histone cluster 1, H4h
chr7_+_81862674 0.941 ENSMUST00000119543.1
Tm6sf1
transmembrane 6 superfamily member 1
chr1_+_12718496 0.934 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr10_-_76442758 0.926 ENSMUST00000001179.5
Pcnt
pericentrin (kendrin)
chr2_-_51972990 0.917 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr10_+_96616998 0.902 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr4_-_118409219 0.890 ENSMUST00000075406.5
Szt2
seizure threshold 2
chr8_-_121944886 0.885 ENSMUST00000057653.7
Car5a
carbonic anhydrase 5a, mitochondrial
chr7_+_30565410 0.879 ENSMUST00000043850.7
Igflr1
IGF-like family receptor 1
chr7_-_87493371 0.860 ENSMUST00000004770.5
Tyr
tyrosinase
chr3_-_84270782 0.848 ENSMUST00000054990.4
Trim2
tripartite motif-containing 2
chr19_-_53371766 0.846 ENSMUST00000086887.1
Gm10197
predicted gene 10197
chr2_+_27676440 0.845 ENSMUST00000129514.1
Rxra
retinoid X receptor alpha
chr2_-_177267036 0.823 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr2_+_143915273 0.804 ENSMUST00000103172.3
Dstn
destrin
chr2_-_104742802 0.798 ENSMUST00000028595.7
Depdc7
DEP domain containing 7
chr4_+_118409331 0.787 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)





chr15_-_50882806 0.782 ENSMUST00000184885.1
Trps1
trichorhinophalangeal syndrome I (human)
chr7_+_90426312 0.781 ENSMUST00000061391.7
Ccdc89
coiled-coil domain containing 89
chr3_-_46447939 0.751 ENSMUST00000166505.1
Pabpc4l
poly(A) binding protein, cytoplasmic 4-like
chr5_-_115098295 0.750 ENSMUST00000100848.2
Gm10401
predicted gene 10401
chr19_+_5041337 0.749 ENSMUST00000116567.2
Brms1
breast cancer metastasis-suppressor 1
chr3_+_96219858 0.748 ENSMUST00000073115.4
Hist2h2ab
histone cluster 2, H2ab
chr11_+_115824029 0.736 ENSMUST00000103032.4
ENSMUST00000133250.1
ENSMUST00000177736.1
Llgl2


lethal giant larvae homolog 2 (Drosophila)


chr17_+_85613432 0.725 ENSMUST00000176081.1
Six3
sine oculis-related homeobox 3
chr1_-_170110491 0.717 ENSMUST00000027985.2
Ddr2
discoidin domain receptor family, member 2
chr19_+_30030439 0.716 ENSMUST00000025739.7
Uhrf2
ubiquitin-like, containing PHD and RING finger domains 2
chr3_-_131344892 0.693 ENSMUST00000090246.4
ENSMUST00000126569.1
Sgms2

sphingomyelin synthase 2

chr9_+_107580117 0.670 ENSMUST00000093785.4
Nat6
N-acetyltransferase 6
chr15_+_59648350 0.662 ENSMUST00000067543.6
Trib1
tribbles homolog 1 (Drosophila)
chr2_-_71055534 0.655 ENSMUST00000090849.5
ENSMUST00000100037.2
ENSMUST00000112186.2
Mettl8


methyltransferase like 8


chrM_+_2743 0.645 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr18_+_4920509 0.641 ENSMUST00000126977.1
Svil
supervillin

