Motif ID: Foxc1

Z-value: 0.641


Transcription factors associated with Foxc1:

Gene SymbolEntrez IDGene Name
Foxc1 ENSMUSG00000050295.2 Foxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc1mm10_v2_chr13_+_31806627_318066500.057.5e-01Click!


Activity profile for motif Foxc1.

activity profile for motif Foxc1


Sorted Z-values histogram for motif Foxc1

Sorted Z-values for motif Foxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 168 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_1010543 4.668 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr15_-_66948419 2.749 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr13_-_54766553 1.820 ENSMUST00000036825.7
 Sncb
synuclein, beta
chr5_+_98854434 1.278 ENSMUST00000031278.4
 Bmp3
bone morphogenetic protein 3
chr1_+_107511489 1.266 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 1.219 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr6_+_47244359 1.069 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr3_-_87263518 1.007 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr1_-_71653162 0.992 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr17_+_3397189 0.986 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr7_-_75308373 0.957 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr1_+_45311538 0.954 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr1_+_72824482 0.947 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr6_-_42324554 0.856 ENSMUST00000095974.3
 Fam131b
family with sequence similarity 131, member B
chr8_-_13494479 0.767 ENSMUST00000033828.5
 Gas6
growth arrest specific 6
chr6_-_42324640 0.749 ENSMUST00000031891.8
ENSMUST00000143278.1
 Fam131b

family with sequence similarity 131, member B

chr11_-_78550777 0.744 ENSMUST00000103242.4
 Tmem97
transmembrane protein 97
chr3_-_87263703 0.742 ENSMUST00000146512.1
 Fcrls
Fc receptor-like S, scavenger receptor
chr13_+_53525703 0.699 ENSMUST00000081132.4
 Gm5449
predicted pseudogene 5449
chr17_-_36951338 0.688 ENSMUST00000173540.1
 Ppp1r11
protein phosphatase 1, regulatory (inhibitor) subunit 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0006413 translational initiation(GO:0006413)
0.2 2.7 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 2.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 2.1 GO:0042417 dopamine metabolic process(GO:0042417)
0.1 1.6 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 1.3 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.1 1.2 GO:0072615 interleukin-17 secretion(GO:0072615)
0.2 1.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.3 1.0 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.2 1.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 0.9 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.1 0.9 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 0.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.3 0.8 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of protein import into nucleus, translocation(GO:0033159) regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0 0.7 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.2 0.6 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.6 GO:0055118 negative regulation of cardiac muscle contraction(GO:0055118)
0.0 0.6 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.2 0.5 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 0.5 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.4 GO:0016234 inclusion body(GO:0016234)
0.1 1.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 1.0 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 0.9 GO:0098835 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.2 0.6 GO:0042584 chromaffin granule membrane(GO:0042584)
0.2 0.5 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.5 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.5 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.1 0.4 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.3 GO:0097433 dense body(GO:0097433) HFE-transferrin receptor complex(GO:1990712)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 2.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 1.8 GO:1903136 cuprous ion binding(GO:1903136)
0.0 1.6 GO:0002020 protease binding(GO:0002020)
0.1 1.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.3 GO:0070700 BMP receptor binding(GO:0070700)
0.3 1.2 GO:0008142 oxysterol binding(GO:0008142)
0.2 1.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 1.0 GO:0045340 mercury ion binding(GO:0045340)
0.1 1.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.9 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.8 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 0.5 GO:0071209 U7 snRNA binding(GO:0071209)
0.2 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.5 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.5 GO:0005523 tropomyosin binding(GO:0005523)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 1.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.4 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.2 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.0 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.9 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.7 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.3 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA Genes involved in Processing of Capped Intronless Pre-mRNA