Motif ID: Foxd1

Z-value: 1.723


Transcription factors associated with Foxd1:

Gene SymbolEntrez IDGene Name
Foxd1 ENSMUSG00000078302.3 Foxd1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxd1mm10_v2_chr13_+_98354234_98354250-0.335.0e-02Click!


Activity profile for motif Foxd1.

activity profile for motif Foxd1


Sorted Z-values histogram for motif Foxd1

Sorted Z-values for motif Foxd1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_144892813 20.959 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893077 16.964 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 14.653 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_-_8518801 9.989 ENSMUST00000061601.7
Ust
uronyl-2-sulfotransferase
chr16_-_22439719 9.665 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr15_+_3270767 9.566 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1



selenoprotein P, plasma, 1



chr8_-_84773381 8.935 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr18_+_69344503 7.891 ENSMUST00000114985.3
Tcf4
transcription factor 4
chr14_-_18239053 7.884 ENSMUST00000090543.5
Nr1d2
nuclear receptor subfamily 1, group D, member 2
chr7_+_141476374 7.470 ENSMUST00000117634.1
Tspan4
tetraspanin 4
chr16_-_22439570 7.426 ENSMUST00000170393.1
Etv5
ets variant gene 5
chr8_-_46294592 6.905 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr8_+_65618009 6.759 ENSMUST00000110258.1
ENSMUST00000110256.1
ENSMUST00000110255.1
March1


membrane-associated ring finger (C3HC4) 1


chr11_+_3332426 6.565 ENSMUST00000136474.1
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr18_+_5593566 6.256 ENSMUST00000160910.1
Zeb1
zinc finger E-box binding homeobox 1
chr3_+_52268337 6.022 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr3_+_5218546 5.626 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr2_+_38511643 5.381 ENSMUST00000054234.3
ENSMUST00000112902.1
ENSMUST00000112895.1
Nek6


NIMA (never in mitosis gene a)-related expressed kinase 6


chr3_+_5218516 5.205 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr3_+_34649987 5.062 ENSMUST00000099151.2
Sox2
SRY-box containing gene 2
chr2_+_128126030 4.990 ENSMUST00000089634.5
ENSMUST00000019281.7
ENSMUST00000110341.2
ENSMUST00000103211.1
ENSMUST00000103210.1
Bcl2l11




BCL2-like 11 (apoptosis facilitator)




chr7_+_19359740 4.912 ENSMUST00000140836.1
Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr11_+_3330781 4.668 ENSMUST00000136536.1
ENSMUST00000093399.4
Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr1_-_45503282 4.614 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr11_+_3330401 4.566 ENSMUST00000045153.4
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr3_+_96557950 4.521 ENSMUST00000074519.6
ENSMUST00000049093.7
Txnip

thioredoxin interacting protein

chr6_+_30541582 4.511 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr19_+_23141183 4.493 ENSMUST00000036884.1
Klf9
Kruppel-like factor 9
chr1_-_97977233 4.487 ENSMUST00000161567.1
Pam
peptidylglycine alpha-amidating monooxygenase
chr7_-_25788635 4.260 ENSMUST00000002677.4
ENSMUST00000085948.4
Axl

AXL receptor tyrosine kinase

chrX_+_169685191 4.187 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr7_+_113207465 4.144 ENSMUST00000047321.7
Arntl
aryl hydrocarbon receptor nuclear translocator-like
chr3_+_5218589 4.123 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr2_+_19658055 4.115 ENSMUST00000052168.4
Otud1
OTU domain containing 1
chr3_-_52104891 3.815 ENSMUST00000121440.1
Maml3
mastermind like 3 (Drosophila)
chr19_+_4855129 3.791 ENSMUST00000119694.1
Ctsf
cathepsin F
chr6_+_53573364 3.626 ENSMUST00000047450.7
Creb5
cAMP responsive element binding protein 5
chr4_+_136357423 3.575 ENSMUST00000182167.1
Gm17388
predicted gene, 17388
chr7_-_142372210 3.573 ENSMUST00000084412.5
Ifitm10
interferon induced transmembrane protein 10
chr13_-_93499803 3.454 ENSMUST00000065537.7
Jmy
junction-mediating and regulatory protein
chr14_-_55560340 3.384 ENSMUST00000066106.3
A730061H03Rik
RIKEN cDNA A730061H03 gene
chr12_-_100725028 3.359 ENSMUST00000043599.6
Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chrX_+_7722267 3.356 ENSMUST00000125991.1
ENSMUST00000148624.1
Wdr45

WD repeat domain 45

chr1_+_36511867 3.233 ENSMUST00000001166.7
ENSMUST00000097776.3
Cnnm3

cyclin M3

chr7_+_126776939 3.229 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
Ypel3






yippee-like 3 (Drosophila)






chr10_-_18234930 3.206 ENSMUST00000052648.8
ENSMUST00000080860.6
ENSMUST00000173243.1
Ccdc28a


coiled-coil domain containing 28A


chr9_-_60838200 3.127 ENSMUST00000063858.7
Gm9869
predicted gene 9869
chr2_+_4718145 3.108 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr12_-_31950210 3.105 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chrX_+_7722214 3.102 ENSMUST00000043045.2
ENSMUST00000116634.1
ENSMUST00000115689.3
ENSMUST00000131077.1
ENSMUST00000115688.1
ENSMUST00000116633.1
Wdr45





WD repeat domain 45





chr7_-_37773555 3.088 ENSMUST00000176534.1
Zfp536
zinc finger protein 536
chr7_-_37772868 3.028 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr15_+_25752860 3.016 ENSMUST00000022882.5
ENSMUST00000135173.1
Myo10

myosin X

chr11_+_97685794 2.980 ENSMUST00000107584.1
ENSMUST00000107585.2
Cisd3

CDGSH iron sulfur domain 3

chrX_+_101254528 2.978 ENSMUST00000062000.4
Foxo4
forkhead box O4
chr12_-_31950170 2.871 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr13_-_103920295 2.849 ENSMUST00000169083.1
Erbb2ip
Erbb2 interacting protein
chr2_+_181837854 2.840 ENSMUST00000029116.7
ENSMUST00000108754.1
Pcmtd2

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

chr1_-_64956807 2.825 ENSMUST00000097713.1
Plekhm3
pleckstrin homology domain containing, family M, member 3
chr11_-_101226414 2.776 ENSMUST00000100417.2
ENSMUST00000107285.1
ENSMUST00000107284.1
Ezh1


enhancer of zeste homolog 1 (Drosophila)


chr10_-_93310963 2.738 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr12_+_35047180 2.728 ENSMUST00000048519.9
ENSMUST00000163677.1
Snx13

sorting nexin 13

chr4_+_133130505 2.698 ENSMUST00000084241.5
ENSMUST00000138831.1
Wasf2

WAS protein family, member 2

chr2_-_73312701 2.683 ENSMUST00000058615.9
Cir1
corepressor interacting with RBPJ, 1
chr11_+_74619594 2.674 ENSMUST00000100866.2
E130309D14Rik
RIKEN cDNA E130309D14 gene
chr16_+_20097554 2.672 ENSMUST00000023509.3
Klhl24
kelch-like 24
chr15_-_58214882 2.629 ENSMUST00000022986.6
Fbxo32
F-box protein 32
chr8_-_119558718 2.614 ENSMUST00000081381.4
ENSMUST00000098362.3
Mbtps1

membrane-bound transcription factor peptidase, site 1

chr7_-_80402743 2.595 ENSMUST00000122232.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr10_-_26373956 2.578 ENSMUST00000105519.3
ENSMUST00000040219.6
L3mbtl3

l(3)mbt-like 3 (Drosophila)

chr15_+_97784355 2.572 ENSMUST00000117892.1
Slc48a1
solute carrier family 48 (heme transporter), member 1
chr7_-_44849075 2.533 ENSMUST00000047085.8
Tbc1d17
TBC1 domain family, member 17
chr9_+_45370185 2.484 ENSMUST00000085939.6
Fxyd6
FXYD domain-containing ion transport regulator 6
chr13_+_75089826 2.454 ENSMUST00000022075.4
Pcsk1
proprotein convertase subtilisin/kexin type 1
chr13_+_80886095 2.426 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr2_-_60125651 2.400 ENSMUST00000112550.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr10_-_93311073 2.365 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr6_-_39557830 2.337 ENSMUST00000036877.3
ENSMUST00000154149.1
Dennd2a

DENN/MADD domain containing 2A

chr5_-_138170992 2.324 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr1_-_64956731 2.312 ENSMUST00000123225.1
Plekhm3
pleckstrin homology domain containing, family M, member 3
chr2_-_51972990 2.238 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr16_-_74411292 2.218 ENSMUST00000117200.1
Robo2
roundabout homolog 2 (Drosophila)
chr13_-_98815408 2.193 ENSMUST00000040340.8
ENSMUST00000099277.4
ENSMUST00000179563.1
ENSMUST00000109403.1
Fcho2



FCH domain only 2



chr6_+_15185203 2.178 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr19_+_26750939 2.176 ENSMUST00000175953.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr16_+_24448082 2.128 ENSMUST00000078988.2
Lpp
LIM domain containing preferred translocation partner in lipoma
chr12_-_84450944 2.123 ENSMUST00000085192.5
Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr14_+_54259227 2.041 ENSMUST00000041197.7
Abhd4
abhydrolase domain containing 4
chr6_-_5496296 2.019 ENSMUST00000019721.4
Pdk4
pyruvate dehydrogenase kinase, isoenzyme 4
chr13_-_52929458 2.000 ENSMUST00000123599.1
Auh
AU RNA binding protein/enoyl-coenzyme A hydratase
chr3_-_146770218 1.967 ENSMUST00000106137.1
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr10_+_60106452 1.903 ENSMUST00000165024.2
Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr14_+_55560480 1.883 ENSMUST00000121622.1
ENSMUST00000143431.1
ENSMUST00000150481.1
Dcaf11


DDB1 and CUL4 associated factor 11


chr5_+_107437908 1.871 ENSMUST00000094541.2
Btbd8
BTB (POZ) domain containing 8
chr6_+_134830145 1.869 ENSMUST00000046303.5
Crebl2
cAMP responsive element binding protein-like 2
chr5_+_3928033 1.864 ENSMUST00000143365.1
Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr9_+_96196246 1.802 ENSMUST00000165120.2
ENSMUST00000034982.9
Tfdp2

transcription factor Dp 2

chr5_-_138171248 1.800 ENSMUST00000153867.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr18_+_9707639 1.790 ENSMUST00000040069.8
Colec12
collectin sub-family member 12
chr5_+_31048627 1.787 ENSMUST00000013766.6
ENSMUST00000173215.1
ENSMUST00000153643.1
ENSMUST00000114659.2
Atraid



all-trans retinoic acid induced differentiation factor



chr14_+_55560904 1.759 ENSMUST00000072530.4
ENSMUST00000128490.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr12_+_71016658 1.740 ENSMUST00000125125.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr6_+_34598530 1.658 ENSMUST00000115027.1
ENSMUST00000115026.1
Cald1

caldesmon 1

chr10_+_96616998 1.649 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr12_-_31950535 1.596 ENSMUST00000172314.2
Hbp1
high mobility group box transcription factor 1
chr1_+_12718496 1.587 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr6_+_34598500 1.567 ENSMUST00000079391.3
ENSMUST00000142512.1
Cald1

caldesmon 1

chr7_+_24907618 1.564 ENSMUST00000151121.1
Arhgef1
Rho guanine nucleotide exchange factor (GEF) 1
chr2_-_51973219 1.553 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chr1_-_179546261 1.551 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chr11_-_86993682 1.534 ENSMUST00000018571.4
Ypel2
yippee-like 2 (Drosophila)
chr5_+_3928267 1.533 ENSMUST00000044492.8
Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr2_+_52072823 1.519 ENSMUST00000112693.2
ENSMUST00000069794.5
Rif1

Rap1 interacting factor 1 homolog (yeast)

chr9_+_110333402 1.503 ENSMUST00000133114.1
ENSMUST00000125759.1
Scap

SREBF chaperone

chr14_+_55561060 1.492 ENSMUST00000117701.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr6_+_92940572 1.489 ENSMUST00000181145.1
ENSMUST00000181840.1
9530026P05Rik

RIKEN cDNA 9530026P05 gene

chr2_+_24976033 1.473 ENSMUST00000045295.7
ENSMUST00000153618.1
ENSMUST00000152777.1
Pnpla7


patatin-like phospholipase domain containing 7


chr7_+_44849581 1.472 ENSMUST00000150335.1
ENSMUST00000107882.1
Akt1s1

AKT1 substrate 1 (proline-rich)

chr3_+_53488677 1.439 ENSMUST00000029307.3
Stoml3
stomatin (Epb7.2)-like 3
chr5_-_31048014 1.437 ENSMUST00000137223.1
Slc5a6
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
chr1_-_195131536 1.427 ENSMUST00000075451.6
Cr1l
complement component (3b/4b) receptor 1-like
chr7_-_133782721 1.418 ENSMUST00000063669.1
Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr14_+_64589802 1.390 ENSMUST00000180610.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr11_+_97685903 1.388 ENSMUST00000107583.2
Cisd3
CDGSH iron sulfur domain 3
chr6_+_135362931 1.375 ENSMUST00000032330.9
Emp1
epithelial membrane protein 1
chr18_-_34624562 1.361 ENSMUST00000003876.3
ENSMUST00000115766.1
ENSMUST00000097626.3
ENSMUST00000115765.1
Brd8



bromodomain containing 8



chr19_-_41848076 1.329 ENSMUST00000059231.2
Frat2
frequently rearranged in advanced T cell lymphomas 2
chr6_-_39725193 1.317 ENSMUST00000101497.3
Braf
Braf transforming gene
chr4_+_11191726 1.297 ENSMUST00000029866.9
ENSMUST00000108324.3
Ccne2

cyclin E2

chr16_-_4880284 1.273 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr11_+_114851142 1.231 ENSMUST00000133245.1
ENSMUST00000122967.2
Gprc5c

G protein-coupled receptor, family C, group 5, member C

chr15_-_96460838 1.225 ENSMUST00000047835.6
Scaf11
SR-related CTD-associated factor 11
chr3_+_90254163 1.220 ENSMUST00000029545.8
Crtc2
CREB regulated transcription coactivator 2
chr6_-_88874597 1.218 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
Podxl2


podocalyxin-like 2


chr19_+_29101375 1.193 ENSMUST00000064393.5
Rcl1
RNA terminal phosphate cyclase-like 1
chr5_+_142629537 1.153 ENSMUST00000036872.9
ENSMUST00000110778.1
Wipi2

WD repeat domain, phosphoinositide interacting 2

chr15_-_53346118 1.136 ENSMUST00000077273.2
Ext1
exostoses (multiple) 1
chr15_+_79347534 1.120 ENSMUST00000096350.3
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr5_-_138171216 1.116 ENSMUST00000147920.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr6_+_134830216 1.069 ENSMUST00000111937.1
Crebl2
cAMP responsive element binding protein-like 2
chr11_-_106920359 1.057 ENSMUST00000167787.1
ENSMUST00000092517.2
Smurf2

SMAD specific E3 ubiquitin protein ligase 2

chr9_-_45955170 1.029 ENSMUST00000162072.1
Sidt2
SID1 transmembrane family, member 2
chr5_-_142817387 1.023 ENSMUST00000036253.6
Tnrc18
trinucleotide repeat containing 18
chr18_-_39489776 1.020 ENSMUST00000025300.6
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr4_+_94739276 0.988 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek

endothelial-specific receptor tyrosine kinase

chr11_+_54438188 0.986 ENSMUST00000046835.7
Fnip1
folliculin interacting protein 1
chr2_+_112265809 0.953 ENSMUST00000110991.2
Slc12a6
solute carrier family 12, member 6
chrX_+_35888808 0.937 ENSMUST00000033419.6
Dock11
dedicator of cytokinesis 11
chrX_+_68678541 0.926 ENSMUST00000088546.5
Fmr1
fragile X mental retardation syndrome 1
chr2_+_28641227 0.900 ENSMUST00000028155.5
ENSMUST00000113869.1
ENSMUST00000113867.2
Tsc1


tuberous sclerosis 1


chrX_+_42149288 0.891 ENSMUST00000115073.2
ENSMUST00000115072.1
Stag2

stromal antigen 2

chr5_-_142817654 0.879 ENSMUST00000151477.1
Tnrc18
trinucleotide repeat containing 18
chr6_-_87809757 0.860 ENSMUST00000032134.7
Rab43
RAB43, member RAS oncogene family
chr6_-_13677930 0.835 ENSMUST00000045235.5
B630005N14Rik
RIKEN cDNA B630005N14 gene
chr11_+_90030295 0.831 ENSMUST00000092788.3
Tmem100
transmembrane protein 100
chr7_+_82175156 0.830 ENSMUST00000180243.1
Sh3gl3
SH3-domain GRB2-like 3
chr5_+_21372642 0.828 ENSMUST00000035799.5
Fgl2
fibrinogen-like protein 2
chr15_+_99393219 0.828 ENSMUST00000159209.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr4_+_11191354 0.818 ENSMUST00000170901.1
Ccne2
cyclin E2
chr6_-_88874045 0.817 ENSMUST00000038409.5
Podxl2
podocalyxin-like 2
chrX_-_140543177 0.807 ENSMUST00000055738.5
Tsc22d3
TSC22 domain family, member 3
chr2_+_26973416 0.806 ENSMUST00000014996.7
ENSMUST00000102891.3
Adamts13

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

chr15_+_89059712 0.797 ENSMUST00000161372.1
ENSMUST00000162424.1
Panx2

pannexin 2

chr11_-_102556122 0.786 ENSMUST00000143842.1
Gpatch8
G patch domain containing 8
chr5_-_31047998 0.778 ENSMUST00000114665.1
ENSMUST00000006817.4
Slc5a6

solute carrier family 5 (sodium-dependent vitamin transporter), member 6

chr5_+_28165690 0.763 ENSMUST00000036177.7
En2
engrailed 2
chr1_+_106171752 0.762 ENSMUST00000061047.6
Phlpp1
PH domain and leucine rich repeat protein phosphatase 1
chr19_+_42090422 0.761 ENSMUST00000066778.4
Pi4k2a
phosphatidylinositol 4-kinase type 2 alpha
chr16_-_4559720 0.754 ENSMUST00000005862.7
Tfap4
transcription factor AP4
chr3_+_118430299 0.745 ENSMUST00000180774.1
Gm26871
predicted gene, 26871
chr2_-_104028287 0.745 ENSMUST00000056170.3
4931422A03Rik
RIKEN cDNA 4931422A03 gene
chr5_+_139389785 0.736 ENSMUST00000100514.2
Gpr146
G protein-coupled receptor 146
chr14_-_68655804 0.731 ENSMUST00000111072.1
ENSMUST00000022642.5
Adam28

a disintegrin and metallopeptidase domain 28

chr6_+_124916863 0.730 ENSMUST00000069553.2
A230083G16Rik
RIKEN cDNA A230083G16 gene
chr4_-_59549243 0.725 ENSMUST00000173699.1
ENSMUST00000173884.1
ENSMUST00000102883.4
ENSMUST00000174586.1
Ptbp3



polypyrimidine tract binding protein 3



chrX_+_68678624 0.715 ENSMUST00000114656.1
Fmr1
fragile X mental retardation syndrome 1
chr13_+_118714678 0.706 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chr2_+_112284561 0.700 ENSMUST00000053666.7
Slc12a6
solute carrier family 12, member 6
chr12_+_4133394 0.697 ENSMUST00000152065.1
ENSMUST00000127756.1
Adcy3

adenylate cyclase 3

chr4_-_154160632 0.696 ENSMUST00000105639.3
ENSMUST00000030896.8
Tprgl

transformation related protein 63 regulated like

chrX_+_68678712 0.690 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
Fmr1



fragile X mental retardation syndrome 1



chr14_-_70766598 0.671 ENSMUST00000167242.1
ENSMUST00000022696.6
Xpo7

exportin 7

chr10_+_29211637 0.661 ENSMUST00000092627.4
9330159F19Rik
RIKEN cDNA 9330159F19 gene
chr6_+_29853746 0.651 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
Ahcyl2



S-adenosylhomocysteine hydrolase-like 2



chr17_+_47505117 0.625 ENSMUST00000183044.1
ENSMUST00000037333.10
Ccnd3

cyclin D3

chr15_+_79348061 0.617 ENSMUST00000163691.1
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr2_+_164486455 0.611 ENSMUST00000069385.8
ENSMUST00000143690.1
Dbndd2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr11_+_85353156 0.607 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
Bcas3





breast carcinoma amplified sequence 3





chr5_-_122988533 0.600 ENSMUST00000086200.4
ENSMUST00000156474.1
Kdm2b

lysine (K)-specific demethylase 2B

chr8_+_20136455 0.600 ENSMUST00000179299.1
ENSMUST00000096485.4
Gm21811

predicted gene, 21811

chr9_-_45955226 0.599 ENSMUST00000038488.9
Sidt2
SID1 transmembrane family, member 2
chr2_-_27475622 0.592 ENSMUST00000138693.1
ENSMUST00000113941.2
ENSMUST00000077737.6
Brd3


bromodomain containing 3


chr15_-_97831460 0.590 ENSMUST00000079838.7
ENSMUST00000118294.1
Hdac7

histone deacetylase 7

chr13_+_104178797 0.587 ENSMUST00000022225.5
ENSMUST00000069187.5
Trim23

tripartite motif-containing 23

chr19_+_53329413 0.584 ENSMUST00000025998.7
Mxi1
Max interacting protein 1
chr12_-_86079019 0.582 ENSMUST00000003687.6
Tgfb3
transforming growth factor, beta 3
chrX_+_42149534 0.581 ENSMUST00000127618.1
Stag2
stromal antigen 2
chr12_-_85270564 0.580 ENSMUST00000019378.6
ENSMUST00000166821.1
Mlh3

mutL homolog 3 (E coli)

chr18_-_43059418 0.570 ENSMUST00000025377.7
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr3_+_32436376 0.564 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 52.6 GO:0042572 retinol metabolic process(GO:0042572)
3.4 17.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
2.3 15.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.5 4.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.4 4.3 GO:0097350 neutrophil clearance(GO:0097350)
1.4 4.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
1.3 3.8 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
1.2 5.0 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
1.1 3.4 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.9 4.5 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.9 2.7 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.9 2.6 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.9 3.5 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.9 2.6 GO:0015886 heme transport(GO:0015886)
0.8 7.6 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.8 2.4 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.8 2.3 GO:0099547 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
0.8 7.0 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.7 3.0 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.7 2.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.7 5.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.7 7.9 GO:0042118 endothelial cell activation(GO:0042118)
0.7 2.1 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.6 2.6 GO:0090472 dibasic protein processing(GO:0090472)
0.6 3.2 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.6 2.2 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.5 6.0 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.5 7.6 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.5 5.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.5 2.0 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.5 8.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.5 4.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.4 8.1 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.4 3.8 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.4 2.1 GO:0033227 dsRNA transport(GO:0033227)
0.4 1.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.4 1.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.4 6.5 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.4 1.8 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.4 6.8 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.3 1.6 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.3 1.0 GO:0048014 Tie signaling pathway(GO:0048014)
0.3 2.8 GO:0097421 liver regeneration(GO:0097421)
0.3 3.4 GO:0009404 toxin metabolic process(GO:0009404)
0.3 1.5 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.3 0.9 GO:0043379 rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.3 1.7 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.3 1.4 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.3 0.9 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.3 0.8 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.3 1.3 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.3 4.9 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.3 1.3 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.3 0.8 GO:0045575 basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575)
0.2 1.2 GO:0021993 initiation of neural tube closure(GO:0021993)
0.2 2.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 1.2 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.2 1.7 GO:0035826 rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476)
0.2 3.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.2 1.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 1.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.2 1.4 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.2 3.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.2 0.6 GO:1904706 detection of oxygen(GO:0003032) negative regulation of macrophage cytokine production(GO:0010936) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.2 1.6 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.2 1.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.2 2.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 0.6 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.2 0.6 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.2 2.0 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.2 1.8 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.2 0.7 GO:0008355 olfactory learning(GO:0008355)
0.2 1.0 GO:2000973 regulation of pro-B cell differentiation(GO:2000973)
0.2 2.5 GO:0016486 peptide hormone processing(GO:0016486)
0.2 2.5 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.2 0.8 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) negative regulation of protein kinase C signaling(GO:0090038)
0.2 4.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 1.5 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 5.4 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.1 0.4 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 2.7 GO:0035855 megakaryocyte development(GO:0035855)
0.1 2.0 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 1.7 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 0.9 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 1.2 GO:0043970 histone H3-K9 acetylation(GO:0043970)
0.1 1.7 GO:0045792 negative regulation of cell size(GO:0045792)
0.1 0.6 GO:0007144 female meiosis I(GO:0007144)
0.1 0.8 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 1.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 0.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.4 GO:0032060 bleb assembly(GO:0032060)
0.1 0.8 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 0.5 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.1 2.1 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.3 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.1 1.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 4.5 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 3.2 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.1 1.5 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 3.6 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 2.9 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 4.9 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 1.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.6 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.6 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 2.5 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.8 GO:1990403 embryonic brain development(GO:1990403)
0.0 6.4 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 1.8 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.2 GO:0034239 regulation of macrophage fusion(GO:0034239)
0.0 2.6 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.8 GO:0019835 cytolysis(GO:0019835)
0.0 0.4 GO:0042659 regulation of cell fate specification(GO:0042659)
0.0 0.7 GO:0055012 ventricular cardiac muscle cell differentiation(GO:0055012)
0.0 0.1 GO:0010616 negative regulation of cardiac muscle adaptation(GO:0010616)
0.0 0.5 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.8 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.8 GO:0002931 response to ischemia(GO:0002931)
0.0 1.5 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.6 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.2 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.1 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.0 0.3 GO:0001569 patterning of blood vessels(GO:0001569)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0005588 collagen type V trimer(GO:0005588)
0.8 3.4 GO:0044307 dendritic branch(GO:0044307)
0.7 2.2 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.7 2.1 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.6 2.3 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.5 4.1 GO:0033391 chromatoid body(GO:0033391)
0.5 7.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.5 5.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.4 1.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.4 3.2 GO:0030478 actin cap(GO:0030478)
0.3 5.2 GO:0042555 MCM complex(GO:0042555)
0.3 0.9 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.2 1.5 GO:0001940 male pronucleus(GO:0001940)
0.2 4.5 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.2 6.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 2.7 GO:0031209 SCAR complex(GO:0031209)
0.2 2.7 GO:0030057 desmosome(GO:0030057)
0.2 2.6 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.2 1.7 GO:0031931 TORC1 complex(GO:0031931)
0.2 2.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 5.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 1.4 GO:0000812 Swr1 complex(GO:0000812)
0.1 2.2 GO:0071564 npBAF complex(GO:0071564)
0.1 2.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.5 GO:0000798 nuclear cohesin complex(GO:0000798)
0.1 4.9 GO:0045171 intercellular bridge(GO:0045171)
0.1 4.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.6 GO:0032300 mismatch repair complex(GO:0032300)
0.1 4.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 27.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 1.2 GO:0031519 PcG protein complex(GO:0031519)
0.1 2.2 GO:0030673 axolemma(GO:0030673)
0.1 3.9 GO:0030667 secretory granule membrane(GO:0030667)
0.1 0.5 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 17.4 GO:0016607 nuclear speck(GO:0016607)
0.0 0.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 3.0 GO:0016459 myosin complex(GO:0016459)
0.0 2.4 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.6 GO:0030315 T-tubule(GO:0030315)
0.0 0.8 GO:0005921 gap junction(GO:0005921)
0.0 2.2 GO:0031526 brush border membrane(GO:0031526)
0.0 2.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 6.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 1.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.7 GO:0005925 focal adhesion(GO:0005925)
0.0 1.4 GO:0005795 Golgi stack(GO:0005795)
0.0 0.9 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 2.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 43.5 GO:0016021 integral component of membrane(GO:0016021)
0.0 2.7 GO:0031252 cell leading edge(GO:0031252)
0.0 5.1 GO:0005813 centrosome(GO:0005813)
0.0 0.7 GO:0005643 nuclear pore(GO:0005643)
0.0 1.5 GO:0000775 chromosome, centromeric region(GO:0000775)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 52.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
5.3 15.8 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
2.0 7.9 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.5 4.5 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
1.3 5.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
1.0 6.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.9 2.6 GO:0015232 heme transporter activity(GO:0015232)
0.6 2.8 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.5 2.1 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.5 6.1 GO:0070888 E-box binding(GO:0070888)
0.5 2.0 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.4 4.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.4 1.2 GO:0005118 sevenless binding(GO:0005118)
0.4 1.2 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.4 2.8 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.4 7.4 GO:0035198 miRNA binding(GO:0035198)
0.4 1.6 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.4 4.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.4 5.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 1.3 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.3 1.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 7.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.3 3.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.3 0.8 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.3 4.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 2.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 1.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 1.4 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.2 1.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 2.6 GO:0048406 nerve growth factor binding(GO:0048406)
0.2 5.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 0.6 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.2 2.2 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.2 1.8 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.2 6.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 2.5 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.2 0.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.2 1.0 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.2 5.0 GO:0070840 dynein complex binding(GO:0070840)
0.2 4.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 0.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 3.5 GO:0042287 MHC protein binding(GO:0042287)
0.1 0.6 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 1.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 4.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.8 GO:0043426 MRF binding(GO:0043426)
0.1 5.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 2.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 0.7 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886) thyroid hormone receptor coactivator activity(GO:0030375)
0.1 0.7 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 1.5 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 7.5 GO:0003823 antigen binding(GO:0003823)
0.1 3.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.7 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 2.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.1 0.8 GO:0005243 gap junction channel activity(GO:0005243)
0.1 2.4 GO:0031690 adrenergic receptor binding(GO:0031690)
0.1 5.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.7 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 1.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 2.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 2.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 4.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 3.0 GO:0030507 spectrin binding(GO:0030507)
0.1 3.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 2.1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 1.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.7 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 3.8 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 1.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 5.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.5 GO:0032934 cholesterol binding(GO:0015485) sterol binding(GO:0032934)
0.0 1.7 GO:0000975 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
0.0 0.1 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.0 1.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 10.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 5.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 2.8 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 4.8 GO:0045296 cadherin binding(GO:0045296)
0.0 1.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.6 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 54.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.6 17.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.4 9.0 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.3 7.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.3 5.0 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3 4.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 2.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.8 PID_ATR_PATHWAY ATR signaling pathway
0.1 4.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 6.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 4.6 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.1 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 1.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 1.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 4.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.6 PID_FOXO_PATHWAY FoxO family signaling
0.1 4.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 5.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.8 PID_E2F_PATHWAY E2F transcription factor network
0.1 2.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.7 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 1.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.0 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 0.2 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 2.6 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.8 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 7.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 3.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.7 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.7 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.6 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.4 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.5 PID_BMP_PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.5 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.4 2.5 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.3 5.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 2.6 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.3 11.5 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 3.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 2.6 REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.2 4.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 7.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 10.0 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.2 2.0 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 4.1 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras
0.1 3.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 7.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.1 REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.1 3.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 4.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.3 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 0.9 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 3.4 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 0.9 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 3.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 2.2 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 0.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 0.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.7 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 3.8 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.1 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 2.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.6 REACTOME_MEIOSIS Genes involved in Meiosis
0.0 0.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling