Motif ID: Foxa3

Z-value: 0.804


Transcription factors associated with Foxa3:

Gene SymbolEntrez IDGene Name
Foxa3 ENSMUSG00000040891.5 Foxa3



Activity profile for motif Foxa3.

activity profile for motif Foxa3


Sorted Z-values histogram for motif Foxa3

Sorted Z-values for motif Foxa3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_91269759 8.463 ENSMUST00000056882.5
Olig1
oligodendrocyte transcription factor 1
chr15_+_3270767 5.859 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1



selenoprotein P, plasma, 1



chr7_-_103813913 4.854 ENSMUST00000098192.3
Hbb-bt
hemoglobin, beta adult t chain
chr8_-_84773381 4.730 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr2_-_77519565 4.348 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr9_+_53850243 3.998 ENSMUST00000048485.5
Sln
sarcolipin
chr7_-_103827922 3.726 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs

hemoglobin, beta adult s chain

chr1_+_51289106 3.287 ENSMUST00000051572.6
Sdpr
serum deprivation response
chr13_+_94173992 3.095 ENSMUST00000121618.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr14_-_101609033 2.734 ENSMUST00000161991.1
ENSMUST00000100340.3
Tbc1d4

TBC1 domain family, member 4

chr7_-_27181149 2.678 ENSMUST00000071986.6
ENSMUST00000121848.1
Mia

melanoma inhibitory activity

chr11_+_78499087 2.665 ENSMUST00000017488.4
Vtn
vitronectin
chr16_+_41532851 2.601 ENSMUST00000078873.4
Lsamp
limbic system-associated membrane protein
chr10_+_60106452 2.538 ENSMUST00000165024.2
Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr3_-_87263518 2.415 ENSMUST00000090986.4
Fcrls
Fc receptor-like S, scavenger receptor
chr1_+_165763746 2.138 ENSMUST00000111432.3
Creg1
cellular repressor of E1A-stimulated genes 1
chr9_-_112187898 2.130 ENSMUST00000178410.1
ENSMUST00000172380.3
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr15_-_54919961 2.084 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr6_-_86765807 1.936 ENSMUST00000123732.1
Anxa4
annexin A4
chr9_-_103222063 1.751 ENSMUST00000170904.1
Trf
transferrin
chr6_-_86765866 1.749 ENSMUST00000113675.1
Anxa4
annexin A4
chr11_-_26210553 1.689 ENSMUST00000101447.3
5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr17_+_70522083 1.660 ENSMUST00000148486.1
ENSMUST00000133717.1
Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr3_-_87263703 1.646 ENSMUST00000146512.1
Fcrls
Fc receptor-like S, scavenger receptor
chr15_-_54920115 1.633 ENSMUST00000171545.1
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr10_-_128744014 1.463 ENSMUST00000026414.7
Dgka
diacylglycerol kinase, alpha
chr1_+_17145357 1.438 ENSMUST00000026879.7
Gdap1
ganglioside-induced differentiation-associated-protein 1
chr13_+_16011851 1.354 ENSMUST00000042603.6
Inhba
inhibin beta-A
chr3_+_33799791 1.332 ENSMUST00000099153.3
Ttc14
tetratricopeptide repeat domain 14
chr8_+_106603351 1.314 ENSMUST00000000312.5
ENSMUST00000167688.1
Cdh1

cadherin 1

chr4_-_116405986 1.274 ENSMUST00000123072.1
ENSMUST00000144281.1
Mast2

microtubule associated serine/threonine kinase 2

chr2_-_170194033 1.267 ENSMUST00000180625.1
Gm17619
predicted gene, 17619
chr10_+_21992216 1.266 ENSMUST00000150089.1
ENSMUST00000100036.3
Sgk1

serum/glucocorticoid regulated kinase 1

chr2_+_140395309 1.265 ENSMUST00000110067.1
ENSMUST00000110064.1
ENSMUST00000110063.1
ENSMUST00000110062.1
ENSMUST00000078027.5
ENSMUST00000043836.7
Macrod2





MACRO domain containing 2





chr18_+_67133713 1.265 ENSMUST00000076605.7
Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr3_-_144202300 1.248 ENSMUST00000121796.1
ENSMUST00000121112.1
Lmo4

LIM domain only 4

chr4_+_94739276 1.244 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek

endothelial-specific receptor tyrosine kinase

chr17_+_70522149 1.232 ENSMUST00000140728.1
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr16_-_43664145 1.188 ENSMUST00000096065.4
Tigit
T cell immunoreceptor with Ig and ITIM domains
chrX_+_142228177 1.186 ENSMUST00000112914.1
Nxt2
nuclear transport factor 2-like export factor 2
chr16_+_33518278 1.184 ENSMUST00000122427.1
ENSMUST00000059056.8
Slc12a8

solute carrier family 12 (potassium/chloride transporters), member 8

chr2_-_84425258 1.178 ENSMUST00000074262.2
Calcrl
calcitonin receptor-like
chrX_+_71663665 1.136 ENSMUST00000070449.5
Gpr50
G-protein-coupled receptor 50
chr15_-_42676967 1.124 ENSMUST00000022921.5
Angpt1
angiopoietin 1
chr11_-_69805617 1.113 ENSMUST00000051025.4
Tmem102
transmembrane protein 102
chr9_-_112187766 1.103 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chrX_+_142227923 1.101 ENSMUST00000042329.5
Nxt2
nuclear transport factor 2-like export factor 2
chr12_-_84450944 1.079 ENSMUST00000085192.5
Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr4_-_87806296 1.074 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr3_-_146781351 1.004 ENSMUST00000005164.7
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr11_-_116024489 0.928 ENSMUST00000016703.7
H3f3b
H3 histone, family 3B
chr3_+_136670076 0.923 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr13_-_83729544 0.922 ENSMUST00000181705.1
Gm26803
predicted gene, 26803
chr4_+_148602527 0.917 ENSMUST00000105701.2
ENSMUST00000052060.6
Masp2

mannan-binding lectin serine peptidase 2

chr4_+_114680769 0.883 ENSMUST00000146346.1
Gm12829
predicted gene 12829
chr19_+_44992127 0.844 ENSMUST00000179305.1
Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr1_+_9848375 0.843 ENSMUST00000097826.4
Sgk3
serum/glucocorticoid regulated kinase 3
chr10_-_128919259 0.806 ENSMUST00000149961.1
ENSMUST00000026406.7
Rdh5

retinol dehydrogenase 5

chr4_+_101717404 0.778 ENSMUST00000102777.3
ENSMUST00000106921.2
ENSMUST00000037552.3
ENSMUST00000145024.1
Lepr



leptin receptor



chr8_-_46124146 0.767 ENSMUST00000170416.1
Snx25
sorting nexin 25
chr3_+_68584154 0.765 ENSMUST00000182997.1
Schip1
schwannomin interacting protein 1
chr2_-_175131864 0.733 ENSMUST00000108929.2
Gm14399
predicted gene 14399
chr11_-_69662625 0.732 ENSMUST00000018905.5
Mpdu1
mannose-P-dolichol utilization defect 1
chr4_-_87806276 0.714 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr2_+_4718145 0.681 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr3_+_95624971 0.652 ENSMUST00000058230.6
ENSMUST00000037983.4
Ensa

endosulfine alpha

chr1_-_45503282 0.639 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr11_-_54860564 0.633 ENSMUST00000144164.1
Lyrm7
LYR motif containing 7
chr8_+_93810832 0.614 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr5_-_103211251 0.609 ENSMUST00000060871.5
ENSMUST00000112846.1
ENSMUST00000170792.1
ENSMUST00000112847.2
Mapk10



mitogen-activated protein kinase 10



chr19_+_26623419 0.594 ENSMUST00000176584.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_-_55532453 0.576 ENSMUST00000132746.1
ENSMUST00000107619.2
Klf4

Kruppel-like factor 4 (gut)

chr15_-_99820072 0.575 ENSMUST00000109024.2
Lima1
LIM domain and actin binding 1
chr2_+_153161303 0.569 ENSMUST00000089027.2
Tm9sf4
transmembrane 9 superfamily protein member 4
chr11_-_69662564 0.559 ENSMUST00000129224.1
ENSMUST00000155200.1
Mpdu1

mannose-P-dolichol utilization defect 1

chr17_-_79896028 0.557 ENSMUST00000068282.5
ENSMUST00000112437.1
Atl2

atlastin GTPase 2

chr18_+_36952621 0.553 ENSMUST00000115661.2
Pcdha2
protocadherin alpha 2
chr2_+_69723071 0.552 ENSMUST00000040915.8
Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr4_+_45965327 0.548 ENSMUST00000107777.2
Tdrd7
tudor domain containing 7
chr16_-_4880284 0.547 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr1_-_180245757 0.541 ENSMUST00000111104.1
Psen2
presenilin 2
chr3_+_106113229 0.539 ENSMUST00000079132.5
ENSMUST00000139086.1
Chia

chitinase, acidic

chr2_+_69722797 0.535 ENSMUST00000090858.3
Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr9_+_109931458 0.520 ENSMUST00000072772.5
ENSMUST00000035055.8
Map4

microtubule-associated protein 4

chr6_-_137571007 0.516 ENSMUST00000100841.2
Eps8
epidermal growth factor receptor pathway substrate 8
chr5_-_124187150 0.513 ENSMUST00000161938.1
Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr8_+_69300776 0.490 ENSMUST00000078257.6
D130040H23Rik
RIKEN cDNA D130040H23 gene
chr10_-_93310963 0.473 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr10_-_57532416 0.472 ENSMUST00000169122.1
Serinc1
serine incorporator 1
chr19_-_37207293 0.469 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
Cpeb3




cytoplasmic polyadenylation element binding protein 3




chr2_+_164833841 0.465 ENSMUST00000152721.1
Ctsa
cathepsin A
chr13_+_49582745 0.459 ENSMUST00000065494.7
Omd
osteomodulin
chr11_-_95041335 0.454 ENSMUST00000038431.7
Pdk2
pyruvate dehydrogenase kinase, isoenzyme 2
chr1_+_75142775 0.450 ENSMUST00000097694.4
Fam134a
family with sequence similarity 134, member A
chr2_-_7395879 0.441 ENSMUST00000182404.1
Celf2
CUGBP, Elav-like family member 2
chr10_-_57532489 0.429 ENSMUST00000020027.4
Serinc1
serine incorporator 1
chr2_-_90479165 0.429 ENSMUST00000111495.2
Ptprj
protein tyrosine phosphatase, receptor type, J
chr17_+_45433823 0.408 ENSMUST00000181149.1
B230354K17Rik
RIKEN cDNA B230354K17 gene
chr1_+_171329015 0.404 ENSMUST00000111300.1
Dedd
death effector domain-containing
chr18_+_37742088 0.398 ENSMUST00000003599.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr8_+_11556061 0.396 ENSMUST00000054399.4
Ing1
inhibitor of growth family, member 1
chr19_-_20727533 0.381 ENSMUST00000025656.3
Aldh1a7
aldehyde dehydrogenase family 1, subfamily A7
chr13_-_96542479 0.375 ENSMUST00000022172.4
Polk
polymerase (DNA directed), kappa
chr10_+_97565436 0.358 ENSMUST00000038160.4
Lum
lumican
chr15_+_9071252 0.345 ENSMUST00000100789.4
ENSMUST00000100790.3
ENSMUST00000067760.4
Nadk2


NAD kinase 2, mitochondrial


chr4_+_42916647 0.342 ENSMUST00000132173.1
ENSMUST00000107975.1
N28178

expressed sequence N28178

chr19_+_55253369 0.321 ENSMUST00000043150.4
Acsl5
acyl-CoA synthetase long-chain family member 5
chr13_+_40859768 0.321 ENSMUST00000110191.2
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr11_-_42000532 0.310 ENSMUST00000070735.3
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr19_-_8713862 0.303 ENSMUST00000010239.4
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr7_+_130692532 0.296 ENSMUST00000033141.6
Tacc2
transforming, acidic coiled-coil containing protein 2
chr2_-_176917518 0.288 ENSMUST00000108931.2
Gm14296
predicted gene 14296
chr1_-_168431695 0.282 ENSMUST00000176790.1
Pbx1
pre B cell leukemia homeobox 1
chrX_+_56786527 0.275 ENSMUST00000144600.1
Fhl1
four and a half LIM domains 1
chr8_-_25785154 0.265 ENSMUST00000038498.8
Bag4
BCL2-associated athanogene 4
chr13_+_96388294 0.254 ENSMUST00000099295.4
Poc5
POC5 centriolar protein homolog (Chlamydomonas)
chr3_+_121531603 0.241 ENSMUST00000180804.1
A530020G20Rik
RIKEN cDNA A530020G20 gene
chr11_-_42000284 0.234 ENSMUST00000109292.2
ENSMUST00000109290.1
Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr9_-_44802951 0.234 ENSMUST00000044694.6
Ttc36
tetratricopeptide repeat domain 36
chr7_+_19228334 0.229 ENSMUST00000063976.8
Opa3
optic atrophy 3
chr11_-_42000834 0.224 ENSMUST00000070725.4
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr3_+_138277489 0.224 ENSMUST00000004232.9
Adh1
alcohol dehydrogenase 1 (class I)
chr11_-_76027726 0.205 ENSMUST00000021207.6
Fam101b
family with sequence similarity 101, member B
chr7_-_65371210 0.204 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr2_+_68117713 0.203 ENSMUST00000112346.2
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr4_+_42922253 0.191 ENSMUST00000139100.1
N28178
expressed sequence N28178
chr2_+_91730127 0.190 ENSMUST00000099712.3
ENSMUST00000111317.2
ENSMUST00000111316.2
ENSMUST00000045705.7
Ambra1



autophagy/beclin 1 regulator 1



chr4_+_126262325 0.188 ENSMUST00000030660.8
Trappc3
trafficking protein particle complex 3
chr7_+_30565410 0.186 ENSMUST00000043850.7
Igflr1
IGF-like family receptor 1
chr4_-_25281752 0.174 ENSMUST00000038705.7
Ufl1
UFM1 specific ligase 1
chrX_+_109095359 0.171 ENSMUST00000033598.8
Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr9_-_101198999 0.164 ENSMUST00000066773.7
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr6_+_8520008 0.161 ENSMUST00000162567.1
ENSMUST00000161217.1
Glcci1

glucocorticoid induced transcript 1

chr11_-_69197809 0.157 ENSMUST00000094078.3
ENSMUST00000021262.3
Alox8

arachidonate 8-lipoxygenase

chr17_+_47505149 0.156 ENSMUST00000183177.1
ENSMUST00000182848.1
Ccnd3

cyclin D3

chr9_+_32116040 0.155 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr1_-_132367879 0.155 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr18_+_52465676 0.151 ENSMUST00000025406.7
Srfbp1
serum response factor binding protein 1
chr11_+_43151599 0.142 ENSMUST00000077659.5
Atp10b
ATPase, class V, type 10B
chr7_+_30751471 0.137 ENSMUST00000182229.1
ENSMUST00000182227.1
ENSMUST00000080518.6
ENSMUST00000182721.1
Sbsn



suprabasin



chr1_-_132390301 0.136 ENSMUST00000132435.1
Tmcc2
transmembrane and coiled-coil domains 2
chr7_-_4844665 0.136 ENSMUST00000066041.5
ENSMUST00000172377.1
Shisa7

shisa homolog 7 (Xenopus laevis)

chr17_+_47505117 0.131 ENSMUST00000183044.1
ENSMUST00000037333.10
Ccnd3

cyclin D3

chr13_+_23531044 0.130 ENSMUST00000102972.3
Hist1h4h
histone cluster 1, H4h
chr18_-_38918642 0.130 ENSMUST00000040647.4
Fgf1
fibroblast growth factor 1
chr1_-_170867761 0.126 ENSMUST00000027974.6
Atf6
activating transcription factor 6
chr17_-_45433682 0.125 ENSMUST00000024727.8
Cdc5l
cell division cycle 5-like (S. pombe)
chr14_-_5455467 0.101 ENSMUST00000180867.1
Gm3194
predicted gene 3194
chr4_+_102430047 0.093 ENSMUST00000172616.1
Pde4b
phosphodiesterase 4B, cAMP specific
chr10_+_96616998 0.079 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr18_-_62756275 0.079 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr12_-_31950210 0.073 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chr17_+_47505043 0.069 ENSMUST00000182129.1
ENSMUST00000171031.1
Ccnd3

cyclin D3

chr2_+_164833781 0.060 ENSMUST00000143780.1
Ctsa
cathepsin A
chr1_-_64121389 0.059 ENSMUST00000055001.3
Klf7
Kruppel-like factor 7 (ubiquitous)
chr12_-_56536895 0.057 ENSMUST00000001536.8
Nkx2-1
NK2 homeobox 1
chr10_-_81230773 0.054 ENSMUST00000047408.4
Atcay
ataxia, cerebellar, Cayman type homolog (human)
chr10_-_93311073 0.042 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr2_+_25180737 0.041 ENSMUST00000104999.2
Nrarp
Notch-regulated ankyrin repeat protein
chr12_-_87200200 0.035 ENSMUST00000037418.5
Tmed8
transmembrane emp24 domain containing 8
chr6_-_23132981 0.034 ENSMUST00000031707.7
Aass
aminoadipate-semialdehyde synthase
chr1_+_15712303 0.030 ENSMUST00000170146.1
Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr11_+_78465697 0.017 ENSMUST00000001126.3
Slc46a1
solute carrier family 46, member 1
chr1_-_75142360 0.011 ENSMUST00000041213.5
Cnppd1
cyclin Pas1/PHO80 domain containing 1
chr9_+_32224246 0.010 ENSMUST00000168954.2
Arhgap32
Rho GTPase activating protein 32
chr13_-_74807913 0.008 ENSMUST00000065629.4
Cast
calpastatin
chr16_+_49699198 0.003 ENSMUST00000046777.4
ENSMUST00000142682.1
Ift57

intraflagellar transport 57


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.8 2.4 GO:0048014 Tie signaling pathway(GO:0048014)
0.6 3.7 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.5 3.7 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.4 1.1 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.3 1.3 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.3 0.9 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.3 2.7 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.3 1.2 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.3 2.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.3 4.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 1.4 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.3 1.3 GO:0060066 oviduct development(GO:0060066)
0.3 0.8 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.2 2.7 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302) liver regeneration(GO:0097421)
0.2 0.9 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.2 2.9 GO:0070842 aggresome assembly(GO:0070842)
0.2 1.8 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.2 0.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 1.3 GO:0009405 pathogenesis(GO:0009405)
0.2 0.6 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.2 1.3 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.2 0.5 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.9 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.5 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.9 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1 1.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 1.0 GO:0010820 positive regulation of T cell chemotaxis(GO:0010820)
0.1 0.5 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 1.5 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 1.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.5 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.6 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 2.6 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 1.2 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.1 1.0 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 1.3 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.4 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.1 1.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.1 0.5 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.1 0.8 GO:0071420 cellular response to histamine(GO:0071420)
0.1 7.4 GO:0048663 neuron fate commitment(GO:0048663)
0.1 0.6 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1 0.2 GO:0034310 primary alcohol catabolic process(GO:0034310)
0.1 0.4 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 3.4 GO:0034605 cellular response to heat(GO:0034605)
0.1 0.3 GO:1903215 regulation of mRNA modification(GO:0090365) negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 0.6 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.3 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1 0.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.6 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 1.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.8 GO:0001553 luteinization(GO:0001553)
0.1 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.3 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.1 0.4 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.1 0.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.8 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.5 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.4 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.2 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 1.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 3.8 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.8 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.7 GO:0040008 regulation of growth(GO:0040008)
0.0 0.3 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.1 GO:0045763 negative regulation of cellular amino acid metabolic process(GO:0045763)
0.0 0.8 GO:0050919 negative chemotaxis(GO:0050919)
0.0 2.3 GO:0051028 mRNA transport(GO:0051028)
0.0 0.2 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.6 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
0.0 0.1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 2.5 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.3 GO:0030325 adrenal gland development(GO:0030325)
0.0 0.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.2 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.6 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.1 GO:0072395 signal transduction involved in cell cycle checkpoint(GO:0072395) signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422)
0.0 0.0 GO:0006553 lysine metabolic process(GO:0006553)
0.0 0.0 GO:0014807 regulation of somitogenesis(GO:0014807)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.5 2.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.5 1.4 GO:0043512 inhibin A complex(GO:0043512)
0.2 1.8 GO:0097433 dense body(GO:0097433)
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.2 4.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 0.9 GO:0005955 calcineurin complex(GO:0005955)
0.2 0.5 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 1.3 GO:0016600 flotillin complex(GO:0016600)
0.1 0.5 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.5 GO:0035253 ciliary rootlet(GO:0035253)
0.0 3.9 GO:0001650 fibrillar center(GO:0001650)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 10.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.0 GO:0005902 microvillus(GO:0005902)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.1 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.6 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.9 3.7 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.4 1.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.3 1.8 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.2 1.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 2.7 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 1.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 1.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2 0.9 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 0.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 1.2 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 1.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.6 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.5 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.6 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 1.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 3.7 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 1.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 0.9 GO:0001846 opsonin binding(GO:0001846)
0.1 0.8 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 0.5 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.7 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 0.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.2 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 0.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 2.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.8 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 3.9 GO:0002039 p53 binding(GO:0002039)
0.0 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.3 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 2.8 GO:0008083 growth factor activity(GO:0008083)
0.0 0.4 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 1.1 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 0.4 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 1.3 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.3 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 2.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 3.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 0.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 1.3 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 0.6 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 3.6 PID_SHP2_PATHWAY SHP2 signaling
0.0 1.0 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.4 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.8 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.3 1.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 1.5 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 0.9 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.8 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.1 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 2.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.5 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.5 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.6 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.1 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.6 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 1.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions