Motif ID: Foxd1

Z-value: 1.723


Transcription factors associated with Foxd1:

Gene SymbolEntrez IDGene Name
Foxd1 ENSMUSG00000078302.3 Foxd1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxd1mm10_v2_chr13_+_98354234_98354250-0.335.0e-02Click!


Activity profile for motif Foxd1.

activity profile for motif Foxd1


Sorted Z-values histogram for motif Foxd1

Sorted Z-values for motif Foxd1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 20.959 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893077 16.964 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 14.653 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_-_8518801 9.989 ENSMUST00000061601.7
 Ust
uronyl-2-sulfotransferase
chr16_-_22439719 9.665 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr15_+_3270767 9.566 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr8_-_84773381 8.935 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr18_+_69344503 7.891 ENSMUST00000114985.3
 Tcf4
transcription factor 4
chr14_-_18239053 7.884 ENSMUST00000090543.5
 Nr1d2
nuclear receptor subfamily 1, group D, member 2
chr7_+_141476374 7.470 ENSMUST00000117634.1
 Tspan4
tetraspanin 4
chr16_-_22439570 7.426 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr8_-_46294592 6.905 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr8_+_65618009 6.759 ENSMUST00000110258.1
ENSMUST00000110256.1
ENSMUST00000110255.1
 March1


membrane-associated ring finger (C3HC4) 1


chr11_+_3332426 6.565 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr18_+_5593566 6.256 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr3_+_52268337 6.022 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr3_+_5218546 5.626 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr2_+_38511643 5.381 ENSMUST00000054234.3
ENSMUST00000112902.1
ENSMUST00000112895.1
 Nek6


NIMA (never in mitosis gene a)-related expressed kinase 6


chr3_+_5218516 5.205 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr3_+_34649987 5.062 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.8 52.6 GO:0042572 retinol metabolic process(GO:0042572)
3.4 17.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
2.3 15.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.5 8.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 8.1 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.7 7.9 GO:0042118 endothelial cell activation(GO:0042118)
0.8 7.6 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.5 7.6 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.8 7.0 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.4 6.8 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.4 6.5 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.0 6.4 GO:0030010 establishment of cell polarity(GO:0030010)
0.5 6.0 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.1 5.4 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.5 5.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.7 5.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.2 5.0 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.3 4.9 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.1 4.9 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
1.5 4.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 43.5 GO:0016021 integral component of membrane(GO:0016021)
0.1 27.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 17.4 GO:0016607 nuclear speck(GO:0016607)
0.5 7.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 6.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 6.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 5.2 GO:0042555 MCM complex(GO:0042555)
0.1 5.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 5.1 GO:0005813 centrosome(GO:0005813)
0.5 5.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 4.9 GO:0045171 intercellular bridge(GO:0045171)
0.1 4.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
1.5 4.6 GO:0005588 collagen type V trimer(GO:0005588)
0.2 4.5 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.1 4.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.5 4.1 GO:0033391 chromatoid body(GO:0033391)
0.1 3.9 GO:0030667 secretory granule membrane(GO:0030667)
0.0 3.7 GO:0005925 focal adhesion(GO:0005925)
0.8 3.4 GO:0044307 dendritic branch(GO:0044307)
0.4 3.2 GO:0030478 actin cap(GO:0030478)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.5 52.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
5.3 15.8 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 10.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
2.0 7.9 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 7.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 7.5 GO:0003823 antigen binding(GO:0003823)
0.4 7.4 GO:0035198 miRNA binding(GO:0035198)
1.0 6.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.5 6.1 GO:0070888 E-box binding(GO:0070888)
0.2 6.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.4 5.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 5.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2 5.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 5.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 5.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.3 5.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 5.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 5.0 GO:0070840 dynein complex binding(GO:0070840)
0.0 4.8 GO:0045296 cadherin binding(GO:0045296)
0.1 4.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 54.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.6 17.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.4 9.0 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.3 7.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 7.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 6.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 5.8 PID_ATR_PATHWAY ATR signaling pathway
0.1 5.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 5.0 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 4.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 4.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 4.6 NABA_COLLAGENS Genes encoding collagen proteins
0.1 4.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 4.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 3.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 3.1 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 2.7 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.6 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.2 2.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.5 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 10.0 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.2 7.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 7.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 5.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 4.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.6 4.5 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 4.1 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 4.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 3.8 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 3.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 3.4 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 3.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 3.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 2.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.3 2.6 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 2.6 REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.4 2.5 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.1 2.2 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor