Motif ID: Foxc2

Z-value: 0.473


Transcription factors associated with Foxc2:

Gene SymbolEntrez IDGene Name
Foxc2 ENSMUSG00000046714.6 Foxc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc2mm10_v2_chr8_+_121116163_1211161770.038.6e-01Click!


Activity profile for motif Foxc2.

activity profile for motif Foxc2


Sorted Z-values histogram for motif Foxc2

Sorted Z-values for motif Foxc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 128 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 3.074 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr9_+_53850243 2.944 ENSMUST00000048485.5
 Sln
sarcolipin
chr4_+_48049080 2.062 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr4_-_87806296 1.803 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr1_-_97977233 1.322 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chr2_+_25180737 1.258 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr2_-_62483637 1.239 ENSMUST00000136686.1
ENSMUST00000102733.3
 Gcg

glucagon

chr17_+_3532554 1.113 ENSMUST00000168560.1
 Cldn20
claudin 20
chr16_+_43363855 1.103 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr12_-_31950170 1.075 ENSMUST00000176520.1
 Hbp1
high mobility group box transcription factor 1
chr12_-_31950210 1.036 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
 Hbp1


high mobility group box transcription factor 1


chr6_+_8520008 0.969 ENSMUST00000162567.1
ENSMUST00000161217.1
 Glcci1

glucocorticoid induced transcript 1

chr16_+_43364145 0.963 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr1_+_177444653 0.952 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr1_-_156034826 0.901 ENSMUST00000141878.1
ENSMUST00000123705.1
 Tor1aip1

torsin A interacting protein 1

chr5_-_111761697 0.875 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr16_-_22439719 0.874 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr13_+_40859768 0.768 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr9_+_70207342 0.758 ENSMUST00000034745.7
 Myo1e
myosin IE
chr13_-_83729544 0.735 ENSMUST00000181705.1
 Gm26803
predicted gene, 26803

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.7 2.9 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.3 2.7 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1 2.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 2.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.7 2.1 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.2 1.9 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 1.3 GO:0009404 toxin metabolic process(GO:0009404)
0.2 1.2 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.1 1.0 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 1.0 GO:0021766 hippocampus development(GO:0021766)
0.2 0.9 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.8 GO:0036438 maintenance of lens transparency(GO:0036438)
0.2 0.7 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.1 0.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.7 GO:0072189 ureter development(GO:0072189)
0.0 0.7 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.2 0.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.6 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.0 0.6 GO:0048268 clathrin coat assembly(GO:0048268)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 2.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.3 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.2 0.8 GO:0032437 cuticular plate(GO:0032437)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.1 0.5 GO:0030478 actin cap(GO:0030478)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.3 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.9 GO:0005521 lamin binding(GO:0005521)
0.4 1.3 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 1.2 GO:0005179 hormone activity(GO:0005179)
0.2 0.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.3 0.8 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 0.7 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 0.7 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 0.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 0.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.5 GO:0071253 connexin binding(GO:0071253)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.3 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.1 0.3 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0031402 sodium ion binding(GO:0031402)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 PID_MYC_PATHWAY C-MYC pathway
0.1 2.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 1.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.1 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.1 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling