Motif ID: Foxb1
Z-value: 0.865
Transcription factors associated with Foxb1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxb1 | ENSMUSG00000059246.4 | Foxb1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxb1 | mm10_v2_chr9_-_69760924_69760940 | 0.30 | 7.6e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | GO:0071649 | negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274) |
| 0.7 | 4.1 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.5 | 5.6 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.5 | 5.6 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.3 | 2.2 | GO:0015670 | carbon dioxide transport(GO:0015670) |
| 0.3 | 1.1 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.3 | 4.2 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.2 | 4.3 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.2 | 2.6 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.2 | 0.9 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.2 | 2.0 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.2 | 0.5 | GO:0009826 | unidimensional cell growth(GO:0009826) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.2 | 1.0 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.2 | 1.1 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.2 | 0.5 | GO:0097274 | urea homeostasis(GO:0097274) |
| 0.1 | 1.4 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.1 | 0.7 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.1 | 0.8 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 0.1 | 3.1 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.1 | 1.2 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.1 | 0.3 | GO:0090004 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.1 | 2.4 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.1 | 0.4 | GO:0009597 | detection of virus(GO:0009597) |
| 0.1 | 0.7 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.1 | 0.9 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.1 | 1.3 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 0.5 | GO:0061368 | maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.1 | 0.3 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 0.1 | 0.6 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.1 | 2.0 | GO:0007129 | synapsis(GO:0007129) |
| 0.0 | 0.3 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.0 | 0.2 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) |
| 0.0 | 0.6 | GO:0060746 | parental behavior(GO:0060746) |
| 0.0 | 3.5 | GO:0060349 | bone morphogenesis(GO:0060349) |
| 0.0 | 0.4 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.0 | 0.3 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.0 | 0.2 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.0 | 0.2 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 0.0 | 1.3 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.0 | 0.2 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.0 | 0.6 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 0.8 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 1.9 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 1.6 | GO:0007098 | centrosome cycle(GO:0007098) |
| 0.0 | 0.5 | GO:0050982 | detection of mechanical stimulus(GO:0050982) |
| 0.0 | 0.2 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.0 | 1.3 | GO:0006334 | nucleosome assembly(GO:0006334) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.0 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.2 | 1.2 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.1 | 1.3 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 0.9 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.1 | 2.6 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 0.8 | GO:0061689 | paranodal junction(GO:0033010) tricellular tight junction(GO:0061689) |
| 0.1 | 0.3 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.1 | 0.8 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 0.4 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 0.3 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.0 | 0.7 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 1.0 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.0 | 0.5 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.0 | 1.6 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.2 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.0 | 1.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.5 | GO:0030904 | retromer complex(GO:0030904) |
| 0.0 | 0.1 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.0 | 1.3 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 1.7 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.0 | GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540) |
| 0.0 | 0.3 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 4.1 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
| 0.6 | 4.3 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.3 | 2.4 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
| 0.2 | 1.1 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.2 | 1.1 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.2 | 2.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.2 | 3.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.9 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.1 | 2.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 1.7 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.1 | 2.2 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.3 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 0.1 | 0.3 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.1 | 1.3 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 1.4 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 2.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 2.8 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.9 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 7.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 3.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 4.6 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 0.3 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.7 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.0 | 0.2 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 0.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.3 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 1.0 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.4 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.0 | 3.5 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.0 | 0.4 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.0 | 0.7 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.0 | 0.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.2 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 0.8 | GO:0048365 | Rac GTPase binding(GO:0048365) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.1 | 2.0 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 2.0 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.9 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.1 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 2.5 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 3.0 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.3 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.5 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.8 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.3 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.8 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.4 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.4 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.3 | 1.1 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 3.5 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 3.1 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 4.1 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 2.0 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.1 | 2.6 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.5 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 1.1 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 2.2 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.9 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.4 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.9 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 1.3 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.5 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