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 21.4 GO:0060023 soft palate development(GO:0060023)
1.8 19.8 GO:0060539 diaphragm development(GO:0060539)
1.7 11.6 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
1.6 3.2 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.5 13.2 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
1.4 4.1 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
1.3 5.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.2 7.4 GO:0003383 apical constriction(GO:0003383)
1.1 3.4 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
1.1 10.1 GO:0071493 cellular response to UV-B(GO:0071493)
1.0 4.1 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
1.0 3.0 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) skeletal muscle fiber differentiation(GO:0098528)
1.0 3.0 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.9 1.8 GO:0002572 pro-T cell differentiation(GO:0002572)
0.9 2.7 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.9 10.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.9 19.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.9 3.4 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.9 12.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.8 4.2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.8 4.1 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.8 4.9 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.8 6.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.7 7.3 GO:0071763 nuclear membrane organization(GO:0071763)
0.7 10.7 GO:0072189 ureter development(GO:0072189)
0.7 1.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.7 8.2 GO:0009404 toxin metabolic process(GO:0009404)
0.6 5.2 GO:0015074 DNA integration(GO:0015074)
0.6 3.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.6 5.3 GO:0014807 regulation of somitogenesis(GO:0014807)
0.6 1.2 GO:0010920 negative regulation of inositol phosphate biosynthetic process(GO:0010920)
0.5 24.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 5.2 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.5 2.5 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.5 5.5 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.5 4.8 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.5 1.9 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.4 1.3 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.4 2.2 GO:0071896 protein localization to adherens junction(GO:0071896)
0.4 0.9 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.4 3.1 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.4 1.2 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.4 9.9 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.4 1.6 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.4 1.2 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.4 4.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 2.2 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.4 13.0 GO:0007129 synapsis(GO:0007129)
0.3 19.0 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.3 2.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 2.3 GO:0032488 Cdc42 protein signal transduction(GO:0032488) anterior/posterior axon guidance(GO:0033564)
0.3 2.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.3 0.8 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.3 1.9 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.3 0.3 GO:0060681 branch elongation involved in ureteric bud branching(GO:0060681)
0.3 1.6 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.3 1.3 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.2 2.2 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.2 0.7 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.2 3.4 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.2 0.9 GO:0014846 gastro-intestinal system smooth muscle contraction(GO:0014831) esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.2 1.3 GO:1901072 glucosamine-containing compound catabolic process(GO:1901072)
0.2 7.0 GO:0043171 peptide catabolic process(GO:0043171)
0.2 0.8 GO:0030043 actin filament fragmentation(GO:0030043)
0.2 5.2 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.2 2.3 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 2.5 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.2 1.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.2 0.9 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.2 1.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.2 1.2 GO:0021559 trigeminal nerve development(GO:0021559)
0.2 2.4 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.2 0.9 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 1.9 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 1.5 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 1.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.4 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.1 2.1 GO:0060746 parental behavior(GO:0060746)
0.1 0.7 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 0.6 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.6 GO:0046684 response to pyrethroid(GO:0046684)
0.1 1.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 2.5 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 0.2 GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003256)
0.1 1.5 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 0.7 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 3.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 3.4 GO:0035411 catenin import into nucleus(GO:0035411)
0.1 0.3 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.2 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 1.2 GO:0033572 transferrin transport(GO:0033572)
0.1 0.4 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 1.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 1.3 GO:0016486 peptide hormone processing(GO:0016486)
0.1 3.2 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.1 0.7 GO:0080009 mRNA methylation(GO:0080009)
0.1 3.4 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.1 1.5 GO:0006625 protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.1 0.9 GO:1990403 embryonic brain development(GO:1990403)
0.1 0.6 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 0.4 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.1 0.5 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 1.0 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 1.2 GO:0006826 iron ion transport(GO:0006826)
0.0 1.6 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 2.7 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.3 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.0 1.5 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.0 1.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.6 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 2.6 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.0 1.8 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
0.0 3.9 GO:0007098 centrosome cycle(GO:0007098)
0.0 1.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.6 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.4 GO:0017144 drug metabolic process(GO:0017144)
0.0 0.9 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.1 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.0 0.6 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.6 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.3 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.9 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.5 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.4 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 0.7 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.6 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.3 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
3.4 10.1 GO:0070557 PCNA-p21 complex(GO:0070557)
2.1 19.0 GO:0030478 actin cap(GO:0030478)
1.2 4.8 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.0 24.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.9 7.4 GO:0033269 internode region of axon(GO:0033269)
0.9 9.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.8 4.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.8 4.8 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.6 4.2 GO:0001940 male pronucleus(GO:0001940)
0.4 1.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.3 2.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.2 0.9 GO:1990130 Iml1 complex(GO:1990130)
0.2 1.0 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.2 3.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 1.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 2.6 GO:0097470 ribbon synapse(GO:0097470)
0.1 0.8 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.6 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.6 GO:1990357 terminal web(GO:1990357)
0.1 0.6 GO:0001652 granular component(GO:0001652)
0.1 8.2 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 5.2 GO:0005876 spindle microtubule(GO:0005876)
0.1 3.2 GO:0030904 retromer complex(GO:0030904)
0.1 0.7 GO:0070822 Sin3-type complex(GO:0070822)
0.1 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 4.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 17.8 GO:0016607 nuclear speck(GO:0016607)
0.0 0.9 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.6 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.3 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 3.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 5.8 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 18.4 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 2.1 GO:0030426 growth cone(GO:0030426)
0.0 3.2 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 3.3 GO:0005819 spindle(GO:0005819)
0.0 1.3 GO:0005814 centriole(GO:0005814)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.3 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
2.7 8.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
2.7 18.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
1.9 7.7 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
1.4 4.1 GO:0016015 morphogen activity(GO:0016015)
0.8 4.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.6 1.9 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.6 0.6 GO:0008502 melatonin receptor activity(GO:0008502)
0.6 3.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.5 1.5 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.4 9.8 GO:0070410 co-SMAD binding(GO:0070410)
0.4 3.0 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.4 12.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.4 6.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.3 2.6 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.3 3.2 GO:0070700 BMP receptor binding(GO:0070700)
0.3 7.3 GO:0005521 lamin binding(GO:0005521)
0.3 55.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 0.9 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.3 0.8 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.3 1.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.3 1.1 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.3 1.6 GO:0033142 progesterone receptor binding(GO:0033142)
0.3 5.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 1.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 0.8 GO:0070644 vitamin D response element binding(GO:0070644)
0.2 0.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 1.9 GO:0035497 cAMP response element binding(GO:0035497)
0.2 5.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 7.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 16.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 2.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.7 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.4 GO:0071723 lipopeptide binding(GO:0071723)
0.1 0.4 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 1.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.5 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 1.1 GO:0071253 connexin binding(GO:0071253)
0.1 1.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.3 GO:0005118 sevenless binding(GO:0005118)
0.1 1.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 0.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 6.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.4 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 1.3 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 0.8 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 1.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.7 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 1.5 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 2.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.6 GO:0015197 peptide transporter activity(GO:0015197)
0.0 12.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 1.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 10.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 13.8 GO:0003779 actin binding(GO:0003779)
0.0 2.1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.6 GO:0031402 sodium ion binding(GO:0031402)
0.0 3.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 2.4 GO:0001047 core promoter binding(GO:0001047)
0.0 0.3 GO:0044548 S100 protein binding(GO:0044548)
0.0 17.1 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.5 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.3 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.9 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0017022 myosin binding(GO:0017022)
0.0 2.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.0 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924)
0.0 0.2 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.6 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0051059 NF-kappaB binding(GO:0051059)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 10.1 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.2 16.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 13.2 PID_MYC_PATHWAY C-MYC pathway
0.3 17.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 3.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.3 3.2 PID_ALK2_PATHWAY ALK2 signaling events
0.2 2.2 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 7.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 4.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 13.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 7.4 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 4.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 5.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 0.4 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 1.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.4 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.4 PID_E2F_PATHWAY E2F transcription factor network
0.0 4.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 5.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.8 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.4 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.1 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.5 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.9 PID_TXA2PATHWAY Thromboxane A2 receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 18.9 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.6 16.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.6 11.6 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.5 18.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.4 12.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.4 2.2 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.4 9.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 4.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 5.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 9.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 4.1 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.2 1.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 2.3 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 1.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 5.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 5.0 REACTOME_KINESINS Genes involved in Kinesins
0.2 8.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.1 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.1 2.6 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 1.9 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle
0.1 2.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.5 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 1.2 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.1 0.8 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 4.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.9 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.3 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 1.0 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.9 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 0.3 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.2 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions