Motif ID: Foxd2

Z-value: 0.680


Transcription factors associated with Foxd2:

Gene SymbolEntrez IDGene Name
Foxd2 ENSMUSG00000055210.3 Foxd2



Activity profile for motif Foxd2.

activity profile for motif Foxd2


Sorted Z-values histogram for motif Foxd2

Sorted Z-values for motif Foxd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd2

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_101840602 6.538 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr14_+_101840501 5.931 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr5_-_104114088 4.595 ENSMUST00000031249.3
 Sparcl1
SPARC-like 1
chr18_+_37504264 4.377 ENSMUST00000052179.6
 Pcdhb20
protocadherin beta 20
chr4_-_136898803 4.348 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr4_-_14621805 3.937 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr15_+_3270767 3.668 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr18_+_51117754 3.663 ENSMUST00000116639.2
 Prr16
proline rich 16
chr13_+_16014457 3.335 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr14_+_80000292 2.807 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr15_+_92597104 2.799 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr14_-_30353468 2.755 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr9_-_20879718 2.040 ENSMUST00000043726.6
 Angptl6
angiopoietin-like 6
chr18_+_37513652 2.037 ENSMUST00000061405.4
 Pcdhb21
protocadherin beta 21
chr4_-_14621669 1.969 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr16_+_43508118 1.958 ENSMUST00000114690.1
 Zbtb20
zinc finger and BTB domain containing 20
chr2_-_45110336 1.950 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr3_+_89520152 1.934 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr19_+_26748268 1.933 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
 Smarca2




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2




chr6_+_77242644 1.797 ENSMUST00000159616.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.4 GO:0007416 synapse assembly(GO:0007416)
0.8 5.9 GO:0019532 oxalate transport(GO:0019532)
0.2 3.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 3.7 GO:0045793 positive regulation of cell size(GO:0045793)
0.7 3.3 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 3.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.8 3.1 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.1 3.1 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.7 2.8 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 2.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.3 1.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 1.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 1.9 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 1.8 GO:0046541 saliva secretion(GO:0046541)
0.0 1.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.3 1.6 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2 1.6 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.2 1.2 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.1 1.2 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 1.1 GO:0046825 regulation of protein export from nucleus(GO:0046825)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 6.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 4.3 GO:0005581 collagen trimer(GO:0005581)
1.1 3.3 GO:0043512 inhibin A complex(GO:0043512)
0.8 3.1 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0 3.0 GO:0030426 growth cone(GO:0030426)
0.3 2.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 2.8 GO:0042581 specific granule(GO:0042581)
0.0 2.4 GO:0030141 secretory granule(GO:0030141)
0.1 1.9 GO:0071564 npBAF complex(GO:0071564)
0.0 1.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.8 GO:0043034 costamere(GO:0043034)
0.1 1.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.5 1.6 GO:0045160 myosin I complex(GO:0045160)
0.0 1.6 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.6 GO:0031528 microvillus membrane(GO:0031528)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.2 GO:0042805 actinin binding(GO:0042805)
0.5 5.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 4.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.6 3.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 3.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 3.1 GO:0015616 DNA translocase activity(GO:0015616)
0.5 1.9 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 1.9 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 1.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 1.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 1.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 1.1 GO:0005521 lamin binding(GO:0005521)
0.1 0.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 0.7 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.6 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.6 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.3 PID_ALK1_PATHWAY ALK1 signaling events
0.0 3.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.1 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.7 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.6 3.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.8 3.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 1.9 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 1.6 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.3 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 0.8 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.8 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.7 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 0.6 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 0.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 0.4 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.3 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects