Motif ID: Foxa3

Z-value: 0.804


Transcription factors associated with Foxa3:

Gene SymbolEntrez IDGene Name
Foxa3 ENSMUSG00000040891.5 Foxa3



Activity profile for motif Foxa3.

activity profile for motif Foxa3


Sorted Z-values histogram for motif Foxa3

Sorted Z-values for motif Foxa3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa3

PNG image of the network

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Top targets:


Showing 1 to 20 of 167 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 8.463 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr15_+_3270767 5.859 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr7_-_103813913 4.854 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr8_-_84773381 4.730 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr2_-_77519565 4.348 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr9_+_53850243 3.998 ENSMUST00000048485.5
 Sln
sarcolipin
chr7_-_103827922 3.726 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr1_+_51289106 3.287 ENSMUST00000051572.6
 Sdpr
serum deprivation response
chr13_+_94173992 3.095 ENSMUST00000121618.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr14_-_101609033 2.734 ENSMUST00000161991.1
ENSMUST00000100340.3
 Tbc1d4

TBC1 domain family, member 4

chr7_-_27181149 2.678 ENSMUST00000071986.6
ENSMUST00000121848.1
 Mia

melanoma inhibitory activity

chr11_+_78499087 2.665 ENSMUST00000017488.4
 Vtn
vitronectin
chr16_+_41532851 2.601 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr10_+_60106452 2.538 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr3_-_87263518 2.415 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr1_+_165763746 2.138 ENSMUST00000111432.3
 Creg1
cellular repressor of E1A-stimulated genes 1
chr9_-_112187898 2.130 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr15_-_54919961 2.084 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr6_-_86765807 1.936 ENSMUST00000123732.1
 Anxa4
annexin A4
chr9_-_103222063 1.751 ENSMUST00000170904.1
 Trf
transferrin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.4 GO:0048663 neuron fate commitment(GO:0048663)
0.3 4.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.0 4.0 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.0 3.8 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.6 3.7 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.5 3.7 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 3.4 GO:0034605 cellular response to heat(GO:0034605)
0.2 2.9 GO:0070842 aggresome assembly(GO:0070842)
0.3 2.7 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.2 2.7 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302) liver regeneration(GO:0097421)
0.1 2.6 GO:0035641 locomotory exploration behavior(GO:0035641)
0.3 2.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 2.5 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.8 2.4 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 2.3 GO:0051028 mRNA transport(GO:0051028)
0.2 1.8 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 1.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.5 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.3 1.4 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 1.4 GO:0008053 mitochondrial fusion(GO:0008053)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.9 GO:0005667 transcription factor complex(GO:0005667)
2.1 8.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 4.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 3.9 GO:0001650 fibrillar center(GO:0001650)
0.0 3.1 GO:0031965 nuclear membrane(GO:0031965)
0.5 2.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 2.0 GO:0005902 microvillus(GO:0005902)
0.0 1.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.8 GO:0097433 dense body(GO:0097433)
0.0 1.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 1.4 GO:0043512 inhibin A complex(GO:0043512)
0.0 1.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 1.3 GO:0016600 flotillin complex(GO:0016600)
0.0 1.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.1 GO:0016363 nuclear matrix(GO:0016363)
0.1 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 0.9 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.8 GO:1902711 GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 8.6 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 3.9 GO:0002039 p53 binding(GO:0002039)
0.9 3.7 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 3.7 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 3.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 2.8 GO:0008083 growth factor activity(GO:0008083)
0.2 2.7 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 2.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 1.8 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 1.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 1.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 1.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 1.3 GO:0019213 deacetylase activity(GO:0019213)
0.2 1.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 1.2 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.4 1.1 GO:0008502 melatonin receptor activity(GO:0008502)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 PID_SHP2_PATHWAY SHP2 signaling
0.1 2.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.4 PID_ALK1_PATHWAY ALK1 signaling events
0.1 1.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.3 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 0.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.8 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.1 0.6 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.2 1.5 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.5 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 1.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.3 1.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.1 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.1 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 0.9 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.8 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.6 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 0.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.5 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs