Motif ID: Foxc2

Z-value: 0.473


Transcription factors associated with Foxc2:

Gene SymbolEntrez IDGene Name
Foxc2 ENSMUSG00000046714.6 Foxc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc2mm10_v2_chr8_+_121116163_1211161770.038.6e-01Click!


Activity profile for motif Foxc2.

activity profile for motif Foxc2


Sorted Z-values histogram for motif Foxc2

Sorted Z-values for motif Foxc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_84773381 3.074 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr9_+_53850243 2.944 ENSMUST00000048485.5
Sln
sarcolipin
chr4_+_48049080 2.062 ENSMUST00000153369.1
Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr4_-_87806296 1.803 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr1_-_97977233 1.322 ENSMUST00000161567.1
Pam
peptidylglycine alpha-amidating monooxygenase
chr2_+_25180737 1.258 ENSMUST00000104999.2
Nrarp
Notch-regulated ankyrin repeat protein
chr2_-_62483637 1.239 ENSMUST00000136686.1
ENSMUST00000102733.3
Gcg

glucagon

chr17_+_3532554 1.113 ENSMUST00000168560.1
Cldn20
claudin 20
chr16_+_43363855 1.103 ENSMUST00000156367.1
Zbtb20
zinc finger and BTB domain containing 20
chr12_-_31950170 1.075 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr12_-_31950210 1.036 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chr6_+_8520008 0.969 ENSMUST00000162567.1
ENSMUST00000161217.1
Glcci1

glucocorticoid induced transcript 1

chr16_+_43364145 0.963 ENSMUST00000148775.1
Zbtb20
zinc finger and BTB domain containing 20
chr1_+_177444653 0.952 ENSMUST00000094276.3
Zbtb18
zinc finger and BTB domain containing 18
chr1_-_156034826 0.901 ENSMUST00000141878.1
ENSMUST00000123705.1
Tor1aip1

torsin A interacting protein 1

chr5_-_111761697 0.875 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr16_-_22439719 0.874 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr13_+_40859768 0.768 ENSMUST00000110191.2
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr9_+_70207342 0.758 ENSMUST00000034745.7
Myo1e
myosin IE
chr13_-_83729544 0.735 ENSMUST00000181705.1
Gm26803
predicted gene, 26803
chr3_+_53488677 0.720 ENSMUST00000029307.3
Stoml3
stomatin (Epb7.2)-like 3
chr6_+_17491216 0.683 ENSMUST00000080469.5
Met
met proto-oncogene
chr4_+_97777606 0.682 ENSMUST00000075448.6
ENSMUST00000092532.6
Nfia

nuclear factor I/A

chr4_-_87806276 0.644 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr12_-_31950535 0.633 ENSMUST00000172314.2
Hbp1
high mobility group box transcription factor 1
chr2_-_77519565 0.631 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr7_+_24271568 0.619 ENSMUST00000032696.6
Zfp93
zinc finger protein 93
chr16_-_74411292 0.600 ENSMUST00000117200.1
Robo2
roundabout homolog 2 (Drosophila)
chr7_+_27591513 0.553 ENSMUST00000108344.2
Akt2
thymoma viral proto-oncogene 2
chr12_+_71016658 0.546 ENSMUST00000125125.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr10_-_93310963 0.526 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr1_+_179546303 0.518 ENSMUST00000040706.8
Cnst
consortin, connexin sorting protein
chr8_-_64205970 0.504 ENSMUST00000066166.4
Tll1
tolloid-like
chr6_+_34709610 0.502 ENSMUST00000031775.6
Cald1
caldesmon 1
chr18_-_74961252 0.493 ENSMUST00000066532.4
Lipg
lipase, endothelial
chr6_+_92940572 0.463 ENSMUST00000181145.1
ENSMUST00000181840.1
9530026P05Rik

RIKEN cDNA 9530026P05 gene

chr1_+_9848375 0.424 ENSMUST00000097826.4
Sgk3
serum/glucocorticoid regulated kinase 3
chr7_+_67655414 0.420 ENSMUST00000107470.1
Ttc23
tetratricopeptide repeat domain 23
chr10_-_93311073 0.417 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr2_-_177267036 0.414 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr14_-_24486994 0.407 ENSMUST00000026322.7
Polr3a
polymerase (RNA) III (DNA directed) polypeptide A
chr1_-_156035891 0.407 ENSMUST00000126448.1
Tor1aip1
torsin A interacting protein 1
chr2_-_51972990 0.405 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr17_+_7925990 0.402 ENSMUST00000036370.7
Tagap
T cell activation Rho GTPase activating protein
chr18_-_54990124 0.399 ENSMUST00000064763.5
Zfp608
zinc finger protein 608
chr2_-_45110336 0.370 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr11_+_32000452 0.352 ENSMUST00000020537.2
ENSMUST00000109409.1
Nsg2

neuron specific gene family member 2

chr3_-_123672321 0.344 ENSMUST00000172537.1
ENSMUST00000029602.6
Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr4_-_118409219 0.337 ENSMUST00000075406.5
Szt2
seizure threshold 2
chr3_+_135825648 0.331 ENSMUST00000180196.1
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr1_-_156036473 0.325 ENSMUST00000097527.3
ENSMUST00000027738.7
Tor1aip1

torsin A interacting protein 1

chr3_+_94837702 0.314 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
Pogz


pogo transposable element with ZNF domain


chr2_-_65529275 0.314 ENSMUST00000126837.1
Scn3a
sodium channel, voltage-gated, type III, alpha
chr4_-_34882919 0.301 ENSMUST00000098163.2
ENSMUST00000047950.5
Zfp292

zinc finger protein 292

chr1_-_156034800 0.289 ENSMUST00000169241.1
Tor1aip1
torsin A interacting protein 1
chr2_-_51973219 0.287 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chr16_-_34263179 0.287 ENSMUST00000114949.1
ENSMUST00000114954.1
Kalrn

kalirin, RhoGEF kinase

chr1_+_9848270 0.284 ENSMUST00000171265.1
Sgk3
serum/glucocorticoid regulated kinase 3
chrX_+_71663665 0.273 ENSMUST00000070449.5
Gpr50
G-protein-coupled receptor 50
chr1_-_179546261 0.270 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chr2_+_4718145 0.260 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr2_-_7395879 0.252 ENSMUST00000182404.1
Celf2
CUGBP, Elav-like family member 2
chr3_-_146781351 0.248 ENSMUST00000005164.7
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr14_-_55643251 0.246 ENSMUST00000120041.1
ENSMUST00000121937.1
ENSMUST00000133707.1
ENSMUST00000002391.8
ENSMUST00000121791.1
Tm9sf1




transmembrane 9 superfamily member 1




chr6_+_15185203 0.242 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr10_-_68278713 0.232 ENSMUST00000020106.7
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr12_-_101958148 0.222 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
Atxn3



ataxin 3



chr13_-_12464925 0.220 ENSMUST00000124888.1
Lgals8
lectin, galactose binding, soluble 8
chr11_+_32000496 0.217 ENSMUST00000093219.3
Nsg2
neuron specific gene family member 2
chr16_-_34262945 0.208 ENSMUST00000114953.1
Kalrn
kalirin, RhoGEF kinase
chr9_+_13619990 0.197 ENSMUST00000159294.1
Maml2
mastermind like 2 (Drosophila)
chr7_-_44849075 0.190 ENSMUST00000047085.8
Tbc1d17
TBC1 domain family, member 17
chr1_+_87404916 0.170 ENSMUST00000173152.1
ENSMUST00000173663.1
Gigyf2

GRB10 interacting GYF protein 2

chr16_-_22657165 0.169 ENSMUST00000089925.3
Dgkg
diacylglycerol kinase, gamma
chr5_-_122988533 0.168 ENSMUST00000086200.4
ENSMUST00000156474.1
Kdm2b

lysine (K)-specific demethylase 2B

chr7_+_44849581 0.159 ENSMUST00000150335.1
ENSMUST00000107882.1
Akt1s1

AKT1 substrate 1 (proline-rich)

chr3_+_94837533 0.152 ENSMUST00000107270.2
Pogz
pogo transposable element with ZNF domain
chr9_+_70679016 0.140 ENSMUST00000144537.1
Adam10
a disintegrin and metallopeptidase domain 10
chr10_+_38965515 0.138 ENSMUST00000019992.5
Lama4
laminin, alpha 4
chr2_-_73312701 0.137 ENSMUST00000058615.9
Cir1
corepressor interacting with RBPJ, 1
chr13_-_103920295 0.137 ENSMUST00000169083.1
Erbb2ip
Erbb2 interacting protein
chr5_-_122989260 0.133 ENSMUST00000118027.1
Kdm2b
lysine (K)-specific demethylase 2B
chr11_-_69662564 0.129 ENSMUST00000129224.1
ENSMUST00000155200.1
Mpdu1

mannose-P-dolichol utilization defect 1

chr14_-_70766598 0.129 ENSMUST00000167242.1
ENSMUST00000022696.6
Xpo7

exportin 7

chr10_-_61979073 0.128 ENSMUST00000105453.1
ENSMUST00000105452.2
ENSMUST00000105454.2
Col13a1


collagen, type XIII, alpha 1


chr2_+_91730127 0.118 ENSMUST00000099712.3
ENSMUST00000111317.2
ENSMUST00000111316.2
ENSMUST00000045705.7
Ambra1



autophagy/beclin 1 regulator 1



chr11_-_107348130 0.115 ENSMUST00000134763.1
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr5_-_138170992 0.112 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr11_+_87699897 0.106 ENSMUST00000040089.4
Rnf43
ring finger protein 43
chr5_+_25247344 0.102 ENSMUST00000114950.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr4_+_141115660 0.095 ENSMUST00000181450.1
4921514A10Rik
RIKEN cDNA 4921514A10 gene
chr17_+_47505149 0.094 ENSMUST00000183177.1
ENSMUST00000182848.1
Ccnd3

cyclin D3

chr19_-_42086338 0.094 ENSMUST00000051772.8
Morn4
MORN repeat containing 4
chr10_-_41303171 0.093 ENSMUST00000043814.3
Fig4
FIG4 homolog (S. cerevisiae)
chr18_+_34759551 0.090 ENSMUST00000097622.3
Fam53c
family with sequence similarity 53, member C
chr4_+_11579647 0.087 ENSMUST00000180239.1
Fsbp
fibrinogen silencer binding protein
chr17_-_79896028 0.080 ENSMUST00000068282.5
ENSMUST00000112437.1
Atl2

atlastin GTPase 2

chr17_+_47505117 0.078 ENSMUST00000183044.1
ENSMUST00000037333.10
Ccnd3

cyclin D3

chr9_-_105521147 0.078 ENSMUST00000176770.1
ENSMUST00000085133.6
Atp2c1

ATPase, Ca++-sequestering

chr1_-_75046639 0.078 ENSMUST00000152855.1
Nhej1
nonhomologous end-joining factor 1
chr11_-_68386974 0.073 ENSMUST00000135141.1
Ntn1
netrin 1
chrX_+_163911401 0.073 ENSMUST00000140845.1
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chrX_-_94123087 0.071 ENSMUST00000113925.1
Zfx
zinc finger protein X-linked
chr1_+_156035705 0.070 ENSMUST00000111754.2
ENSMUST00000133152.1
Tor1aip2

torsin A interacting protein 2

chr4_-_127970951 0.069 ENSMUST00000030614.2
CK137956
cDNA sequence CK137956
chr16_-_43664145 0.063 ENSMUST00000096065.4
Tigit
T cell immunoreceptor with Ig and ITIM domains
chr11_-_68386821 0.063 ENSMUST00000021284.3
Ntn1
netrin 1
chr11_+_78465697 0.060 ENSMUST00000001126.3
Slc46a1
solute carrier family 46, member 1
chr4_-_82885148 0.059 ENSMUST00000048430.3
Cer1
cerberus 1 homolog (Xenopus laevis)
chr6_+_14901440 0.058 ENSMUST00000128567.1
Foxp2
forkhead box P2
chrX_+_159303266 0.054 ENSMUST00000112491.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr6_+_135065651 0.050 ENSMUST00000050104.7
Gprc5a
G protein-coupled receptor, family C, group 5, member A
chr5_-_122989086 0.049 ENSMUST00000046073.9
Kdm2b
lysine (K)-specific demethylase 2B
chr13_+_42681513 0.049 ENSMUST00000149235.1
Phactr1
phosphatase and actin regulator 1
chr17_+_47505211 0.044 ENSMUST00000182935.1
ENSMUST00000182506.1
Ccnd3

cyclin D3

chr3_+_63295815 0.037 ENSMUST00000029400.1
Mme
membrane metallo endopeptidase
chr13_-_30974023 0.035 ENSMUST00000021785.6
Exoc2
exocyst complex component 2
chr1_+_156838915 0.029 ENSMUST00000111720.1
Angptl1
angiopoietin-like 1
chr18_+_34758890 0.028 ENSMUST00000049281.5
Fam53c
family with sequence similarity 53, member C
chr2_-_71055534 0.027 ENSMUST00000090849.5
ENSMUST00000100037.2
ENSMUST00000112186.2
Mettl8


methyltransferase like 8


chr2_+_73312601 0.026 ENSMUST00000090811.4
ENSMUST00000112050.1
Scrn3

secernin 3

chr4_+_148591482 0.025 ENSMUST00000006611.8
Srm
spermidine synthase
chr4_+_114680769 0.023 ENSMUST00000146346.1
Gm12829
predicted gene 12829
chr7_+_27195781 0.021 ENSMUST00000108379.1
ENSMUST00000179391.1
BC024978

cDNA sequence BC024978

chr7_+_44849216 0.011 ENSMUST00000054343.8
Akt1s1
AKT1 substrate 1 (proline-rich)
chr14_+_46832127 0.009 ENSMUST00000068532.8
Cgrrf1
cell growth regulator with ring finger domain 1
chr10_-_30600662 0.002 ENSMUST00000019927.6
Trmt11
tRNA methyltransferase 11
chr1_+_156036133 0.001 ENSMUST00000128941.1
Tor1aip2
torsin A interacting protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.7 2.1 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.3 2.7 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.2 0.7 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.2 0.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 1.9 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 1.2 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.2 0.9 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 0.5 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.2 3.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 2.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.8 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.5 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 1.3 GO:0009404 toxin metabolic process(GO:0009404)
0.1 0.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 0.6 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1 0.5 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.1 0.5 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.1 1.0 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 0.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 0.3 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.1 0.3 GO:0046684 response to pyrethroid(GO:0046684)
0.1 2.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.5 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.3 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.7 GO:0072189 ureter development(GO:0072189)
0.0 0.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.3 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.5 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.2 GO:0060613 fat pad development(GO:0060613)
0.0 0.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.1 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.0 0.7 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.1 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.0 0.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.1 GO:0042117 monocyte activation(GO:0042117)
0.0 0.1 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.2 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.0 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.1 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 1.0 GO:0021766 hippocampus development(GO:0021766)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0032437 cuticular plate(GO:0032437)
0.1 2.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.3 GO:1990130 Iml1 complex(GO:1990130)
0.1 0.5 GO:0030478 actin cap(GO:0030478)
0.0 2.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.3 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.3 0.8 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 0.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 0.7 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 0.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.3 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.1 1.9 GO:0005521 lamin binding(GO:0005521)
0.1 0.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 0.3 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 2.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.5 GO:0071253 connexin binding(GO:0071253)
0.1 0.7 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.1 GO:0016015 morphogen activity(GO:0016015)
0.0 0.1 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.0 1.2 GO:0005179 hormone activity(GO:0005179)
0.0 3.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID_MYC_PATHWAY C-MYC pathway
0.1 2.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 1.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.1 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.1 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation