Motif ID: Foxc1

Z-value: 0.641


Transcription factors associated with Foxc1:

Gene SymbolEntrez IDGene Name
Foxc1 ENSMUSG00000050295.2 Foxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc1mm10_v2_chr13_+_31806627_318066500.057.5e-01Click!


Activity profile for motif Foxc1.

activity profile for motif Foxc1


Sorted Z-values histogram for motif Foxc1

Sorted Z-values for motif Foxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_1010543 4.668 ENSMUST00000091197.3
Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr15_-_66948419 2.749 ENSMUST00000167817.1
Ndrg1
N-myc downstream regulated gene 1
chr13_-_54766553 1.820 ENSMUST00000036825.7
Sncb
synuclein, beta
chr5_+_98854434 1.278 ENSMUST00000031278.4
Bmp3
bone morphogenetic protein 3
chr1_+_107511489 1.266 ENSMUST00000064916.2
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 1.219 ENSMUST00000009356.4
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr6_+_47244359 1.069 ENSMUST00000060839.6
Cntnap2
contactin associated protein-like 2
chr3_-_87263518 1.007 ENSMUST00000090986.4
Fcrls
Fc receptor-like S, scavenger receptor
chr1_-_71653162 0.992 ENSMUST00000055226.6
Fn1
fibronectin 1
chr17_+_3397189 0.986 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr7_-_75308373 0.957 ENSMUST00000085164.5
Sv2b
synaptic vesicle glycoprotein 2 b
chr1_+_45311538 0.954 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chr1_+_72824482 0.947 ENSMUST00000047328.4
Igfbp2
insulin-like growth factor binding protein 2
chr6_-_42324554 0.856 ENSMUST00000095974.3
Fam131b
family with sequence similarity 131, member B
chr8_-_13494479 0.767 ENSMUST00000033828.5
Gas6
growth arrest specific 6
chr6_-_42324640 0.749 ENSMUST00000031891.8
ENSMUST00000143278.1
Fam131b

family with sequence similarity 131, member B

chr11_-_78550777 0.744 ENSMUST00000103242.4
Tmem97
transmembrane protein 97
chr3_-_87263703 0.742 ENSMUST00000146512.1
Fcrls
Fc receptor-like S, scavenger receptor
chr13_+_53525703 0.699 ENSMUST00000081132.4
Gm5449
predicted pseudogene 5449
chr17_-_36951338 0.688 ENSMUST00000173540.1
Ppp1r11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr12_+_105336922 0.684 ENSMUST00000180503.1
2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr18_-_33463615 0.671 ENSMUST00000051087.8
Nrep
neuronal regeneration related protein
chr3_+_94377432 0.628 ENSMUST00000107292.1
Rorc
RAR-related orphan receptor gamma
chrX_-_102252154 0.626 ENSMUST00000050551.3
Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr3_-_141982224 0.621 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr9_-_86880414 0.613 ENSMUST00000074501.5
ENSMUST00000098495.3
ENSMUST00000074468.6
ENSMUST00000036347.6
Snap91



synaptosomal-associated protein 91



chr17_+_46254017 0.603 ENSMUST00000095262.4
Lrrc73
leucine rich repeat containing 73
chr16_-_21947536 0.594 ENSMUST00000023562.7
Tmem41a
transmembrane protein 41a
chr5_+_8046077 0.580 ENSMUST00000088786.4
Sri
sorcin
chr1_+_84839833 0.574 ENSMUST00000097672.3
Fbxo36
F-box protein 36
chr3_+_94377505 0.565 ENSMUST00000098877.2
Rorc
RAR-related orphan receptor gamma
chr7_+_16309577 0.544 ENSMUST00000002152.6
Bbc3
BCL2 binding component 3
chr15_+_78597047 0.543 ENSMUST00000043069.5
Cyth4
cytohesin 4
chr2_+_4976113 0.542 ENSMUST00000167607.1
ENSMUST00000115010.2
Ucma

upper zone of growth plate and cartilage matrix associated

chr15_+_6422240 0.528 ENSMUST00000163082.1
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr11_-_102296618 0.522 ENSMUST00000107132.2
ENSMUST00000073234.2
Atxn7l3

ataxin 7-like 3

chr17_-_36951636 0.514 ENSMUST00000040402.7
ENSMUST00000174711.1
Ppp1r11

protein phosphatase 1, regulatory (inhibitor) subunit 11

chr4_-_40948196 0.511 ENSMUST00000030125.4
ENSMUST00000108089.1
Bag1

BCL2-associated athanogene 1

chr11_+_32300069 0.511 ENSMUST00000020535.1
Hbq1a
hemoglobin, theta 1A
chr11_-_45944910 0.496 ENSMUST00000129820.1
Lsm11
U7 snRNP-specific Sm-like protein LSM11
chr9_-_21037775 0.488 ENSMUST00000180870.1
Gm26592
predicted gene, 26592
chr2_-_172370506 0.480 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
Aurka


aurora kinase A


chr8_+_106870827 0.479 ENSMUST00000176144.1
ENSMUST00000175987.1
Has3

hyaluronan synthase 3

chr17_+_45686322 0.473 ENSMUST00000024734.7
Mrpl14
mitochondrial ribosomal protein L14
chr3_+_95124476 0.472 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
Tmod4


tropomodulin 4


chr18_+_78349754 0.471 ENSMUST00000164064.1
Gm6133
predicted gene 6133
chr6_+_86371489 0.449 ENSMUST00000089558.5
Snrpg
small nuclear ribonucleoprotein polypeptide G
chr9_-_106891401 0.443 ENSMUST00000069036.7
Manf
mesencephalic astrocyte-derived neurotrophic factor
chr7_-_89941084 0.440 ENSMUST00000075010.4
ENSMUST00000153470.1
l7Rn6

lethal, Chr 7, Rinchik 6

chr16_-_46155077 0.439 ENSMUST00000059524.5
Gm4737
predicted gene 4737
chr15_-_102667749 0.436 ENSMUST00000075630.3
Atp5g2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)
chr2_-_126709567 0.434 ENSMUST00000099423.2
Gm10774
predicted pseudogene 10774
chr3_+_124321031 0.412 ENSMUST00000058994.4
Tram1l1
translocation associated membrane protein 1-like 1
chr2_+_151542483 0.411 ENSMUST00000044011.5
Fkbp1a
FK506 binding protein 1a
chr13_-_49320219 0.408 ENSMUST00000110086.1
Fgd3
FYVE, RhoGEF and PH domain containing 3
chr4_+_117550326 0.394 ENSMUST00000037127.8
Eri3
exoribonuclease 3
chr14_-_31128924 0.360 ENSMUST00000064032.4
ENSMUST00000049732.5
ENSMUST00000090205.3
Smim4


small itegral membrane protein 4


chr15_-_102257449 0.349 ENSMUST00000043172.8
Rarg
retinoic acid receptor, gamma
chr17_+_16972910 0.348 ENSMUST00000071374.5
BC002059
cDNA sequence BC002059
chr3_-_89998656 0.344 ENSMUST00000079724.4
Hax1
HCLS1 associated X-1
chr1_+_120602405 0.339 ENSMUST00000079721.7
En1
engrailed 1
chr11_-_98625661 0.336 ENSMUST00000104933.1
Gm12355
predicted gene 12355
chr13_-_34077992 0.336 ENSMUST00000056427.8
Tubb2a
tubulin, beta 2A class IIA
chr2_-_12301914 0.334 ENSMUST00000028106.4
Itga8
integrin alpha 8
chr18_+_33464163 0.331 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr6_-_29212240 0.329 ENSMUST00000160878.1
ENSMUST00000078155.5
Impdh1

inosine 5'-phosphate dehydrogenase 1

chr15_-_76656905 0.328 ENSMUST00000176274.1
Cyhr1
cysteine and histidine rich 1
chrX_-_102251852 0.316 ENSMUST00000101336.3
ENSMUST00000136277.1
Cited1

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

chr3_-_95282076 0.311 ENSMUST00000015855.7
Prune
prune homolog (Drosophila)
chr3_+_90079540 0.311 ENSMUST00000029549.9
ENSMUST00000118566.1
ENSMUST00000119158.1
Tpm3


tropomyosin 3, gamma


chr10_+_77864623 0.308 ENSMUST00000092366.2
Tspear
thrombospondin type laminin G domain and EAR repeats
chr14_+_113314602 0.294 ENSMUST00000072359.6
Tpm3-rs7
tropomyosin 3, related sequence 7
chr14_-_48662740 0.290 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr11_+_6415443 0.287 ENSMUST00000132846.1
Ppia
peptidylprolyl isomerase A
chr6_-_88045190 0.285 ENSMUST00000113596.1
ENSMUST00000113600.3
Rab7

RAB7, member RAS oncogene family

chr17_-_70851710 0.282 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr2_-_156839790 0.280 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
Gm14230


predicted gene 14230


chr7_+_44816088 0.280 ENSMUST00000057195.9
ENSMUST00000107891.1
Nup62

nucleoporin 62

chr8_-_25840440 0.279 ENSMUST00000110609.1
Ash2l
ash2 (absent, small, or homeotic)-like (Drosophila)
chr11_+_70017085 0.278 ENSMUST00000108589.2
Dlg4
discs, large homolog 4 (Drosophila)
chr9_+_72806874 0.275 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr13_+_42680565 0.273 ENSMUST00000128646.1
Phactr1
phosphatase and actin regulator 1
chr9_-_103222063 0.273 ENSMUST00000170904.1
Trf
transferrin
chr12_-_73047179 0.270 ENSMUST00000050029.7
Six1
sine oculis-related homeobox 1
chr3_+_145987835 0.269 ENSMUST00000039517.6
Syde2
synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
chr2_+_30807826 0.268 ENSMUST00000041830.3
ENSMUST00000152374.1
Ntmt1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

chr9_-_86880647 0.263 ENSMUST00000167014.1
Snap91
synaptosomal-associated protein 91
chr3_-_96197580 0.262 ENSMUST00000016087.3
Bola1
bolA-like 1 (E. coli)
chr1_+_74284930 0.259 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
Pnkd


paroxysmal nonkinesiogenic dyskinesia


chr13_-_54611332 0.257 ENSMUST00000091609.4
Cltb
clathrin, light polypeptide (Lcb)
chr13_-_54611274 0.248 ENSMUST00000049575.7
Cltb
clathrin, light polypeptide (Lcb)
chr15_-_82244716 0.244 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr8_-_41417042 0.241 ENSMUST00000033999.6
Frg1
FSHD region gene 1
chr2_-_79908389 0.238 ENSMUST00000090756.4
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr16_-_97170707 0.237 ENSMUST00000056102.7
Dscam
Down syndrome cell adhesion molecule
chr13_-_8871751 0.233 ENSMUST00000175958.1
Wdr37
WD repeat domain 37
chr1_-_87394721 0.229 ENSMUST00000113212.3
Kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr15_+_80255184 0.228 ENSMUST00000109605.3
Atf4
activating transcription factor 4
chr4_-_59783800 0.227 ENSMUST00000107526.1
ENSMUST00000095063.4
Inip

INTS3 and NABP interacting protein

chr19_-_53944621 0.211 ENSMUST00000135402.2
Bbip1
BBSome interacting protein 1
chrX_+_120290259 0.207 ENSMUST00000113358.3
ENSMUST00000050239.9
ENSMUST00000113364.3
Pcdh11x


protocadherin 11 X-linked


chr18_-_78123324 0.205 ENSMUST00000160292.1
ENSMUST00000091813.5
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr13_-_107414742 0.199 ENSMUST00000061241.6
Apoo-ps
apolipoprotein O, pseudogene
chr17_-_83631892 0.195 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr2_+_163994960 0.194 ENSMUST00000018470.3
Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr9_-_67049143 0.188 ENSMUST00000113687.1
ENSMUST00000113693.1
ENSMUST00000113701.1
ENSMUST00000034928.5
ENSMUST00000113685.3
ENSMUST00000030185.4
ENSMUST00000050905.9
ENSMUST00000113705.1
ENSMUST00000113697.1
ENSMUST00000113707.2
Tpm1









tropomyosin 1, alpha









chr4_+_40948401 0.188 ENSMUST00000030128.5
Chmp5
charged multivesicular body protein 5
chr16_-_59632520 0.184 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr4_-_43030440 0.183 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chr5_-_149636164 0.179 ENSMUST00000076410.4
Hsph1
heat shock 105kDa/110kDa protein 1
chr5_-_97111565 0.179 ENSMUST00000112969.3
Paqr3
progestin and adipoQ receptor family member III
chr13_+_46669517 0.178 ENSMUST00000099547.3
C78339
expressed sequence C78339
chr2_-_79908428 0.178 ENSMUST00000102652.3
ENSMUST00000102651.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr1_-_74284636 0.168 ENSMUST00000178235.1
ENSMUST00000006462.7
Aamp

angio-associated migratory protein

chr11_+_69935796 0.167 ENSMUST00000018698.5
Ybx2
Y box protein 2
chr11_+_70017199 0.163 ENSMUST00000133140.1
Dlg4
discs, large homolog 4 (Drosophila)
chr17_-_57011271 0.161 ENSMUST00000002733.6
Gtf2f1
general transcription factor IIF, polypeptide 1
chr2_+_172370658 0.157 ENSMUST00000151511.1
ENSMUST00000116375.1
Cstf1

cleavage stimulation factor, 3' pre-RNA, subunit 1

chr7_-_44816586 0.151 ENSMUST00000047356.8
Atf5
activating transcription factor 5
chr6_+_55203381 0.145 ENSMUST00000053094.7
Fam188b
family with sequence similarity 188, member B
chr6_+_68161415 0.140 ENSMUST00000168090.1
Igkv1-115
immunoglobulin kappa variable 1-115
chr3_+_61364507 0.139 ENSMUST00000049064.2
Rap2b
RAP2B, member of RAS oncogene family
chr2_-_103485068 0.136 ENSMUST00000111168.3
Cat
catalase
chr10_-_14705459 0.133 ENSMUST00000149485.1
ENSMUST00000154132.1
Vta1

Vps20-associated 1 homolog (S. cerevisiae)

chr9_-_71592265 0.133 ENSMUST00000169573.1
ENSMUST00000166843.1
ENSMUST00000163998.1
Myzap
Gcom1

myocardial zonula adherens protein
GRINL1A complex locus

chr15_-_78405824 0.130 ENSMUST00000058659.7
Tst
thiosulfate sulfurtransferase, mitochondrial
chr7_-_127026479 0.123 ENSMUST00000032916.4
Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr6_+_17281185 0.123 ENSMUST00000000058.6
Cav2
caveolin 2
chr15_+_80623499 0.121 ENSMUST00000043149.7
Grap2
GRB2-related adaptor protein 2
chr12_-_69198419 0.119 ENSMUST00000021356.5
Dnaaf2
dynein, axonemal assembly factor 2
chr8_+_69088646 0.116 ENSMUST00000006435.7
Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
chr16_-_94370450 0.113 ENSMUST00000138514.1
Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr12_+_44328882 0.104 ENSMUST00000020939.8
ENSMUST00000110748.2
Nrcam

neuron-glia-CAM-related cell adhesion molecule

chr2_+_35622010 0.103 ENSMUST00000091010.5
Dab2ip
disabled 2 interacting protein
chrX_-_101222426 0.103 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
Snx12


sorting nexin 12


chr1_+_34439851 0.101 ENSMUST00000027303.7
Imp4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr8_-_105933832 0.101 ENSMUST00000034368.6
Ctrl
chymotrypsin-like
chr7_-_44892358 0.097 ENSMUST00000003049.6
Med25
mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)
chr9_-_83146601 0.096 ENSMUST00000162246.2
ENSMUST00000161796.2
Hmgn3

high mobility group nucleosomal binding domain 3

chr17_+_37045980 0.093 ENSMUST00000174456.1
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr11_+_3202612 0.091 ENSMUST00000110049.1
Eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr11_-_4594750 0.089 ENSMUST00000109943.3
Mtmr3
myotubularin related protein 3
chr1_+_189728264 0.085 ENSMUST00000097442.2
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr12_-_113422730 0.081 ENSMUST00000177715.1
ENSMUST00000103426.1
Ighm

immunoglobulin heavy constant mu

chr13_-_18382041 0.074 ENSMUST00000139064.2
ENSMUST00000175703.2
Pou6f2

POU domain, class 6, transcription factor 2

chr12_+_4234023 0.072 ENSMUST00000179139.1
Ptrhd1
peptidyl-tRNA hydrolase domain containing 1
chr11_-_96829959 0.065 ENSMUST00000081775.5
Nfe2l1
nuclear factor, erythroid derived 2,-like 1
chr3_+_95160449 0.063 ENSMUST00000090823.1
ENSMUST00000090821.3
Sema6c

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

chr7_-_100547620 0.062 ENSMUST00000064334.2
D630004N19Rik
RIKEN cDNA D630004N19 gene
chr15_+_88819584 0.058 ENSMUST00000024042.3
Creld2
cysteine-rich with EGF-like domains 2
chr7_-_142656018 0.057 ENSMUST00000178921.1
Igf2
insulin-like growth factor 2
chr19_+_53944870 0.043 ENSMUST00000025932.7
Shoc2
soc-2 (suppressor of clear) homolog (C. elegans)
chrX_-_57338598 0.043 ENSMUST00000033468.4
ENSMUST00000114736.1
Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr9_-_110476637 0.040 ENSMUST00000111934.1
ENSMUST00000068025.6
Klhl18

kelch-like 18

chr9_+_110419750 0.040 ENSMUST00000035061.6
Ngp
neutrophilic granule protein
chr13_+_23934434 0.036 ENSMUST00000072391.1
Hist1h2aa
histone cluster 1, H2aa
chr16_+_35983424 0.035 ENSMUST00000173555.1
Kpna1
karyopherin (importin) alpha 1
chr2_-_181365306 0.031 ENSMUST00000108808.1
ENSMUST00000170190.1
ENSMUST00000127988.1
Arfrp1


ADP-ribosylation factor related protein 1


chr11_+_68968107 0.026 ENSMUST00000102606.3
ENSMUST00000018884.5
Slc25a35

solute carrier family 25, member 35

chr7_+_129257027 0.020 ENSMUST00000094018.4
Ppapdc1a
phosphatidic acid phosphatase type 2 domain containing 1A
chr10_+_115569986 0.012 ENSMUST00000173620.1
A930009A15Rik
RIKEN cDNA A930009A15 gene
chr5_-_135573036 0.010 ENSMUST00000004936.6
Ccl24
chemokine (C-C motif) ligand 24
chr7_-_51862216 0.009 ENSMUST00000169357.1
Fancf
Fanconi anemia, complementation group F
chr12_-_87443800 0.005 ENSMUST00000162961.1
Alkbh1
alkB, alkylation repair homolog 1 (E. coli)
chr1_+_75236439 0.004 ENSMUST00000082158.6
ENSMUST00000055223.7
Dnajb2

DnaJ (Hsp40) homolog, subfamily B, member 2

chr11_-_74724670 0.003 ENSMUST00000021091.8
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr13_+_65512678 0.003 ENSMUST00000081471.2
Gm10139
predicted gene 10139
chr7_+_19228334 0.002 ENSMUST00000063976.8
Opa3
optic atrophy 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.3 0.8 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of protein import into nucleus, translocation(GO:0033159) regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.2 2.7 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.2 0.9 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.2 1.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.2 1.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 0.5 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.2 0.6 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 1.2 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 0.4 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.1 0.5 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.9 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 0.5 GO:0007056 spindle assembly involved in female meiosis(GO:0007056) positive regulation of oocyte development(GO:0060282)
0.1 0.6 GO:0055118 negative regulation of cardiac muscle contraction(GO:0055118)
0.1 0.3 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.1 0.3 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.1 0.5 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.1 0.5 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 1.6 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 0.3 GO:0061743 motor learning(GO:0061743)
0.1 0.3 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.2 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.1 0.5 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 0.3 GO:1903542 negative regulation of exosomal secretion(GO:1903542)
0.1 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 0.2 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.3 GO:0018201 peptidyl-glycine modification(GO:0018201)
0.1 0.3 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 0.3 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.5 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.2 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 0.2 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 0.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 2.1 GO:0042417 dopamine metabolic process(GO:0042417)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:1903441 protein localization to ciliary membrane(GO:1903441)
0.0 0.2 GO:1903750 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135) regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0 0.1 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 4.5 GO:0006413 translational initiation(GO:0006413)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.3 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 1.3 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.2 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.4 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.4 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.0 0.1 GO:0060161 positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.0 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0036324 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144) vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.0 0.6 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.5 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0002339 B cell selection(GO:0002339)
0.0 2.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.1 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.1 GO:0009650 UV protection(GO:0009650)
0.0 0.2 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.7 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.3 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0005577 fibrinogen complex(GO:0005577)
0.3 0.9 GO:0098835 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.2 0.6 GO:0042584 chromaffin granule membrane(GO:0042584)
0.2 0.5 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.5 GO:0005683 U7 snRNP(GO:0005683)
0.1 1.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 2.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 1.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.4 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 0.2 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.0 0.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.2 GO:0070876 SOSS complex(GO:0070876)
0.0 0.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.3 GO:0097433 dense body(GO:0097433) HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.3 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.5 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 2.4 GO:0016234 inclusion body(GO:0016234)
0.0 0.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.2 GO:0034464 BBSome(GO:0034464)
0.0 0.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0045340 mercury ion binding(GO:0045340)
0.3 1.2 GO:0008142 oxysterol binding(GO:0008142)
0.2 1.8 GO:1903136 cuprous ion binding(GO:1903136)
0.2 0.5 GO:0071209 U7 snRNA binding(GO:0071209)
0.2 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 1.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 1.3 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.3 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.5 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.9 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.3 GO:0051425 PTB domain binding(GO:0051425)
0.1 4.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.4 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.5 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.8 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 2.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 0.3 GO:1990188 euchromatin binding(GO:1990188)
0.1 0.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 2.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.4 GO:0048185 activin binding(GO:0048185)
0.0 0.2 GO:0015265 urea channel activity(GO:0015265)
0.0 0.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.3 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.1 GO:0004096 aminoacylase activity(GO:0004046) catalase activity(GO:0004096)
0.0 0.1 GO:0030519 snoRNP binding(GO:0030519)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.3 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.2 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.1 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.2 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.3 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.6 GO:0002020 protease binding(GO:0002020)
0.0 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.2 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID_ALK2_PATHWAY ALK2 signaling events
0.0 2.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.2 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.0 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.3 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.5 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.7 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.0 0.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters