Motif ID: Foxb1

Z-value: 0.865


Transcription factors associated with Foxb1:

Gene SymbolEntrez IDGene Name
Foxb1 ENSMUSG00000059246.4 Foxb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxb1mm10_v2_chr9_-_69760924_697609400.307.6e-02Click!


Activity profile for motif Foxb1.

activity profile for motif Foxb1


Sorted Z-values histogram for motif Foxb1

Sorted Z-values for motif Foxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_14901344 4.522 ENSMUST00000115477.1
 Foxp2
forkhead box P2
chr10_+_26229707 4.429 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr6_-_56362356 4.303 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr3_+_55782500 3.546 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr1_-_158814469 3.521 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr10_+_37139558 3.288 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr18_-_47333311 3.117 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr2_+_181767040 2.792 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr2_+_181767283 2.778 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr6_+_8948608 2.632 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr17_-_70851710 2.534 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr7_+_67655414 2.528 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr3_-_123672321 2.506 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr3_+_76075583 2.465 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chrX_+_106920618 2.436 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr17_+_93199348 2.236 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr3_-_95904683 2.219 ENSMUST00000147962.1
ENSMUST00000036181.8
 Car14

carbonic anhydrase 14

chr6_+_14901440 2.063 ENSMUST00000128567.1
 Foxp2
forkhead box P2
chr3_+_134236483 1.817 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr7_-_37773555 1.698 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.6 GO:0060539 diaphragm development(GO:0060539)
0.5 5.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.2 4.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.3 4.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7 4.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 3.5 GO:0060349 bone morphogenesis(GO:0060349)
0.1 3.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.2 2.6 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 2.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.7 2.2 GO:0071649 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.3 2.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.2 2.0 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1 2.0 GO:0007129 synapsis(GO:0007129)
0.0 1.9 GO:0006342 chromatin silencing(GO:0006342)
0.0 1.6 GO:0007098 centrosome cycle(GO:0007098)
0.1 1.4 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 1.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 1.3 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.0 1.3 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.7 2.0 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 1.7 GO:0043195 terminal bouton(GO:0043195)
0.0 1.6 GO:0097440 apical dendrite(GO:0097440)
0.1 1.3 GO:0030478 actin cap(GO:0030478)
0.0 1.3 GO:0005811 lipid particle(GO:0005811)
0.0 1.3 GO:0030315 T-tubule(GO:0030315)
0.2 1.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.0 GO:0070822 Sin3-type complex(GO:0070822)
0.1 0.9 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.8 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.1 0.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.5 GO:0070852 cell body fiber(GO:0070852)
0.0 0.5 GO:0030904 retromer complex(GO:0030904)
0.1 0.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.6 4.3 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
1.0 4.1 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.0 3.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.5 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.2 3.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 2.8 GO:0030507 spectrin binding(GO:0030507)
0.1 2.5 GO:0070410 co-SMAD binding(GO:0070410)
0.3 2.4 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 2.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 2.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 2.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 1.4 GO:0005521 lamin binding(GO:0005521)
0.1 1.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.2 1.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 1.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 1.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.0 PID_MYC_PATHWAY C-MYC pathway
0.0 1.8 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 3.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 2.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.2 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 2.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 1.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 1.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.9 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha